From Brazil:
Elevated adipokines and myokines are associated with fatigue in #longCOVID patients
www.frontiersin.org/journals/med...
"This study offers a novel perspective on the interplay between critical illness, muscle metabolism, & persistent fatigue in postCOVID patients”
#PASC #PostCovid
Elevated adipokines and myokines are associated with fatigue in #longCOVID patients
www.frontiersin.org/journals/med...
"This study offers a novel perspective on the interplay between critical illness, muscle metabolism, & persistent fatigue in postCOVID patients”
#PASC #PostCovid
Frontiers | Elevated adipokines and myokines are associated with fatigue in long COVID patients
BackgroundPersistent fatigue is one of the most common and debilitating symptoms experienced by patients recovering from COVID-19, contributing significantly...
www.frontiersin.org
May 25, 2025 at 4:43 PM
From Brazil:
Elevated adipokines and myokines are associated with fatigue in #longCOVID patients
www.frontiersin.org/journals/med...
"This study offers a novel perspective on the interplay between critical illness, muscle metabolism, & persistent fatigue in postCOVID patients”
#PASC #PostCovid
Elevated adipokines and myokines are associated with fatigue in #longCOVID patients
www.frontiersin.org/journals/med...
"This study offers a novel perspective on the interplay between critical illness, muscle metabolism, & persistent fatigue in postCOVID patients”
#PASC #PostCovid
Adipokines like #ANGPTL2, #FGF21, and #Osteopontin are pivotal in #HeartFailure pathogenesis, offering potential for advanced #Biomarkers in prediction, diagnosis, and prognosis.
#openaccess: cvia-journal.org/adipokines-p...
#Cardiology #MedicalResearch #HealthInnovation @scienceopen.bsky.social
#openaccess: cvia-journal.org/adipokines-p...
#Cardiology #MedicalResearch #HealthInnovation @scienceopen.bsky.social
Adipokines Pathogenesis in Heart Failure
Explore the role of adipokines in heart failure pathogenesis, including ANGPTL2, FGF21, and osteopontin, and their impact on prediction, diagnosis, and prognosis.
cvia-journal.org
January 21, 2025 at 6:04 AM
Adipokines like #ANGPTL2, #FGF21, and #Osteopontin are pivotal in #HeartFailure pathogenesis, offering potential for advanced #Biomarkers in prediction, diagnosis, and prognosis.
#openaccess: cvia-journal.org/adipokines-p...
#Cardiology #MedicalResearch #HealthInnovation @scienceopen.bsky.social
#openaccess: cvia-journal.org/adipokines-p...
#Cardiology #MedicalResearch #HealthInnovation @scienceopen.bsky.social
• Gum disease doesn't just stay in your mouth. It triggers body-wide inflammation through adipokines, causes neutrophil dysfunction, and creates advanced glycation end-products that worsen insulin resistance.
October 1, 2026 at 2:09 PM
• Gum disease doesn't just stay in your mouth. It triggers body-wide inflammation through adipokines, causes neutrophil dysfunction, and creates advanced glycation end-products that worsen insulin resistance.
Inter-organ communication in Drosophila: Lipoproteins, adipokines, and immune-metabolic coordination
#Drosophila
#Drosophila
Inter-organ communication in Drosophila: Lipoproteins, adipokines, and immune-metabolic coordination
#Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
April 6, 2025 at 9:23 AM
Inter-organ communication in Drosophila: Lipoproteins, adipokines, and immune-metabolic coordination
#Drosophila
#Drosophila
ok🤯
[lower] adiponectin significantly predicted ketamine’s antidepressant efficacy, suggesting an adverse metabolic state
…adiponectin significantly improves insulin sensitivity & is potently anti-inflammatory[, suggesting] specific systemic abnormalities [to] predict positive response to ketamine
[lower] adiponectin significantly predicted ketamine’s antidepressant efficacy, suggesting an adverse metabolic state
…adiponectin significantly improves insulin sensitivity & is potently anti-inflammatory[, suggesting] specific systemic abnormalities [to] predict positive response to ketamine
The role of adipokines in the rapid antidepressant effects of ketamine - Molecular Psychiatry
Molecular Psychiatry - The role of adipokines in the rapid antidepressant effects of ketamine
www.nature.com
June 19, 2024 at 6:28 PM
ok🤯
[lower] adiponectin significantly predicted ketamine’s antidepressant efficacy, suggesting an adverse metabolic state
…adiponectin significantly improves insulin sensitivity & is potently anti-inflammatory[, suggesting] specific systemic abnormalities [to] predict positive response to ketamine
[lower] adiponectin significantly predicted ketamine’s antidepressant efficacy, suggesting an adverse metabolic state
…adiponectin significantly improves insulin sensitivity & is potently anti-inflammatory[, suggesting] specific systemic abnormalities [to] predict positive response to ketamine
妊娠期糖尿病从从分类上一般也会被分为二型糖尿病 ｜ 非胰岛素依赖糖尿病，因为高血糖的诱因也是胰岛素抵抗。机制上目前认为和你之前说的促炎adipokines -> M1 macrophages inflamation -> insulin 受体异常类似。只是诱发慢性炎症的不是adipokines， 但是危险因素可以和肥胖/PCOS叠加。
空腹口服糖耐量实验（OGTT）虽然理论上不能胰岛素实验，但确实很多情况下还是比较有效的初筛指标。我也认为至在有明确危险因素，或者OGTT 已经提示胰岛素抵抗的情况下再测胰岛素测试是合理的。 检验是要考虑现实性的。
空腹口服糖耐量实验（OGTT）虽然理论上不能胰岛素实验，但确实很多情况下还是比较有效的初筛指标。我也认为至在有明确危险因素，或者OGTT 已经提示胰岛素抵抗的情况下再测胰岛素测试是合理的。 检验是要考虑现实性的。
February 8, 2025 at 4:18 AM
妊娠期糖尿病从从分类上一般也会被分为二型糖尿病 ｜ 非胰岛素依赖糖尿病，因为高血糖的诱因也是胰岛素抵抗。机制上目前认为和你之前说的促炎adipokines -> M1 macrophages inflamation -> insulin 受体异常类似。只是诱发慢性炎症的不是adipokines， 但是危险因素可以和肥胖/PCOS叠加。
空腹口服糖耐量实验（OGTT）虽然理论上不能胰岛素实验，但确实很多情况下还是比较有效的初筛指标。我也认为至在有明确危险因素，或者OGTT 已经提示胰岛素抵抗的情况下再测胰岛素测试是合理的。 检验是要考虑现实性的。
空腹口服糖耐量实验（OGTT）虽然理论上不能胰岛素实验，但确实很多情况下还是比较有效的初筛指标。我也认为至在有明确危险因素，或者OGTT 已经提示胰岛素抵抗的情况下再测胰岛素测试是合理的。 检验是要考虑现实性的。
Agree! A big question I have been wondering for a long time is how general fat metabolism and dynamics affect the release of adipokines and other lipid mediators of inflammation.
November 28, 2024 at 3:59 PM
Agree! A big question I have been wondering for a long time is how general fat metabolism and dynamics affect the release of adipokines and other lipid mediators of inflammation.
🧵 1/7 From @dream-diabetes.bsky.social and the Next Generation cohort study: Differential effects of type 2 #diabetes and gestational diabetes on maternal and cord blood adipokines and newborn weight #DOHaD @dohadcanada.bsky.social rdcu.be/eQ0e2
BMC Journals | Open access, community-focused
BMC is a leader in open access publishing, driving progress in the life sciences, health sciences, medicine and applied sciences.
rdcu.be
December 20, 2025 at 10:24 PM
🧵 1/7 From @dream-diabetes.bsky.social and the Next Generation cohort study: Differential effects of type 2 #diabetes and gestational diabetes on maternal and cord blood adipokines and newborn weight #DOHaD @dohadcanada.bsky.social rdcu.be/eQ0e2
Obesity, linked to disease risk and early death, involves complex mechanisms like insulin resistance and inflammation. Blood-based biomarkers, including adipokines and cytokines, could clarify how… PMID:41540119, Nat Rev Endocrinol 2026, @NatureRevEndo https://doi.org/10.1038/s41574-025-01229-2
Blood-based obesity biomarkers and their relevance for disease risk | Nature Reviews Endocrinology
Obesity is a risk factor for chronic diseases and early death; however, the underlying mechanisms are not fully understood. Whereas insulin resistance and inflammation are established pathways in several of these relationships, it is less clear how increases in body adipose tissue relate to these pathways and disease risk. Several adipose tissue-derived blood-based biomarkers have been identified as purported mediators, including adipokines, inflammatory cytokines and sex steroid hormones. Traditionally, these markers were discovered in animal models and their relevance in humans has then been investigated in epidemiological studies. Today, proteomics and metabolomics approaches in human observational studies are used to discover obesity biomarkers in blood, supported by Mendelian randomization studies to draw causal inferences. Here we review adipose tissue-derived blood-based obesity biomarkers and their relevance for disease risk, along with their potential role as mediators. Proteo
doi.org
June 20, 2026 at 7:00 AM
Obesity, linked to disease risk and early death, involves complex mechanisms like insulin resistance and inflammation. Blood-based biomarkers, including adipokines and cytokines, could clarify how… PMID:41540119, Nat Rev Endocrinol 2026, @NatureRevEndo https://doi.org/10.1038/s41574-025-01229-2
Dr. Milton Packer proposes that hypertrophied, inflamed fat cells secrete molecules—adipokines—that drive cardiac remodeling, inflammation, and fibrosis.
In other words: HFpEF may begin in fat, not the heart.
In other words: HFpEF may begin in fat, not the heart.
October 13, 2025 at 2:20 PM
Dr. Milton Packer proposes that hypertrophied, inflamed fat cells secrete molecules—adipokines—that drive cardiac remodeling, inflammation, and fibrosis.
In other words: HFpEF may begin in fat, not the heart.
In other words: HFpEF may begin in fat, not the heart.
Themes emerge:
• It’s about fat distribution, not just BMI.
• Adipokines act through endocrine-paracrine signaling.
• Sex, race, and metabolic context all shape expression and risk.
• New therapies (GLP-1RA, SGLT2i) may restore adipokine balance.
• It’s about fat distribution, not just BMI.
• Adipokines act through endocrine-paracrine signaling.
• Sex, race, and metabolic context all shape expression and risk.
• New therapies (GLP-1RA, SGLT2i) may restore adipokine balance.
October 13, 2025 at 2:23 PM
Themes emerge:
• It’s about fat distribution, not just BMI.
• Adipokines act through endocrine-paracrine signaling.
• Sex, race, and metabolic context all shape expression and risk.
• New therapies (GLP-1RA, SGLT2i) may restore adipokine balance.
• It’s about fat distribution, not just BMI.
• Adipokines act through endocrine-paracrine signaling.
• Sex, race, and metabolic context all shape expression and risk.
• New therapies (GLP-1RA, SGLT2i) may restore adipokine balance.
Cancer cachexia, a wasting syndrome
Bone Health and Cognition
Myokines and Brain Function
The Gut-Brain Axis
Adipokines and Cognitive Health
Hypothalamic-Pituitary-Adrenal (HPA) Axis and stress
Bone Health and Cognition
Myokines and Brain Function
The Gut-Brain Axis
Adipokines and Cognitive Health
Hypothalamic-Pituitary-Adrenal (HPA) Axis and stress
November 27, 2024 at 7:38 PM
Cancer cachexia, a wasting syndrome
Bone Health and Cognition
Myokines and Brain Function
The Gut-Brain Axis
Adipokines and Cognitive Health
Hypothalamic-Pituitary-Adrenal (HPA) Axis and stress
Bone Health and Cognition
Myokines and Brain Function
The Gut-Brain Axis
Adipokines and Cognitive Health
Hypothalamic-Pituitary-Adrenal (HPA) Axis and stress
New content online: Blood–brain barrier permeability of adipokines and myokines
Blood–brain barrier permeability of adipokines and myokines
Nature Reviews Endocrinology, Published online: 03 February 2026; doi:10.1038/s41574-026-01232-1The use of adipokines and myokines measured in serum or cerebrospinal fluid as biomarkers or disease modifiers in neurological disorders is limited. Their permeability to the blood–brain barrier is either unknown or overlooked. A novel classification of adipokines and myokines on the basis of their cerebrospinal fluid to serum ratio is warranted.
dlvr.it
February 4, 2026 at 9:13 AM
New content online: Blood–brain barrier permeability of adipokines and myokines
Metabolic syndrome and its components were associated with lower clinical response rates in patients with rheumatoid arthritis after starting a new advanced therapy, independent of BMI
In Arthritis & Rheumatology
acr.tw/4havOht
In Arthritis & Rheumatology
acr.tw/4havOht
Metabolic Syndrome, Adipokines, and Response to Advanced Therapies in Rheumatoid Arthritis
Purpose
We determined if metabolic syndrome, its components, and adipokines (adiponectin, leptin, Fibroblast Growth Factor-21) were associated with response to advanced therapies among patients with.....
acr.tw
October 24, 2024 at 8:04 PM
Metabolic syndrome and its components were associated with lower clinical response rates in patients with rheumatoid arthritis after starting a new advanced therapy, independent of BMI
In Arthritis & Rheumatology
acr.tw/4havOht
In Arthritis & Rheumatology
acr.tw/4havOht
Visceral fat, which is found in and around abdominal organs including the stomach, liver and intestines, is the driver of metabolic disease, says Kessler. Visceral fat leeches fatty acids called adipokines or chemokines, which cause systemic inflammation in the body.
June 16, 2025 at 11:04 PM
Visceral fat, which is found in and around abdominal organs including the stomach, liver and intestines, is the driver of metabolic disease, says Kessler. Visceral fat leeches fatty acids called adipokines or chemokines, which cause systemic inflammation in the body.
Elevated adipokines and myokines are associated with fatigue in long COVID patients pubmed.ncbi.nlm.nih.gov/40458645/
June 5, 2025 at 3:23 AM
Elevated adipokines and myokines are associated with fatigue in long COVID patients pubmed.ncbi.nlm.nih.gov/40458645/
This new study demonstrates, for the first time, the pattern of gene and protein expression of adipokines and their receptors in the plasma, hypothalamus, ovary, and periovarian adipose tissue of PCOS rats.
https://doi.org/10.1016/j.rbmo.2024.104693
#PolycysticOvarySyndrome #pcos #adipokines
https://doi.org/10.1016/j.rbmo.2024.104693
#PolycysticOvarySyndrome #pcos #adipokines
December 13, 2024 at 9:35 AM
This new study demonstrates, for the first time, the pattern of gene and protein expression of adipokines and their receptors in the plasma, hypothalamus, ovary, and periovarian adipose tissue of PCOS rats.
https://doi.org/10.1016/j.rbmo.2024.104693
#PolycysticOvarySyndrome #pcos #adipokines
https://doi.org/10.1016/j.rbmo.2024.104693
#PolycysticOvarySyndrome #pcos #adipokines
Study of 341 patients with early rheumatoid arthritis showed no association between baseline adiponectin, leptin, and resistin levels and the likelihood of achieving CDAI remission over 48 weeks of treatment
In ACR Open Rheumatology
acr.tw/40uulg6
🩺
In ACR Open Rheumatology
acr.tw/40uulg6
🩺
Circulating Adipokines and Response to Treatment in Patients With Early Rheumatoid Arthritis
Objective
The objective of this study was to determine if baseline adiponectin, leptin, and resistin levels are associated with response to antirheumatic treatment in early rheumatoid arthritis (RA).....
acr.tw
November 11, 2024 at 1:41 PM
Study of 341 patients with early rheumatoid arthritis showed no association between baseline adiponectin, leptin, and resistin levels and the likelihood of achieving CDAI remission over 48 weeks of treatment
In ACR Open Rheumatology
acr.tw/40uulg6
🩺
In ACR Open Rheumatology
acr.tw/40uulg6
🩺
Study reveals shifts in key inflammatory markers known as Adipokines in COVID-19 patients
www.thailandmedical.news/news/study-r...
www.thailandmedical.news/news/study-r...
Study reveals shifts in key inflammatory markers known as Adipokines in COVID-19 patients - Thailand Medical News
www.thailandmedical.news
August 15, 2024 at 1:55 AM
Study reveals shifts in key inflammatory markers known as Adipokines in COVID-19 patients
www.thailandmedical.news/news/study-r...
www.thailandmedical.news/news/study-r...
Gestational #diabetes mellitus (GDM) is linked to significant adverse outcomes for both mothers and their offspring. Since #SPINA-GBeta outperforms #HOMA-Beta, its use is advised as a preferred calculated #biomarker for the evolution and pathophysiology of #GDM.
pubmed.ncbi.nlm.nih.gov/40943638/
pubmed.ncbi.nlm.nih.gov/40943638/
September 20, 2025 at 3:57 PM
Gestational #diabetes mellitus (GDM) is linked to significant adverse outcomes for both mothers and their offspring. Since #SPINA-GBeta outperforms #HOMA-Beta, its use is advised as a preferred calculated #biomarker for the evolution and pathophysiology of #GDM.
pubmed.ncbi.nlm.nih.gov/40943638/
pubmed.ncbi.nlm.nih.gov/40943638/
Congratulations to 1st year PhD students Anna Malicka and Aysha Ali and Fellow Amanda MacCannell on publication of their review in #ExpPhys on brown adipose tissue-derived bioactive metabolite interorgan signalling. #brownadipose #metabokines
physoc.onlinelibrary.wiley.com/doi/10.1113/...
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Brown and beige adipose tissue‐derived metabokine and lipokine inter‐organ signalling in health and disease
Adipose tissue has an established endocrine function through the secretion of adipokines. However, a role for bioactive metabolites and lipids, termed metabokines and lipokines, is emerging in adipos...
physoc.onlinelibrary.wiley.com
November 27, 2024 at 7:12 AM
Congratulations to 1st year PhD students Anna Malicka and Aysha Ali and Fellow Amanda MacCannell on publication of their review in #ExpPhys on brown adipose tissue-derived bioactive metabolite interorgan signalling. #brownadipose #metabokines
physoc.onlinelibrary.wiley.com/doi/10.1113/...
physoc.onlinelibrary.wiley.com/doi/10.1113/...
ICYMI: New content online: Blood-based obesity biomarkers and their relevance for disease risk
Blood-based obesity biomarkers and their relevance for disease risk
Nature Reviews Endocrinology, Published online: 15 January 2026; doi:10.1038/s41574-025-01229-2Obesity is associated with changes in levels of many blood-based factors, such as cytokines and adipokines. This Review explores the utility of such factors as biomarkers for quantifying and predicting obesity-associated disease risk, including the identification of causal relationships.
dlvr.it
January 17, 2026 at 3:15 PM
ICYMI: New content online: Blood-based obesity biomarkers and their relevance for disease risk
Here the authors propose that select adipokines and communication networks link subcutaneous adipose tissue with physical and cognitive performance in older adults www.sciencedirect.com/science/arti...
Subcutaneous Adipose Tissue-Secreted Proteins as Endocrine Regulators of Physical and Cognitive Function in Older Adults
Declines in skeletal muscle and cognitive function in older adults have been linked to abnormalities in abdominal subcutaneous adipose tissue (ASAT), …
www.sciencedirect.com
July 15, 2025 at 9:54 PM
Here the authors propose that select adipokines and communication networks link subcutaneous adipose tissue with physical and cognitive performance in older adults www.sciencedirect.com/science/arti...
RRIDs were included in this Cureus paper. RRIDs improve reproducibility in scientific research. #ReproducibleResearch #accelerateopenscience #accelerateopenscience
Role of Adipokines in the Development of Metabolic Syndrome in Patients With Polycystic Ovary Syndrome
doi.org
May 29, 2025 at 7:00 AM
RRIDs were included in this Cureus paper. RRIDs improve reproducibility in scientific research. #ReproducibleResearch #accelerateopenscience #accelerateopenscience