Moving on to metabokines in obesity with @leerobertslab.bsky.social
July 8, 2025 at 2:51 PM
Moving on to metabokines in obesity with @leerobertslab.bsky.social
Congratulations to 1st year PhD students Anna Malicka and Aysha Ali and Fellow Amanda MacCannell on publication of their review in #ExpPhys on brown adipose tissue-derived bioactive metabolite interorgan signalling. #brownadipose #metabokines
physoc.onlinelibrary.wiley.com/doi/10.1113/...
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Brown and beige adipose tissue‐derived metabokine and lipokine inter‐organ signalling in health and disease
Adipose tissue has an established endocrine function through the secretion of adipokines. However, a role for bioactive metabolites and lipids, termed metabokines and lipokines, is emerging in adipos...
physoc.onlinelibrary.wiley.com
November 27, 2024 at 7:12 AM
Congratulations to 1st year PhD students Anna Malicka and Aysha Ali and Fellow Amanda MacCannell on publication of their review in #ExpPhys on brown adipose tissue-derived bioactive metabolite interorgan signalling. #brownadipose #metabokines
physoc.onlinelibrary.wiley.com/doi/10.1113/...
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Kicking off 2025 with a highlight from our 2024 study in #CellReportsMedicine @cellpress.bsky.social
We uncovered the potential role of a metabokine-sphingolipid axis in sustaining weight loss in humans with #obesity.
1/10 🧵👇
We uncovered the potential role of a metabokine-sphingolipid axis in sustaining weight loss in humans with #obesity.
1/10 🧵👇
Weight-loss maintenance is accompanied by interconnected alterations in circulating FGF21-adiponectin-leptin and bioactive sphingolipids
Fiorenza et al. reveal selective and dynamic alterations in energy-balance-regulating metabokines and sphingolipids throughout weight loss, weight-loss maintenance, and weight regain in adults with obesity. Weight-loss maintenance elicits distinct remodeling patterns within the FGF21-adiponectin-leptin-sphingolipid axis as compared with weight regain, and these changes are associated with cardiometabolic health outcomes.
www.cell.com
January 6, 2025 at 4:07 PM
Kicking off 2025 with a highlight from our 2024 study in #CellReportsMedicine @cellpress.bsky.social
We uncovered the potential role of a metabokine-sphingolipid axis in sustaining weight loss in humans with #obesity.
1/10 🧵👇
We uncovered the potential role of a metabokine-sphingolipid axis in sustaining weight loss in humans with #obesity.
1/10 🧵👇
Anna Malicka, Aysha Ali, Amanda D. V. MacCannell and @leerobertslab.bsky.social (@universityofleeds.bsky.social) explore the the inter-organ signalling mechanisms of brown and beige adipose tissue-derived metabokines and lipokines.
📜 buff.ly/isAId5k
📜 buff.ly/isAId5k
July 8, 2025 at 2:25 AM
Anna Malicka, Aysha Ali, Amanda D. V. MacCannell and @leerobertslab.bsky.social (@universityofleeds.bsky.social) explore the the inter-organ signalling mechanisms of brown and beige adipose tissue-derived metabokines and lipokines.
📜 buff.ly/isAId5k
📜 buff.ly/isAId5k
7/ To interrogate the putative contribution of metabokines and sphingolipids to sustained weight loss per se independent of the weight-loss maintenance treatment, we performed subgroup analyses of participants who either maintained or regained weight during the weight-loss maintenance phase.
January 6, 2025 at 4:07 PM
7/ To interrogate the putative contribution of metabokines and sphingolipids to sustained weight loss per se independent of the weight-loss maintenance treatment, we performed subgroup analyses of participants who either maintained or regained weight during the weight-loss maintenance phase.
5/ Given the interplay between metabokines and #ceramides, we explored whether the observed alterations in circulating metabokines were associated with changes in the plasma sphingolipid profile.
An FGF21-Adiponectin-Ceramide Axis Controls Energy Expenditure and Insulin Action in Mice
FGF21, a member of the fibroblast growth factor (FGF) superfamily, has recently emerged as a regulator of metabolism and energy utilization. However, …
www.sciencedirect.com
January 6, 2025 at 4:07 PM
5/ Given the interplay between metabokines and #ceramides, we explored whether the observed alterations in circulating metabokines were associated with changes in the plasma sphingolipid profile.
4/ As the metabolic effects of FGF21 and GDF15 are partly mediated by #adiponectin and #leptin, we quantified these adipose-derived metabokines and reported that their circulating profiles were ameliorated following weight-loss maintenance with exercise, GLP-1 analog, and their combined treatment.
January 6, 2025 at 4:07 PM
4/ As the metabolic effects of FGF21 and GDF15 are partly mediated by #adiponectin and #leptin, we quantified these adipose-derived metabokines and reported that their circulating profiles were ameliorated following weight-loss maintenance with exercise, GLP-1 analog, and their combined treatment.
2/ Through exploratory analyses of a four-arm RCT(www.nejm.org/doi/10.1056/NEJMoa2028198), we profiled circulating metabokines and sphingolipids in adults with obesity undergoing an initial weight loss and subsequent weight-loss maintenance phase with #exercise, and/or #GLP-1 analog treatment.
January 6, 2025 at 4:07 PM
2/ Through exploratory analyses of a four-arm RCT(www.nejm.org/doi/10.1056/NEJMoa2028198), we profiled circulating metabokines and sphingolipids in adults with obesity undergoing an initial weight loss and subsequent weight-loss maintenance phase with #exercise, and/or #GLP-1 analog treatment.