Published in ACS synthetic biology

Objectives Several studies have reported an elevated risk of cancer, including lymphoid malignancies (LM), among farmers, particularly in relation to pesticide use. Chloroacetanilides are among the be...

Abstract. The aneuploidy-inducing activity of alachlor and dichlorvos, two pesticides representing an important source of human exposure to potential carci

In today's episode we're diving into the findings of the International Agency for Research on Cancer (IARC) Working Group, which evaluated the carcinogenicity of three common chemicals: atrazine, alachlor, and vinclozolin. A group of 22 scientists from 12 countries met to classify atrazine and alachlor as "probably carcinogenic to humans" (Group 2A), and vinclozolin as "possibly carcinogenic to humans" (Group 2B). We examine the evidence, including limited human links between atrazine and non-Hodgkin lymphoma (NHL) that is positive for the t(14;18) chromosomal translocation and a strong association between alachlor use and laryngeal cancer. Exposure is high for agricultural workers via inhalation and dermal absorption, but the general public is also exposed primarily through drinking water and foodstuffs. Resource: https://doi.org/10.1016/S1470-2045(25)00702-8 on Carcinogenicity of atrazine, alachlor, and vinclozolin.

In November 2025, IARC, through the World Health Organization, designated the endocrine-disrupting herbicide atrazine as “probably carcinogenic to humans.”

Atrazina e alachlor, herbicidas proibidos na União Europeia, foram reavaliados pela IARC e receberam nova classificação de risco

A Agência Internacional de Pesquisa em Câncer (IARC, na sigla em inglês), da Organização Mundial da Saúde (OMS), divulgou novas avaliações que classificam dois herbicidas amplamente usados no Brasil — a atrazina e o alachlor — como substâncias cancerígenas para humanos. A decisão se baseia em evidências em animais, mecanismos biológicos e estudos que sugerem associação com tumores em humanos. Entre os dez agrotóxicos mais usados no país, sete são proibidos na União Europeia — entre eles, atrazina e alachlor. Há uma década, eram três em cada dez, o que mostra o quanto a situação vem se degradando no Brasil, afirma Larissa Bombardi, coordenadora científica do International Pesticide Standard Alliance (IPSA). Para a brasileira, que é pesquisadora na Université Libre de Bruxelles, o acordo entre Mercosul e União Europeia — que o presidente Lula afirmou que deve ser fechado em 20 de dezembro — pode ser uma janela para que se alcance paridade nas práticas brasileiras e europeias. Matéria exclusiva para assinantes. Para ter acesso completo, acesse o link da matéria e faça o seu cadastro.

The results from the study on the genotoxic potential of the newly synthesized Bulgarian preparation alachlor are presented in the present communication. The preparation is the active ingredient of the herbicide laso. The studies were carri...

The results from the study on the genotoxic potential of the newly synthesized Bulgarian preparation alachlor are presented in the present communication. The preparation is the active ingredient of the herbicide laso. The studies were carri...

ABSTRACT Alachlor, acetochlor, and metolachlor are organochlorine herbicides extensively used for weed control in agricultural practices, yet their use is prohibited within the European Union due to environmental and health concerns. These compounds and their degradation products exhibit high environmental persistence, necessitating reliable and rapid analytical methods for monitoring. Conventional reversed-phase liquid chromatography employing C18 columns is commonly utilized for their analysis. However, alkyl silica columns, and especially C18 columns, are not suitable for the effective separation of isomers, necessitating the integration of tandem mass spectrometry for enhanced analytical accuracy. This study explores the application of a porous graphitic carbon-based column to overcome these limitations. High-temperature chromatography enabled improved efficiency and selectivity in separating the target compounds. The influence of temperature, flow rate, pH, and mobile phase composition on the retention of alachlor, acetochlor, metolachlor, and their degradation products was systematically evaluated. A method suitable for separation and quantification of the herbicides was developed, highlighting the potential of porous graphitic carbon columns for robust and precise analysis in complex environmental matrices.