An innovative method to reduce neurodegenerative disease: replace the microglial brain immune cells. Worked in a rare lysosomal storage disease, mouse model, efficient, without immune rejection
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Therapeutic genetic restoration through allogeneic brain microglia replacement - Nature
Nature - Therapeutic genetic restoration through allogeneic brain microglia replacement
www.nature.com
August 6, 2025 at 3:33 PM
An innovative method to reduce neurodegenerative disease: replace the microglial brain immune cells. Worked in a rare lysosomal storage disease, mouse model, efficient, without immune rejection
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Severe, refractory lupus successfully treated with engineered T cells derived from a healthy donor
nature.com/articles/s41...
nature.com/articles/s41...
Allogeneic CD19-targeting T cells for treatment-refractory systemic lupus erythematosus: a phase 1 trial - Nature Medicine
In a small trial of patients with severe systemic lupus erythematosus and nephritis, treatment with allogeneic T cells with a CD19 chimeric antigen receptor inserted into the T cell receptor locus and...
nature.com
August 27, 2025 at 3:06 PM
Severe, refractory lupus successfully treated with engineered T cells derived from a healthy donor
nature.com/articles/s41...
nature.com/articles/s41...
Important first-in-human report today for donor pancreatic islet beta-cell transplant to an individual w/Type 1 diabetes. With genome editing, there was no immune response induced or need for immunosuppression. Major implications for transplantation in general @nejm.org
www.nejm.org/doi/pdf/10.1...
www.nejm.org/doi/pdf/10.1...
Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | NEJM
The need to suppress a patient’s immune system after the transplantation of allogeneic
cells is associated with wide-ranging side effects. We report the outcomes of transplantation
of genetically m...
www.nejm.org
August 4, 2025 at 11:38 PM
Important first-in-human report today for donor pancreatic islet beta-cell transplant to an individual w/Type 1 diabetes. With genome editing, there was no immune response induced or need for immunosuppression. Major implications for transplantation in general @nejm.org
www.nejm.org/doi/pdf/10.1...
www.nejm.org/doi/pdf/10.1...
LE PORT OBLIGATOIRE DU MASQUE FFP2 A RÉDUIT L'INCIDENCE DES INFECTIONS RESPIRATOIRES VIRALES (IRV) de 22,1 % à seulement 2,1 % des PATIENTS !!!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Consistent FFP2-masking as part of reducing viral respiratory infections on medical wards for allogeneic hematopoietic stem cell transplantation - Scientific Reports
Scientific Reports - Consistent FFP2-masking as part of reducing viral respiratory infections on medical wards for allogeneic hematopoietic stem cell transplantation
www.nature.com
November 18, 2024 at 5:57 AM
LE PORT OBLIGATOIRE DU MASQUE FFP2 A RÉDUIT L'INCIDENCE DES INFECTIONS RESPIRATOIRES VIRALES (IRV) de 22,1 % à seulement 2,1 % des PATIENTS !!!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
They’ve done it.
They’ve found a cure for type 1 diabetes.
Now it’s just a question of “Will our broken and useless healthcare system allow it to be used for the people who need it?”
Forgive me if I’m not optimistic.
www.nejm.org/doi/full/10....
They’ve found a cure for type 1 diabetes.
Now it’s just a question of “Will our broken and useless healthcare system allow it to be used for the people who need it?”
Forgive me if I’m not optimistic.
www.nejm.org/doi/full/10....
Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | NEJM
The need to suppress a patient’s immune system after the transplantation of allogeneic
cells is associated with wide-ranging side effects. We report the outcomes of transplantation
of genetically m...
www.nejm.org
August 10, 2025 at 2:42 AM
They’ve done it.
They’ve found a cure for type 1 diabetes.
Now it’s just a question of “Will our broken and useless healthcare system allow it to be used for the people who need it?”
Forgive me if I’m not optimistic.
www.nejm.org/doi/full/10....
They’ve found a cure for type 1 diabetes.
Now it’s just a question of “Will our broken and useless healthcare system allow it to be used for the people who need it?”
Forgive me if I’m not optimistic.
www.nejm.org/doi/full/10....
This is pretty promising. Here's the original science article www.nejm.org/doi/full/10....
Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | NEJM
The need to suppress a patient’s immune system after the transplantation of allogeneic
cells is associated with wide-ranging side effects. We report the outcomes of transplantation
of genetically m...
www.nejm.org
May 22, 2026 at 10:34 PM
This is pretty promising. Here's the original science article www.nejm.org/doi/full/10....
Ten people with type 1 diabetes, who had recurrent severe hypoglycemia and hypoglycemic unawareness, have remained insulin-independent for over a year following allogeneic stem cell-derived islet-cell therapy with immunosuppression, according to new Phase I/II data from the multicenter FORWARD study
June 23, 2025 at 4:02 PM
Ten people with type 1 diabetes, who had recurrent severe hypoglycemia and hypoglycemic unawareness, have remained insulin-independent for over a year following allogeneic stem cell-derived islet-cell therapy with immunosuppression, according to new Phase I/II data from the multicenter FORWARD study
Phase II trial of giving probiotics in allogeneic stem cell transplants to reduce infectious complications
Well tolerated but unfortunately didn't show any benefit
#escmidglobal2026
Well tolerated but unfortunately didn't show any benefit
#escmidglobal2026
April 19, 2026 at 9:31 AM
Phase II trial of giving probiotics in allogeneic stem cell transplants to reduce infectious complications
Well tolerated but unfortunately didn't show any benefit
#escmidglobal2026
Well tolerated but unfortunately didn't show any benefit
#escmidglobal2026
This is absolutely the most significant glycobiology paper so far this year. Increasing cell surface N-glycosylation makes viable allo CAR-T cells without deleting the endogenous TCR #glycotime
Glycan shielding enables TCR-sufficient allogeneic CAR-T therapy
SPPL3 deletion modifies glycosylation on primary T cells, reducing allogeneic immune
responses without impairing tumor control by anti-CD19 allogeneic CAR-T cells. SPPL3-null,
TCR-sufficient anti-CD19...
www.cell.com
August 31, 2025 at 8:41 PM
This is absolutely the most significant glycobiology paper so far this year. Increasing cell surface N-glycosylation makes viable allo CAR-T cells without deleting the endogenous TCR #glycotime
10 people with type 1 #diabetes have remained insulin-independent for over a year following allogeneic stem cell-derived islet-cell therapy. Story by @miriametucker.bsky.social via @medscape.com from #ADA2025 in Chicago.
#T1D #MedSky #EndoSky #endocrinology
#T1D #MedSky #EndoSky #endocrinology
Stem Cell-Derived Islets Still Producing Insulin at 1 Year
One-year data suggest allogeneic stem cell-derived islet-cell therapy could become a future option for those with type 1 diabetes in whom the benefits outweigh the risks of immunosuppression.
www.medscape.com
June 21, 2025 at 8:25 PM
10 people with type 1 #diabetes have remained insulin-independent for over a year following allogeneic stem cell-derived islet-cell therapy. Story by @miriametucker.bsky.social via @medscape.com from #ADA2025 in Chicago.
#T1D #MedSky #EndoSky #endocrinology
#T1D #MedSky #EndoSky #endocrinology
Progress.. allogeneic haematopoietic stem-cell transplant induced long term remission in two patients with NMOSD, formerly Davic’s Disease.
Two people were the first to receive the therapy for a condition that damages the spinal cord and optic nerve
Stem cells banish severe autoimmune disease for 15 years
Two people were the first to receive the therapy for a condition that damages the spinal cord and optic nerve
www.scientificamerican.com
June 23, 2026 at 7:37 AM
Progress.. allogeneic haematopoietic stem-cell transplant induced long term remission in two patients with NMOSD, formerly Davic’s Disease.
"Consistent FFP2-masking as part of reducing viral respiratory infections on medical wards for allogeneic hematopoietic stem cell transplantation"
doi.org/10.1038/s415...
#CovidIsNotOver #MaskUp
1/2
doi.org/10.1038/s415...
#CovidIsNotOver #MaskUp
1/2
Consistent FFP2-masking as part of reducing viral respiratory infections on medical wards for allogeneic hematopoietic stem cell transplantation - Scientific Reports
Scientific Reports - Consistent FFP2-masking as part of reducing viral respiratory infections on medical wards for allogeneic hematopoietic stem cell transplantation
doi.org
September 15, 2024 at 3:44 PM
"Consistent FFP2-masking as part of reducing viral respiratory infections on medical wards for allogeneic hematopoietic stem cell transplantation"
doi.org/10.1038/s415...
#CovidIsNotOver #MaskUp
1/2
doi.org/10.1038/s415...
#CovidIsNotOver #MaskUp
1/2
Not a RCT (would be unethical) but this study with historical no-mask controls showed dramatic reduction in viral respiratory infections in patients receiving stem cell transplants after a FFP2 masking policy was introduced.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Consistent FFP2-masking as part of reducing viral respiratory infections on medical wards for allogeneic hematopoietic stem cell transplantation - Scientific Reports
Scientific Reports - Consistent FFP2-masking as part of reducing viral respiratory infections on medical wards for allogeneic hematopoietic stem cell transplantation
www.nature.com
September 16, 2024 at 8:00 AM
Not a RCT (would be unethical) but this study with historical no-mask controls showed dramatic reduction in viral respiratory infections in patients receiving stem cell transplants after a FFP2 masking policy was introduced.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
💉 Gene-edited cells help man with type 1 diabetes
A trial transplanted donor insulin-producing cells, edited to avoid immune attack, into a patient’s arm muscle. No anti-rejection drugs were needed, and they worked for 12 weeks.
🔗 doi.org/10.1056/NEJM...
#SciComm 🧪 #Diabetes
A trial transplanted donor insulin-producing cells, edited to avoid immune attack, into a patient’s arm muscle. No anti-rejection drugs were needed, and they worked for 12 weeks.
🔗 doi.org/10.1056/NEJM...
#SciComm 🧪 #Diabetes
Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | NEJM
The need to suppress a patient’s immune system after the transplantation of allogeneic
cells is associated with wide-ranging side effects. We report the outcomes of transplantation
of genetically m...
doi.org
August 13, 2025 at 6:48 AM
💉 Gene-edited cells help man with type 1 diabetes
A trial transplanted donor insulin-producing cells, edited to avoid immune attack, into a patient’s arm muscle. No anti-rejection drugs were needed, and they worked for 12 weeks.
🔗 doi.org/10.1056/NEJM...
#SciComm 🧪 #Diabetes
A trial transplanted donor insulin-producing cells, edited to avoid immune attack, into a patient’s arm muscle. No anti-rejection drugs were needed, and they worked for 12 weeks.
🔗 doi.org/10.1056/NEJM...
#SciComm 🧪 #Diabetes
Allogeneic stem cell transplant can be a life-saving therapy for pts w cancer or other conditions such as sickle cell disease. JAMA Fellow Hermioni Amonoo, harvardmed, joins JAMA Deputy Editor Kristin Walter to discuss allogeneic stem cell donation.
https://ja.ma/41tyj9b
https://ja.ma/41tyj9b
December 12, 2024 at 11:00 AM
Allogeneic stem cell transplant can be a life-saving therapy for pts w cancer or other conditions such as sickle cell disease. JAMA Fellow Hermioni Amonoo, harvardmed, joins JAMA Deputy Editor Kristin Walter to discuss allogeneic stem cell donation.
https://ja.ma/41tyj9b
https://ja.ma/41tyj9b
Wenn Krankenhauspersonal euch einen vom "Masken nutzen eh nicht viel" erzählt schickt ihnen diese aktuelle Studie:
#covid #covidisnotover #diemaskebleibtauf
www.nature.com/articles/s41...
#covid #covidisnotover #diemaskebleibtauf
www.nature.com/articles/s41...
Consistent FFP2-masking as part of reducing viral respiratory infections on medical wards for allogeneic hematopoietic stem cell transplantation - Scientific Reports
Scientific Reports - Consistent FFP2-masking as part of reducing viral respiratory infections on medical wards for allogeneic hematopoietic stem cell transplantation
www.nature.com
September 15, 2024 at 2:17 PM
Wenn Krankenhauspersonal euch einen vom "Masken nutzen eh nicht viel" erzählt schickt ihnen diese aktuelle Studie:
#covid #covidisnotover #diemaskebleibtauf
www.nature.com/articles/s41...
#covid #covidisnotover #diemaskebleibtauf
www.nature.com/articles/s41...
Presented at the #ADASciSessions:
Zimislecel is an allogeneic stem cell–derived islet-cell therapy. This phase 1–2 study supports the hypothesis that zimislecel can restore physiologic islet function and thus treat persons with type 1 diabetes. Full study results: nej.md/3ZGupbv
Zimislecel is an allogeneic stem cell–derived islet-cell therapy. This phase 1–2 study supports the hypothesis that zimislecel can restore physiologic islet function and thus treat persons with type 1 diabetes. Full study results: nej.md/3ZGupbv
Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes | NEJM
Zimislecel is an allogeneic stem cell–derived islet-cell therapy. Data on the safety
and efficacy of zimislecel in persons with type 1 diabetes are needed. We conducted
a phase 1–2 study of zimisle...
nej.md
June 21, 2025 at 2:53 AM
Presented at the #ADASciSessions:
Zimislecel is an allogeneic stem cell–derived islet-cell therapy. This phase 1–2 study supports the hypothesis that zimislecel can restore physiologic islet function and thus treat persons with type 1 diabetes. Full study results: nej.md/3ZGupbv
Zimislecel is an allogeneic stem cell–derived islet-cell therapy. This phase 1–2 study supports the hypothesis that zimislecel can restore physiologic islet function and thus treat persons with type 1 diabetes. Full study results: nej.md/3ZGupbv
Now online! Glycan shielding enables TCR-sufficient allogeneic CAR-T therapy
Glycan shielding enables TCR-sufficient allogeneic CAR-T therapy
SPPL3 deletion modifies glycosylation on primary T cells, reducing allogeneic immune responses without impairing tumor control by anti-CD19 allogeneic CAR-T cells. SPPL3-null, TCR-sufficient anti-CD19 allogeneic CAR-T therapy is safe in three patients with lymphoma or leukemia.
dlvr.it
August 21, 2025 at 6:51 PM
Now online! Glycan shielding enables TCR-sufficient allogeneic CAR-T therapy
New @nejm.org
Pluripotent stem cells for Type 1 diabetes restored pancreatic islet cell function, improved glucose regulation, and decreased the need for insulin in 14 participants #ADASciSessions www.nejm.org/doi/full/10....
Pluripotent stem cells for Type 1 diabetes restored pancreatic islet cell function, improved glucose regulation, and decreased the need for insulin in 14 participants #ADASciSessions www.nejm.org/doi/full/10....
Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes | NEJM
Zimislecel is an allogeneic stem cell–derived islet-cell therapy. Data on the safety and efficacy of zimislecel in persons with type 1 diabetes are needed. We conducted a phase 1–2 study of zimisle...
www.nejm.org
June 21, 2025 at 1:55 PM
New @nejm.org
Pluripotent stem cells for Type 1 diabetes restored pancreatic islet cell function, improved glucose regulation, and decreased the need for insulin in 14 participants #ADASciSessions www.nejm.org/doi/full/10....
Pluripotent stem cells for Type 1 diabetes restored pancreatic islet cell function, improved glucose regulation, and decreased the need for insulin in 14 participants #ADASciSessions www.nejm.org/doi/full/10....
A new HIV cure case has just been reported. A patient in Oslo has achieved long-term HIV remission after a stem cell transplant from a sibling donor with a rare genetic mutation (CCR5Δ32/Δ32).
This is now one of only a handful of documented cases worldwide.
www.nature.com/articles/s41...
This is now one of only a handful of documented cases worldwide.
www.nature.com/articles/s41...
Long-term HIV-1 remission achieved through allogeneic haematopoietic stem cell transplant from a CCR5Δ32/Δ32 sibling donor - Nature Microbiology
This case study reports human immunodeficiency virus remission without antiretroviral treatment in an individual who received an allogeneic haematopoietic stem cell transplantation from a sibling dono...
www.nature.com
April 16, 2026 at 3:48 PM
A new HIV cure case has just been reported. A patient in Oslo has achieved long-term HIV remission after a stem cell transplant from a sibling donor with a rare genetic mutation (CCR5Δ32/Δ32).
This is now one of only a handful of documented cases worldwide.
www.nature.com/articles/s41...
This is now one of only a handful of documented cases worldwide.
www.nature.com/articles/s41...
Ablation of FAS confers allogeneic CAR T cells with resistance to rejection by T cells and NK cells
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Ablation of FAS confers allogeneic CD3– CAR T cells with resistance to rejection by T cells and natural killer cells - Nature Biomedical Engineering
The ablation of FAS and CD3 in allogeneic chimeric antigen receptor T cells confers them with partial protection from rejection by T cells and natural killer cells in immunocompetent hosts.
www.nature.com
November 18, 2024 at 8:04 PM
Ablation of FAS confers allogeneic CAR T cells with resistance to rejection by T cells and NK cells
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The hypoimmune mouse (MHC-deletion, CD47 overexpression) and all of its organs are completely invisible to allogeneic immune cells
www.cell.com/iscience/ful...
www.cell.com/iscience/ful...
November 29, 2024 at 7:58 PM
The hypoimmune mouse (MHC-deletion, CD47 overexpression) and all of its organs are completely invisible to allogeneic immune cells
www.cell.com/iscience/ful...
www.cell.com/iscience/ful...
holy shit. if/when this replicates in humans, we've cured type I diabetes. finance.yahoo.com/news/sana-bi...
Sana Biotechnology Announces Publication of Preclinical Diabetes Data in Cell Stem Cell Demonstrating Insulin Independence Following Transplantation of Hypoimmune Allogeneic Primary Islet Cells Withou...
Transplant of HIP-modified pancreatic islet cells provided lasting glucose control in a fully immunocompetent non-human primate (NHP), enabling the achievement of exogenous insulin independence withou...
finance.yahoo.com
February 15, 2024 at 6:45 PM
holy shit. if/when this replicates in humans, we've cured type I diabetes. finance.yahoo.com/news/sana-bi...