The allosteric landscape of the Src kinase
by Toni Beltran, @ajfaure.bsky.social , @crg.eu @sangerinstitute.bsky.social @alloxbio.bsky.social
www.science.org/doi/10.1126/...
by Toni Beltran, @ajfaure.bsky.social , @crg.eu @sangerinstitute.bsky.social @alloxbio.bsky.social
www.science.org/doi/10.1126/...
The allosteric landscape of the Src kinase
Comprehensive allosteric mapping prioritizes all possible druggable surface pockets in the Src kinase for allosteric inhibition.
www.science.org
February 20, 2026 at 2:03 PM
The allosteric landscape of the Src kinase
by Toni Beltran, @ajfaure.bsky.social , @crg.eu @sangerinstitute.bsky.social @alloxbio.bsky.social
www.science.org/doi/10.1126/...
by Toni Beltran, @ajfaure.bsky.social , @crg.eu @sangerinstitute.bsky.social @alloxbio.bsky.social
www.science.org/doi/10.1126/...
and the allosteric site is plugged too? 😳
June 15, 2026 at 5:50 AM
and the allosteric site is plugged too? 😳
Artificial allosteric protein switches with machine-learning-designed receptors - @arccoesb.bsky.social go.nature.com/4cshpM3
Artificial allosteric protein switches with machine-learning-designed receptors - Nature Biotechnology
Allosteric biosensors are constructed by combining reporter proteins with machine-learning-designed receptor domains.
go.nature.com
April 15, 2026 at 2:50 PM
Artificial allosteric protein switches with machine-learning-designed receptors - @arccoesb.bsky.social go.nature.com/4cshpM3
July 21, 2025 at 12:59 PM
Highly multiplexed design of an allosteric transcription factor to sense new ligands
doi.org/10.1038/s414...
doi.org/10.1038/s414...
November 19, 2024 at 12:22 PM
Highly multiplexed design of an allosteric transcription factor to sense new ligands
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Protein function depends on dynamic conformational changes. Patrick Barth &co present AlloPool, a #DeepLearning framework that reveals how protein motions give rise to biological function across diverse systems. 🧪 #ProteinStructure buff.ly/sTHTDBQ
September 25, 2026 at 4:30 PM
Protein function depends on dynamic conformational changes. Patrick Barth &co present AlloPool, a #DeepLearning framework that reveals how protein motions give rise to biological function across diverse systems. 🧪 #ProteinStructure buff.ly/sTHTDBQ
Allosteric Biosensors Unravel GTPase-Effector Feedback by Klaus Hahn and team: www.biorxiv.org/content/10.6...
May 19, 2026 at 9:46 AM
Allosteric Biosensors Unravel GTPase-Effector Feedback by Klaus Hahn and team: www.biorxiv.org/content/10.6...
Check out the new pre-print from our lab on phage-assisted evolution of light-switchable, allosteric proteins. Congrats to first author @neuroscinikolai.bsky.social, co-corresponding author @jmathony.bsky.social and everyone from the @niopeklab.bsky.social involved!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Phage-Assisted Evolution of Allosteric Protein Switches
Allostery, the transmission of locally induced conformational changes to distant functional sites, is a key mechanism for protein regulation. Artificial allosteric effectors enable remote manipulation...
www.biorxiv.org
June 13, 2025 at 10:13 AM
Check out the new pre-print from our lab on phage-assisted evolution of light-switchable, allosteric proteins. Congrats to first author @neuroscinikolai.bsky.social, co-corresponding author @jmathony.bsky.social and everyone from the @niopeklab.bsky.social involved!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Nature research paper: Identification of an allosteric site on the E3 ligase adapter cereblon
go.nature.com/3NHFcPj
go.nature.com/3NHFcPj
Identification of an allosteric site on the E3 ligase adapter cereblon - Nature
An allosteric site on the E3 ligase adapter cereblon can be targeted to modulate the efficacy of cereblon in targeted protein degradation applications.
go.nature.com
January 22, 2026 at 7:19 PM
Nature research paper: Identification of an allosteric site on the E3 ligase adapter cereblon
go.nature.com/3NHFcPj
go.nature.com/3NHFcPj
Large scale investigation of GPCR molecular dynamics data uncovers allosteric sites and lateral gateways
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Large scale investigation of GPCR molecular dynamics data uncovers allosteric sites and lateral gateways - Nature Communications
GPCR dynamics are critical for signal transmission into the cell. Here, the authors probe receptor plasticity using molecular dynamics simulations, enabling the detection of allosteric sites and drug ...
www.nature.com
March 2, 2025 at 9:18 AM
Large scale investigation of GPCR molecular dynamics data uncovers allosteric sites and lateral gateways
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Nature research paper: Allosteric modulation and biased signalling at free fatty acid receptor 2
https://go.nature.com/4jSLeqJ
https://go.nature.com/4jSLeqJ
Allosteric modulation and biased signalling at free fatty acid receptor 2 - Nature
Structural, pharmacological and computational studies reveal how different classes of positive allosteric modulators bind to distinct allosteric sites and use noncanonical mechanisms to activate the free-fatty acid receptor FFA2.
go.nature.com
June 23, 2025 at 8:22 PM
Nature research paper: Allosteric modulation and biased signalling at free fatty acid receptor 2
https://go.nature.com/4jSLeqJ
https://go.nature.com/4jSLeqJ
Check out our latest paper on the glycine receptor with
@chakrapanilab.bsky.social
where we show the interplay between the orthosteric and allosteric binding sites.
www.science.org/doi/10.1126/...
@chakrapanilab.bsky.social
where we show the interplay between the orthosteric and allosteric binding sites.
www.science.org/doi/10.1126/...
Structural basis for domain coupling in heteromeric glycine receptors revealed by an atypical allosteric agonist
Counteracting ligands stabilize glycine receptor states revealing mechanisms of pentameric ligand-gated channel allostery.
www.science.org
February 14, 2026 at 8:24 AM
Check out our latest paper on the glycine receptor with
@chakrapanilab.bsky.social
where we show the interplay between the orthosteric and allosteric binding sites.
www.science.org/doi/10.1126/...
@chakrapanilab.bsky.social
where we show the interplay between the orthosteric and allosteric binding sites.
www.science.org/doi/10.1126/...
Allosteric inhibition of human mitochondrial ClpP by hijacking the dordaviprone (ONC201) binding site #nature #MassSpecRSS
Allosteric inhibition of human mitochondrial ClpP by hijacking the dordaviprone (ONC201) binding site - Nature Communications
ClpP is a mitochondrial protease and a validated cancer target. Here, the authors develop quinazolinone compounds that bind to the same site as the FDA-approved activator ClpP dordaviprone, yet they inhibit ClpP, reducing tumor burden in leukemia mouse models.
dlvr.it
September 28, 2026 at 9:02 AM
Allosteric inhibition of human mitochondrial ClpP by hijacking the dordaviprone (ONC201) binding site #nature #MassSpecRSS
don't you know it's racist to criticize the girl who fucked off with $15k of other trannies money to go party, get wedgie tattoos, and use ChatGPT to cry "hot allosteric load"? 😔
January 19, 2026 at 2:40 AM
don't you know it's racist to criticize the girl who fucked off with $15k of other trannies money to go party, get wedgie tattoos, and use ChatGPT to cry "hot allosteric load"? 😔
Protein function depends on dynamic conformational changes. Patrick Barth &co present AlloPool, a #DeepLearning framework that reveals how protein motions give rise to biological function across diverse systems. 🧪 #ProteinStructure buff.ly/sTHTDBQ
September 24, 2026 at 8:01 AM
Protein function depends on dynamic conformational changes. Patrick Barth &co present AlloPool, a #DeepLearning framework that reveals how protein motions give rise to biological function across diverse systems. 🧪 #ProteinStructure buff.ly/sTHTDBQ
Our new preprint describes an allosteric glue. Here, "glue" refers to a compound that causes two proteins to stick together. Usually the glue touches both proteins but here it only has to touch one!
foldingathome.org/2024/12/18/a...
foldingathome.org/2024/12/18/a...
An allosteric glue – Folding@home
foldingathome.org
December 18, 2024 at 6:42 PM
Our new preprint describes an allosteric glue. Here, "glue" refers to a compound that causes two proteins to stick together. Usually the glue touches both proteins but here it only has to touch one!
foldingathome.org/2024/12/18/a...
foldingathome.org/2024/12/18/a...
This is very nice work & a great approach to engineering new allosteric TFs. Massively parallel FTW
Highly multiplexed design of an allosteric transcription factor to sense new ligands
doi.org/10.1038/s414...
doi.org/10.1038/s414...
November 19, 2024 at 1:56 PM
This is very nice work & a great approach to engineering new allosteric TFs. Massively parallel FTW
TF-MAPS: fast high-resolution functional and allosteric mapping of DNA-binding proteins by @XianghuaLi2
Are Transcription Factors really 'undruggable'?
www.biorxiv.org/content/10.1...
Are Transcription Factors really 'undruggable'?
www.biorxiv.org/content/10.1...
TF-MAPS: fast high-resolution functional and allosteric mapping of DNA-binding proteins
Transcription factors (TFs) bind specific DNA sequences to control gene expression. Modulating TF activity is of considerable therapeutic interest but very few TFs have been successfully drugged. TF D...
www.biorxiv.org
October 23, 2025 at 12:50 PM
TF-MAPS: fast high-resolution functional and allosteric mapping of DNA-binding proteins by @XianghuaLi2
Are Transcription Factors really 'undruggable'?
www.biorxiv.org/content/10.1...
Are Transcription Factors really 'undruggable'?
www.biorxiv.org/content/10.1...
Inspired by how nature evolves trigger responsiveness through alternating pressures, we are excited to present POGO-PANCE and RAMPhaGE:
Phage-assisted evolution platforms for engineering allosteric protein switches under dynamic selection.
Preprint: doi.org/10.1101/2025...
Phage-assisted evolution platforms for engineering allosteric protein switches under dynamic selection.
Preprint: doi.org/10.1101/2025...
Phage-Assisted Evolution of Allosteric Protein Switches
Allostery, the transmission of locally induced conformational changes to distant functional sites, is a key mechanism for protein regulation. Artificial allosteric effectors enable remote manipulation...
doi.org
June 13, 2025 at 1:29 PM
Inspired by how nature evolves trigger responsiveness through alternating pressures, we are excited to present POGO-PANCE and RAMPhaGE:
Phage-assisted evolution platforms for engineering allosteric protein switches under dynamic selection.
Preprint: doi.org/10.1101/2025...
Phage-assisted evolution platforms for engineering allosteric protein switches under dynamic selection.
Preprint: doi.org/10.1101/2025...
This hot-off-press paper reveals how eukaryotic eIF4F recognizes & activates messenger RNA by stochastically sampling along its length & utilizing allosteric communication between its subunits. We get a revised model for mRNA activation & translation initiation.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The mechanism of mRNA cap recognition - Nature
Allosteric communication between the eIF4F subunits drives mRNA cap-recognition and subsequent activation of the message.
www.nature.com
December 19, 2024 at 8:31 AM
This hot-off-press paper reveals how eukaryotic eIF4F recognizes & activates messenger RNA by stochastically sampling along its length & utilizing allosteric communication between its subunits. We get a revised model for mRNA activation & translation initiation.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Phage-Assisted Evolution of Allosteric Protein Switches https://www.biorxiv.org/content/10.1101/2025.06.12.659331v1
June 13, 2025 at 6:03 AM
Phage-Assisted Evolution of Allosteric Protein Switches https://www.biorxiv.org/content/10.1101/2025.06.12.659331v1
Happy to join bluesky.
My lab uses structural biology to investigate GPCRs. Specifically, we are interested in chemokine receptors and 1) how differences in ligand interactions leads to pathway-selective signaling, as well as 2) allosteric modulation via the intracelluar allosteric binding site.
My lab uses structural biology to investigate GPCRs. Specifically, we are interested in chemokine receptors and 1) how differences in ligand interactions leads to pathway-selective signaling, as well as 2) allosteric modulation via the intracelluar allosteric binding site.
January 17, 2025 at 3:19 PM
Happy to join bluesky.
My lab uses structural biology to investigate GPCRs. Specifically, we are interested in chemokine receptors and 1) how differences in ligand interactions leads to pathway-selective signaling, as well as 2) allosteric modulation via the intracelluar allosteric binding site.
My lab uses structural biology to investigate GPCRs. Specifically, we are interested in chemokine receptors and 1) how differences in ligand interactions leads to pathway-selective signaling, as well as 2) allosteric modulation via the intracelluar allosteric binding site.
Allosteric activation of a ubiquitin ligase by an internal kinase domain! Congratulations to our team member Thornton Fokkens for this fascinating discovery in a neglected disease area with strong therapeutic need. Many thanks to all our great collaborators!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
A Leishmania virulence factor harnesses an allosteric kinase switch to regulate its ubiquitin ligase activity
Stringent control of ubiquitylation is a central requirement of signaling specificity in eukaryotes. Here, we discover a domain module integrating pro…
www.sciencedirect.com
September 24, 2025 at 3:30 PM
Allosteric activation of a ubiquitin ligase by an internal kinase domain! Congratulations to our team member Thornton Fokkens for this fascinating discovery in a neglected disease area with strong therapeutic need. Many thanks to all our great collaborators!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...