Are you using ceftriaxone for bloodstream infections caused by organisms at low-risk for AmpC production? Recent article out of Detroit 👇 #IDSky
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Ceftriaxone versus cefepime or carbapenems for definitive treatment of low-risk AmpC-Harboring Enterobacterales bloodstream infections in hospitalized adults: A retrospective cohort study
To compare outcomes of ceftriaxone to AmpC-stable therapies in patients with bacteremia caused by low-risk AmpC harboring Enterobacterales.IRB-approve…
www.sciencedirect.com
November 14, 2024 at 12:44 PM
Are you using ceftriaxone for bloodstream infections caused by organisms at low-risk for AmpC production? Recent article out of Detroit 👇 #IDSky
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
🌟 ABX Pearl of the Day: AmpC or ESBL?
📋 Q: How can I quickly spot the difference in AmpC and ESBL resistance patterns? 🤔
🩺 A: Step 1: Look at the organism. Step 2: Check ceftriaxone susceptibility. Here’s a quick & handy decision tree to inform ABX Rx 👇 #IDsky #MedSky #PharmSky
🔗 IDSA AMR Guidance
📋 Q: How can I quickly spot the difference in AmpC and ESBL resistance patterns? 🤔
🩺 A: Step 1: Look at the organism. Step 2: Check ceftriaxone susceptibility. Here’s a quick & handy decision tree to inform ABX Rx 👇 #IDsky #MedSky #PharmSky
🔗 IDSA AMR Guidance
November 25, 2024 at 7:37 PM
#ARVO2026 was fantastic! I’m really honored to have been elected to the AMPC and STOKED to serve alongside one of my favorite scientist (and human), @blockintheback.bsky.social
May 8, 2026 at 2:25 PM
#ARVO2026 was fantastic! I’m really honored to have been elected to the AMPC and STOKED to serve alongside one of my favorite scientist (and human), @blockintheback.bsky.social
🔥🔥Just published 🔥🔥
IDSA AMR Guidance 2026
IDSA 2026 Guidance on the Treatment of Antimicrobial Resistant Gram-Negative Infections
🔺ESBL , AmpC Enterobacterales
🔺CRE
🔺DTR P. aeruginosa
🔺CRAB
🔺Stenotrophomonas maltophilia #idsky
www.idsociety.org/practice-gui...
IDSA AMR Guidance 2026
IDSA 2026 Guidance on the Treatment of Antimicrobial Resistant Gram-Negative Infections
🔺ESBL , AmpC Enterobacterales
🔺CRE
🔺DTR P. aeruginosa
🔺CRAB
🔺Stenotrophomonas maltophilia #idsky
www.idsociety.org/practice-gui...
July 27, 2026 at 4:06 PM
🔥🔥Just published 🔥🔥
IDSA AMR Guidance 2026
IDSA 2026 Guidance on the Treatment of Antimicrobial Resistant Gram-Negative Infections
🔺ESBL , AmpC Enterobacterales
🔺CRE
🔺DTR P. aeruginosa
🔺CRAB
🔺Stenotrophomonas maltophilia #idsky
www.idsociety.org/practice-gui...
IDSA AMR Guidance 2026
IDSA 2026 Guidance on the Treatment of Antimicrobial Resistant Gram-Negative Infections
🔺ESBL , AmpC Enterobacterales
🔺CRE
🔺DTR P. aeruginosa
🔺CRAB
🔺Stenotrophomonas maltophilia #idsky
www.idsociety.org/practice-gui...
Me siento un jodido imbécil aquí en serio, ni a escribir atino ya.
ampc
ampc
April 25, 2026 at 2:03 PM
Me siento un jodido imbécil aquí en serio, ni a escribir atino ya.
ampc
ampc
🆕️🔥Systematic review & meta-analysis
20 studies (1 RCTs, 1 case-control study,18 cohort studies)
Pip/tazo vs. cefepime or carbapenems for the treatment of BSI due to bacteria producing chromosomal AmpC beta-lactamas #idsky #medsky #AMSsky
link.springer.com/article/10.1...
20 studies (1 RCTs, 1 case-control study,18 cohort studies)
Pip/tazo vs. cefepime or carbapenems for the treatment of BSI due to bacteria producing chromosomal AmpC beta-lactamas #idsky #medsky #AMSsky
link.springer.com/article/10.1...
Piperacillin/tazobactam vs. cefepime or carbapenems for the treatment of bloodstream infections due to bacteria producing chromosomal AmpC beta-lactamase: a systematic review and meta-analysis - Infec...
Background The best treatment for bloodstream infections (BSI) due to chromosomal AmpC (c-AmpC) producing Enterobacterales is not clearly defined. Objectives To describe the clinical and microbiologic...
link.springer.com
December 4, 2024 at 7:13 PM
🆕️🔥Systematic review & meta-analysis
20 studies (1 RCTs, 1 case-control study,18 cohort studies)
Pip/tazo vs. cefepime or carbapenems for the treatment of BSI due to bacteria producing chromosomal AmpC beta-lactamas #idsky #medsky #AMSsky
link.springer.com/article/10.1...
20 studies (1 RCTs, 1 case-control study,18 cohort studies)
Pip/tazo vs. cefepime or carbapenems for the treatment of BSI due to bacteria producing chromosomal AmpC beta-lactamas #idsky #medsky #AMSsky
link.springer.com/article/10.1...
The combination ATM/AVI allows aztreonam to act against MBL (whose activity cannot inhibit monobactams) and avibactam to contrast the contextual presence of SHV, TEM, CTX-M, AmpC, KPC and OXA #idsky
November 17, 2024 at 11:26 PM
The combination ATM/AVI allows aztreonam to act against MBL (whose activity cannot inhibit monobactams) and avibactam to contrast the contextual presence of SHV, TEM, CTX-M, AmpC, KPC and OXA #idsky
Useful summary of inducible AmpC - strength of inducement and susceptibility to hydrolysis #escmidglobal
April 14, 2025 at 8:33 AM
Useful summary of inducible AmpC - strength of inducement and susceptibility to hydrolysis #escmidglobal
Hello fellow nerds! The upcoming Australasian Mathematical Psych Conference (AMPC) is going to be on Feb 23-25, and they've just put out the call for abstracts.
Details below. This is one of my favourite conferences and this year it's in Singapore(!!) which should be awesome.
Details below. This is one of my favourite conferences and this year it's in Singapore(!!) which should be awesome.
November 13, 2025 at 7:33 AM
Hello fellow nerds! The upcoming Australasian Mathematical Psych Conference (AMPC) is going to be on Feb 23-25, and they've just put out the call for abstracts.
Details below. This is one of my favourite conferences and this year it's in Singapore(!!) which should be awesome.
Details below. This is one of my favourite conferences and this year it's in Singapore(!!) which should be awesome.
Cefepime versus Carbapenem Therapy for the Treatment of Invasive Infections with Inducible Chromosomal AmpC-Producing Enterobacterales - A Systematic Review and Meta-Analysis
✅ Just Accepted
#IDSky
✅ Just Accepted
#IDSky
Cefepime versus Carbapenem Therapy for the Treatment of Invasive Infections with Inducible Chromosomal AmpC-Producing Enterobacterales - A Systematic Review and Meta-Analysis
Optimal antibiotic choice for AmpC-producing Enterobacterales bloodstream infections (BSIs) and complicated urinary tract infections (cUTIs) remains to be clearly defined.
doi.org
July 23, 2025 at 9:11 PM
Cefepime versus Carbapenem Therapy for the Treatment of Invasive Infections with Inducible Chromosomal AmpC-Producing Enterobacterales - A Systematic Review and Meta-Analysis
✅ Just Accepted
#IDSky
✅ Just Accepted
#IDSky
Cefepime represents an excellent alternative to carbapenems for BSI due to AmpC-producing strains, whereas piperacillin/tazobactam is associated with a higher rate of clinical and microbiological failure
Do we need an RCT? #idsky #medsky #AMSsky
Do we need an RCT? #idsky #medsky #AMSsky
🆕️🔥Systematic review & meta-analysis
20 studies (1 RCTs, 1 case-control study,18 cohort studies)
Pip/tazo vs. cefepime or carbapenems for the treatment of BSI due to bacteria producing chromosomal AmpC beta-lactamas #idsky #medsky #AMSsky
link.springer.com/article/10.1...
20 studies (1 RCTs, 1 case-control study,18 cohort studies)
Pip/tazo vs. cefepime or carbapenems for the treatment of BSI due to bacteria producing chromosomal AmpC beta-lactamas #idsky #medsky #AMSsky
link.springer.com/article/10.1...
Piperacillin/tazobactam vs. cefepime or carbapenems for the treatment of bloodstream infections due to bacteria producing chromosomal AmpC beta-lactamase: a systematic review and meta-analysis - Infec...
Background The best treatment for bloodstream infections (BSI) due to chromosomal AmpC (c-AmpC) producing Enterobacterales is not clearly defined. Objectives To describe the clinical and microbiologic...
link.springer.com
December 4, 2024 at 7:27 PM
New paper alert 🚨 Genomic insights into extended-spectrum β-lactamase- and plasmid-borne AmpC-producing Escherichia coli transmission between humans and livestock in rural Cambodia. Incredible effort from Ebraheem Elmarghani and others for their contributions! 👏💩🧫🦠🧬
doi.org/10.1099/jmm....
doi.org/10.1099/jmm....
Genomic insights into extended-spectrum β-lactamase- and plasmid-borne AmpC-producing Escherichia coli transmission between humans and livestock in rural Cambodia
Introduction. The global spread of extended-spectrum cephalosporinase-producing Escherichia coli (producing extended-spectrum β-lactamase or plasmid-borne AmpC, hereafter ESC-Ec) is a major public hea...
doi.org
March 14, 2025 at 7:12 AM
New paper alert 🚨 Genomic insights into extended-spectrum β-lactamase- and plasmid-borne AmpC-producing Escherichia coli transmission between humans and livestock in rural Cambodia. Incredible effort from Ebraheem Elmarghani and others for their contributions! 👏💩🧫🦠🧬
doi.org/10.1099/jmm....
doi.org/10.1099/jmm....
Tazobactam does not inhibit AmpC-mediated hydrolysis of ceftolozane and demonstrates poor binding affinity for both wild-type and mutant AmpC enzymes
🆕💫 #AAC
Restoring ceftolozane susceptibility: a role for diazabicyclooctane β-lactamase inhibitors #idsky #microsky
journals.asm.org/doi/10.1128/...
🆕💫 #AAC
Restoring ceftolozane susceptibility: a role for diazabicyclooctane β-lactamase inhibitors #idsky #microsky
journals.asm.org/doi/10.1128/...
Restoring ceftolozane susceptibility: a role for diazabicyclooctane β-lactamase inhibitors? | Antimicrobial Agents and Chemotherapy
Ceftolozane–tazobactam (TOL-TAZ) is recommended as the front-line therapy for infections
caused by multidrug-resistant (MDR) and difficult-to-treat resistant Pseudomonas aeruginosa (1, 2). Compared to...
journals.asm.org
January 29, 2025 at 10:53 AM
Tazobactam does not inhibit AmpC-mediated hydrolysis of ceftolozane and demonstrates poor binding affinity for both wild-type and mutant AmpC enzymes
🆕💫 #AAC
Restoring ceftolozane susceptibility: a role for diazabicyclooctane β-lactamase inhibitors #idsky #microsky
journals.asm.org/doi/10.1128/...
🆕💫 #AAC
Restoring ceftolozane susceptibility: a role for diazabicyclooctane β-lactamase inhibitors #idsky #microsky
journals.asm.org/doi/10.1128/...
🆕💫 Retrospective multicentre
study #JAC
Temocillin efficacy against AmpC β-lactamase-producing Enterobacterales: a relevant alternative to cefepime? #idsky #medsky #EMIMCC #utisky
academic.oup.com/jac/advance-...
study #JAC
Temocillin efficacy against AmpC β-lactamase-producing Enterobacterales: a relevant alternative to cefepime? #idsky #medsky #EMIMCC #utisky
academic.oup.com/jac/advance-...
Temocillin efficacy against AmpC β-lactamase-producing Enterobacterales: a relevant alternative to cefepime?
AbstractIntroduction. Temocillin is a semi-synthetic β-lactam with a narrow spectrum but high stability against hydrolysis by β-lactamases, including AmpC.
academic.oup.com
December 23, 2024 at 10:51 AM
Super excited to be hosting Australasian Mathematical Psychology conference this week in Singapore! #ampc26sg
ampc2026.com
ampc2026.com
AMPC 2026 | Website for the Australasian Mathematical Psychology Conference 2026
ampc2026.com
February 20, 2026 at 10:42 PM
Super excited to be hosting Australasian Mathematical Psychology conference this week in Singapore! #ampc26sg
ampc2026.com
ampc2026.com
AmpC-producing Enterobacterales:
Expected phenotypes for wild-type strains and in cases of AmpC derepression and ESBL production
doi.org/10.3390/phar...
#IDSky
Expected phenotypes for wild-type strains and in cases of AmpC derepression and ESBL production
doi.org/10.3390/phar...
#IDSky
January 4, 2025 at 5:18 PM
AmpC-producing Enterobacterales:
Expected phenotypes for wild-type strains and in cases of AmpC derepression and ESBL production
doi.org/10.3390/phar...
#IDSky
Expected phenotypes for wild-type strains and in cases of AmpC derepression and ESBL production
doi.org/10.3390/phar...
#IDSky
Battle of the mnemonics, SPACE, SPICE Vs HECK-Yes!
🆕💥🟢Cross-sectional,nationwide survey of ID clinicians to evaluate clinical & microbiologic practice patterns for infections caused by Enterobacterales at risk of inducible AmpC production #idsky #microsky academic.oup.com/jacamr/artic...
🆕💥🟢Cross-sectional,nationwide survey of ID clinicians to evaluate clinical & microbiologic practice patterns for infections caused by Enterobacterales at risk of inducible AmpC production #idsky #microsky academic.oup.com/jacamr/artic...
Battle of the mnemonics, SPACE versus HECK-Yes! A cross-sectional, nationwide survey of infectious diseases clinicians to evaluate clinical and microbiologic practice patterns for infections caused by...
AbstractBackground. Enterobacterales considered at risk of inducible AmpC production are denoted by mnemonics including SPACE and HECK-Yes! However, these
academic.oup.com
May 11, 2026 at 5:05 PM
Battle of the mnemonics, SPACE, SPICE Vs HECK-Yes!
🆕💥🟢Cross-sectional,nationwide survey of ID clinicians to evaluate clinical & microbiologic practice patterns for infections caused by Enterobacterales at risk of inducible AmpC production #idsky #microsky academic.oup.com/jacamr/artic...
🆕💥🟢Cross-sectional,nationwide survey of ID clinicians to evaluate clinical & microbiologic practice patterns for infections caused by Enterobacterales at risk of inducible AmpC production #idsky #microsky academic.oup.com/jacamr/artic...
Can we still rely on cefepime to treat invasive infections with AmpC-producing organisms? According to this systematic review and meta-analysis, yes!
doi.org/10.1093/ofid...
#PharmSky #IDSky
doi.org/10.1093/ofid...
#PharmSky #IDSky
Cefepime versus Carbapenem Therapy for the Treatment of Invasive Infections with Inducible Chromosomal AmpC-Producing Enterobacterales—A Systematic Review and Meta-Analysis
AbstractObjectives. Optimal antibiotic choice for AmpC-producing Enterobacterales bloodstream infections (BSIs) and complicated urinary tract infections (c
doi.org
July 16, 2025 at 12:00 PM
Can we still rely on cefepime to treat invasive infections with AmpC-producing organisms? According to this systematic review and meta-analysis, yes!
doi.org/10.1093/ofid...
#PharmSky #IDSky
doi.org/10.1093/ofid...
#PharmSky #IDSky
I find cefepime very useful to diversify empiric antipseudomonal treatments among immunocompromised hosts, and as a carbapenem-sparing agent against ampC producers.
This recent metaanalysis made me wonder if I should stop using it… 🧵(1/5)
jamanetwork.com/journals/jam... #IDSky #AMSsky #IDOnc
This recent metaanalysis made me wonder if I should stop using it… 🧵(1/5)
jamanetwork.com/journals/jam... #IDSky #AMSsky #IDOnc
Cefepime and Mortality
This systematic review with bayesian meta-analysis of randomized clinical trials examined the association of cefepime with all-cause mortality compared with other β-lactam antibiotics.
jamanetwork.com
September 20, 2026 at 2:52 AM
I find cefepime very useful to diversify empiric antipseudomonal treatments among immunocompromised hosts, and as a carbapenem-sparing agent against ampC producers.
This recent metaanalysis made me wonder if I should stop using it… 🧵(1/5)
jamanetwork.com/journals/jam... #IDSky #AMSsky #IDOnc
This recent metaanalysis made me wonder if I should stop using it… 🧵(1/5)
jamanetwork.com/journals/jam... #IDSky #AMSsky #IDOnc
I think you can intuit mechanism of resistance here based on Cefoxitin resistance (Likely AMP-C?). A lot of the times the abx choice will be similar though. But probably can use cefepime here.
academic.oup.com/cid/article/...
academic.oup.com/cid/article/...
A Primer on AmpC β-Lactamases: Necessary Knowledge for an Increasingly Multidrug-resistant World
This review summarizes mechanisms of resistance resulting in AmpC expression, triggers of AmpC expression, the species-specific epidemiology of AmpC β-lact
academic.oup.com
January 9, 2025 at 2:40 PM
I think you can intuit mechanism of resistance here based on Cefoxitin resistance (Likely AMP-C?). A lot of the times the abx choice will be similar though. But probably can use cefepime here.
academic.oup.com/cid/article/...
academic.oup.com/cid/article/...
www.aerzteblatt.de/news/rohmilc...
www.bvl.bund.de/SharedDocs/P...
⏩Etwa 10 % der Proben enthielten bestimmte multiresistente Bakterien wie ESBL/AmpC-bildende E. coli.⏪
Multiresistente Keime.
www.bvl.bund.de/SharedDocs/P...
⏩Etwa 10 % der Proben enthielten bestimmte multiresistente Bakterien wie ESBL/AmpC-bildende E. coli.⏪
Multiresistente Keime.
Rohmilch: Studie sieht hohes Infektionsrisiko – Deutsches Ärzteblatt
www.aerzteblatt.de
July 23, 2025 at 7:37 AM
www.aerzteblatt.de/news/rohmilc...
www.bvl.bund.de/SharedDocs/P...
⏩Etwa 10 % der Proben enthielten bestimmte multiresistente Bakterien wie ESBL/AmpC-bildende E. coli.⏪
Multiresistente Keime.
www.bvl.bund.de/SharedDocs/P...
⏩Etwa 10 % der Proben enthielten bestimmte multiresistente Bakterien wie ESBL/AmpC-bildende E. coli.⏪
Multiresistente Keime.
Das @bmdv schreibt, dass in 5 bzw 10% der Rohmilchproben Campylobacter spp. und STEC bzw multiresistente Bakterien wie ESBL/AmpC-bildende E. coli. gefunden wurden.
5/
www.bvl.bund.de/SharedDocs/P...
5/
www.bvl.bund.de/SharedDocs/P...
Pressemitteilungen - Rohmilch kann krankmachende Keime enthalten
Die Ergebnisse des Zoonosen-Monitorings 2019 zeigen, dass Rohmilch potenziell krankmachende Keime enthalten kann. In bis zu 5 % der rund 360 untersuchten Rohmilch-Proben wurden Keime wie Campylobacter...
www.bvl.bund.de
May 17, 2024 at 12:34 PM
Das @bmdv schreibt, dass in 5 bzw 10% der Rohmilchproben Campylobacter spp. und STEC bzw multiresistente Bakterien wie ESBL/AmpC-bildende E. coli. gefunden wurden.
5/
www.bvl.bund.de/SharedDocs/P...
5/
www.bvl.bund.de/SharedDocs/P...
#OTILT Aztreonam is stable against metallo-beta-lactamase (MBL) hydrolysis, due to its monocyclic structure preventing MBL binding to the active site. However, ESBL and AmpC B-lactamases production limit monotherapy. Avibactam helps protect aztreonam because it inhibits these serine B-lactamases.
September 22, 2026 at 9:38 PM
#OTILT Aztreonam is stable against metallo-beta-lactamase (MBL) hydrolysis, due to its monocyclic structure preventing MBL binding to the active site. However, ESBL and AmpC B-lactamases production limit monotherapy. Avibactam helps protect aztreonam because it inhibits these serine B-lactamases.