Life is sustained at the cellular level by maintaining a fine balance of ions across phospholipid membranes. Transmembrane anion transport by small molecul

Sustainable recovery of critical resources from complex aqueous streams is constrained by membranes that fail to combine rapid ion transport with precise mono/multivalent discrimination. Here, we repo...

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Metal-organic frameworks (MOFs) often undergo structural reconstruction during oxygen evolution, but controlling this transformation remains challenging. Here, we demonstrate that Cr incorporation into a Hofmann-type MOF regulates local coordination and directs surface-selective reconstruction into active oxyhydroxide species while maintaining framework integrity. This Cr-mediated strategy converts uncontrolled MOF degradation into a controllable activation process, enabling efficient oxygen evolution and high-performance anion-exchange membrane water electrolysis.

AbstractThe rapid separation and identification of disaccharide isomers pose a significant analytical challenge in fields such as food science and glycobiology. This study developed a fast, simple, and low-cost analytical method based on electrospray ionization ion mobility spectrometry (ESI-IMS) combined with an ion adduction strategy for the efficient separation of eight common disaccharide isomers. The principle involves introducing specific metal cations or anions into the disaccharide solution to form stable adducts, thereby significantly altering their drift behavior during IMS analysis. Systematic screening of seven cations and nine anions and mass spectrometry result revealed that in positive ion mode, Cu+ forms structurally rigid dimeric adducts [Cu + 2M]+ with disaccharides, effectively amplifying subtle stereostructural differences into significant distinctions in collision cross section (CCS) and increasing the proportion of fully separated disaccharide pairs to 71.4%. In negative ion mode, I− forms predominantly single [I + M]− adducts, substantially simplifying the complex original spectra and achieving a full separation rate of 60.7%. Theoretical calculations indicated stable electronic structures within the complex systems and the differences in both the strength and interaction characteristics between the two types of adducts. This method requires no complex pretreatment or expensive advanced instrumentation, and is readily implementable on conventional drift-tube IMS platforms. It thus offers a robust, cost-effective, and high-throughput solution for disaccharide isomer analysis, with potential applications in food science, biomedicine, and materials characterization.

A multi-institutional team reports a platinum-free iron catalyst reaching 902 mW/cm² in an anion-exchange membrane fuel cell cathode, setting a new performance benchmark for metal-phthalocyanine-based systems, according…

Aion is an anion-conducting, bistable channelrhodopsin that enables long-term silencing of neuronal networks, as demonstrated in organotypic hippocampal cultures and Drosophila melanogaster larvae.

Host–guest mismatch between cyclodextrins and the decatungstate anion leads to high site-selectivity in hydrogen atom transfer between them.

Oncogene-driven endoplasmic reticulum (ER) stress is common in cancer. Here, authors show breast cancers extend Golgi anion channel GPR89 to the ER to mitigate this stress, creating a potentially targetable dependency and new therapeutic strategy.