In this work, we present our efforts to develop a Grignard reagent free, low valent cobalt-catalysed C-H arylation, using high-throughput experimentation (HTE). Although we did not succeed to obtain a...

Nature Chemistry, Published online: 18 August 2026; doi:10.1038/s41557-026-02231-5The α-arylation of carbonyl compounds remains a central challenge in chemical synthesis. Now it has been shown that BisTrip, a recyclable aryl group transporter, enables rapid and regiospecific α-arylation of diverse carbonyl compounds, providing access to challenging arylated ketones including quaternary carbon centres within intricate molecules.

The first effective base metal-catalyzed protocol for C−O cross-coupling of primary, secondary, and tertiary alcohol-containing N-Boc protected amino alcohols with (hetero)aryl chlorides, affording a....

We report the discovery of a boron-driven ortho-arylation reaction of N-aryl amides and ureas. This novel method enables directed borylation of a wide range of substrates, leading to the synthesis of...

Lactam rings can be introduced to a diverse range of arenes and heteroarenes employing our mild and efficient photoredox method. The N-(het)arylation of lactams also works in aqueous media, allowing ...

Selectivity is an essential part of organic synthesis and key to synthetic efficiency. However, selectivity is challenging to achieve in hydrocarbon molecules. Herein we report a mild and direct meth....

The perceived toxicity of organometallic reagents has limited their use in living systems. Now it has been shown that balancing flexible chelation with biocompatible ligands without precluding chemica...

A new class of 6,8-diaryl-substituted DBPHZs has been synthesized via regioselective Pd-catalyzed C─H arylation and oxidative skeletal rearrangement. Strategically introduced bulky aryl groups bearin...

π-conjugated polymers (CPs) that are concurrently soft and stretchable are needed for deformable electronics. This systematic molecular weight study on promising candidates for soft CPs, poly(indacen...

Nature Chemistry, Published online: 12 June 2026; doi:10.1038/s41557-026-02148-zN-aryl pyrazole is a prevalent motif among pharmaceuticals across various therapeutic areas but can be challenging to synthesize due to the high similarity of the two nitrogen atoms. Now it has been shown that the use of copper catalysis and arynes provides a switchable protocol to access both regioisomers.

The development of broadly useful C-P cross-couplings of (hetero)aryl chlorides and HP(O)(R/OR)2 nucleophiles by use of nickel/DalPhos-based catalysts is described, along with findings from DFT studi....