Shabaz Lab
@shabazlab.bsky.social
Reposted by Shabaz Lab
To all: I think we need more voices in science, and not necessarily in short form on social platforms. So this is my plea for you to start a blog (bring back the aughts' blog rings!). Use this template, it comes with an easy compose window so no markdown or commit(ment) needed. neely.github.io/hyde/
Hyde
I never wrote up the other repo I actually use the most, which is Hyde, the thing this blog runs on. Btw, now is the time to start YOUR blog, really.
neely.github.io
August 20, 2026 at 5:35 PM
To all: I think we need more voices in science, and not necessarily in short form on social platforms. So this is my plea for you to start a blog (bring back the aughts' blog rings!). Use this template, it comes with an easy compose window so no markdown or commit(ment) needed. neely.github.io/hyde/
Reposted by Shabaz Lab
Join Professor Philipp Kukura FRS for the Clifford Paterson Prize Lecture on 9 February. He will describe the development of mass photometry, a method that measures the mass of molecules and viruses: royalsociety.org/science-even... @kavlioxford.bsky.social
January 12, 2026 at 3:05 PM
Join Professor Philipp Kukura FRS for the Clifford Paterson Prize Lecture on 9 February. He will describe the development of mass photometry, a method that measures the mass of molecules and viruses: royalsociety.org/science-even... @kavlioxford.bsky.social
Reposted by Shabaz Lab
Introducing a phospho-switch for allosterically regulating target proteins in response to ERK kinase activity. @toettch.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Design and optimization of a kinase-controlled allosteric switch - Nature Methods
This Article introduces a phospho-switch for allosterically regulating target proteins in response to ERK kinase activity.
www.nature.com
July 23, 2026 at 5:56 PM
Introducing a phospho-switch for allosterically regulating target proteins in response to ERK kinase activity. @toettch.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Shabaz Lab
My article is published but I have to ask a co-author for the pdf because Wiley decided it was too expensive for them to email an author's copy
July 9, 2026 at 1:28 PM
My article is published but I have to ask a co-author for the pdf because Wiley decided it was too expensive for them to email an author's copy
Reposted by Shabaz Lab
🚨🚨NEW PREPRINT ALERT!🚨🚨Proud to present our recent study, out now on bioRxiv, in which we reveal an RNA-dependent positive feedback loop that drives malignant ribosome biogenesis and tumour growth (1/15).
🔗
www.biorxiv.org/content/10.6...
🔗
www.biorxiv.org/content/10.6...
July 3, 2026 at 7:18 PM
🚨🚨NEW PREPRINT ALERT!🚨🚨Proud to present our recent study, out now on bioRxiv, in which we reveal an RNA-dependent positive feedback loop that drives malignant ribosome biogenesis and tumour growth (1/15).
🔗
www.biorxiv.org/content/10.6...
🔗
www.biorxiv.org/content/10.6...
Reposted by Shabaz Lab
We have a new preprint!!!
Our very talented PhD student Tom McGirr, along with our outstanding collaborators, show that translational attenuation is critical for avoiding proteotoxic stress upon exposure to ionizing radiation.
#RNASky, #RNA,
www.biorxiv.org/content/10.6...
Our very talented PhD student Tom McGirr, along with our outstanding collaborators, show that translational attenuation is critical for avoiding proteotoxic stress upon exposure to ionizing radiation.
#RNASky, #RNA,
www.biorxiv.org/content/10.6...
GIGYF2/4EHP-Mediated Translational Attenuation Maintains Cellular Homeostasis Following Ionizing Radiation
Translational regulation is a critical component of the cellular response to environmental stress. Ionizing radiation (IR) exists naturally at low doses (e.g., cosmic rays and radioactive materials) b...
www.biorxiv.org
July 3, 2026 at 1:23 PM
We have a new preprint!!!
Our very talented PhD student Tom McGirr, along with our outstanding collaborators, show that translational attenuation is critical for avoiding proteotoxic stress upon exposure to ionizing radiation.
#RNASky, #RNA,
www.biorxiv.org/content/10.6...
Our very talented PhD student Tom McGirr, along with our outstanding collaborators, show that translational attenuation is critical for avoiding proteotoxic stress upon exposure to ionizing radiation.
#RNASky, #RNA,
www.biorxiv.org/content/10.6...
Reposted by Shabaz Lab
Update: very happy to announce we added @victoryin.bsky.social and Hans Wessels to our lineup of instructors.
Our PhD course Advanced Proteomics for Drug Discovery and Biotherapeutics happens in September, still some spots available.
Register now:
www.eventbrite.nl/e/advanced-p...
Our PhD course Advanced Proteomics for Drug Discovery and Biotherapeutics happens in September, still some spots available.
Register now:
www.eventbrite.nl/e/advanced-p...
July 1, 2026 at 11:25 AM
Update: very happy to announce we added @victoryin.bsky.social and Hans Wessels to our lineup of instructors.
Our PhD course Advanced Proteomics for Drug Discovery and Biotherapeutics happens in September, still some spots available.
Register now:
www.eventbrite.nl/e/advanced-p...
Our PhD course Advanced Proteomics for Drug Discovery and Biotherapeutics happens in September, still some spots available.
Register now:
www.eventbrite.nl/e/advanced-p...
I am thrilled to share that our work evaluating - deep breath - UVPD, ECD, AI-ECD, sceHCD (sceCID really), and EID for glycopeptides is out now!
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Evaluating the Performance of Photon- and Electron-Based Fragmentation Methods in Omnitrap-LCMS Analysis of N-Glycopeptides
To date, collision-induced dissociation and methods based on electron transfer dissociation are considered the ‘best’ approaches for the mass spectrometry analysis of N- and O-glycopeptides, respectiv...
pubs.acs.org
June 29, 2026 at 2:02 PM
I am thrilled to share that our work evaluating - deep breath - UVPD, ECD, AI-ECD, sceHCD (sceCID really), and EID for glycopeptides is out now!
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Wordle 1,835 5/6
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Another doozy. Doozy would have been an easier word.
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Another doozy. Doozy would have been an easier word.
June 28, 2026 at 3:31 PM
Wordle 1,835 5/6
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🟨🟨⬛⬛⬛
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Another doozy. Doozy would have been an easier word.
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Another doozy. Doozy would have been an easier word.
When it comes to reviews, I have a high resistance level to performing experiments that prove obvious points. I have died on this hill many times and I will continue sabotaging myself on this point.
June 26, 2026 at 11:01 AM
When it comes to reviews, I have a high resistance level to performing experiments that prove obvious points. I have died on this hill many times and I will continue sabotaging myself on this point.
June 25, 2026 at 9:12 AM
June 5, 2026 at 9:23 AM
Reposted by Shabaz Lab
(ACS Anal Chem) [ASAP] Large-Scale Stereolithography Precision Manufactured Solid Cone-Jet Emitters for Electrospray Mass Spectrometry: Analytical ChemistryDOI: 10.1021/acs.analchem.6c02479 #MassSpecRSS #ACSAChem
[ASAP] Large-Scale Stereolithography Precision Manufactured Solid Cone-Jet Emitters for Electrospray Mass Spectrometry
Analytical ChemistryDOI: 10.1021/acs.analchem.6c02479
dlvr.it
June 5, 2026 at 4:02 AM
(ACS Anal Chem) [ASAP] Large-Scale Stereolithography Precision Manufactured Solid Cone-Jet Emitters for Electrospray Mass Spectrometry: Analytical ChemistryDOI: 10.1021/acs.analchem.6c02479 #MassSpecRSS #ACSAChem
Reposted by Shabaz Lab
Between 1985--2023, MIT's faculty grew 9%. Administrative staff grew 189%. 📈 Why? In new @pnas.org paper, we use dynamical system model to show administrative bloat can emerge without empire-building--just from well-intentioned problem-solving gone awry
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
June 2, 2026 at 6:46 PM
Between 1985--2023, MIT's faculty grew 9%. Administrative staff grew 189%. 📈 Why? In new @pnas.org paper, we use dynamical system model to show administrative bloat can emerge without empire-building--just from well-intentioned problem-solving gone awry
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Reposted by Shabaz Lab
🔬 New preprint from KPL ApS: Arg-C Zero, recombinant arginyl endopeptidase with >99% cleavage efficiency, R-P bond cleavage, acid-compatible labile PTM workflows, and histone analysis without derivatization.
📄 doi.org/10.64898/202...
🛒 kplbio.com/arg-c-zero/
#Proteomics #MassSpec #PTM #Enzymes
📄 doi.org/10.64898/202...
🛒 kplbio.com/arg-c-zero/
#Proteomics #MassSpec #PTM #Enzymes
May 29, 2026 at 7:55 PM
🔬 New preprint from KPL ApS: Arg-C Zero, recombinant arginyl endopeptidase with >99% cleavage efficiency, R-P bond cleavage, acid-compatible labile PTM workflows, and histone analysis without derivatization.
📄 doi.org/10.64898/202...
🛒 kplbio.com/arg-c-zero/
#Proteomics #MassSpec #PTM #Enzymes
📄 doi.org/10.64898/202...
🛒 kplbio.com/arg-c-zero/
#Proteomics #MassSpec #PTM #Enzymes
Reposted by Shabaz Lab
(MS Reviews) Carlito B. Lebrilla: Building Instruments, Fields and Opportunities From the Ground up: Mass Spectrometry Reviews, EarlyView. #MassSpectromRev #MassSpecRSS
Carlito B. Lebrilla: Building Instruments, Fields and Opportunities From the Ground up
Mass Spectrometry Reviews, EarlyView.
dlvr.it
May 16, 2026 at 4:07 PM
(MS Reviews) Carlito B. Lebrilla: Building Instruments, Fields and Opportunities From the Ground up: Mass Spectrometry Reviews, EarlyView. #MassSpectromRev #MassSpecRSS
Reposted by Shabaz Lab
Well, its out. Honored to play a small part in this huge project using multi-omics to profile human biology and variations at unprecedented scale.
www.sciencedirect.com/science/arti...
Thanks to a great team of co-authors and collaborators!
@fbmh-uom.bsky.social @uom-dcs.bsky.social
www.sciencedirect.com/science/arti...
Thanks to a great team of co-authors and collaborators!
@fbmh-uom.bsky.social @uom-dcs.bsky.social
A comparison of deep multiomics profiles across ethnicity, geography, and age
Despite extensive research, molecular differences in human populations and the influence of ancestry, age, geography, and diet are poorly understood. …
www.sciencedirect.com
May 15, 2026 at 9:44 AM
Well, its out. Honored to play a small part in this huge project using multi-omics to profile human biology and variations at unprecedented scale.
www.sciencedirect.com/science/arti...
Thanks to a great team of co-authors and collaborators!
@fbmh-uom.bsky.social @uom-dcs.bsky.social
www.sciencedirect.com/science/arti...
Thanks to a great team of co-authors and collaborators!
@fbmh-uom.bsky.social @uom-dcs.bsky.social
Reposted by Shabaz Lab
We've just published a preprint describing GlyComboCLI, a command-line tool for glycan composition assignment in MS data. Open-source, FAIR-compliant, and built for integration into automated bioinformatic workflows. #glycotime
Link: www.biorxiv.org/content/10.6...
Link: www.biorxiv.org/content/10.6...
May 14, 2026 at 1:36 PM
We've just published a preprint describing GlyComboCLI, a command-line tool for glycan composition assignment in MS data. Open-source, FAIR-compliant, and built for integration into automated bioinformatic workflows. #glycotime
Link: www.biorxiv.org/content/10.6...
Link: www.biorxiv.org/content/10.6...
Reposted by Shabaz Lab
Meet Chris Crittenden, our most recent #FacesOfMassSpec feature. At @Genentech, Chris uses tandem mass spectrometry to support clinical candidates while also championing mentorship and scientific collaboration. https://bit.ly/3RaRCRu
May 12, 2026 at 7:14 PM
Meet Chris Crittenden, our most recent #FacesOfMassSpec feature. At @Genentech, Chris uses tandem mass spectrometry to support clinical candidates while also championing mentorship and scientific collaboration. https://bit.ly/3RaRCRu
Reposted by Shabaz Lab
Meet Chris Crittenden, our most recent #FacesOfMassSpec feature. At @Genentech, Chris uses tandem mass spectrometry to support clinical candidates while also championing mentorship and scientific collaboration. https://bit.ly/3RaRCRu
May 12, 2026 at 7:14 PM
Meet Chris Crittenden, our most recent #FacesOfMassSpec feature. At @Genentech, Chris uses tandem mass spectrometry to support clinical candidates while also championing mentorship and scientific collaboration. https://bit.ly/3RaRCRu
Reposted by Shabaz Lab
Short write-up of our journey. Searching for T cell transcription factors, Marc v/d Wetering stumbled across Wnt signaling. Vladja Korinek linked Wnt to colon cancer and crypt biology. Nick Barker discovered the gut stem cell. Toshi Sato invented organoids authors.elsevier.com/a/1n3No6tu0C...
May 10, 2026 at 8:06 AM
Short write-up of our journey. Searching for T cell transcription factors, Marc v/d Wetering stumbled across Wnt signaling. Vladja Korinek linked Wnt to colon cancer and crypt biology. Nick Barker discovered the gut stem cell. Toshi Sato invented organoids authors.elsevier.com/a/1n3No6tu0C...
Reposted by Shabaz Lab
Our new study characterises the assembly of two functionally distinct chloroplast protein import complexes (TOC-P and TOC-N) in the outer membrane of plant chloroplasts.
Huge thanks to @Ivan Ahel's lab and @sykhalid.bsky.social's lab, for a fantastic collaboration!
www.biorxiv.org/content/10.1...
Huge thanks to @Ivan Ahel's lab and @sykhalid.bsky.social's lab, for a fantastic collaboration!
www.biorxiv.org/content/10.1...
www.biorxiv.org
May 8, 2026 at 4:44 PM
Our new study characterises the assembly of two functionally distinct chloroplast protein import complexes (TOC-P and TOC-N) in the outer membrane of plant chloroplasts.
Huge thanks to @Ivan Ahel's lab and @sykhalid.bsky.social's lab, for a fantastic collaboration!
www.biorxiv.org/content/10.1...
Huge thanks to @Ivan Ahel's lab and @sykhalid.bsky.social's lab, for a fantastic collaboration!
www.biorxiv.org/content/10.1...
Reposted by Shabaz Lab
Congratulations to Bjarne Feddersen for his work on benchmarking umbrella sampling workflows for PMF calculations of membrane permeation! Systematic work that provides guidance on how to approach these to minimise compute resource. @oxfordbiochemistry.bsky.social.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Umbrella Sampling Workflows for Fast-Converging PMF Calculations without Artificial WHAM Constraints
Umbrella sampling is a powerful tool to investigate the underlying free-energy landscapes that govern the permeation properties of small molecules through complex lipid bilayers. However, obtaining co...
pubs.acs.org
May 6, 2026 at 7:55 AM
Congratulations to Bjarne Feddersen for his work on benchmarking umbrella sampling workflows for PMF calculations of membrane permeation! Systematic work that provides guidance on how to approach these to minimise compute resource. @oxfordbiochemistry.bsky.social.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
The deadline (May 19th) is getting awfully close. Don't miss out!
Don't miss this great opportunity to participate in the #Brixen #Proteomics Summerschool. As every year, the line up is very impressive. Registration Deadline is on the 19th of May!
May 5, 2026 at 4:47 PM
The deadline (May 19th) is getting awfully close. Don't miss out!
Watching the football in the UK and I just witnessed an Eli Lilly funded advert about 'obesity awareness'....... we did get this with 'labido stuff' read viagra too but not sure if that was internet only... Anyway, not sure what to make of it. No 'Ask your physician' stuff thankfully.
May 4, 2026 at 3:18 PM
Watching the football in the UK and I just witnessed an Eli Lilly funded advert about 'obesity awareness'....... we did get this with 'labido stuff' read viagra too but not sure if that was internet only... Anyway, not sure what to make of it. No 'Ask your physician' stuff thankfully.