Nature research paper: Human assembloid model of the ascending neural sensory pathway
https://go.nature.com/3YsLAwn
https://go.nature.com/3YsLAwn
Human assembloid model of the ascending neural sensory pathway - Nature
A human ascending somatosensory assembloid model was developed, which integrates multiple organoids to simulate the spinothalamic pathway, demonstrating functional connectivity and responsiveness to stimuli and revealing insights into pain-related genetic mutations.
go.nature.com
April 15, 2025 at 3:13 PM
Nature research paper: Human assembloid model of the ascending neural sensory pathway
https://go.nature.com/3YsLAwn
https://go.nature.com/3YsLAwn
UCSF scientists build brain organoids at scale equipped with blood vessels, "leading to high fidelity neurodevelopment." Preprint: www.biorxiv.org/content/10.6...
January 11, 2026 at 2:40 PM
UCSF scientists build brain organoids at scale equipped with blood vessels, "leading to high fidelity neurodevelopment." Preprint: www.biorxiv.org/content/10.6...
In a new #SciencePolicyForum, researchers review the growing ethical and social concerns related to advances in organoid and assembloid research and call for international collaboration and oversight to monitor and advise this rapidly developing field. https://scim.ag/47KMGY2
The need for a global effort to attend to human neural organoid and assembloid research
A continuing international process is needed to monitor and advise this rapidly progressing field
scim.ag
November 10, 2025 at 5:11 PM
In a new #SciencePolicyForum, researchers review the growing ethical and social concerns related to advances in organoid and assembloid research and call for international collaboration and oversight to monitor and advise this rapidly developing field. https://scim.ag/47KMGY2
I think there is a need for a complete re-think for organoid modeling.
As long as the architecture of organoids that you produce is not directly compared to a 3D map of the organ (say, a fallopian tube) or disease to be modeled, it will be approximate.
More here: www.science.org/doi/full/10....
As long as the architecture of organoids that you produce is not directly compared to a 3D map of the organ (say, a fallopian tube) or disease to be modeled, it will be approximate.
More here: www.science.org/doi/full/10....
Combined assembloid modeling and 3D whole-organ mapping captures the microanatomy and function of the human fallopian tube
Tunable assembloid modeling and CODA tissue mapping, in tandem, design a tissue-validated in vitro model of the fallopian tube.
www.science.org
March 1, 2026 at 8:17 PM
I think there is a need for a complete re-think for organoid modeling.
As long as the architecture of organoids that you produce is not directly compared to a 3D map of the organ (say, a fallopian tube) or disease to be modeled, it will be approximate.
More here: www.science.org/doi/full/10....
As long as the architecture of organoids that you produce is not directly compared to a 3D map of the organ (say, a fallopian tube) or disease to be modeled, it will be approximate.
More here: www.science.org/doi/full/10....
We use CODA to map human endometrial tissue at single-cell resolution, a map that then serves as a blueprint to design a multi-compartment multicellular assembloid of the endometrium.
Read about our approach to organoids/assembloids here: www.biorxiv.org/content/10.1...
Read about our approach to organoids/assembloids here: www.biorxiv.org/content/10.1...
October 18, 2025 at 3:41 PM
We use CODA to map human endometrial tissue at single-cell resolution, a map that then serves as a blueprint to design a multi-compartment multicellular assembloid of the endometrium.
Read about our approach to organoids/assembloids here: www.biorxiv.org/content/10.1...
Read about our approach to organoids/assembloids here: www.biorxiv.org/content/10.1...
We now have a list of confirmed speakers for the first @cshlnews.bsky.social meeting on #Assembloids in December 2025
Amazing group and two spectacular Keynotes: Joanna Wysocka & Ruslan Medzhitov!
Check it out👇
Amazing group and two spectacular Keynotes: Joanna Wysocka & Ruslan Medzhitov!
Check it out👇
February 5, 2025 at 6:59 PM
This spring, we reported in Nature a therapeutic approach for Timothy syndrome
This has been a long journey starting with making hiPS cell-derived neurons in 2D cultured 15 years ago when I was a postdoc & continued with creating in the lab #organoid and then #assembloid models of this disease
This has been a long journey starting with making hiPS cell-derived neurons in 2D cultured 15 years ago when I was a postdoc & continued with creating in the lab #organoid and then #assembloid models of this disease
November 16, 2024 at 7:56 PM
This spring, we reported in Nature a therapeutic approach for Timothy syndrome
This has been a long journey starting with making hiPS cell-derived neurons in 2D cultured 15 years ago when I was a postdoc & continued with creating in the lab #organoid and then #assembloid models of this disease
This has been a long journey starting with making hiPS cell-derived neurons in 2D cultured 15 years ago when I was a postdoc & continued with creating in the lab #organoid and then #assembloid models of this disease
"We established four-part assembloids from human pluripotent stem cells, integrating somatosensory, spinal, thalamic & cortical organoids [...to...] accelerate understanding of sensory circuits & facilitate therapeutic development." Elegant work by the @sergiuppasca.bsky.social lab in @nature.com. 🧪
Human assembloid model of the ascending neural sensory pathway - Nature
A human ascending somatosensory assembloid model was developed, which integrates multiple organoids to simulate the spinothalamic pathway, demonstrating functional connectivity and responsiveness to s...
www.nature.com
April 9, 2025 at 6:05 PM
"We established four-part assembloids from human pluripotent stem cells, integrating somatosensory, spinal, thalamic & cortical organoids [...to...] accelerate understanding of sensory circuits & facilitate therapeutic development." Elegant work by the @sergiuppasca.bsky.social lab in @nature.com. 🧪
A clever forebrain assembloid model! Congratulations!
Ryan’s paper out in Neuron (bit.ly/3IICGFX). He derived bona fide parvalbumin (PV+) cortical interneurons from hPSCs, one the slowest developing neurons, and could capturing interneuron-related disease phenotypes linked to schizophrenia - including impaired gamma-oscillations - in his assembloids.
Redirecting
bit.ly
July 25, 2025 at 5:10 PM
A clever forebrain assembloid model! Congratulations!
We will post soon two major papers on women’s health.
The first paper could change clinical practice for the early detection of ovarian cancer.
The second paper shows the creation of new cell assembloid that reflects the complex composition and architecture of endometrial tissue mapped in 3D.
The first paper could change clinical practice for the early detection of ovarian cancer.
The second paper shows the creation of new cell assembloid that reflects the complex composition and architecture of endometrial tissue mapped in 3D.
August 16, 2025 at 12:31 PM
We will post soon two major papers on women’s health.
The first paper could change clinical practice for the early detection of ovarian cancer.
The second paper shows the creation of new cell assembloid that reflects the complex composition and architecture of endometrial tissue mapped in 3D.
The first paper could change clinical practice for the early detection of ovarian cancer.
The second paper shows the creation of new cell assembloid that reflects the complex composition and architecture of endometrial tissue mapped in 3D.
Heart #Assembloid Vascularization (+pericyte coverage) & Innervation
1⃣#hiPSC-derived epicardium-myocardium #Organoid + 2⃣Sympathetic neuron #Spheroid
Beautiful vascular network!
Can we further differentiate it into A-C-V microcirculatory unit?😁
bioRxiv 2025
www.biorxiv.org/content/10.1...
1⃣#hiPSC-derived epicardium-myocardium #Organoid + 2⃣Sympathetic neuron #Spheroid
Beautiful vascular network!
Can we further differentiate it into A-C-V microcirculatory unit?😁
bioRxiv 2025
www.biorxiv.org/content/10.1...
January 18, 2025 at 12:44 PM
Heart #Assembloid Vascularization (+pericyte coverage) & Innervation
1⃣#hiPSC-derived epicardium-myocardium #Organoid + 2⃣Sympathetic neuron #Spheroid
Beautiful vascular network!
Can we further differentiate it into A-C-V microcirculatory unit?😁
bioRxiv 2025
www.biorxiv.org/content/10.1...
1⃣#hiPSC-derived epicardium-myocardium #Organoid + 2⃣Sympathetic neuron #Spheroid
Beautiful vascular network!
Can we further differentiate it into A-C-V microcirculatory unit?😁
bioRxiv 2025
www.biorxiv.org/content/10.1...
This week we welcome on campus 2025 class of students for our hands-on Stanford Brain Organogenesis course.
With students joining from across the globe, this is our most international class yet—diving into cutting-edge neural #organoid and #assembloid methods, ready to bring them back to their labs.
With students joining from across the globe, this is our most international class yet—diving into cutting-edge neural #organoid and #assembloid methods, ready to bring them back to their labs.
May 7, 2025 at 4:46 PM
This week we welcome on campus 2025 class of students for our hands-on Stanford Brain Organogenesis course.
With students joining from across the globe, this is our most international class yet—diving into cutting-edge neural #organoid and #assembloid methods, ready to bring them back to their labs.
With students joining from across the globe, this is our most international class yet—diving into cutting-edge neural #organoid and #assembloid methods, ready to bring them back to their labs.
In our new paper, we use a new 3D single-cell reference map to guide the design and validation of a new multi-compartment assembloid that mimics the function and architecture of the human endometrial tissue, exhibiting stromal decidualization.
More here: www.biorxiv.org/content/10.1...
More here: www.biorxiv.org/content/10.1...
August 23, 2025 at 1:10 PM
In our new paper, we use a new 3D single-cell reference map to guide the design and validation of a new multi-compartment assembloid that mimics the function and architecture of the human endometrial tissue, exhibiting stromal decidualization.
More here: www.biorxiv.org/content/10.1...
More here: www.biorxiv.org/content/10.1...
Superb assembloid model of the kidney
Generation of multi-lineage kidney assembloids with integration between nephrons and a single exiting collecting duct https://www.biorxiv.org/content/10.1101/2025.02.27.640561v1
March 11, 2025 at 4:01 AM
Superb assembloid model of the kidney
Researchers from @merihuchlab.bsky.social, together with colleagues from @labshevchenko.bsky.social and clinicians from Dresden and Leipzig developed a patient-specific human periportal liver assembloid. Publication in @nature.com. Full news: www.mpi-cbg.de/news-outreac...
Patient-specific human liver model to understand disease mechanisms
Dresden research team develops human modular “LEGO-like” model that lays foundation for a new era in liver research.
www.mpi-cbg.de
December 17, 2025 at 4:21 PM
Researchers from @merihuchlab.bsky.social, together with colleagues from @labshevchenko.bsky.social and clinicians from Dresden and Leipzig developed a patient-specific human periportal liver assembloid. Publication in @nature.com. Full news: www.mpi-cbg.de/news-outreac...
Fake kidney. This lab-grown human kidney ‘assembloid’ is a step towards creating artificial kidneys. Tiny filtering units have formed around a central drainage tube, similar to the organization of a real kidney.
December 15, 2025 at 5:05 PM
Fake kidney. This lab-grown human kidney ‘assembloid’ is a step towards creating artificial kidneys. Tiny filtering units have formed around a central drainage tube, similar to the organization of a real kidney.
Excellent perspective from @sergiuppasca.bsky.social, Paola Arlotta, @silvianeuro.bsky.social, @studerl.bsky.social & others on the need to improve experimental design & carefully characterise hPSC quality to improve the reproducibility of organoid & assembloid models.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A framework for neural organoids, assembloids and transplantation studies - Nature
Nature - A framework for neural organoids, assembloids and transplantation studies
www.nature.com
December 11, 2024 at 9:06 AM
Excellent perspective from @sergiuppasca.bsky.social, Paola Arlotta, @silvianeuro.bsky.social, @studerl.bsky.social & others on the need to improve experimental design & carefully characterise hPSC quality to improve the reproducibility of organoid & assembloid models.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A 3D multi-compartment assembloid to study
combined immune cell infiltration and cytotoxicity
Contains different compartments with different ECM.
Especially useful to test infiltration and cytotoxicity of CAR T cell therapies.
More here: www.cell.com/cell-reports...
combined immune cell infiltration and cytotoxicity
Contains different compartments with different ECM.
Especially useful to test infiltration and cytotoxicity of CAR T cell therapies.
More here: www.cell.com/cell-reports...
February 19, 2026 at 2:19 PM
A 3D multi-compartment assembloid to study
combined immune cell infiltration and cytotoxicity
Contains different compartments with different ECM.
Especially useful to test infiltration and cytotoxicity of CAR T cell therapies.
More here: www.cell.com/cell-reports...
combined immune cell infiltration and cytotoxicity
Contains different compartments with different ECM.
Especially useful to test infiltration and cytotoxicity of CAR T cell therapies.
More here: www.cell.com/cell-reports...
Assembloid, an emerging and powerful tool for future neuroscience research 🧠!
Great review from @sergiuppasca.bsky.social 's lab on this topic.
Great review from @sergiuppasca.bsky.social 's lab on this topic.
Assembloids have emerged as a powerful tool for studying previously inaccessible processes of development and tissue homeostasis.
In our article in Cell Stem Cell, we summarize advances in the generation & application of neural and non-neural #assembloids to explore complex cell-cell interactions.
In our article in Cell Stem Cell, we summarize advances in the generation & application of neural and non-neural #assembloids to explore complex cell-cell interactions.
November 18, 2024 at 1:27 PM
Assembloid, an emerging and powerful tool for future neuroscience research 🧠!
Great review from @sergiuppasca.bsky.social 's lab on this topic.
Great review from @sergiuppasca.bsky.social 's lab on this topic.
Bevor ich nach Frankfurt gefahren bin, wollte ich noch schnell checken, ob sich unser neues 3D-Modell gut assembliert hat – und ja: es hat! 🧠🙌
Wir haben zum ersten Mal primäre Makrophagen in unsere Ko-Kultur integriert – gemeinsam mit gesunden neuralen Zellen und Krebszellen.
Wir haben zum ersten Mal primäre Makrophagen in unsere Ko-Kultur integriert – gemeinsam mit gesunden neuralen Zellen und Krebszellen.
May 14, 2025 at 8:47 PM
Bevor ich nach Frankfurt gefahren bin, wollte ich noch schnell checken, ob sich unser neues 3D-Modell gut assembliert hat – und ja: es hat! 🧠🙌
Wir haben zum ersten Mal primäre Makrophagen in unsere Ko-Kultur integriert – gemeinsam mit gesunden neuralen Zellen und Krebszellen.
Wir haben zum ersten Mal primäre Makrophagen in unsere Ko-Kultur integriert – gemeinsam mit gesunden neuralen Zellen und Krebszellen.
Researchers at @uclastemcell.bsky.social & @dgsomucla.bsky.social created the first human hippocampal #assembloid model, which can be used to study epilepsy as well as neurodevelopmental, neurodegenerative, and other brain disorders.
stemcell.ucla.edu/news/ucla-re...
#devbio #neuroskyence 🧪
stemcell.ucla.edu/news/ucla-re...
#devbio #neuroskyence 🧪
UCLA researchers find how epilepsy genes disrupt different brain regions using stem cell models
For families of children with severe epilepsy, controlling seizures is often just the beginning of their challenges. Even in cases where powerful medications can reduce seizures, many children continu...
stemcell.ucla.edu
September 19, 2025 at 11:50 AM
Researchers at @uclastemcell.bsky.social & @dgsomucla.bsky.social created the first human hippocampal #assembloid model, which can be used to study epilepsy as well as neurodevelopmental, neurodegenerative, and other brain disorders.
stemcell.ucla.edu/news/ucla-re...
#devbio #neuroskyence 🧪
stemcell.ucla.edu/news/ucla-re...
#devbio #neuroskyence 🧪
Time to celebrate two more postdocs from the Pasca lab who are departing this month to start their own groups– at Johns Hopkins and in Shanghai.
Warmest congratulations Xiao & Jin, and all the best!
Traditional selfie at our lab party with a now classical #assembloid cake (not shown).
Warmest congratulations Xiao & Jin, and all the best!
Traditional selfie at our lab party with a now classical #assembloid cake (not shown).
May 20, 2025 at 11:12 AM
Time to celebrate two more postdocs from the Pasca lab who are departing this month to start their own groups– at Johns Hopkins and in Shanghai.
Warmest congratulations Xiao & Jin, and all the best!
Traditional selfie at our lab party with a now classical #assembloid cake (not shown).
Warmest congratulations Xiao & Jin, and all the best!
Traditional selfie at our lab party with a now classical #assembloid cake (not shown).
Exciting News! Researchers from the Pasca Lab at Stanford have built a functional human Pain Circuit in a Dish to model and manipulate the sensory pathway in vitro. This could lead to discovery of new analgesic drugs! #Painresearch #Neuroscience #StemCell #Organoid www.nature.com/articles/s41...
Human assembloid model of the ascending neural sensory pathway - Nature
A human ascending somatosensory assembloid model was developed, which integrates multiple organoids to simulate the spinothalamic pathway, demonstrating functional connectivity and responsiveness to s...
www.nature.com
April 11, 2025 at 3:57 PM
Exciting News! Researchers from the Pasca Lab at Stanford have built a functional human Pain Circuit in a Dish to model and manipulate the sensory pathway in vitro. This could lead to discovery of new analgesic drugs! #Painresearch #Neuroscience #StemCell #Organoid www.nature.com/articles/s41...