Our new paper in Chem. Sci. discloses traceless translators that enable fast reverse grafting of cell-penetrating poly(disulfide)s to lysines rather than cysteines and are compatible with TMU of antibodies and modern bioconjugation technology.
doi.org/10.1039/d6sc06111g
doi.org/10.1039/d6sc06111g
October 14, 2026 at 6:53 PM
Our new paper in Chem. Sci. discloses traceless translators that enable fast reverse grafting of cell-penetrating poly(disulfide)s to lysines rather than cysteines and are compatible with TMU of antibodies and modern bioconjugation technology.
doi.org/10.1039/d6sc06111g
doi.org/10.1039/d6sc06111g
Zhou et. al UBC Chemistry explore the influence of surface crystallography on the bioconjugation of fluorophore-labeled DNA to SAM-modified gold surfaces via carbodiimide chemistry.
#EdChoice in this month's Special Issue!
📄https://ow.ly/3QM450ZTIWM
#surfacescience #electrochemistry
#EdChoice in this month's Special Issue!
📄https://ow.ly/3QM450ZTIWM
#surfacescience #electrochemistry
October 12, 2026 at 12:00 PM
Zhou et. al UBC Chemistry explore the influence of surface crystallography on the bioconjugation of fluorophore-labeled DNA to SAM-modified gold surfaces via carbodiimide chemistry.
#EdChoice in this month's Special Issue!
📄https://ow.ly/3QM450ZTIWM
#surfacescience #electrochemistry
#EdChoice in this month's Special Issue!
📄https://ow.ly/3QM450ZTIWM
#surfacescience #electrochemistry
RRIDs were included in this in Current Protocols paper. RRIDs improve reproducibility in scientific research. #OpenResearch #ReproducibleResearch #BetterScience
MccB‐catalyzed C‐terminal Thioesterification for Protein Bioconjugation
Read the full paper: MccB‐catalyzed C‐terminal Thioesterification for Protein Bioconjugation
doi.org
October 10, 2026 at 7:01 AM
RRIDs were included in this in Current Protocols paper. RRIDs improve reproducibility in scientific research. #OpenResearch #ReproducibleResearch #BetterScience
Congratulations to Morgan Guyan (C2MCI Nano HQP) on her successful MSc defence!
As a member of the @cathleencrudden.bsky.social lab, Morgan contributed to C2MCI’s research on modulating NHC-protected gold nanoclusters for bioconjugation.
We look forward to celebrating her future successes!
As a member of the @cathleencrudden.bsky.social lab, Morgan contributed to C2MCI’s research on modulating NHC-protected gold nanoclusters for bioconjugation.
We look forward to celebrating her future successes!
October 9, 2026 at 4:00 PM
Congratulations to Morgan Guyan (C2MCI Nano HQP) on her successful MSc defence!
As a member of the @cathleencrudden.bsky.social lab, Morgan contributed to C2MCI’s research on modulating NHC-protected gold nanoclusters for bioconjugation.
We look forward to celebrating her future successes!
As a member of the @cathleencrudden.bsky.social lab, Morgan contributed to C2MCI’s research on modulating NHC-protected gold nanoclusters for bioconjugation.
We look forward to celebrating her future successes!
Senior Scientist, Bioconjugation & Targeted Nanomedicine
Bristol Myers Squibb - Cambridge, US
Read the full job description and apply⤵️
jobrxiv.org/job/senior-s...
#ScienceJobs
Bristol Myers Squibb - Cambridge, US
Read the full job description and apply⤵️
jobrxiv.org/job/senior-s...
#ScienceJobs
October 8, 2026 at 3:30 PM
Senior Scientist, Bioconjugation & Targeted Nanomedicine
Bristol Myers Squibb - Cambridge, US
Read the full job description and apply⤵️
jobrxiv.org/job/senior-s...
#ScienceJobs
Bristol Myers Squibb - Cambridge, US
Read the full job description and apply⤵️
jobrxiv.org/job/senior-s...
#ScienceJobs
👋 Meet the team behind SYNLETT
This week, we're featuring our Associate Editor Monika Raj✨
Based at Emory University, her research focuses on chemical probes, #bioconjugation, and selective modification of #peptides and #proteins.
👀 Who's next? Meet another editor in 2 weeks!
buff.ly/li6XiJv
This week, we're featuring our Associate Editor Monika Raj✨
Based at Emory University, her research focuses on chemical probes, #bioconjugation, and selective modification of #peptides and #proteins.
👀 Who's next? Meet another editor in 2 weeks!
buff.ly/li6XiJv
October 7, 2026 at 7:01 AM
👋 Meet the team behind SYNLETT
This week, we're featuring our Associate Editor Monika Raj✨
Based at Emory University, her research focuses on chemical probes, #bioconjugation, and selective modification of #peptides and #proteins.
👀 Who's next? Meet another editor in 2 weeks!
buff.ly/li6XiJv
This week, we're featuring our Associate Editor Monika Raj✨
Based at Emory University, her research focuses on chemical probes, #bioconjugation, and selective modification of #peptides and #proteins.
👀 Who's next? Meet another editor in 2 weeks!
buff.ly/li6XiJv
Job ID: 16892
Extract: The Faculty of Science at Leiden University seeks a postdoctoral researcher with expertise in synthetic organic chemistry and bioconjugation to develop oncology nanocarriers. The role involves creating new conjugation strategies and scaling up reactions.
Extract: The Faculty of Science at Leiden University seeks a postdoctoral researcher with expertise in synthetic organic chemistry and bioconjugation to develop oncology nanocarriers. The role involves creating new conjugation strategies and scaling up reactions.
October 3, 2026 at 3:11 AM
Job ID: 16892
Extract: The Faculty of Science at Leiden University seeks a postdoctoral researcher with expertise in synthetic organic chemistry and bioconjugation to develop oncology nanocarriers. The role involves creating new conjugation strategies and scaling up reactions.
Extract: The Faculty of Science at Leiden University seeks a postdoctoral researcher with expertise in synthetic organic chemistry and bioconjugation to develop oncology nanocarriers. The role involves creating new conjugation strategies and scaling up reactions.
Leiden University (@unileiden.bsky.social) is hiring:
Postdoctoral Researcher in Bioconjugation for Oncology Nanocarriers
#postdoc #cancerresearch #medicine
Postdoctoral Researcher in Bioconjugation for Oncology Nanocarriers
#postdoc #cancerresearch #medicine
October 3, 2026 at 3:11 AM
Leiden University (@unileiden.bsky.social) is hiring:
Postdoctoral Researcher in Bioconjugation for Oncology Nanocarriers
#postdoc #cancerresearch #medicine
Postdoctoral Researcher in Bioconjugation for Oncology Nanocarriers
#postdoc #cancerresearch #medicine
Interesting Flash Talk by @wahyuwidodo.bsky.social at the 6th Virtual @chembiotalks.bsky.social.
He tagged about the enzymatic tagging of proteins using the ADD technology based on the flavin transferase ApbE.
pubs.acs.org/bcches/artic...
#ChemBioTalks #ChemBio #ChemSky #Science #Protein
He tagged about the enzymatic tagging of proteins using the ADD technology based on the flavin transferase ApbE.
pubs.acs.org/bcches/artic...
#ChemBioTalks #ChemBio #ChemSky #Science #Protein
One-Pot
Enzymatic ADDing of Click Chemistry Handles
for Protein Immobilization and Bioconjugation of Small and Biomolecules
Abstract. Site-specifically attaching biorthogonal handles to proteins
is
an essential tool for chemical biology research and diverse applications,
includi
pubs.acs.org
September 29, 2026 at 1:17 PM
Interesting Flash Talk by @wahyuwidodo.bsky.social at the 6th Virtual @chembiotalks.bsky.social.
He tagged about the enzymatic tagging of proteins using the ADD technology based on the flavin transferase ApbE.
pubs.acs.org/bcches/artic...
#ChemBioTalks #ChemBio #ChemSky #Science #Protein
He tagged about the enzymatic tagging of proteins using the ADD technology based on the flavin transferase ApbE.
pubs.acs.org/bcches/artic...
#ChemBioTalks #ChemBio #ChemSky #Science #Protein
How Can AI-Driven Bioconjugation Optimization Improve Antibody-Drug Conjugates in 2026? — https://aidrugsearch.com/knowledge/how_can_ai-driven_bioconjugation_optimization_improve_antibody-drug_conjugates_in_2026.php
September 29, 2026 at 8:03 AM
How Can AI-Driven Bioconjugation Optimization Improve Antibody-Drug Conjugates in 2026? — https://aidrugsearch.com/knowledge/how_can_ai-driven_bioconjugation_optimization_improve_antibody-drug_conjugates_in_2026.php
They developed a lot of variants of the chemistry for various applications involving many great scientists including Mark de Geus (@mardegeus.bsky.social) and Christian Stieger. (5/13)
onlinelibrary.wiley.com/doi/full/10....
pubs.acs.org/jacsat/artic...
onlinelibrary.wiley.com/doi/full/10....
pubs.acs.org/jacsat/artic...
DFT‐Guided Discovery of Ethynyl‐Triazolyl‐Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling
By means of density functional theory calculations, ethynyl-triazolyl-phosphinates (ETPs) were discovered as modular and cysteine-selective electrophiles for bioconjugation. Using CuI-click chemistry...
onlinelibrary.wiley.com
September 25, 2026 at 9:56 AM
They developed a lot of variants of the chemistry for various applications involving many great scientists including Mark de Geus (@mardegeus.bsky.social) and Christian Stieger. (5/13)
onlinelibrary.wiley.com/doi/full/10....
pubs.acs.org/jacsat/artic...
onlinelibrary.wiley.com/doi/full/10....
pubs.acs.org/jacsat/artic...
Postdoctoral Researcher Bioconjugation for Oncology Nanocarriers https://www.academictransfer.com/364186/ @unileiden
September 24, 2026 at 6:43 AM
Postdoctoral Researcher Bioconjugation for Oncology Nanocarriers https://www.academictransfer.com/364186/ @unileiden
Site-selective Au(III)-mediated metalloenzyme conjugations
Site-selective Au(III)-mediated metalloenzyme conjugations
Au(III)-mediated cysteine S-arylation enables site-selective covalent modification of metalloenzymes while preserving the integrity of their active metal sites. This organometallic bioconjugation strategy establishes a blueprint for predictable metalloprotein functionalization and broader applications in chemical biology, protein engineering, and biotechnology.
www.cell.com
September 18, 2026 at 12:37 PM
Site-selective Au(III)-mediated metalloenzyme conjugations
A programmable, low-cost & wavelength-customizable #OpenSource benchtop #photocrosslinking chamber for controlled #bioconjugation:
-6 reaction chambers
-low sample heating
-cost: ~$250
doi.org/10.1016/j.oh...
#DIYbio #DIYchem #lab #instruments #UV #MINT #STEM #education #imaging #fluorescence
-6 reaction chambers
-low sample heating
-cost: ~$250
doi.org/10.1016/j.oh...
#DIYbio #DIYchem #lab #instruments #UV #MINT #STEM #education #imaging #fluorescence
September 11, 2026 at 11:17 PM
A programmable, low-cost & wavelength-customizable #OpenSource benchtop #photocrosslinking chamber for controlled #bioconjugation:
-6 reaction chambers
-low sample heating
-cost: ~$250
doi.org/10.1016/j.oh...
#DIYbio #DIYchem #lab #instruments #UV #MINT #STEM #education #imaging #fluorescence
-6 reaction chambers
-low sample heating
-cost: ~$250
doi.org/10.1016/j.oh...
#DIYbio #DIYchem #lab #instruments #UV #MINT #STEM #education #imaging #fluorescence
Online now: Site-selective Au(III)-mediated metalloenzyme conjugations
Site-selective Au(III)-mediated metalloenzyme conjugations
Au(III)-mediated cysteine S-arylation enables site-selective covalent modification of metalloenzymes while preserving the integrity of their active metal sites. This organometallic bioconjugation strategy establishes a blueprint for predictable metalloprotein functionalization and broader applications in chemical biology, protein engineering, and biotechnology.
dlvr.it
September 11, 2026 at 3:34 PM
Online now: Site-selective Au(III)-mediated metalloenzyme conjugations
Centre National de la Recherche Scientifique is hiring:
Postdoctoral Researcher in Synthetic Chemistry and Bioconjugation
#postdoc #chemsky #bioconjugation
Postdoctoral Researcher in Synthetic Chemistry and Bioconjugation
#postdoc #chemsky #bioconjugation
September 4, 2026 at 4:03 PM
Centre National de la Recherche Scientifique is hiring:
Postdoctoral Researcher in Synthetic Chemistry and Bioconjugation
#postdoc #chemsky #bioconjugation
Postdoctoral Researcher in Synthetic Chemistry and Bioconjugation
#postdoc #chemsky #bioconjugation
Material-Efficient Optimization of Peptide Bioconjugation via Sub-Micromole Automated Flow and Bayesian Optimization http://dx.doi.org/10.1055/a-2942-7756
September 2, 2026 at 3:20 AM
Material-Efficient Optimization of Peptide Bioconjugation via Sub-Micromole Automated Flow and Bayesian Optimization http://dx.doi.org/10.1055/a-2942-7756
Extract: We are seeking a talented postdoctoral researcher to join our ERC-funded project on bioconjugation strategies. The role involves project management and developing a protein bioconjugation screening platform.
September 1, 2026 at 9:41 PM
Extract: We are seeking a talented postdoctoral researcher to join our ERC-funded project on bioconjugation strategies. The role involves project management and developing a protein bioconjugation screening platform.
Centre National de la Recherche Scientifique is hiring:
Postdoctoral Researcher in Bioconjugation and Oligonucleotide Chemistry
#postdoc #chemsky #bioconjugation
Postdoctoral Researcher in Bioconjugation and Oligonucleotide Chemistry
#postdoc #chemsky #bioconjugation
September 1, 2026 at 9:41 PM
Centre National de la Recherche Scientifique is hiring:
Postdoctoral Researcher in Bioconjugation and Oligonucleotide Chemistry
#postdoc #chemsky #bioconjugation
Postdoctoral Researcher in Bioconjugation and Oligonucleotide Chemistry
#postdoc #chemsky #bioconjugation
Extract: The position involves developing a new bioconjugation method for delivering proteins and peptides with fluorescence tracking. Requires proficiency in chemical synthesis and analysis.
September 1, 2026 at 7:57 PM
Extract: The position involves developing a new bioconjugation method for delivering proteins and peptides with fluorescence tracking. Requires proficiency in chemical synthesis and analysis.
Jun is now an Early Career Board member of the Bioconjugate Chemistry journal! If you have any ideas to make the bioconjugation and relevant fields better, feel free to reach out to him!!
axial.acs.org/biological-c...
axial.acs.org/biological-c...
Bioconjugate Chemistry Announces Inaugural Early Career Board | ACS Publications Chemistry Blog
Meet the next generation of leaders in bioconjugate chemistry and learn about their research, ideas, and aspirations for the field’s future.
axial.acs.org
August 31, 2026 at 6:16 PM
Jun is now an Early Career Board member of the Bioconjugate Chemistry journal! If you have any ideas to make the bioconjugation and relevant fields better, feel free to reach out to him!!
axial.acs.org/biological-c...
axial.acs.org/biological-c...
August 31, 2026 at 1:53 PM
Cyclopropanol can function as a caged dual-functional warhead for selective electrochemical bioconjugation #chemsky
Cyclopropanol can function as a caged dual-functional warhead for selective electrochemical bioconjugation
Nature Chemistry, Published online: 28 August 2026; doi:10.1038/s41557-026-02227-1Spatiotemporal control over bioorthogonal reactions remains challenging. Now cyclopropanol has been shown to act as a functional moity that is inert under physiological conditions but can be selectively activated by mild electrochemical stimuli to preferentially modify acidic amino acids, such as glutamate and aspartate, within hydrophobic regions of proteins.
dlvr.it
August 28, 2026 at 9:44 AM
Cyclopropanol can function as a caged dual-functional warhead for selective electrochemical bioconjugation #chemsky
The paper covers many exciting aspects of Chemical Biology:
- Bioconjugation and bioorthogonal chemistry
- Visualization and sensing
- Interaction profiling
- Precision control of biological systems
- Emerging modalities in drug discovery
- Synthetic chemical biology
(6/13)
- Bioconjugation and bioorthogonal chemistry
- Visualization and sensing
- Interaction profiling
- Precision control of biological systems
- Emerging modalities in drug discovery
- Synthetic chemical biology
(6/13)
August 22, 2026 at 1:12 PM
The paper covers many exciting aspects of Chemical Biology:
- Bioconjugation and bioorthogonal chemistry
- Visualization and sensing
- Interaction profiling
- Precision control of biological systems
- Emerging modalities in drug discovery
- Synthetic chemical biology
(6/13)
- Bioconjugation and bioorthogonal chemistry
- Visualization and sensing
- Interaction profiling
- Precision control of biological systems
- Emerging modalities in drug discovery
- Synthetic chemical biology
(6/13)
Now, this review is published in ChemBioChem for all of us to read. The students really did a great job selecting papers that highlight the breadth of Chemical Biology with synthetic tools and writing insightful summaries of the main finding. (4/13)
doi.org/10.1002/cbic...
doi.org/10.1002/cbic...
Chemical Biology 2025: Highlights From the Ch/Bi145 Course at Caltech
This student-authored review highlights notable advances in synthetically enabled chemical biology from 2025, spanning bioconjugation and bioorthogonal chemistry, visualization and sensing, precision...
doi.org
August 22, 2026 at 1:12 PM
Now, this review is published in ChemBioChem for all of us to read. The students really did a great job selecting papers that highlight the breadth of Chemical Biology with synthetic tools and writing insightful summaries of the main finding. (4/13)
doi.org/10.1002/cbic...
doi.org/10.1002/cbic...