Got confirmation for getting back on a bisphosphonate for my bones today (after like a decade of increased pain & crunching bones, AND new Wheelie art? Today's SICK.
Thanks for the art, @blankieplush.bsky.social you made wheelie look real cute 🥺
Thanks for the art, @blankieplush.bsky.social you made wheelie look real cute 🥺
September 18, 2025 at 11:06 PM
Got confirmation for getting back on a bisphosphonate for my bones today (after like a decade of increased pain & crunching bones, AND new Wheelie art? Today's SICK.
Thanks for the art, @blankieplush.bsky.social you made wheelie look real cute 🥺
Thanks for the art, @blankieplush.bsky.social you made wheelie look real cute 🥺
Since my last bone scan 6 months ago, I've had reduced metabolic activity in two areas of bone metastases. I'm on a CDK 4/6 inhibitor, aromatase inhibitor, & bisphosphonate line of treatment
I thought "stable" was the best. But this is actual improvement
Feeling lucky! 👍 #Science
#Cansky #oncosky
I thought "stable" was the best. But this is actual improvement
Feeling lucky! 👍 #Science
#Cansky #oncosky
August 4, 2025 at 5:12 PM
Good luck with the dentist. I am also working towards my next round of bisphosphonate treatment. One more dentist visit…
April 16, 2026 at 6:02 AM
Good luck with the dentist. I am also working towards my next round of bisphosphonate treatment. One more dentist visit…
#ThrowbackThursday in JHC: "Alendronate Alters the Release of EVs by Raw 264.7 Osteoclasts."
Click to read for FREE: bit.ly/4oz6iVQ
#alendronate #bisphosphonate #osteoclast
Click to read for FREE: bit.ly/4oz6iVQ
#alendronate #bisphosphonate #osteoclast
October 8, 2026 at 3:48 PM
#ThrowbackThursday in JHC: "Alendronate Alters the Release of EVs by Raw 264.7 Osteoclasts."
Click to read for FREE: bit.ly/4oz6iVQ
#alendronate #bisphosphonate #osteoclast
Click to read for FREE: bit.ly/4oz6iVQ
#alendronate #bisphosphonate #osteoclast
Sagen wir mal so: ich habe auch oft erlebt, dass Patient*innen wegen sowas Zähne verloren haben oder der Kiefer gebrochen ist.
Stichwort BRONJ.
Rechtfertigt keinen Rant über Bisphosphonate, aber es würde helfen, wenn man sie vor Therapiebeginn zum Zahnarzt schickt und auch regelmäßig kontrolliert.
Stichwort BRONJ.
Rechtfertigt keinen Rant über Bisphosphonate, aber es würde helfen, wenn man sie vor Therapiebeginn zum Zahnarzt schickt und auch regelmäßig kontrolliert.
May 13, 2025 at 6:08 PM
Sagen wir mal so: ich habe auch oft erlebt, dass Patient*innen wegen sowas Zähne verloren haben oder der Kiefer gebrochen ist.
Stichwort BRONJ.
Rechtfertigt keinen Rant über Bisphosphonate, aber es würde helfen, wenn man sie vor Therapiebeginn zum Zahnarzt schickt und auch regelmäßig kontrolliert.
Stichwort BRONJ.
Rechtfertigt keinen Rant über Bisphosphonate, aber es würde helfen, wenn man sie vor Therapiebeginn zum Zahnarzt schickt und auch regelmäßig kontrolliert.
🦴🔬 A 'forever unpublished' image! This histological section of the human jaw bone shows large amounts of new bone (intensely stained areas) after switching from a bisphosphonate (alendronate) to denosumab as the anti-osteoporotic drug.
Thoughts?
#bone #histology #histopathology #microscopy 🧪
Thoughts?
#bone #histology #histopathology #microscopy 🧪
March 19, 2025 at 9:15 PM
🦴🔬 A 'forever unpublished' image! This histological section of the human jaw bone shows large amounts of new bone (intensely stained areas) after switching from a bisphosphonate (alendronate) to denosumab as the anti-osteoporotic drug.
Thoughts?
#bone #histology #histopathology #microscopy 🧪
Thoughts?
#bone #histology #histopathology #microscopy 🧪
DE: Knochenschwund-Medikamente gegen Corona? www.dmz-news.eu/2023/11/09/d...
DE: Knochenschwund-Medikamente gegen Corona?
DMZ – MEDIZIN ¦ Markus Golla ¦ Bisphosphonate sind Arzneien, die seit vielen Jahren in erster Linie erfolgreich gegen die Osteoporose eingesetzt werden. In einer US-amerikanischen Studie – mit B...
www.dmz-news.eu
November 8, 2023 at 9:36 PM
DE: Knochenschwund-Medikamente gegen Corona? www.dmz-news.eu/2023/11/09/d...
Been to the dentist, and I’m still *very* numb so watching the cricket while it all recovers 😱.
I shall be back there again soon for a ‘proactive crown’ prior to resuming bisphosphonate treatment. Terrifying to me, but I love my new dentist, which really helps.
I shall be back there again soon for a ‘proactive crown’ prior to resuming bisphosphonate treatment. Terrifying to me, but I love my new dentist, which really helps.
February 11, 2026 at 4:59 PM
Been to the dentist, and I’m still *very* numb so watching the cricket while it all recovers 😱.
I shall be back there again soon for a ‘proactive crown’ prior to resuming bisphosphonate treatment. Terrifying to me, but I love my new dentist, which really helps.
I shall be back there again soon for a ‘proactive crown’ prior to resuming bisphosphonate treatment. Terrifying to me, but I love my new dentist, which really helps.
A podcast all about falls & fractures: screening for falls & ways to decrease falls, Vitamin D(?), ways to decrease fracture risk, and when should we prescribe vs deprescribe bisphosphonate therapy? This and so much more on this week's podcast. #FOAMed #medsky #GeriSky
geripal.org/falls-and-fr...
geripal.org/falls-and-fr...
Falls and Fractures: A Podcast with Sarah Berry
On this week's podcast, we talk about Falls and Fractures with Dr. Sarah Berry, including ways to decrease the risk of falling for older adults.
geripal.org
November 17, 2024 at 12:28 AM
A podcast all about falls & fractures: screening for falls & ways to decrease falls, Vitamin D(?), ways to decrease fracture risk, and when should we prescribe vs deprescribe bisphosphonate therapy? This and so much more on this week's podcast. #FOAMed #medsky #GeriSky
geripal.org/falls-and-fr...
geripal.org/falls-and-fr...
Therapie & Behandlung:
• NSAR zur Schmerzlinderung 💊
• DMARDs zur Immunmodulation 🛡️
• Biologika bei schwereren Verläufen 💉
• Bisphosphonate zur Kontrolle der Knochenentzündung 🦴
Ziel: Entzündung reduzieren & Lebensqualität verbessern.
• NSAR zur Schmerzlinderung 💊
• DMARDs zur Immunmodulation 🛡️
• Biologika bei schwereren Verläufen 💉
• Bisphosphonate zur Kontrolle der Knochenentzündung 🦴
Ziel: Entzündung reduzieren & Lebensqualität verbessern.
February 28, 2026 at 5:17 AM
Therapie & Behandlung:
• NSAR zur Schmerzlinderung 💊
• DMARDs zur Immunmodulation 🛡️
• Biologika bei schwereren Verläufen 💉
• Bisphosphonate zur Kontrolle der Knochenentzündung 🦴
Ziel: Entzündung reduzieren & Lebensqualität verbessern.
• NSAR zur Schmerzlinderung 💊
• DMARDs zur Immunmodulation 🛡️
• Biologika bei schwereren Verläufen 💉
• Bisphosphonate zur Kontrolle der Knochenentzündung 🦴
Ziel: Entzündung reduzieren & Lebensqualität verbessern.
Researchers have developed a standardized protocol for creating minimally invasive mouse models to study bisphosphonate-related and radiation-induced jaw osteonecrosis.
🔗 Source: https://pubmed.ncbi.nlm.nih.gov/42832338/
🔗 Source: https://pubmed.ncbi.nlm.nih.gov/42832338/
October 7, 2026 at 8:58 AM
Researchers have developed a standardized protocol for creating minimally invasive mouse models to study bisphosphonate-related and radiation-induced jaw osteonecrosis.
🔗 Source: https://pubmed.ncbi.nlm.nih.gov/42832338/
🔗 Source: https://pubmed.ncbi.nlm.nih.gov/42832338/
DE: Knochenschwund-Medikamente gegen Corona? www.dmz-news.eu/2023/12/08/d...
DE: Knochenschwund-Medikamente gegen Corona?
DMZ – MEDIZIN ¦ Markus Golla ¦ Bisphosphonate sind Arzneien, die seit vielen Jahren in erster Linie erfolgreich gegen die Osteoporose eingesetzt werden. In einer US-amerikanischen Studie – mit B...
www.dmz-news.eu
December 8, 2023 at 7:54 AM
DE: Knochenschwund-Medikamente gegen Corona? www.dmz-news.eu/2023/12/08/d...
What exasperated me was that in 2023, the oncologists wanted to prescribe bisphosphonate infusion therapy for osteoporosis, which I did not have and still do not have. I have mild osteopenia, which is common in women my age.
December 19, 2025 at 7:50 PM
What exasperated me was that in 2023, the oncologists wanted to prescribe bisphosphonate infusion therapy for osteoporosis, which I did not have and still do not have. I have mild osteopenia, which is common in women my age.
Last #apaperaday this month en route to @worldduchenne.bsky.social round table meeting in Rome (going on holiday after). The pick is from journal of pediatric endocrinology and metabolism by McCarrison et al on the use of bisphosphonate and testosterone in Duchenne doi DOI: 10.1515/jpem-2025-0039
May 5, 2025 at 9:47 AM
Last #apaperaday this month en route to @worldduchenne.bsky.social round table meeting in Rome (going on holiday after). The pick is from journal of pediatric endocrinology and metabolism by McCarrison et al on the use of bisphosphonate and testosterone in Duchenne doi DOI: 10.1515/jpem-2025-0039
What’s the eGFR? 31 is probably different than 59 for the risk of adverse events. I don’t think I would have any concerns re: bisphosphonate but would monitor PTH more closely than usual and if it drops or there is an AE consider an alternative.
February 24, 2025 at 2:47 PM
What’s the eGFR? 31 is probably different than 59 for the risk of adverse events. I don’t think I would have any concerns re: bisphosphonate but would monitor PTH more closely than usual and if it drops or there is an AE consider an alternative.
Marvin grapples daily with balancing the benefits of therapy against possible ADRs and pill burden. 🐱⚕️
Does he recommend a bisphosphonate in a 94yo who's not really ambulating anymore anyway? FRAX score doesn't even go past 92yo
Does he recommend a bisphosphonate in a 94yo who's not really ambulating anymore anyway? FRAX score doesn't even go past 92yo
October 13, 2023 at 6:22 PM
Marvin grapples daily with balancing the benefits of therapy against possible ADRs and pill burden. 🐱⚕️
Does he recommend a bisphosphonate in a 94yo who's not really ambulating anymore anyway? FRAX score doesn't even go past 92yo
Does he recommend a bisphosphonate in a 94yo who's not really ambulating anymore anyway? FRAX score doesn't even go past 92yo
Check out this very interesting article by Dr. Borghoff (@kborghoff.bsky.social) and team about "Use of bisphosphonates in chronic kidney disease is associated with cardiovascular death"!!!
pubmed.ncbi.nlm.nih.gov/39545393/
pubmed.ncbi.nlm.nih.gov/39545393/
Use of bisphosphonates in chronic kidney disease is associated with cardiovascular death - PubMed
Contrary to our hypothesis, bisphosphonate use was associated with a trend toward increased incident CVD and a two-fold higher risk of CVD mortality in CKD.
pubmed.ncbi.nlm.nih.gov
December 16, 2024 at 12:08 PM
Check out this very interesting article by Dr. Borghoff (@kborghoff.bsky.social) and team about "Use of bisphosphonates in chronic kidney disease is associated with cardiovascular death"!!!
pubmed.ncbi.nlm.nih.gov/39545393/
pubmed.ncbi.nlm.nih.gov/39545393/
Would indeed prefer a bisphosphonate in most of these scenarios
February 25, 2025 at 6:34 AM
Would indeed prefer a bisphosphonate in most of these scenarios
There are no good trials I’m aware showing impact on fracture risk in CKD with concomitant low BMD and secondary hyperparathyroidism which presumably is what the patient has
As the benefit is uncertain give the least risky med (if anything!) which is probably the bisphosphonate
As the benefit is uncertain give the least risky med (if anything!) which is probably the bisphosphonate
February 24, 2025 at 9:48 PM
There are no good trials I’m aware showing impact on fracture risk in CKD with concomitant low BMD and secondary hyperparathyroidism which presumably is what the patient has
As the benefit is uncertain give the least risky med (if anything!) which is probably the bisphosphonate
As the benefit is uncertain give the least risky med (if anything!) which is probably the bisphosphonate
Bisphosphonate drug holidays in osteoporosis according to fracture risk profile pubmed.ncbi.nlm.nih.gov/39623217/
December 3, 2024 at 8:15 AM
Bisphosphonate drug holidays in osteoporosis according to fracture risk profile pubmed.ncbi.nlm.nih.gov/39623217/
The ROS article said patients may be offered bisphosphonate treatment afterwards, so that fits with what you were told. Good luck with it all. And huge respect for injecting yourself! Not sure I’d be so good at that.
June 5, 2026 at 6:37 AM
The ROS article said patients may be offered bisphosphonate treatment afterwards, so that fits with what you were told. Good luck with it all. And huge respect for injecting yourself! Not sure I’d be so good at that.
🧪🔬🦴 "Micrometer-Sized Magnesium Whitlockite Crystals in Micropetrosis of Bisphosphonate-Exposed Human Alveolar Bone"
Not everything is great with the use of antiresorptive drugs for treating #osteoporosis if they cause pathological calcifications
pubs.acs.org/doi/full/10....
#bone #biomaterials
Not everything is great with the use of antiresorptive drugs for treating #osteoporosis if they cause pathological calcifications
pubs.acs.org/doi/full/10....
#bone #biomaterials
Micrometer-Sized Magnesium Whitlockite Crystals in Micropetrosis of Bisphosphonate-Exposed Human Alveolar Bone
Osteocytes are contained within spaces called lacunae and play a central role in bone remodelling. Administered frequently to prevent osteoporotic fractures, antiresorptive agents such as bisphosphona...
pubs.acs.org
July 17, 2024 at 7:12 AM
🧪🔬🦴 "Micrometer-Sized Magnesium Whitlockite Crystals in Micropetrosis of Bisphosphonate-Exposed Human Alveolar Bone"
Not everything is great with the use of antiresorptive drugs for treating #osteoporosis if they cause pathological calcifications
pubs.acs.org/doi/full/10....
#bone #biomaterials
Not everything is great with the use of antiresorptive drugs for treating #osteoporosis if they cause pathological calcifications
pubs.acs.org/doi/full/10....
#bone #biomaterials