Osteoclast-derived angiopoietin-2 in the dura mater impairs lymphatic vessel function and weakens anti-tumour immunity against dural metastases, which offers new therapeutic approaches to restore meningeal lymphatic function through selective osteoclast targeting.

Excessive osteoclast activation disrupts bone homeostasis, contributing to osteoporosis (OP). While Runx2 is known to regulate osteoblast differentiation, its role in osteoclasts is less clear. Using conditional knockout models, we demonstrate that Runx2 directly drives osteoclast differentiation by regulating Ctsk transcription. However, its dual function in both osteoblasts and osteoclasts limits therapeutic potential. We identify Ip6k2 as a Runx2-interacting protein that enhances Runx2-dependent Ctsk transcription specifically in osteoclasts. Genetic deletion of Ip6k2 phenocopies Runx2 loss in osteoclasts, suppressing osteoclastogenesis and increasing bone mass without affecting osteoblast function. Notably, dual deletion of Runx2 and Ip6k2 yields no additive effects, indicating a shared regulatory pathway. Importantly, both genetic and pharmacological inhibition of Ip6k2 protect against estrogen deficiency- and age-induced bone loss. Collectively, our findings position Ip6k2 as a p

Severe acute respiratory syndrome coronavirus infection leads to acute bone loss, and increased osteoclast number. This bone loss could decrease whole-bone mechanical strength and increase the risk o....

Purpose of Review SARS-CoV-2 infection, the culprit of the COVID-19 pandemic, has been associated with significant long-term effects on various organ systems, including bone health. This review explor...

Severe acute respiratory syndrome coronavirus infection leads to acute bone loss, and increased osteoclast number. This bone loss could decrease whole-bone mechanical strength and increase the risk o....

Nature Reviews Rheumatology, Published online: 13 November 2025; doi:10.1038/s41584-025-01323-9The factors and mechanisms that regulate osteoclast-induced inflammatory bone loss are complex. The authors of this Review provide an overview of osteoclast regulation in the context of inflammatory bone loss and rheumatoid arthritis and provide insights into potential treatment strategies.

The factors and mechanisms that regulate osteoclast-induced inflammatory bone loss are complex. The authors of this Review provide an overview of osteoclast regulation in the context of inflammatory b...

Chronic alcohol consumption (CAC) is associated with an enhanced risk of bone fracture, reduced bone density, and osteoporosis. Previous studies, using a rhesus macaque model of voluntary ethanol cons...

Signaling lymphocytic activation molecule family 7 (SLAMF7), an important therapeutic target of myeloma cells, is highly expressed in osteoclasts. Ex vivo-expanded human Vγ9Vδ2 T cells are able to ef...