#CellSignaling
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jcb.org
Adhesion integrity activates mechanosensitive proliferative signaling. New study from Lídia Faria, Florence Janody and colleagues @i3suporto.bsky.social:
rupress.org/jcb/article/...

#CellSignaling #Biophysics #Cancer #Cytoskeleton #Mechanobiology #Cadherin
October 30, 2026 at 1:31 PM
jcb.org
ClC-7 links PIKfyve inhibition to Rab-dependent LRRK2 activity at #lysosomes. New study from Devin Clegg, Shawn M. Ferguson @shawnferguson.bsky.social and colleagues @yalecellbiology.bsky.social:
rupress.org/jcb/article/...

#CellSignaling #Disease #Organelles
October 27, 2026 at 7:03 PM
jcb.org
Biogenesis of nuclear #LipidDroplets is regulated by a Sir2-Csa1-Lro1 signaling pathway at the INM. new study from Lauren Carson, Hui Jin, and Hong-Guo Yu (Florida State University):
rupress.org/jcb/article/...

#CellMetabolism #Genetics #CellSignaling
October 26, 2026 at 1:31 PM
sigtrans-sttt.bsky.social
Maintaining social memory requires synaptic remodeling.

Social interaction triggers Neuroligin 1 cleavage, producing NLG1-CTD, which regulates cofilin signaling and supports social memory maintenance. @utoronto.ca

#STTT #OpenAccess: doi.org/10.1038/s413...

#CellSignaling #AIinMedicine
Social memory maintenance relies on social interaction-induced proteolytic products of neuroligin 1
October 29, 2026 at 6:15 AM
sigtrans-sttt.bsky.social
How does LPA signaling shape health and disease?

This review explores its multimodal signaling networks and #AI-based modeling to advance understanding of disease mechanisms and precision therapies.

#STTT #OpenAccess: doi.org/10.1038/s413...
#CellSignaling #AIinMedicine #DiseaseMechanisms
Decoding lysophosphatidic acid signaling in physiology and disease: mapping the multimodal and multinodal signaling networks
October 28, 2026 at 3:30 PM
jcb.org
Clegg, @shawnferguson.bsky.social et al. @yalecellbiology.bsky.social show that LRRK2 integrates distinct lysosomal stress signals through stimulus-specific combinations of interactions with Rab GTPases and GABARAP. rupress.org/jcb/article/...

#Lysosomes #CellSignaling #Disease #Organelles
October 20, 2026 at 8:00 PM
rupress.org
In @jcb.org, Clegg, @shawnferguson.bsky.social et al. @yalecellbiology.bsky.social show that LRRK2 integrates distinct lysosomal stress signals through stimulus-specific combinations of interactions with Rab GTPases and GABARAP. rupress.org/jcb/article/...

#Lysosomes #CellSignaling #Disease
October 20, 2026 at 8:15 PM
sigtrans-sttt.bsky.social
#ChronicPain is a major global health challenge requiring precise molecular insights & innovative therapeutics. This work reviews neural circuit mechanisms, current therapeutic interventions, and emerging #Neuromodulation strategies.

#STTT #OpenAccess: doi.org/10.1038/s413...
#CellSignaling
Progress in pain mechanisms and management
October 16, 2026 at 6:00 AM
sigtrans-sttt.bsky.social
#AcneVulgaris presents significant clinical challenges and psychological comorbidities that demand precision therapeutic strategies.

This review explores molecular mechanisms, emerging biologics, and novel #Vaccines.

#STTT #OpenAccess: doi.org/10.1038/s413...
#CellSignaling #TherapeuticTargets
Acne: epidemiology, risk factors, pathogenesis, management and cutting-edge research
October 16, 2026 at 12:15 PM
csisingapore.bsky.social
Earlier this month, CSI Singapore hosted Dr. Minkyu Kim from University of Texas Health San Antonio. He spoke on the topic “Studying Cancer Biology with Quantitative Functional Proteomics: Mapping the SPN-PP1 Axis”.

#proteomics #functionalproteomics #molecularbiology #cellsignaling #cancerresearch
October 14, 2026 at 8:12 AM
iamashish008.bsky.social
Excited to share my first paper as a co-first author, now published in the Journal of Clinical Investigation! 🎉
📄 J Clin Invest. 2026
🔗 doi.org/10.1172/JCI2...

#Diabetes #BetaCells #CellSignaling #BiomedicalResearch #JCI #PhDResearchhttps://www.jci.org/articles/view/202344
JCI - Acute activation of Gq-signaling in pancreatic islet macrophages inhibits insulin secretion through AMPK-sphingolipid axis
www.jci.org
September 16, 2026 at 11:43 AM
jcb.org
Spatially ordered zygotic genome activation fulfills embryo quality control. New study from Wenchao Qian, Hui Chen, Hongju Lee, and Matthew C. Good @buenoscience.bsky.social @upenn.edu:
rupress.org/jcb/article/...

#Technology #Development #CellCycle #CellDdivision #CellSignaling
September 15, 2026 at 1:45 PM
pierre-maisonneuve.bsky.social
🧬 Announcing the French Kinase Conference - 1st edition! Nov 9–10, 2026, @iecb.bsky.social

We aim to bring together the French community of biologists, structural biologists, and medicinal chemists working on protein kinases.

🔗 fkc2026.sciencesconf.org

#Kinases #cellsignaling #DrugDiscovery
September 3, 2026 at 2:03 PM
johanajnabi.com
A fantastic thread on epithelial mechanics of apoptotic cell extrusion by @zoya-mann.bsky.social

#epithelialmechanics #mechanobiology #apoptosis #cellsignaling
epimechfc.bsky.social epithelial mechanics fan club @epimechfc.bsky.social · Feb 22
How do epithelial monolayers respond to apoptotic cells? What happens to these cells within hypertensile epithelia?More importantly, what is hypertensile epithelia and what leads to it?

I am @zoya-mann.bsky.social and I will talk about epithelial mechanics of apoptotic cell extrusion.
September 2, 2026 at 8:56 AM
jcb.org
#Integrins and #tetraspanins mediate CD36-#actin coupling and regulate CD36 organization and signaling. New study from Soma Jana, Huong-Tra Ngo, Aparajita Dasgupta, Khuloud Jaqaman and colleagues (UT Southwestern Medical Center):
rupress.org/jcb/article/...

#Biophysics #CellSignaling
August 28, 2026 at 2:45 PM
bionewscentral.com
New findings suggest that abnormal ERBB4 expression—a #CellSignaling protein—in excitatory #neurons may contribute to several hallmarks of #AlzheimersDisease, including #SynapseLoss, #amyloid accumulation, and #MemoryImpairment. 
#CognitiveDecline
A rogue neuronal signal lies at the root of Alzheimer’s disease – BioNews Central
New findings suggest that abnormal ERBB4 expression—a cell-signaling protein—in excitatory neurons may contribute to several hallmarks of Alzheimer’s disease, including synapse loss, amyloid accumulation, and memory impairment. ...
sbee.link
August 26, 2026 at 10:22 PM
tenuretracker.bsky.social
Institut de Recerca Biomedica Barcelona is hiring:
Postdoctoral Fellow (Ref. PD/26/11)

#postdoc #biology #cellsignaling
August 25, 2026 at 10:29 AM
jcb.org
Jana, Ngo, Dasgupta, Jaqaman et al. reveal that β1-#integrin and the #tetraspanins CD9, CD81, and CD151 link the surface receptor CD36 to cortical #actin, thereby regulating its dynamic organization and signaling. rupress.org/jcb/article/...

#Biophysics #ComputationalBiology #CellSignaling
August 21, 2026 at 4:00 PM
jcb.org
STAT5A-α-actinin axis links #actin integrity to #mitochondria homeostasis and innate immune activation. New study from Boyue Sun, Gideon Schreiber and colleagues @weizmann.ac.il:
rupress.org/jcb/article/...

📽️ See video summary: youtu.be/T2FKooepFDo

#Cytoskeleton #Biochemistry #CellSignaling
August 14, 2026 at 1:30 PM
jcb.org
FGFR2 residence in primary #cilia is necessary for epithelial #CellSignaling. From Alexandru Nita, Michaela Bosakova and colleagues (Masaryk University): rupress.org/jcb/article/...

📕 Part of #Centrosomes and #Cilia 2026: rupress.org/jcb/collecti...
August 14, 2026 at 3:15 PM
jcb.org
Super-resolution imaging reveals altered #actin architecture at CAR-T cell immune synapses. New study from Olivia P.L. Dalby, Sabrina Simoncelli and colleagues @ucl.ac.uk:
rupress.org/jcb/article/...

#Cytoskeleton #Immunology #CellSignaling #Biophysics
August 12, 2026 at 1:45 PM
jcb.org
Activity-dependent astrocytic cholesterol release fine-tunes modes of synaptic exo- and endocytosis. New study from Jongyun Myeong and Vitaly A. Klyachko @washumedicine.bsky.social:
rupress.org/jcb/article/...

#CellSignaling #Neuroscience
August 11, 2026 at 3:30 PM
ismaelmingarro.bsky.social
Preparing my lecture for the upcoming #CellSignaling #WinterSchool #ForthemAlliance to be held next week (23-24 Jan) in person at #JyväskyläUniversity and online.

You are still on time to register for free: www.jyu.fi/en/events/fo...
January 19, 2025 at 11:27 AM
jexpzoo-a.bsky.social
PP1γ2 is key to sperm maturation and motility in tree shrews. This study shows PKA activates SRC, which then inhibits PP1γ2-mediated Ser/Thr phosphatase activity, boosting caudal sperm motility #CellSignaling
onlinelibrary.wiley.com/doi/10.1002/...
February 27, 2026 at 9:05 PM
proteintech.bsky.social
Save 20% on Phospho-Specific Antibodies This February

Convenient 20 µL vials available with next-day delivery.

Browse and order now: https://bit.ly/4rAPWxM

#CellSignaling
February 11, 2026 at 7:11 PM