E-cadherin clustering as a regulator of morphogenesis prelights.biologists.com/highlights/e...
E-cadherin clustering as a regulator of morphogenesis - preLights
Hand in hand - E-cadherin with E-cadherin: The number of E-cadherin connections influences morphogenetic tissue movements.
prelights.biologists.com
September 17, 2026 at 5:44 PM
E-cadherin clustering as a regulator of morphogenesis prelights.biologists.com/highlights/e...
Hand in hand - E-cadherin with E-cadherin 🤝
Supported by @girishkalephd.bsky.social, Chiara Hüttner highlights work showing that the number of E-cadherin connections influences morphogenetic tissue movements. #preprint Lerchbaumer et al. #TepassLab
#preLight⬇️
prelights.biologists.com/highlights/e...
Supported by @girishkalephd.bsky.social, Chiara Hüttner highlights work showing that the number of E-cadherin connections influences morphogenetic tissue movements. #preprint Lerchbaumer et al. #TepassLab
#preLight⬇️
prelights.biologists.com/highlights/e...
E-cadherin clustering as a regulator of morphogenesis - preLights
Hand in hand - E-cadherin with E-cadherin: The number of E-cadherin connections influences morphogenetic tissue movements.
prelights.biologists.com
September 14, 2026 at 11:11 AM
Hand in hand - E-cadherin with E-cadherin 🤝
Supported by @girishkalephd.bsky.social, Chiara Hüttner highlights work showing that the number of E-cadherin connections influences morphogenetic tissue movements. #preprint Lerchbaumer et al. #TepassLab
#preLight⬇️
prelights.biologists.com/highlights/e...
Supported by @girishkalephd.bsky.social, Chiara Hüttner highlights work showing that the number of E-cadherin connections influences morphogenetic tissue movements. #preprint Lerchbaumer et al. #TepassLab
#preLight⬇️
prelights.biologists.com/highlights/e...
A perfectly round liver organoid stained for mitochondria (yellowish/green), e-cadherin in blue and nuclei in pink for #MicroscopyMonday
June 2, 2025 at 6:31 PM
A perfectly round liver organoid stained for mitochondria (yellowish/green), e-cadherin in blue and nuclei in pink for #MicroscopyMonday
Cadherin 1 negatively regulates SARS-CoV-2 infection in the olfactory epithelium
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Cadherin 1 negatively regulates SARS-CoV-2 infection in the olfactory epithelium - EMBO Reports
Olfactory dysfunction is a major symptom of COVID-19 syndrome. The critical genes contributing to SARS-CoV-2 infection are not fully understood. Here, we identified Cadherin 1 (CDH1), a hub in the int...
link.springer.com
September 24, 2026 at 1:24 PM
Cadherin 1 negatively regulates SARS-CoV-2 infection in the olfactory epithelium
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Finally I can join #FluorescenceFriday as a theorist 😊.
This is a DNA-PAINT recording of E-Cadherin and F-actin in Drosophila embryonic epidermis. You can see E-cadherin clusters and their counterparts across junctions. Cover in @biophysj.bsky.social . doi.org/10.1016/j.bp... #devbio #cellbio
This is a DNA-PAINT recording of E-Cadherin and F-actin in Drosophila embryonic epidermis. You can see E-cadherin clusters and their counterparts across junctions. Cover in @biophysj.bsky.social . doi.org/10.1016/j.bp... #devbio #cellbio
March 6, 2026 at 10:18 AM
Finally I can join #FluorescenceFriday as a theorist 😊.
This is a DNA-PAINT recording of E-Cadherin and F-actin in Drosophila embryonic epidermis. You can see E-cadherin clusters and their counterparts across junctions. Cover in @biophysj.bsky.social . doi.org/10.1016/j.bp... #devbio #cellbio
This is a DNA-PAINT recording of E-Cadherin and F-actin in Drosophila embryonic epidermis. You can see E-cadherin clusters and their counterparts across junctions. Cover in @biophysj.bsky.social . doi.org/10.1016/j.bp... #devbio #cellbio
Ever wondered how epithelial cells clear apoptotic cells while maintaining tissue cohesion?🍝🔗 Check our new paper in which we show that E-cadherin plays a dual role in regulating basal cortex dynamics upon phagocytosis while maintaining connected tissue organization www.nature.com/articles/s41...
De novo E-cadherin/catenin complex formation controls basal epithelial mechanics and force transmission for apoptotic cell clearance - Nature Communications
Epithelial cells remodel their shape during phagocytosis while preserving tissue cohesion. Here, authors show that the E-cadherin/catenin adhesion complex is repurposed at phagocytic contacts, where i...
www.nature.com
August 27, 2026 at 10:57 AM
Ever wondered how epithelial cells clear apoptotic cells while maintaining tissue cohesion?🍝🔗 Check our new paper in which we show that E-cadherin plays a dual role in regulating basal cortex dynamics upon phagocytosis while maintaining connected tissue organization www.nature.com/articles/s41...
A bit delayed, but excited to still share our latest paper, showing that intercellular forces transduced by E-cadherin activate EGFR-ERK signaling in epithelia by inducing EGFR ligand shedding! Mechanical and biochemical signals can act together within a single, linear cascade! tinyurl.com/mr9mj9j2
E-cadherin mechanotransduction activates EGFR-ERK signaling in epithelial monolayers by inducing ADAM-mediated ligand shedding
Epithelial stretching promotes the release of EGF receptor ligands that stimulate ERK activation.
tinyurl.com
September 13, 2025 at 6:05 PM
A bit delayed, but excited to still share our latest paper, showing that intercellular forces transduced by E-cadherin activate EGFR-ERK signaling in epithelia by inducing EGFR ligand shedding! Mechanical and biochemical signals can act together within a single, linear cascade! tinyurl.com/mr9mj9j2
Happy to present the final version of our Cadherin and gastruloid manuscript, online at @cp-cellreports.bsky.social.
www.cell.com/cell-reports...
Initially in BiorXiv (www.biorxiv.org/content/10.1...) 1/12
www.cell.com/cell-reports...
Initially in BiorXiv (www.biorxiv.org/content/10.1...) 1/12
Cadherins modulate the self-organizing potential of pseudo-embryos
Gastruloids derived from ES cells mimic embryonic patterning through robust self-organization.
Mayran et al. uncover that this competence depends on a cadherin switch regulated
by Snai1-driven E-cadhe...
www.cell.com
November 17, 2025 at 10:37 AM
Happy to present the final version of our Cadherin and gastruloid manuscript, online at @cp-cellreports.bsky.social.
www.cell.com/cell-reports...
Initially in BiorXiv (www.biorxiv.org/content/10.1...) 1/12
www.cell.com/cell-reports...
Initially in BiorXiv (www.biorxiv.org/content/10.1...) 1/12
Some happy news. Pleased to see our paper showing how afadin strengthens cytoskeletal engagement by the cadherin-catenin cell adhesion complex out in Science Advances: bit.ly/3EFpD6h
Afadin mediates cadherin-catenin complex clustering on F-actin linked to cooperative binding and filament curvature
Afadin strengthens adherens junctions by stabilizing cadherin-catenin complex clusters on curved F-actin.
bit.ly
February 18, 2025 at 3:37 AM
Some happy news. Pleased to see our paper showing how afadin strengthens cytoskeletal engagement by the cadherin-catenin cell adhesion complex out in Science Advances: bit.ly/3EFpD6h
Guttieres et al. suggest that core molecular interactions of the cadherin–catenin complex are conserved in ctenophore Mnemiopsis leidyi, suggesting this was an ancestral trait foundational to the evolution of multicellular animals.
🔗 doi.org/10.1093/molbev/msag123
#evobio #molbio
🔗 doi.org/10.1093/molbev/msag123
#evobio #molbio
Evidence for an early cadherin–catenin interaction network in ctenophores
Abstract. The cadherin–catenin complex (CCC) is a calcium-dependent assembly that is essential for the organization and function of animal cells and tissue
doi.org
June 9, 2026 at 10:15 AM
Guttieres et al. suggest that core molecular interactions of the cadherin–catenin complex are conserved in ctenophore Mnemiopsis leidyi, suggesting this was an ancestral trait foundational to the evolution of multicellular animals.
🔗 doi.org/10.1093/molbev/msag123
#evobio #molbio
🔗 doi.org/10.1093/molbev/msag123
#evobio #molbio
I am happy to announce our newest publication in Communications Biology where we use our method of Metal-Induced Energy Transfer (MIET) Imaging together with Fluorescence Correlation Spectroscopy (FCS) for studying Epithelial cadherin (E-cad) mediated cell-cell junctions.
rdcu.be/d2gGC
rdcu.be/d2gGC
Observation of E-cadherin adherens junction dynamics with metal-induced energy transfer imaging and spectroscopy
Communications Biology - Metal-induced energy transfer imaging was utilized to monitor changes in intermembrane distance during adhesion mediated by epithelial cadherin, providing insights into the...
rdcu.be
December 3, 2024 at 11:59 AM
I am happy to announce our newest publication in Communications Biology where we use our method of Metal-Induced Energy Transfer (MIET) Imaging together with Fluorescence Correlation Spectroscopy (FCS) for studying Epithelial cadherin (E-cad) mediated cell-cell junctions.
rdcu.be/d2gGC
rdcu.be/d2gGC
Nature research paper: A pro-carcinogenic bacterial toxin binds claudin-4 to cleave E-cadherin
go.nature.com/4cDKGUd
go.nature.com/4cDKGUd
A pro-carcinogenic bacterial toxin binds claudin-4 to cleave E-cadherin - Nature
CRISPR screening shows that claudin-4 is a receptor for the pro-carcinogenic B. fragilis toxin on colonic epithelial cells, and that this interaction promotes cleavage of E-cadherin, leading to epithelial barrier disruption and inflammation.
go.nature.com
April 24, 2026 at 1:48 PM
Nature research paper: A pro-carcinogenic bacterial toxin binds claudin-4 to cleave E-cadherin
go.nature.com/4cDKGUd
go.nature.com/4cDKGUd
New work from @spinalorga.bsky.social & co
PAX3 doesn't just pattern the dorsal neural tube, it links metabolism to mechanics
PAX3 sustains upper glycolysis and mannose-dependent glycosylation, which cluster N-cadherin & strengthens adherens junctions
www.biorxiv.org/content/10.6...
PAX3 doesn't just pattern the dorsal neural tube, it links metabolism to mechanics
PAX3 sustains upper glycolysis and mannose-dependent glycosylation, which cluster N-cadherin & strengthens adherens junctions
www.biorxiv.org/content/10.6...
Transcriptional coupling of metabolism and cell mechanics controls human neuroepithelium morphogenesis
Tissue morphogenesis integrates developmental programs with cell mechanics, yet the mechanisms coupling these processes remain poorly understood. We investigated this link during neuroepithelial morph...
www.biorxiv.org
September 25, 2026 at 8:53 AM
New work from @spinalorga.bsky.social & co
PAX3 doesn't just pattern the dorsal neural tube, it links metabolism to mechanics
PAX3 sustains upper glycolysis and mannose-dependent glycosylation, which cluster N-cadherin & strengthens adherens junctions
www.biorxiv.org/content/10.6...
PAX3 doesn't just pattern the dorsal neural tube, it links metabolism to mechanics
PAX3 sustains upper glycolysis and mannose-dependent glycosylation, which cluster N-cadherin & strengthens adherens junctions
www.biorxiv.org/content/10.6...
Fat cadherin cleavage releases a transcriptionally active nuclear fragment to regulate target gene expression.
New preprint from Helen McNeill and colleagues
doi.org/10.1101/2025...
New preprint from Helen McNeill and colleagues
doi.org/10.1101/2025...
Fat cadherin cleavage releases a transcriptionally active nuclear fragment to regulate target gene expression
The conserved atypical cadherin fat (ft) controls cellular processes such as growth, planar cell polarity, and mitochondrial function, in organisms ranging from fruit flies to mammals. Working at the ...
doi.org
May 10, 2025 at 11:27 AM
Fat cadherin cleavage releases a transcriptionally active nuclear fragment to regulate target gene expression.
New preprint from Helen McNeill and colleagues
doi.org/10.1101/2025...
New preprint from Helen McNeill and colleagues
doi.org/10.1101/2025...
New article! Here we dissect the role of SGEF, a RhoG-GEF, in regulating E-cadherin and ZO-1 expression in epithelial cells. In SGEF KD, E-cadherin reduction enhances β-catenin signaling, which upregulates Slug, forming a positive feedback loop that further decreases E-cadherin levels bit.ly/3zWYxpf
October 14, 2024 at 11:38 AM
New article! Here we dissect the role of SGEF, a RhoG-GEF, in regulating E-cadherin and ZO-1 expression in epithelial cells. In SGEF KD, E-cadherin reduction enhances β-catenin signaling, which upregulates Slug, forming a positive feedback loop that further decreases E-cadherin levels bit.ly/3zWYxpf
DNA-PAINT resolves E-cadherin-independent cross-junctional F-actin organization in Drosophila embryonic tissue
#Drosophila
#Drosophila
DNA-PAINT resolves E-cadherin-independent cross-junctional F-actin organization in Drosophila embryonic tissue
#Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
January 18, 2026 at 1:23 PM
DNA-PAINT resolves E-cadherin-independent cross-junctional F-actin organization in Drosophila embryonic tissue
#Drosophila
#Drosophila
Systemic delivery of cadherin 17–specific CAR T cells allows effective and safe targeting of colorectal cancer liver metastases | Science Translational Medicine www.science.org/doi/10.1126/... 🧪
Systemic delivery of cadherin 17–specific CAR T cells allows effective and safe targeting of colorectal cancer liver metastases
Systemic cadherin-17–specific CAR T cell therapy is efficacious against colorectal cancer liver metastases in multiple preclinical models.
www.science.org
May 28, 2025 at 7:01 PM
Systemic delivery of cadherin 17–specific CAR T cells allows effective and safe targeting of colorectal cancer liver metastases | Science Translational Medicine www.science.org/doi/10.1126/... 🧪
My monocyte, with a fluorescent membrane (EGFP-CAAX 💛), is transmigrating across the brain microvascular endothelium (VE-cadherin 💙)
#FluorescenceFriday #SciArt
#FluorescenceFriday #SciArt
April 4, 2025 at 1:54 PM
My monocyte, with a fluorescent membrane (EGFP-CAAX 💛), is transmigrating across the brain microvascular endothelium (VE-cadherin 💙)
#FluorescenceFriday #SciArt
#FluorescenceFriday #SciArt
Hayase, Xu, Bi et al. show that E-cadherin promotes bile canaliculus elongation via RhoA activation and oriented cell division, while N-cadherin maintains hepatic #polarity by attenuating RhoA, defining distinct roles of dual #cadherin expression in #hepatocytes. rupress.org/jcb/article/...
May 27, 2026 at 4:01 PM
Hayase, Xu, Bi et al. show that E-cadherin promotes bile canaliculus elongation via RhoA activation and oriented cell division, while N-cadherin maintains hepatic #polarity by attenuating RhoA, defining distinct roles of dual #cadherin expression in #hepatocytes. rupress.org/jcb/article/...
Actomyosin contractility and a threshold of cadherin cell adhesion is required during tissue fusion, say Camilla Teng @xsciteng.bsky.social, Jeffrey Bush @jeffbush.bsky.social and colleagues @ctbatucsf.bsky.social: rupress.org/jcb/article/...
#Development #Adhesion
#Development #Adhesion
November 20, 2025 at 7:45 PM
Actomyosin contractility and a threshold of cadherin cell adhesion is required during tissue fusion, say Camilla Teng @xsciteng.bsky.social, Jeffrey Bush @jeffbush.bsky.social and colleagues @ctbatucsf.bsky.social: rupress.org/jcb/article/...
#Development #Adhesion
#Development #Adhesion
Nature research paper: Targeting GRPR for sex hormone-dependent cancer after loss of E-cadherin
https://go.nature.com/4jKbcN6
https://go.nature.com/4jKbcN6
Targeting GRPR for sex hormone-dependent cancer after loss of E-cadherin - Nature
A study finding an oestrogen-sensing signalling pathway that promotes melanoma metastasis only in female mice emphasizes the importance of recognizing sex-specific factors in cancer management.
go.nature.com
June 13, 2025 at 7:49 AM
Nature research paper: Targeting GRPR for sex hormone-dependent cancer after loss of E-cadherin
https://go.nature.com/4jKbcN6
https://go.nature.com/4jKbcN6
VE-cadherin RGD motifs are dispensable for cell–cell junctions, endothelial barrier function and monocyte extravasation: Tissue Barriers: Vol 0, No 0 www.tandfonline.com/doi/metrics/...
March 27, 2025 at 4:19 PM
VE-cadherin RGD motifs are dispensable for cell–cell junctions, endothelial barrier function and monocyte extravasation: Tissue Barriers: Vol 0, No 0 www.tandfonline.com/doi/metrics/...
Paper alert! β-catenin forms condensates that help build cell–cell adhesions - showing its role goes beyond simply linking E-cadherin to α-cat/actin. Great collaboration with the Schuijers lab!
👉 nature.com/articles/s41...
👉 nature.com/articles/s41...
December 16, 2025 at 9:25 AM
Paper alert! β-catenin forms condensates that help build cell–cell adhesions - showing its role goes beyond simply linking E-cadherin to α-cat/actin. Great collaboration with the Schuijers lab!
👉 nature.com/articles/s41...
👉 nature.com/articles/s41...
During embryogenesis, how do cells self-organize to support tissue-specific functions? @melanielaurin.bsky.social &co show that ARHGEF3 regulates #cadherin patterning & #placode polarization in early #HairFollicle development, influencing #morphogenesis @plosbiology.org 🧪 plos.io/450aBm5
January 7, 2026 at 1:55 PM
During embryogenesis, how do cells self-organize to support tissue-specific functions? @melanielaurin.bsky.social &co show that ARHGEF3 regulates #cadherin patterning & #placode polarization in early #HairFollicle development, influencing #morphogenesis @plosbiology.org 🧪 plos.io/450aBm5