#placode
LightNews LightNews
mariebreau.bsky.social
Check out our latest article now out in eLife! We identify key roles of basement membranes in olfactory placode morphogenesis and axon growth. Congrats to P. Tignard and all authors! Fruitful collaboration with @trembleaudusart

elifesciences.org/articles/92004
Basement membranes are crucial for proper olfactory placode shape, position and boundary with the brain, and for olfactory axon development
Laminin gamma1-dependent basement membranes are required for multiple aspects of olfactory system development in zebrafish, including the maintenance of placode tissue shape and the growth of the olfa...
elifesciences.org
December 30, 2024 at 9:06 PM
elife.bsky.social
The importance of basement membranes in the development of the olfactory placode.
https://elifesciences.org/articles/92004?utm_source=bluesky&utm_medium=social&utm_campaign=organic
January 5, 2025 at 9:01 PM
harschnitz.bsky.social
Placode is feeling seriously excluded here 🤣
November 18, 2024 at 7:17 PM
devbiol.bsky.social
#DBfeature #ICYMI 🐸

Identification, expression and function of 28 new candidate regulators of placodal neurogenesis in Xenopus laevis

By Bertrand Hutlet, Gerhard Schlosser

tinyurl.com/34szsky6
Expression patterns of eya1 and its candidate interaction partners at mid-tailbud stage. Xenopus laevis embryos after whole-mount in situ hybridization at stage 27, in lateral views (anterior is to the left). The schematic drawing (A) shows the distribution of placodes in a mid-tailbud stage embryo. Arrows indicate expression in placodes and display the colour code used in the drawing (yellow: profundal placode; dark green: trigeminal placode; light green: olfactory placode, pink: otic placode; brown: lateral line placode; orange: epibranchial placodes). For placodes derived from the posterior placodal area, only the otic placode and one lateral line placode are indicated in panels C–L. Arrowheads and asterisks indicate other areas of expression. Pink arrowhead: somites; white asterisks: pharyngeal pouches. Blue asterisks (neural crest streams) and arrowheads indicate expression in areas where eya1 is not expressed. Panels D, F, H, J, L are magnifications of panels C, E, G, I, K, respectively. Abbreviations: B, blood islands; E, prospective eye, including lens (L) placode; EB, epibranchial placodes; F: forebrain; H: hindbrain; LL, lateral line placodes; LPM, lateral plate mesoderm; M: midbrain; Ol, olfactory placode; Ot, otic placode; P, pronephros; Pr, profundal placode; V, trigeminal placode.
July 23, 2026 at 2:31 PM
filodelbene.bsky.social
doi.org/10.7554/eLif...
Basement membranes are crucial for proper olfactory placode shape, position and boundary with the brain, and for olfactory axon development
Laminin gamma1-dependent basement membranes are required for multiple aspects of olfactory system development in zebrafish, including the maintenance of placode tissue shape and the growth of the olfa...
doi.org
December 30, 2024 at 7:57 PM
socdevbio.bsky.social
🐣✨ TUJ1 staining reveals the forming trigeminal ganglion in a chick embryo! Image taken by Rocio Márquez from @pstrobl.bsky.social lab, where they investigate how neural crest and placode cells communicate during the formation of this sensory structure 🔬🧪
#FluorescenceFriday
July 18, 2025 at 1:27 PM
cp-trendsneuro.bsky.social
'Making sense of vertebrate senses from a neural crest and cranial placode evo-devo perspective'

by Brittany Edens & Marianne Bronner

www.cell.com/trends/neuro...
March 13, 2025 at 1:06 PM
r3rt0.bsky.social
This you @borrell-lab.bsky.social ??
"not placode-derived 𝙗𝙪𝙩 𝙢𝙚𝙘𝙝𝙖𝙣𝙞𝙘𝙖𝙡𝙡𝙮 𝙨𝙚𝙡𝙛-𝙤𝙧𝙜𝙖𝙣𝙞𝙯𝙚𝙙"
Love it!! 😍
levayerr.bsky.social Levayer Lab @levayerr.bsky.social · Nov 18
Polygonal pattern in the mammalian nose skin is driven by epidermal buckling promoted by growth and patterned by local stiff blood vessels.
www.cell.com/current-biol...
November 18, 2024 at 8:02 PM
cabd-upo-csic.bsky.social
Great start of the #CABDseminars 2026/2027 with the talk of Berta Alsina @bertaalsinalab.bsky.social @melisupf.bsky.social
Berta explained the work uncovering the extrinsic and intrinsic cues shaping the early otic placode. Berta was hosted by @jrmarmor.bsky.social

Thanks for coming Berta!
September 17, 2026 at 10:19 AM
plosbiology.org
How does transcriptional patterning regulate #SalivaryGland #morphogenesis? Annabel May & @katjaroeper.bsky.social use #scRNAseq of early morphogenesis of the #Drosophila salivary gland placode to reveal regulation by induction & exclusion of regulatory factors @plosbiology.org 🧪 plos.io/4cUw827
Top: Immunofluorescence images and matching schematics of the anterior ventral half of Drosophila embryos at the indicated stages, highlighting the cells of the salivary gland placode, labelled with fkhGal4 x UAS-srcGFP. All cell outlines are labeled for phosphotyrosine to label adherens junctions (PY20, magenta) and srcGFP is in green, the stage 10 panel is shown with increased exposure, other panels are identical exposure. Scale bar is 100µm. Middle panels are matched schematics, showing the position of the salivary gland placode in pale green, the area of initial apical constriction in bright green and the forming invagination pit in black. Lower panels show schematics of cross sections (positioned indicated by magenta dotted lines in middle panels) of the invaginating tube. Bottom: A salivary gland placode in the Drosophila embryo at the onset of tube morphogenesis, labelled for four jointed (fj) (cyan) and fkh (magenta) expression by HCR and with cell outlines labelled by PY-20, detecting phospho-tyrosine at adherens junctions (yellow).
April 23, 2025 at 2:02 PM
harschnitz.bsky.social
This is an excellent meeting for both #neuralcrest and #placode afficionados! An amazing line up of speakers at a great location. I have signed up and would highly recommend this to others.
labonnelab.bsky.social @LaBonneLaB @labonnelab.bsky.social · Jan 18
Dear #neuralcrest afficionados Please Apply for the Neural Crest and Cranial Placodes GRC - the current application numbers put it at risk for cancellation going forward. Come to beautiful Tuscany and engage with interesting science! www.grc.org/neural-crest...
2025 Neural Crest and Cranial Placodes (GRS) Seminar GRC
The 2025 Gordon Research Seminar on Neural Crest and Cranial Placodes (GRS) will be held in Lucca (Barga), Lucca Italy. Apply today to reserve your spot.
www.grc.org
January 18, 2025 at 6:22 PM
juliebatut.bsky.social
❗️Our new paper "Local activation of Cxcl12a signaling controls olfactory placode morphogenesis in zebrafish embryos" is out 👇
bioRxiv.🙏 Thanks so much to all coauthors: fantastic people😍🤩 ✨️fantastic work. Mathematical modeling to understand morphogenesis. Get in touch if interessed, more to come😉
December 22, 2024 at 1:19 PM
harschnitz.bsky.social
Exciting! Will keep an eye out. Love everything placode and crest related 😁
January 17, 2025 at 7:20 PM
etche.bsky.social
Thank you for making your paper open access! I am excited to read it as there are probably similar constraints in place for other evolutionarily constrained processes, like placode development into feathers, scales and hair, or vascularisation of developing organs 🤩🧪
January 25, 2025 at 8:39 AM
anderssonlab.bsky.social
Hot off the press! 🧬🔬

We developed in utero nano-injection to label & trace the mouse neural plate and otic placode using next generation single cell lineage tracing. We couple progenitors to mature cell types in the CNS & resolve the lineages of cells in the hearing organ:

doi.org/10.1126/scie...
Ectoderm barcoding reveals neural and cochlear compartmentalization
Placodes and the neural crest are defining features of vertebrates. In this study, we investigate their lineages in mice using in utero approaches. We demonstrated that nanoinjection at embryonic day ...
doi.org
April 4, 2025 at 6:24 AM
mikepiacentino.bsky.social
I’m thrilled to share the first preprint from the Piacentino Lab @hopkinsmedicine.bsky.social! We show that developing inner ear requires a secreted lipid chaperone, APOD, working in a positive feedback loop to amplify FGF/MAPK signaling. 👂 #DevBio Check it out! www.biorxiv.org/content/10.6...
Lipid-mediated reinforcement of FGF/MAPK signaling enables robust otic placode specification
The formation of cranial placodes requires groups of ectodermal cells to interpret inductive signals in a robust and organized manner, yet how signaling responses are coordinated across a developing f...
www.biorxiv.org
January 8, 2026 at 10:56 PM
Planar cell polarity-directed cell crawling drives polarized epithelial morphogenesis: Current Biology www.cell.com/current-biol...
Planar cell polarity-directed cell crawling drives polarized epithelial morphogenesis
Sharan et al. investigate how planar cell polarity (PCP) directs counter-rotational cell flows during hair placode morphogenesis by coordinating cell crawling at the basal surface. 3D imaging and comp...
www.cell.com
June 24, 2026 at 11:12 AM
plosbiology.org
During embryogenesis, how do cells self-organize to support tissue-specific functions? @melanielaurin.bsky.social &co show that ARHGEF3 regulates #cadherin patterning & #placode polarization in early #HairFollicle development, influencing #morphogenesis @plosbiology.org 🧪 plos.io/450aBm5
The image depicts P-cadherin levels at cell–cell junctions in a planar view of whole-mount preparation of embryonic mouse skin. The image was derived from confocal microscopy data and artistically enhanced for visual clarity. Image credit: Krithika Kalyanakrishnan and Alexandra Jetté
January 7, 2026 at 1:55 PM
djdavid.bsky.social
Third paper to highlight!
Here, Lisa Manning, @sarawickstrom.bsky.social, &c olleagues show contractility, pressure, signalling cooperating in vertebrate development, w/thorough combination of expertise in cell biology, signalling, & biophysics.

(Open Access) www.nature.com/articles/s41...
Mechanical forces across compartments coordinate cell shape and fate transitions to generate tissue architecture - Nature Cell Biology
Villeneuve et al. report coordination of contractile forces during mammalian hair follicle development, with actomyosin contractility and mechanical forces from the epidermis and underlying tissue regulating placode invagination and Sox9 expression.
www.nature.com
September 30, 2025 at 7:28 PM
devbiol.bsky.social
#DBfeature #LatestResearch 🐣

Gene knockout in chick reveals a new in vivo role for Cxcl14 during trigeminal ganglion development

By Hugo Urrutia, Junpeng Gao, Marianne Bronner

doi.org/10.1016/j.ydbio.2026.06.001
Perturbation of Cxcl14 specifically in placode cells disrupts trigeminal ganglion development. A. Schematic illustrating the in ovo experimental design to perturb Cxcl14, specifically targeting placode cells. Experimental (red) reagents were delivered unilaterally into the ectoderm of HH11 (13 somites) chick embryos. B-E″. Either a Cxcl14 specific gRNA-CRISPR/Cas9 construct (B-C′) or Cxcl14 MO (D-E′) were introduced onto the right side of the embryo. Immunolabeling of SOX10 (magenta) and TUJ1 (green) reveals the effects of loss of Cxcl14 within the trigeminal ganglion, specifically in placode cells at HH16. Arrows indicate position of neural crest-derived cells. Arrowheads indicate position of placode-derived cells.
July 16, 2026 at 8:43 AM
devbiol.bsky.social
#DBfeature

In vitro modeling of cranial placode differentiation: Recent advances, challenges, and perspectives

by Casey Griffin, Jean-Pierre Saint-Jeannet
www.sciencedirect.com/science/arti...
March 21, 2024 at 4:12 PM
biorxiv-devbio.bsky.social
A protocadherin mediates cell-cell adhesion and integrity of the oral placode in the tunicate Ciona https://www.biorxiv.org/content/10.1101/2025.07.11.664433v1
July 14, 2025 at 4:31 PM
biorxiv-devbio.bsky.social
Local activation of Cxcl12a signaling controls olfactory placode morphogenesis in zebrafish embryos https://www.biorxiv.org/content/10.1101/2024.12.20.629493v1
December 21, 2024 at 1:31 AM
shifengxue.bsky.social
Excited to share our new manuscript! Why do people with Bosma #arhinia microphthalmia syndrome (BAMS) not form noses? We show that #iPSCs from these patients are less able to form cranial placode cells, one of the cell types that make up the nose. www.cell.com/stem-cell-re...
Cranial placode differentiation defect in individuals born without a nose
Xue and colleagues show that iPSCs from Bosma syndrome (BAMS) individuals have a reduced capacity of differentiation into cranial placode cells and the subsequent lens and olfactory lineages. These ce...
www.cell.com
April 11, 2026 at 8:50 AM
plosbiology.org
How does transcriptional patterning regulate #SalivaryGland #morphogenesis? Annabel May & @katjaroeper.bsky.social use #scRNAseq of early morphogenesis of the #Drosophila salivary gland placode to reveal regulation by induction & exclusion of regulatory factors @plosbiology.org 🧪 plos.io/4cUw827
Top: Immunofluorescence images and matching schematics of the anterior ventral half of Drosophila embryos at the indicated stages, highlighting the cells of the salivary gland placode, labelled with fkhGal4 x UAS-srcGFP. All cell outlines are labeled for phosphotyrosine to label adherens junctions (PY20, magenta) and srcGFP is in green, the stage 10 panel is shown with increased exposure, other panels are identical exposure. Scale bar is 100µm. Middle panels are matched schematics, showing the position of the salivary gland placode in pale green, the area of initial apical constriction in bright green and the forming invagination pit in black. Lower panels show schematics of cross sections (positioned indicated by magenta dotted lines in middle panels) of the invaginating tube. Bottom: A salivary gland placode in the Drosophila embryo at the onset of tube morphogenesis, labelled for four jointed (fj) (cyan) and fkh (magenta) expression by HCR and with cell outlines labelled by PY-20, detecting phospho-tyrosine at adherens junctions (yellow).
April 24, 2025 at 8:01 AM