Polybia wasps: bioengineers with pharmaceutical potential
Their venom's Polybia-MP1 peptide targets cancer cells (phosphatidylserine specificity), while mastoparans combat Trypanosoma cruzi (Chagas disease vector). 🧪
Their venom's Polybia-MP1 peptide targets cancer cells (phosphatidylserine specificity), while mastoparans combat Trypanosoma cruzi (Chagas disease vector). 🧪
April 5, 2025 at 12:14 AM
Polybia wasps: bioengineers with pharmaceutical potential
Their venom's Polybia-MP1 peptide targets cancer cells (phosphatidylserine specificity), while mastoparans combat Trypanosoma cruzi (Chagas disease vector). 🧪
Their venom's Polybia-MP1 peptide targets cancer cells (phosphatidylserine specificity), while mastoparans combat Trypanosoma cruzi (Chagas disease vector). 🧪
Nature research paper: Exposed phosphatidylserine is an inhibitory molecule in T cell exhaustion
go.nature.com/4rTbG7w
go.nature.com/4rTbG7w
Exposed phosphatidylserine is an inhibitory molecule in T cell exhaustion - Nature
Insights into the mechanism by which phosphatidylserine functions as a non-classical inhibitory molecule during T cell exhaustion, and how phosphatidylserine-targeting antibodies enhance T cell responses are explored.
go.nature.com
March 26, 2026 at 8:58 AM
Nature research paper: Exposed phosphatidylserine is an inhibitory molecule in T cell exhaustion
go.nature.com/4rTbG7w
go.nature.com/4rTbG7w
200mg Phosphatidylserine daily.
April 20, 2026 at 3:43 PM
200mg Phosphatidylserine daily.
CD300ld on pathologically activated neutrophils promotes tumor immune suppression by binding phosphatidylserine on CD8+ T cells @natcancer.nature.com
www.nature.com/articles/s43...
www.nature.com/articles/s43...
CD300ld on pathologically activated neutrophils promotes tumor immune suppression by binding phosphatidylserine on CD8+ T cells - Nature Cancer
Zhao and colleagues show that CD300ld, upregulated in pathologically activated neutrophils, mediates contact-dependent suppression of cytotoxic CD8+ T cells by binding to phosphatidylserine, inhibitin...
www.nature.com
May 15, 2026 at 6:50 PM
CD300ld on pathologically activated neutrophils promotes tumor immune suppression by binding phosphatidylserine on CD8+ T cells @natcancer.nature.com
www.nature.com/articles/s43...
www.nature.com/articles/s43...
We determined structures with and without activating membrane lipid, phosphatidylserine (PS). Working with the Smith lab, we use a combination of methods to propose a mechanism whereby PS stabilizes and induces conformational changes in receptor:ligand complexes to promote kinase domain activation.
October 1, 2026 at 5:21 PM
We determined structures with and without activating membrane lipid, phosphatidylserine (PS). Working with the Smith lab, we use a combination of methods to propose a mechanism whereby PS stabilizes and induces conformational changes in receptor:ligand complexes to promote kinase domain activation.
Pussy in Bio, phosphatidylserine in biochemistry, PSI in engineering, ψ in Math, etcetera.
March 21, 2024 at 9:55 PM
Pussy in Bio, phosphatidylserine in biochemistry, PSI in engineering, ψ in Math, etcetera.
Phosphatidylserine and RhoB connect PI4P and PA #metabolism to maintain plasma #membrane identity. New study from Shiying Huang, Tamas Balla, Jeremy M. Baskin @jeremybaskin.bsky.social, @weillinstitute.bsky.social and colleagues:
rupress.org/jcb/article/...
#lipid
rupress.org/jcb/article/...
#lipid
July 3, 2026 at 1:45 PM
Phosphatidylserine and RhoB connect PI4P and PA #metabolism to maintain plasma #membrane identity. New study from Shiying Huang, Tamas Balla, Jeremy M. Baskin @jeremybaskin.bsky.social, @weillinstitute.bsky.social and colleagues:
rupress.org/jcb/article/...
#lipid
rupress.org/jcb/article/...
#lipid
How does the plasma #membrane preserve its #lipid identity under stress? The Baskin and Balla labs report a homeostatic circuit linking PI4P, phosphatidylserine, RhoB, and phospholipase D-driven phosphatidic acid. rupress.org/jcb/article/...
@jeremybaskin.bsky.social
@jeremybaskin.bsky.social
June 26, 2026 at 4:30 PM
How does the plasma #membrane preserve its #lipid identity under stress? The Baskin and Balla labs report a homeostatic circuit linking PI4P, phosphatidylserine, RhoB, and phospholipase D-driven phosphatidic acid. rupress.org/jcb/article/...
@jeremybaskin.bsky.social
@jeremybaskin.bsky.social
Structural basis of phosphatidylserine enhancement of Gas6 ligand-induced Axl activation https://www.biorxiv.org/content/10.64898/2026.09.30.755801v1
October 1, 2026 at 2:48 PM
Structural basis of phosphatidylserine enhancement of Gas6 ligand-induced Axl activation https://www.biorxiv.org/content/10.64898/2026.09.30.755801v1
💫NEW: Here the authors show that LC3-associated #phagocytosis is initiated by various receptors, which enrich #phosphatidylserine in the membrane domains proximal to the phagosome, recruiting Rubicon to the membrane for #phagosome maturation.
bit.ly/4qckc2b
bit.ly/4qckc2b
Membrane receptors cluster phosphatidylserine to activate LC3-associated phagocytosis - Nature Cell Biology
Here the authors show that LC3-associated phagocytosis is initiated by various receptors, which enrich phosphatidylserine in the membrane domains proximal to the phagosome, recruiting Rubicon to the membrane for phagosome maturation.
bit.ly
October 4, 2025 at 2:26 PM
💫NEW: Here the authors show that LC3-associated #phagocytosis is initiated by various receptors, which enrich #phosphatidylserine in the membrane domains proximal to the phagosome, recruiting Rubicon to the membrane for #phagosome maturation.
bit.ly/4qckc2b
bit.ly/4qckc2b
Phosphatidylserine Supplement Market Forecasting Growth 2035 | WiseGuyReports www.wiseguyreports.com/reports/phos...
Phosphatidylserine Supplement Market Forecasting Growth 2035
The Phosphatidylserine Supplement Market is expected to grow from 800 USD Million in 2025 to 1,500 USD Million by 2035. The Phosphatidylserine Supplement Market CAGR (growth rate) is expected to be ar...
www.wiseguyreports.com
October 5, 2026 at 8:10 AM
Phosphatidylserine Supplement Market Forecasting Growth 2035 | WiseGuyReports www.wiseguyreports.com/reports/phos...
New paper alert 🎇 in @biologists.bsky.social Journal of Cell Science..
Cell surface remodeling caused by the loss of the flippase subunit TMEM30A in immune cells:
journals.biologists.com/jcs/article/...
Cell surface remodeling caused by the loss of the flippase subunit TMEM30A in immune cells:
journals.biologists.com/jcs/article/...
Cell surface remodeling caused by the loss of the flippase subunit TMEM30A in immune cells
Summary: TMEM30A loss disrupts membrane lipid asymmetry, increasing phosphatidylserine exposure, membrane dynamics and surface remodeling, linking flippase dysfunction to immune cell interactions.
journals.biologists.com
August 22, 2026 at 1:23 PM
New paper alert 🎇 in @biologists.bsky.social Journal of Cell Science..
Cell surface remodeling caused by the loss of the flippase subunit TMEM30A in immune cells:
journals.biologists.com/jcs/article/...
Cell surface remodeling caused by the loss of the flippase subunit TMEM30A in immune cells:
journals.biologists.com/jcs/article/...
Membrane receptors cluster phosphatidylserine to activate LC3-associated phagocytosis
www.nature.com/articles/s41...
@natcellbio.nature.com @stjuderesearch.bsky.social
www.nature.com/articles/s41...
@natcellbio.nature.com @stjuderesearch.bsky.social
September 22, 2025 at 4:54 PM
Membrane receptors cluster phosphatidylserine to activate LC3-associated phagocytosis
www.nature.com/articles/s41...
@natcellbio.nature.com @stjuderesearch.bsky.social
www.nature.com/articles/s41...
@natcellbio.nature.com @stjuderesearch.bsky.social
Pamper Phosphatidylserine
October 27, 2024 at 12:56 AM
Pamper Phosphatidylserine
Masking phosphatidylserine prevents neuronal loss in two distinct Drosophila models of neurodegeneration #NeuroDegeneration 🧪🧠
https://www.pnas.org/doi/abs/10.1073/pnas.2622558123?af=R
https://www.pnas.org/doi/abs/10.1073/pnas.2622558123?af=R
October 8, 2026 at 10:04 AM
Masking phosphatidylserine prevents neuronal loss in two distinct Drosophila models of neurodegeneration #NeuroDegeneration 🧪🧠
https://www.pnas.org/doi/abs/10.1073/pnas.2622558123?af=R
https://www.pnas.org/doi/abs/10.1073/pnas.2622558123?af=R
Assessing Extracellular Vesicle Turnover In vivo Using Highly Sensitive Phosphatidylserine-Binding Reagents https://www.biorxiv.org/content/10.1101/2024.11.14.623541v1
Assessing Extracellular Vesicle Turnover In vivo Using Highly Sensitive Phosphatidylserine-Binding Reagents https://www.biorxiv.org/content/10.1101/2024.11.14.623541v1
Phosphatidylserine (PS) is a well-established marker for apoptotic cells and activated platelets, an
www.biorxiv.org
November 15, 2024 at 11:30 AM
Assessing Extracellular Vesicle Turnover In vivo Using Highly Sensitive Phosphatidylserine-Binding Reagents https://www.biorxiv.org/content/10.1101/2024.11.14.623541v1
8 ) The pathway analysis of lipids highlighted several genes, including Phosphatidylserine synthase 1 (PTDSS1) which was upregulated in ME/CFS. It was highlighted in an older ME/CFS genetics study from 2016
pubmed.ncbi.nlm.nih....
pubmed.ncbi.nlm.nih....
January 16, 2026 at 9:23 AM
8 ) The pathway analysis of lipids highlighted several genes, including Phosphatidylserine synthase 1 (PTDSS1) which was upregulated in ME/CFS. It was highlighted in an older ME/CFS genetics study from 2016
pubmed.ncbi.nlm.nih....
pubmed.ncbi.nlm.nih....
Phosphatidylserine synthesis tunes IP3R-mediated ER Ca2+ release via phospholipid homeostasis
Phosphatidylserine synthesis tunes IP3R-mediated ER Ca2+ release via phospholipid homeostasis
Zhou et al. found that phosphatidylserine (PS) regulates ER Ca2+ homeostasis by modulating IP3R-mediated Ca2+ release. Manipulating phospholipid composition through the phospholipid-SREBP axis normalizes IP3R-mediated Ca2+ release during PS deficiency.
dlvr.it
August 29, 2026 at 11:23 PM
Phosphatidylserine synthesis tunes IP3R-mediated ER Ca2+ release via phospholipid homeostasis
Xenophagocytosis, where host macrophages eliminate xenogeneic donor cells due to elevated phosphatidylserine, can be blocked to boost interspecies chimerism and tackle organ shortages. PMID:42248141, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00575-1 #Medsky #Pharmsky #RNA 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00575-1
No description available
www.cell.com
October 6, 2026 at 3:00 AM
Xenophagocytosis, where host macrophages eliminate xenogeneic donor cells due to elevated phosphatidylserine, can be blocked to boost interspecies chimerism and tackle organ shortages. PMID:42248141, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00575-1 #Medsky #Pharmsky #RNA 🧪
TDP-43 suppression of ATP8A2 cryptic splicing implicates phosphatidylserine-driven neuroinflammation in ALS/FTD www.biorxiv.org/content/10.1...
TDP-43 suppression of ATP8A2 cryptic splicing implicates phosphatidylserine-driven neuroinflammation in ALS/FTD
Inappropriate externalization of phosphatidylserine (PS) is a candidate mechanism of pathogenic neuroinflammation, a critical driver of neurodegenerative disease. ATP8A2, a flippase that maintains PS ...
www.biorxiv.org
November 29, 2025 at 2:31 PM
TDP-43 suppression of ATP8A2 cryptic splicing implicates phosphatidylserine-driven neuroinflammation in ALS/FTD www.biorxiv.org/content/10.1...
Exposed phosphatidylserine is an inhibitory molecule in T cell exhaustion @nature.com @emoryuniversity.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
March 26, 2026 at 3:44 AM
Exposed phosphatidylserine is an inhibitory molecule in T cell exhaustion @nature.com @emoryuniversity.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
How are #phospholipids transferred within #mitochondria? A study in #Drosophila shows that SLMO transfers phosphatidylserine (PS) from the outer to the inner mitochondrial membrane, where it is converted into PE, so contributing to mitochondrial form & function 🧪 #PLOSBiology plos.io/4iHc9qg
December 18, 2024 at 2:17 PM
How are #phospholipids transferred within #mitochondria? A study in #Drosophila shows that SLMO transfers phosphatidylserine (PS) from the outer to the inner mitochondrial membrane, where it is converted into PE, so contributing to mitochondrial form & function 🧪 #PLOSBiology plos.io/4iHc9qg
Enjoyed visiting Montreal Diabetes Research Centre @crchum.bsky.social to give a talk on our new stories on cardiolipin and phosphatidylserine on MASLD. Thanks for hosting @glim2016.bsky.social @alquierthierry.bsky.social @dnachicken.bsky.social!
March 25, 2026 at 2:26 AM
Enjoyed visiting Montreal Diabetes Research Centre @crchum.bsky.social to give a talk on our new stories on cardiolipin and phosphatidylserine on MASLD. Thanks for hosting @glim2016.bsky.social @alquierthierry.bsky.social @dnachicken.bsky.social!