Medical professionals exiting twitter like valproic acid when it sees a carbapenem.
November 14, 2024 at 10:38 PM
Medical professionals exiting twitter like valproic acid when it sees a carbapenem.
Let's talk about using carbapenem antibiotics in patients with valproic acid (VPA) poisoning
/1🧵
/1🧵
April 10, 2025 at 6:50 PM
Let's talk about using carbapenem antibiotics in patients with valproic acid (VPA) poisoning
/1🧵
/1🧵
Welcome for complicated UTIs w/ resistant bugs but oral carbapenem lower the last barrier protecting this important antibiotic class Convenience for patients must not become convenience for prescribers, otherwise we may pay with increased carbapenem resistance
#AMR
www.cidrap.umn.edu/antimicrobia...
#AMR
www.cidrap.umn.edu/antimicrobia...
FDA approves new oral antibiotic for complicated urinary tract infections
Utebzi is the first oral carbapenem antibiotic approved in the US.
www.cidrap.umn.edu
June 21, 2026 at 7:36 PM
Welcome for complicated UTIs w/ resistant bugs but oral carbapenem lower the last barrier protecting this important antibiotic class Convenience for patients must not become convenience for prescribers, otherwise we may pay with increased carbapenem resistance
#AMR
www.cidrap.umn.edu/antimicrobia...
#AMR
www.cidrap.umn.edu/antimicrobia...
The infection rate of one type of carbapenem-resistant Enterobacterales bacteria has risen by more than 460 percent in recent years. Scientists say people receiving treatment in hospitals are at highest risk
CDC Sounds Alarm over ‘Nightmare Bacteria’ That Resist Last-Resort Antibiotics
The infection rate of one type of carbapenem-resistant Enterobacterales bacteria has risen by more than 460 percent in recent years. Scientists say people receiving treatment in hospitals are at highe...
www.scientificamerican.com
September 25, 2025 at 12:58 PM
The infection rate of one type of carbapenem-resistant Enterobacterales bacteria has risen by more than 460 percent in recent years. Scientists say people receiving treatment in hospitals are at highest risk
De-escalation of carbapenem prescriptions: noble objective, not so easy to do well in practice!
#IDSky #ClinMicro #AMR @jac-amr.bsky.social
academic.oup.com/jacamr/artic...
#IDSky #ClinMicro #AMR @jac-amr.bsky.social
academic.oup.com/jacamr/artic...
Carbapenem de-escalation as an antimicrobial stewardship strategy: a narrative review
Abstract. Increased carbapenem prescribing has contributed to rising rates of carbapenem-resistant bacterial pathogens. Although antimicrobial stewardship
academic.oup.com
March 12, 2025 at 12:07 AM
De-escalation of carbapenem prescriptions: noble objective, not so easy to do well in practice!
#IDSky #ClinMicro #AMR @jac-amr.bsky.social
academic.oup.com/jacamr/artic...
#IDSky #ClinMicro #AMR @jac-amr.bsky.social
academic.oup.com/jacamr/artic...
Study suggests carbapenem-resistant Acinetobacter may spread through the air
Researchers say airborne dispersal of the healthcare-associated pathogen could present an important mode of spread.
Read more: https://bit.ly/4rcpOKp
📷: Dan Higgins, James Archer/CDC
Researchers say airborne dispersal of the healthcare-associated pathogen could present an important mode of spread.
Read more: https://bit.ly/4rcpOKp
📷: Dan Higgins, James Archer/CDC
September 16, 2026 at 8:35 PM
Study suggests carbapenem-resistant Acinetobacter may spread through the air
Researchers say airborne dispersal of the healthcare-associated pathogen could present an important mode of spread.
Read more: https://bit.ly/4rcpOKp
📷: Dan Higgins, James Archer/CDC
Researchers say airborne dispersal of the healthcare-associated pathogen could present an important mode of spread.
Read more: https://bit.ly/4rcpOKp
📷: Dan Higgins, James Archer/CDC
🆕✨Super interesting
How high-risk ESBL-Ecoli initially adapt to carbapenem exposures prior to acquiring carbapenem resistance?
ST131 mutants ▶️Erta exposure 🔼ESBL gene copies via IS26 mediated PCTns or mutations in outer membrane porin(Omp) genes
#idsky #microsky
academic.oup.com/jid/advance-...
How high-risk ESBL-Ecoli initially adapt to carbapenem exposures prior to acquiring carbapenem resistance?
ST131 mutants ▶️Erta exposure 🔼ESBL gene copies via IS26 mediated PCTns or mutations in outer membrane porin(Omp) genes
#idsky #microsky
academic.oup.com/jid/advance-...
Comprehensive Assessment of Initial Adaptation of ESBL Positive ST131 Escherichia coli to Carbapenem Exposure
High-risk ST131 E. coli strains, particularly C2/H30Rx subclades, adapt to initial carbapenem exposure by IS-mediated ESBL gene amplification. This gene am
academic.oup.com
November 28, 2024 at 6:46 AM
🆕✨Super interesting
How high-risk ESBL-Ecoli initially adapt to carbapenem exposures prior to acquiring carbapenem resistance?
ST131 mutants ▶️Erta exposure 🔼ESBL gene copies via IS26 mediated PCTns or mutations in outer membrane porin(Omp) genes
#idsky #microsky
academic.oup.com/jid/advance-...
How high-risk ESBL-Ecoli initially adapt to carbapenem exposures prior to acquiring carbapenem resistance?
ST131 mutants ▶️Erta exposure 🔼ESBL gene copies via IS26 mediated PCTns or mutations in outer membrane porin(Omp) genes
#idsky #microsky
academic.oup.com/jid/advance-...
1/2 New publication from the lab from the talented postdoc Dr. Andy Perrault in collaboration with Dr. Alejandro Pironti! pubmed.ncbi.nlm.nih.gov/39977318/
Enterobacter hormaechei replaces virulence with carbapenem resistance via porin loss - PubMed
Pathogenic <i>Enterobacter</i> species are of increasing clinical concern due to the multidrug-resistant nature of these bacteria, including resistance to carbapenem antibiotics. Our understanding of ...
pubmed.ncbi.nlm.nih.gov
February 22, 2025 at 3:42 PM
1/2 New publication from the lab from the talented postdoc Dr. Andy Perrault in collaboration with Dr. Alejandro Pironti! pubmed.ncbi.nlm.nih.gov/39977318/
Always get more nervous for trainee talks than my own, but Leslie Lopez, one of only ~2 RA's to speak at this year's #BBM2026, absolutely crushed it, presenting follow-up work from her co-1st author paper (w/ @alexclinmicro.bsky.social) #proudPI
Great meeting as always, @bostonbacteria.bsky.social
Great meeting as always, @bostonbacteria.bsky.social
The carbapenem inoculum effect provides insights into the molecular mechanisms underlying carbapenem resistance in the Enterobacterales | mBio
Infections caused by carbapenem-resistant Enterobacterales (CRE) pose significant
threats to patients and public health worldwide. Carbapenem resistance can occur through
several molecular mechanisms,...
journals.asm.org
June 24, 2026 at 1:16 AM
Always get more nervous for trainee talks than my own, but Leslie Lopez, one of only ~2 RA's to speak at this year's #BBM2026, absolutely crushed it, presenting follow-up work from her co-1st author paper (w/ @alexclinmicro.bsky.social) #proudPI
Great meeting as always, @bostonbacteria.bsky.social
Great meeting as always, @bostonbacteria.bsky.social
Study finds carbapenem-resistant bacteria in nearly 2% of gram-negative isolates from dogs, cats
Researchers with the New York City Health Department say the results suggest real-time veterinary surveillance for carbapenem-resistant organisms is needed.
www.cidrap.umn.edu/a...
Researchers with the New York City Health Department say the results suggest real-time veterinary surveillance for carbapenem-resistant organisms is needed.
www.cidrap.umn.edu/a...
October 8, 2025 at 8:24 PM
Study finds carbapenem-resistant bacteria in nearly 2% of gram-negative isolates from dogs, cats
Researchers with the New York City Health Department say the results suggest real-time veterinary surveillance for carbapenem-resistant organisms is needed.
www.cidrap.umn.edu/a...
Researchers with the New York City Health Department say the results suggest real-time veterinary surveillance for carbapenem-resistant organisms is needed.
www.cidrap.umn.edu/a...
www.nature.com/articles/s41...
New paper out!!
New paper out!!
A plasmid-chromosome crosstalk in multidrug resistant enterobacteria - Nature Communications
The authors describe a new crosstalk between a globally disseminated carbapenem resistance plasmid and clinical enterobacteria clones. This crosstalk provides a fitness advantage to the plasmid-carryi...
www.nature.com
December 30, 2024 at 6:33 PM
www.nature.com/articles/s41...
New paper out!!
New paper out!!
🔥Just approved 🔥
The FDA has approved Utebzi (tebipenem pivoxil) tablets as the first oral carbapenem therapy for adults with complicated urinary tract infections, including pyelonephritis #idsky #EMIMCC
www.fda.gov/drugs/news-e...
The FDA has approved Utebzi (tebipenem pivoxil) tablets as the first oral carbapenem therapy for adults with complicated urinary tract infections, including pyelonephritis #idsky #EMIMCC
www.fda.gov/drugs/news-e...
FDA approves first oral carbapenem therapy for complicated urinary tra
FDA approves first oral carbapenem therapy for complicated urinary tract infections
www.fda.gov
June 18, 2026 at 10:35 AM
🔥Just approved 🔥
The FDA has approved Utebzi (tebipenem pivoxil) tablets as the first oral carbapenem therapy for adults with complicated urinary tract infections, including pyelonephritis #idsky #EMIMCC
www.fda.gov/drugs/news-e...
The FDA has approved Utebzi (tebipenem pivoxil) tablets as the first oral carbapenem therapy for adults with complicated urinary tract infections, including pyelonephritis #idsky #EMIMCC
www.fda.gov/drugs/news-e...
Screening patients for colonisation of drug resistant organisms can help reduce carbapenem use and duration of antibiotics in febrile neutropenia
#escmidglobal2026
#escmidglobal2026
April 19, 2026 at 9:12 AM
Screening patients for colonisation of drug resistant organisms can help reduce carbapenem use and duration of antibiotics in febrile neutropenia
#escmidglobal2026
#escmidglobal2026
#JustPublished:
Rapid risk assessment - Carbapenem-resistant Enterobacterales – third update.
Increase in carbapenem-resistant Enterobacterales (CRE) poses a significant threat to patients and healthcare systems in the EU/EEA.
Press release: bit.ly/4hnx9RK
Full report: bit.ly/3Q5cy8R
#AMR
Rapid risk assessment - Carbapenem-resistant Enterobacterales – third update.
Increase in carbapenem-resistant Enterobacterales (CRE) poses a significant threat to patients and healthcare systems in the EU/EEA.
Press release: bit.ly/4hnx9RK
Full report: bit.ly/3Q5cy8R
#AMR
Increase in carbapenem-resistant Enterobacterales (CRE) poses a significant threat to patients and healthcare systems in the EU/EEA
Increasing incidence of bloodstream infections with Enterobacterales resistant to carbapenem antibiotics poses a significant threat to patients and healthcare systems in the EU/EEA.
bit.ly
February 3, 2025 at 4:56 PM
#JustPublished:
Rapid risk assessment - Carbapenem-resistant Enterobacterales – third update.
Increase in carbapenem-resistant Enterobacterales (CRE) poses a significant threat to patients and healthcare systems in the EU/EEA.
Press release: bit.ly/4hnx9RK
Full report: bit.ly/3Q5cy8R
#AMR
Rapid risk assessment - Carbapenem-resistant Enterobacterales – third update.
Increase in carbapenem-resistant Enterobacterales (CRE) poses a significant threat to patients and healthcare systems in the EU/EEA.
Press release: bit.ly/4hnx9RK
Full report: bit.ly/3Q5cy8R
#AMR
Neuer Wirkstoff gegen das Carbapenem-resistente Bakterium Acinetobacter baumannii (CRAB)?
Arzneistoff-Entwicklung: Neue Antibiotika-Klasse zielt auf den Lipopolysaccharid-Transporter
Dringend werden neue Antibiotika benötigt. Dies gilt besonders für das Carbapenem-resistente Bakterium Acinetobacter baumannii. Eine neue Wirksto...
www.pharmazeutische-zeitung.de
January 5, 2024 at 3:05 PM
Neuer Wirkstoff gegen das Carbapenem-resistente Bakterium Acinetobacter baumannii (CRAB)?
Meropenem–Colistin Combination Mitigates Porin-Associated Carbapenem Resistance Development in Ertapenem-Mono-Resistant Enterobacterales
🔁 Repost
🔗 https://t.co/1eQbLlRwnp
🔁 Repost
🔗 https://t.co/1eQbLlRwnp
October 2, 2026 at 9:21 PM
Meropenem–Colistin Combination Mitigates Porin-Associated Carbapenem Resistance Development in Ertapenem-Mono-Resistant Enterobacterales
🔁 Repost
🔗 https://t.co/1eQbLlRwnp
🔁 Repost
🔗 https://t.co/1eQbLlRwnp
ECDC warns of rise in carbapenem-resistant Enterobacterales infections
Twenty-three EU/EEA member states have seen a rise in carbapenem-resistant Klebsiella pneumoniae bloodstream infections since 2019.
www.cidrap.umn.edu/a...
Twenty-three EU/EEA member states have seen a rise in carbapenem-resistant Klebsiella pneumoniae bloodstream infections since 2019.
www.cidrap.umn.edu/a...
February 3, 2025 at 9:48 PM
ECDC warns of rise in carbapenem-resistant Enterobacterales infections
Twenty-three EU/EEA member states have seen a rise in carbapenem-resistant Klebsiella pneumoniae bloodstream infections since 2019.
www.cidrap.umn.edu/a...
Twenty-three EU/EEA member states have seen a rise in carbapenem-resistant Klebsiella pneumoniae bloodstream infections since 2019.
www.cidrap.umn.edu/a...
A recent study from the CDC found a nearly 70% increase in the spread of carbapenem-resistant Enterobacterales (CRE).
Drug-resistant 'nightmare' bacterial infections are on the rise, CDC warns. What to know.
A recent study from the CDC found a nearly 70% increase in the spread of carbapenem-resistant Enterobacterales (CRE).
bit.ly
October 11, 2025 at 12:30 PM
A recent study from the CDC found a nearly 70% increase in the spread of carbapenem-resistant Enterobacterales (CRE).
‘Nightmare Bacteria’ Infections Spiking, Leaving Key Carbapenem Antibiotics Useless, CDC Warns.
The infection rate of one type of carbapenem-resistant Enterobacterales bacteria has risen by more than 460 percent in recent years.
www.scientificamerican.com/article/nigh...
The infection rate of one type of carbapenem-resistant Enterobacterales bacteria has risen by more than 460 percent in recent years.
www.scientificamerican.com/article/nigh...
CDC Sounds Alarm over ‘Nightmare Bacteria’ That Resist Last-Resort Antibiotics
The infection rate of one type of carbapenem-resistant Enterobacterales bacteria has risen by more than 460 percent in recent years. Scientists say people receiving treatment in hospitals are at highe...
www.scientificamerican.com
September 26, 2025 at 9:23 AM
‘Nightmare Bacteria’ Infections Spiking, Leaving Key Carbapenem Antibiotics Useless, CDC Warns.
The infection rate of one type of carbapenem-resistant Enterobacterales bacteria has risen by more than 460 percent in recent years.
www.scientificamerican.com/article/nigh...
The infection rate of one type of carbapenem-resistant Enterobacterales bacteria has risen by more than 460 percent in recent years.
www.scientificamerican.com/article/nigh...
Laboratory detection of carbapenemases among Gram-negative organisms
Patricia Simner, Johan Pitout, and Tanis Dingle 🤩
#ClinMicroReviews
journals.asm.org/doi/10.1128/... (Paywall) #IDSky #MicroSky
Patricia Simner, Johan Pitout, and Tanis Dingle 🤩
#ClinMicroReviews
journals.asm.org/doi/10.1128/... (Paywall) #IDSky #MicroSky
November 15, 2024 at 4:41 PM
Laboratory detection of carbapenemases among Gram-negative organisms
Patricia Simner, Johan Pitout, and Tanis Dingle 🤩
#ClinMicroReviews
journals.asm.org/doi/10.1128/... (Paywall) #IDSky #MicroSky
Patricia Simner, Johan Pitout, and Tanis Dingle 🤩
#ClinMicroReviews
journals.asm.org/doi/10.1128/... (Paywall) #IDSky #MicroSky
Nacubactam - a novel antibiotic which in combination with aztreonam looks a promising new therapy for difficult to treat carbapenem resistant organisms
#escmidglobal2026
#escmidglobal2026
April 18, 2026 at 9:09 AM
Nacubactam - a novel antibiotic which in combination with aztreonam looks a promising new therapy for difficult to treat carbapenem resistant organisms
#escmidglobal2026
#escmidglobal2026
Long-reads exposed plasmid-driven carbapenem resistance transmission missed by routine diagnostics
📌Resolving plasmid-encoded carbapenem resistance dynamics and reservoirs in a hospital setting through nanopore sequencing
www.doi.org/10.1099/mgen.0.001644
🖥️🧬💻
#AcademicSky
#MicroSky
#IDSky
🧪🧫🦠
📌Resolving plasmid-encoded carbapenem resistance dynamics and reservoirs in a hospital setting through nanopore sequencing
www.doi.org/10.1099/mgen.0.001644
🖥️🧬💻
#AcademicSky
#MicroSky
#IDSky
🧪🧫🦠
Resolving plasmid-encoded carbapenem resistance dynamics and reservoirs in a hospital setting through nanopore sequencing
The growing resistance of Enterobacterales to last-resort antibiotics such as carbapenems puts a significant burden on healthcare systems, also due to plasmids driving a rapid spread of carbapenem res...
www.doi.org
February 13, 2026 at 7:21 PM
Long-reads exposed plasmid-driven carbapenem resistance transmission missed by routine diagnostics
📌Resolving plasmid-encoded carbapenem resistance dynamics and reservoirs in a hospital setting through nanopore sequencing
www.doi.org/10.1099/mgen.0.001644
🖥️🧬💻
#AcademicSky
#MicroSky
#IDSky
🧪🧫🦠
📌Resolving plasmid-encoded carbapenem resistance dynamics and reservoirs in a hospital setting through nanopore sequencing
www.doi.org/10.1099/mgen.0.001644
🖥️🧬💻
#AcademicSky
#MicroSky
#IDSky
🧪🧫🦠
Exposure to Ertapenem is associated with carbapenem resistant Pseudomonas aeruginosa and now non carbapenemase CRE #idsky #microsky #medsky #OPAT
🆕✨Super interesting
How high-risk ESBL-Ecoli initially adapt to carbapenem exposures prior to acquiring carbapenem resistance?
ST131 mutants ▶️Erta exposure 🔼ESBL gene copies via IS26 mediated PCTns or mutations in outer membrane porin(Omp) genes
#idsky #microsky
academic.oup.com/jid/advance-...
How high-risk ESBL-Ecoli initially adapt to carbapenem exposures prior to acquiring carbapenem resistance?
ST131 mutants ▶️Erta exposure 🔼ESBL gene copies via IS26 mediated PCTns or mutations in outer membrane porin(Omp) genes
#idsky #microsky
academic.oup.com/jid/advance-...
Comprehensive Assessment of Initial Adaptation of ESBL Positive ST131 Escherichia coli to Carbapenem Exposure
High-risk ST131 E. coli strains, particularly C2/H30Rx subclades, adapt to initial carbapenem exposure by IS-mediated ESBL gene amplification. This gene am
academic.oup.com
November 29, 2024 at 11:08 AM
Initial Carbapenem Choice Versus Sustained Single-Group Therapy in the Albumin-Carbapenem Interaction
🔁 Repost
🔗 https://t.co/Zas0YSNOAs
🔁 Repost
🔗 https://t.co/Zas0YSNOAs
October 3, 2026 at 11:13 PM
Initial Carbapenem Choice Versus Sustained Single-Group Therapy in the Albumin-Carbapenem Interaction
🔁 Repost
🔗 https://t.co/Zas0YSNOAs
🔁 Repost
🔗 https://t.co/Zas0YSNOAs
The final version of our latest paper is now published in @natcomms.nature.com!
This study illustrates how #AntibioticResistance mechanisms can reshape bacterial physiology beyond resistance itself, ultimately influencing infection dynamics in clinically relevant ways🦠
www.nature.com/articles/s41...
This study illustrates how #AntibioticResistance mechanisms can reshape bacterial physiology beyond resistance itself, ultimately influencing infection dynamics in clinically relevant ways🦠
www.nature.com/articles/s41...
June 9, 2026 at 8:38 AM
The final version of our latest paper is now published in @natcomms.nature.com!
This study illustrates how #AntibioticResistance mechanisms can reshape bacterial physiology beyond resistance itself, ultimately influencing infection dynamics in clinically relevant ways🦠
www.nature.com/articles/s41...
This study illustrates how #AntibioticResistance mechanisms can reshape bacterial physiology beyond resistance itself, ultimately influencing infection dynamics in clinically relevant ways🦠
www.nature.com/articles/s41...