Dynamic duo at the cell's edge: Caveolae and the actin cytoskeleton work together to sense and respond to mechanical stress. Caveolae buffer tension, while actin provides structure and force. Ultimate biomechanics team. #CellBiology #Mechanotransduction
December 21, 2024 at 5:38 PM
Dynamic duo at the cell's edge: Caveolae and the actin cytoskeleton work together to sense and respond to mechanical stress. Caveolae buffer tension, while actin provides structure and force. Ultimate biomechanics team. #CellBiology #Mechanotransduction
New perspective on caveolae www.nature.com/articles/s41...
A lipid-centric view of endocytosis by caveolae - Nature Cell Biology
This Perspective discusses the mechanisms underlying both the formation and scission of caveolae, with a focus on highlighting the role of specific lipids in regulating and coupling these processes.
www.nature.com
April 26, 2026 at 1:29 PM
New perspective on caveolae www.nature.com/articles/s41...
💥I am excited to present our first research paper from the lab about caveolae lipid trafficking 🎉 Led by my fantastic PhD candidate @estherocket.bsky.social
Here we looked into caveolae mediated dietary lipid uptake and how this process is mechanistically facilitated 👇 1/n
Here we looked into caveolae mediated dietary lipid uptake and how this process is mechanistically facilitated 👇 1/n
Lipid-induced Caveolin1-Lipid droplet trafficking is associated with lipid droplet growth https://www.biorxiv.org/content/10.64898/2025.12.10.693432v1
December 11, 2025 at 7:08 AM
💥I am excited to present our first research paper from the lab about caveolae lipid trafficking 🎉 Led by my fantastic PhD candidate @estherocket.bsky.social
Here we looked into caveolae mediated dietary lipid uptake and how this process is mechanistically facilitated 👇 1/n
Here we looked into caveolae mediated dietary lipid uptake and how this process is mechanistically facilitated 👇 1/n
💥 Quick thread on some stunning actin filament swirls🌪️ spotted under platinum replica EM, often forming nest-like structures around caveolae🏐
#ActinAesthetics #ElectronMicroscopy
#ActinAesthetics #ElectronMicroscopy
February 12, 2025 at 2:30 PM
💥 Quick thread on some stunning actin filament swirls🌪️ spotted under platinum replica EM, often forming nest-like structures around caveolae🏐
#ActinAesthetics #ElectronMicroscopy
#ActinAesthetics #ElectronMicroscopy
Hello Blue sky, I like caveolae and lipid droplets
October 5, 2023 at 12:39 PM
Hello Blue sky, I like caveolae and lipid droplets
We have a preprint for you
EHD2 forms rings on caveolae necks, in contrast to most EHDs forming helices. We determined its structure on membranes and show that N-term acts as a spacer
By Elena, Vasya @vasiliimikirtumov.bsky.social, Jeff &Oli Daumke www.biorxiv.org/content/10.1...
EHD2 forms rings on caveolae necks, in contrast to most EHDs forming helices. We determined its structure on membranes and show that N-term acts as a spacer
By Elena, Vasya @vasiliimikirtumov.bsky.social, Jeff &Oli Daumke www.biorxiv.org/content/10.1...
June 8, 2025 at 11:22 AM
We have a preprint for you
EHD2 forms rings on caveolae necks, in contrast to most EHDs forming helices. We determined its structure on membranes and show that N-term acts as a spacer
By Elena, Vasya @vasiliimikirtumov.bsky.social, Jeff &Oli Daumke www.biorxiv.org/content/10.1...
EHD2 forms rings on caveolae necks, in contrast to most EHDs forming helices. We determined its structure on membranes and show that N-term acts as a spacer
By Elena, Vasya @vasiliimikirtumov.bsky.social, Jeff &Oli Daumke www.biorxiv.org/content/10.1...
Caveolins are conserved (metazoan) proteins essential for forming membrane-derived vesicles called caveolae.
While evolutionarily distant caveolins have similar structures, we found they do not maintain caveolae-generating capabilities (movie).
What determines this? Check out our new preprint!
While evolutionarily distant caveolins have similar structures, we found they do not maintain caveolae-generating capabilities (movie).
What determines this? Check out our new preprint!
February 9, 2026 at 12:53 PM
Caveolins are conserved (metazoan) proteins essential for forming membrane-derived vesicles called caveolae.
While evolutionarily distant caveolins have similar structures, we found they do not maintain caveolae-generating capabilities (movie).
What determines this? Check out our new preprint!
While evolutionarily distant caveolins have similar structures, we found they do not maintain caveolae-generating capabilities (movie).
What determines this? Check out our new preprint!
@robparton.bsky.social has moved over to bluer skies. Follow him for spectacular EM, + all things, caveolae, lipids & ….a touch of water bears
November 11, 2024 at 4:10 AM
@robparton.bsky.social has moved over to bluer skies. Follow him for spectacular EM, + all things, caveolae, lipids & ….a touch of water bears
Take a look at our new paper on the structure of the EHD2 that, upon oligomerization, forms rings that remodel the plasma membrane and form caveolae.
Beautiful work by Elena, Vasya @vasiliimikirtumov.bsky.social, Jeff & Oliver Dumke's team; take a look: www.nature.com/articles/s41...
Beautiful work by Elena, Vasya @vasiliimikirtumov.bsky.social, Jeff & Oliver Dumke's team; take a look: www.nature.com/articles/s41...
August 1, 2026 at 5:56 PM
Take a look at our new paper on the structure of the EHD2 that, upon oligomerization, forms rings that remodel the plasma membrane and form caveolae.
Beautiful work by Elena, Vasya @vasiliimikirtumov.bsky.social, Jeff & Oliver Dumke's team; take a look: www.nature.com/articles/s41...
Beautiful work by Elena, Vasya @vasiliimikirtumov.bsky.social, Jeff & Oliver Dumke's team; take a look: www.nature.com/articles/s41...
ICYMI: New Online! Caveolae mechanics in cellular functions and disease
Caveolae mechanics in cellular functions and disease
Nature Reviews Molecular Cell Biology, Published online: 02 June 2026; doi:10.1038/s41580-026-00964-2Caveolae are membrane invaginations that facilitate cell signalling and act as membrane reservoirs. This Review discusses recent insights into caveolae assembly and disassembly, their roles in mechanotransduction and how impaired caveolae mechanics contribute to human disease.
dlvr.it
June 5, 2026 at 5:59 PM
ICYMI: New Online! Caveolae mechanics in cellular functions and disease
Lipid packing contributes to the confinement of caveolae to the plasma membrane
Lipid packing contributes to the confinement of caveolae to the plasma membrane
Membrane insertion of Dyngo-4a results in a dynamin-independent inhibition of caveola dynamics, revealing that outer leaflet lipid packing in the plasma membrane contributes to the confinement of caveolae.
buff.ly
August 23, 2026 at 8:21 AM
Lipid packing contributes to the confinement of caveolae to the plasma membrane
sometimes surrounding both caveolae & clathrin-coated pits 🏐⚽
February 12, 2025 at 2:30 PM
sometimes surrounding both caveolae & clathrin-coated pits 🏐⚽
☕Mani, Tardif, Rossier et al. show that mechanical stress triggers caveolin-1 release from caveolae, enabling its diffusion in the plasma membrane and interaction with signaling effectors to regulate intracellular signaling.
👉https://rdcu.be/frvPe
www.nature.com/articles/s41...
👉https://rdcu.be/frvPe
www.nature.com/articles/s41...
Diffusing caveolin-1 scaffolds regulate mechanosignalling - Nature Cell Biology
Mani, Tardif, Rossier et al. show that mechanical stress triggers caveolin-1 release from caveolae, enabling its diffusion in the plasma membrane and interaction with signalling effectors to regulate ...
www.nature.com
July 1, 2026 at 1:50 PM
☕Mani, Tardif, Rossier et al. show that mechanical stress triggers caveolin-1 release from caveolae, enabling its diffusion in the plasma membrane and interaction with signaling effectors to regulate intracellular signaling.
👉https://rdcu.be/frvPe
www.nature.com/articles/s41...
👉https://rdcu.be/frvPe
www.nature.com/articles/s41...
Hello new followers 🖖 I like looking at the plasma membrane by high res microscopy. Here, you see a platinum replica EM of a fibroblast plasma membrane with clathrin dome (in the center) and caveolae (small invaginations on the side)
November 28, 2024 at 8:11 PM
Hello new followers 🖖 I like looking at the plasma membrane by high res microscopy. Here, you see a platinum replica EM of a fibroblast plasma membrane with clathrin dome (in the center) and caveolae (small invaginations on the side)
Another interesting new paper showing cellular insights in caveolae mediated fatty acid uptake by Richard Lundmarks lab and @robparton.bsky.social they show caveolae -ER contact sites that might fuel fatty acids from the plasma membrane into the ER. Very exciting!
Membrane contacts between caveolae and the endoplasmic reticulum regulate uptake and metabolic trapping of long-chain fatty acids https://www.biorxiv.org/content/10.64898/2025.12.22.695939v1
December 24, 2025 at 4:33 AM
Another interesting new paper showing cellular insights in caveolae mediated fatty acid uptake by Richard Lundmarks lab and @robparton.bsky.social they show caveolae -ER contact sites that might fuel fatty acids from the plasma membrane into the ER. Very exciting!
Had the pleasure to present my PhD project "In-situ Cryo-ET of Caveolae" this past week at the MDC Berlin Newbies Symposium 2025.
Excited to be part of such a brilliant scientific community and looking forward to the science ahead! ❄️🔬
#CryoET #Caveolae #MDCBerlin
Excited to be part of such a brilliant scientific community and looking forward to the science ahead! ❄️🔬
#CryoET #Caveolae #MDCBerlin
May 24, 2025 at 11:36 AM
Had the pleasure to present my PhD project "In-situ Cryo-ET of Caveolae" this past week at the MDC Berlin Newbies Symposium 2025.
Excited to be part of such a brilliant scientific community and looking forward to the science ahead! ❄️🔬
#CryoET #Caveolae #MDCBerlin
Excited to be part of such a brilliant scientific community and looking forward to the science ahead! ❄️🔬
#CryoET #Caveolae #MDCBerlin
Congratulations to Ya Gao for this work from her PhD thesis. She discovered and characterised nano bodies that can bind and label the Cavin1 protein essential for forming caveolae. Another fun collaboration with @robparton.bsky.social www.biorxiv.org/content/10.1...
Cavin1 binding nanobodies reveal structural flexibility and regulated interactions of the N-terminal coiled-coil domain
Caveolae are abundant plasma membrane structures that regulate signalling, membrane homeostasis, and mechanoprotection. Their formation is driven by caveolins and cavins and their coordinated interact...
www.biorxiv.org
November 29, 2024 at 1:13 AM
Congratulations to Ya Gao for this work from her PhD thesis. She discovered and characterised nano bodies that can bind and label the Cavin1 protein essential for forming caveolae. Another fun collaboration with @robparton.bsky.social www.biorxiv.org/content/10.1...
Looks like caveolae
November 28, 2024 at 6:36 PM
Looks like caveolae
Lipid packing contributes to the confinement of caveolae to the plasma membrane
elifesciences.org/articles/108...
elifesciences.org/articles/108...
Lipid packing contributes to the confinement of caveolae to the plasma membrane
Membrane insertion of Dyngo-4a results in a dynamin-independent inhibition of caveola dynamics, revealing that outer leaflet lipid packing in the plasma membrane contributes to the confinement of caveolae.
elifesciences.org
August 22, 2026 at 1:59 PM
Lipid packing contributes to the confinement of caveolae to the plasma membrane
elifesciences.org/articles/108...
elifesciences.org/articles/108...
Perspective: Harriet Lo, Robert Parton et al. provide a perspective on the role of #skeletalmuscle #caveolae, focusing on the cellular processes impaired by caveola dysfunction in muscle disease. They propose a new classification for disease-associated CAV3 variants. rupress.org/jcb/article/...
September 9, 2026 at 5:30 PM
Perspective: Harriet Lo, Robert Parton et al. provide a perspective on the role of #skeletalmuscle #caveolae, focusing on the cellular processes impaired by caveola dysfunction in muscle disease. They propose a new classification for disease-associated CAV3 variants. rupress.org/jcb/article/...
Disease stage-sensitive MFSD2A-caveolae axis insigates hippocampal blood-brain barrier disruption in Alzheimer's disease https://www.biorxiv.org/content/10.64898/2026.09.30.755839v1
October 8, 2026 at 12:18 PM
Disease stage-sensitive MFSD2A-caveolae axis insigates hippocampal blood-brain barrier disruption in Alzheimer's disease https://www.biorxiv.org/content/10.64898/2026.09.30.755839v1
Dysfunction of #caveolae in muscle disease: a cell biological perspective. From Harriet P. Lo, Robert G. Parton and colleagues (The University of Queensland)
rupress.org/jcb/article/...
#Organelles #Development #Membrane #lipid #Disease #SkeletalMuscle
rupress.org/jcb/article/...
#Organelles #Development #Membrane #lipid #Disease #SkeletalMuscle
September 16, 2026 at 2:31 PM
Dysfunction of #caveolae in muscle disease: a cell biological perspective. From Harriet P. Lo, Robert G. Parton and colleagues (The University of Queensland)
rupress.org/jcb/article/...
#Organelles #Development #Membrane #lipid #Disease #SkeletalMuscle
rupress.org/jcb/article/...
#Organelles #Development #Membrane #lipid #Disease #SkeletalMuscle
Disease stage-sensitive MFSD2A-caveolae axis insigates hippocampal blood-brain barrier disruption in Alzheimer's disease https://www.biorxiv.org/content/10.64898/2026.09.30.755839v1
October 8, 2026 at 12:18 PM
Disease stage-sensitive MFSD2A-caveolae axis insigates hippocampal blood-brain barrier disruption in Alzheimer's disease https://www.biorxiv.org/content/10.64898/2026.09.30.755839v1
Caveolae help cells withstand mechanical stress, take up nutrients, and regulate signaling. How are these tiny membrane structures stabilized?
#mdcBerlin researchers have now resolved the structure of the EHD2 protein chain that does the job.
Learn how it works:
👉 www.mdc-berlin.de/news/press/h...
#mdcBerlin researchers have now resolved the structure of the EHD2 protein chain that does the job.
Learn how it works:
👉 www.mdc-berlin.de/news/press/h...
September 18, 2026 at 7:00 AM
Caveolae help cells withstand mechanical stress, take up nutrients, and regulate signaling. How are these tiny membrane structures stabilized?
#mdcBerlin researchers have now resolved the structure of the EHD2 protein chain that does the job.
Learn how it works:
👉 www.mdc-berlin.de/news/press/h...
#mdcBerlin researchers have now resolved the structure of the EHD2 protein chain that does the job.
Learn how it works:
👉 www.mdc-berlin.de/news/press/h...
Disease stage-sensitive MFSD2A-caveolae axis insigates hippocampal blood-brain barrier disruption in Alzheimer's disease #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.09.30.755839v1
https://www.biorxiv.org/content/10.64898/2026.09.30.755839v1
October 8, 2026 at 1:02 PM
Disease stage-sensitive MFSD2A-caveolae axis insigates hippocampal blood-brain barrier disruption in Alzheimer's disease #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.09.30.755839v1
https://www.biorxiv.org/content/10.64898/2026.09.30.755839v1