I am extremely proud to see our work about Hepatitis B now published in @cellpress.bsky.social
From basic research to identifying the key step of infection & a potential first drug for curing this devastating disease. This has been an incredible journey.🧵
www.cell.com/cell/fulltex...
From basic research to identifying the key step of infection & a potential first drug for curing this devastating disease. This has been an incredible journey.🧵
www.cell.com/cell/fulltex...
A nucleosome switch primes hepatitis B virus infection
A reconstituted cccDNA platform facilitated the discovery of an early chromatinization
event that promotes transcription of the hepatitis B virus (HBV) regulatory X gene.
The use of a small-molecule c...
www.cell.com
February 21, 2025 at 5:31 PM
I am extremely proud to see our work about Hepatitis B now published in @cellpress.bsky.social
From basic research to identifying the key step of infection & a potential first drug for curing this devastating disease. This has been an incredible journey.🧵
www.cell.com/cell/fulltex...
From basic research to identifying the key step of infection & a potential first drug for curing this devastating disease. This has been an incredible journey.🧵
www.cell.com/cell/fulltex...
Guttaviren (Familie Guttaviridae) heißen so, weil sie aussehen wie ein Tropfen (von lat. gutta = Tropfen).
Diese Viren infizieren Archaeen und haben ein ringförmig geschlossenes DNA-Genom (cccDNA, covalenty closed circular DNA).
Diese Viren infizieren Archaeen und haben ein ringförmig geschlossenes DNA-Genom (cccDNA, covalenty closed circular DNA).
January 15, 2024 at 8:21 PM
Guttaviren (Familie Guttaviridae) heißen so, weil sie aussehen wie ein Tropfen (von lat. gutta = Tropfen).
Diese Viren infizieren Archaeen und haben ein ringförmig geschlossenes DNA-Genom (cccDNA, covalenty closed circular DNA).
Diese Viren infizieren Archaeen und haben ein ringförmig geschlossenes DNA-Genom (cccDNA, covalenty closed circular DNA).
A new #antiviral mechanism may help tackle #HepatitisBvirus persistence.
FAM151A suppresses HBV replication by inhibiting cccDNA transcription without reducing its abundance, revealing a host defense mechanism against HBV infection.
#GenesAndDiseases: doi.org/10.1016/j.ge...
FAM151A suppresses HBV replication by inhibiting cccDNA transcription without reducing its abundance, revealing a host defense mechanism against HBV infection.
#GenesAndDiseases: doi.org/10.1016/j.ge...
September 25, 2026 at 3:19 PM
A new #antiviral mechanism may help tackle #HepatitisBvirus persistence.
FAM151A suppresses HBV replication by inhibiting cccDNA transcription without reducing its abundance, revealing a host defense mechanism against HBV infection.
#GenesAndDiseases: doi.org/10.1016/j.ge...
FAM151A suppresses HBV replication by inhibiting cccDNA transcription without reducing its abundance, revealing a host defense mechanism against HBV infection.
#GenesAndDiseases: doi.org/10.1016/j.ge...
The U.S. FDA has granted fast track designation for Precision BioSciences’ lead in vivo #GeneEditing program designed to cure chronic #HepatitisB by eliminating cccDNA, the key source of replicating hepatitis B virus (HBV), and inactivating integrated HBV DNA in hepatocytes. 🧪🧬⑂
#GeneTherapy
#GeneTherapy
Precision wins fast track tag for hep B gene editing therapy
The FDA has fast tracked Precision’s lead in vivo gene editing program, PBGENE-HBV, designed to cure chronic hepatitis B by eliminating cccDNA.
www.cellgenetherapyreview.com
April 16, 2025 at 5:21 PM
The U.S. FDA has granted fast track designation for Precision BioSciences’ lead in vivo #GeneEditing program designed to cure chronic #HepatitisB by eliminating cccDNA, the key source of replicating hepatitis B virus (HBV), and inactivating integrated HBV DNA in hepatocytes. 🧪🧬⑂
#GeneTherapy
#GeneTherapy
This review provides an overview of #cccDNA biology, describing the various host factors and #ViralProteins regulating its transcription, while discussing novel anti-HBV approaches for eliminating cccDNA transcription.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
January 29, 2026 at 1:25 AM
This review provides an overview of #cccDNA biology, describing the various host factors and #ViralProteins regulating its transcription, while discussing novel anti-HBV approaches for eliminating cccDNA transcription.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
A nucleosome switch primes hepatitis B virus infection @CellCellPress
"The nucleosome-destabilizing drug CBL137 treatment effectively inhibits HBV infection in primary human hepatocytes"
www.cell.com/cell/abstrac...
"The nucleosome-destabilizing drug CBL137 treatment effectively inhibits HBV infection in primary human hepatocytes"
www.cell.com/cell/abstrac...
A nucleosome switch primes hepatitis B virus infection
A reconstituted cccDNA platform facilitated the discovery of an early chromatinization
event that promotes transcription of the hepatitis B virus (HBV) regulatory X gene.
The use of a small-molecule c...
www.cell.com
February 25, 2025 at 9:17 AM
A nucleosome switch primes hepatitis B virus infection @CellCellPress
"The nucleosome-destabilizing drug CBL137 treatment effectively inhibits HBV infection in primary human hepatocytes"
www.cell.com/cell/abstrac...
"The nucleosome-destabilizing drug CBL137 treatment effectively inhibits HBV infection in primary human hepatocytes"
www.cell.com/cell/abstrac...
FAM151A emerges as a novel host factor that suppresses #HBV replication by inhibiting #cccDNA transcriptional activity without reducing its abundance, offering fresh insight into #antiviral strategies against persistent HBV infection.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
April 11, 2026 at 1:45 PM
FAM151A emerges as a novel host factor that suppresses #HBV replication by inhibiting #cccDNA transcriptional activity without reducing its abundance, offering fresh insight into #antiviral strategies against persistent HBV infection.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
SARS-CoV-2 nsp13 suppresses hepatitis B virus replication by targeting cccDNA transcription journals.asm.org/doi/10.1128/...
SARS-CoV-2 nsp13 suppresses hepatitis B virus replication by targeting cccDNA transcription | Journal of Virology
To effectively combat hepatitis B virus (HBV), it is imperative to develop potent
antiviral medications targeting covalently closed circular DNA (cccDNA). Our investigation
aimed to assess the impact ...
journals.asm.org
October 7, 2024 at 3:32 PM
SARS-CoV-2 nsp13 suppresses hepatitis B virus replication by targeting cccDNA transcription journals.asm.org/doi/10.1128/...
A protein that defends the liver against the hepatitis B virus!
Ming Shi & team show human PGLYRP2 mediates HBV clearance in hepatocytes by targeting viral cccDNA and capsid assembly, and by modulating host antiviral immune responses: buff.ly/GpYNqPN
Ming Shi & team show human PGLYRP2 mediates HBV clearance in hepatocytes by targeting viral cccDNA and capsid assembly, and by modulating host antiviral immune responses: buff.ly/GpYNqPN
May 1, 2025 at 1:20 PM
A protein that defends the liver against the hepatitis B virus!
Ming Shi & team show human PGLYRP2 mediates HBV clearance in hepatocytes by targeting viral cccDNA and capsid assembly, and by modulating host antiviral immune responses: buff.ly/GpYNqPN
Ming Shi & team show human PGLYRP2 mediates HBV clearance in hepatocytes by targeting viral cccDNA and capsid assembly, and by modulating host antiviral immune responses: buff.ly/GpYNqPN
A nucleosome switch primes #hepatitis B virus infection.
Chromatinization of cccDNA promotes transcription of the critical HBV X gene.
The nucleosome-destabilizing drug CBL137 disrupts chromatin organization of the X gene & inhibits #HBV infection.
www.cell.com/cell/abstrac... #MicroSky #IDSky
Chromatinization of cccDNA promotes transcription of the critical HBV X gene.
The nucleosome-destabilizing drug CBL137 disrupts chromatin organization of the X gene & inhibits #HBV infection.
www.cell.com/cell/abstrac... #MicroSky #IDSky
February 21, 2025 at 10:04 AM
A nucleosome switch primes #hepatitis B virus infection.
Chromatinization of cccDNA promotes transcription of the critical HBV X gene.
The nucleosome-destabilizing drug CBL137 disrupts chromatin organization of the X gene & inhibits #HBV infection.
www.cell.com/cell/abstrac... #MicroSky #IDSky
Chromatinization of cccDNA promotes transcription of the critical HBV X gene.
The nucleosome-destabilizing drug CBL137 disrupts chromatin organization of the X gene & inhibits #HBV infection.
www.cell.com/cell/abstrac... #MicroSky #IDSky
The cccDNA provides the template from which HBV RNAs are synthesized — these are vital for both viral replication and viral protein production, including hepatitis B surface antigen (HBsAg). 4/15
December 9, 2024 at 7:43 PM
The cccDNA provides the template from which HBV RNAs are synthesized — these are vital for both viral replication and viral protein production, including hepatitis B surface antigen (HBsAg). 4/15
HBV uses the cell-surface sodium taurocholate cotransporting polypeptide (NTCP) to enter hepatocytes, after which its genome becomes a covalently closed circular DNA (cccDNA); a reservoir of HBV cccDNAs is then established in the cell nucleus. 3/15
December 9, 2024 at 7:43 PM
HBV uses the cell-surface sodium taurocholate cotransporting polypeptide (NTCP) to enter hepatocytes, after which its genome becomes a covalently closed circular DNA (cccDNA); a reservoir of HBV cccDNAs is then established in the cell nucleus. 3/15
Now online! A nucleosome switch primes hepatitis B virus infection
A nucleosome switch primes hepatitis B virus infection
A reconstituted cccDNA platform facilitated the discovery of an early chromatinization event that promotes transcription of the hepatitis B virus (HBV) regulatory X gene. The use of a small-molecule chromatin destabilizer inhibits viral transcription and…
dlvr.it
February 20, 2025 at 4:00 PM
Now online! A nucleosome switch primes hepatitis B virus infection
International #HBV meeting this morning in #Berlin hosted by @ice-hbv.bsky.social ...targeting the #liver reservoir by gene editing, technologies working for #DNA & #RNA.
Great to see investment in new antiviral therapeutics emerging, aiming for #hepatitis B #cure.
#NoHep #LiverSky #HepSky #MedSky 🧪
Great to see investment in new antiviral therapeutics emerging, aiming for #hepatitis B #cure.
#NoHep #LiverSky #HepSky #MedSky 🧪
September 12, 2025 at 7:47 AM
The downstream effects of interferon alfa can result in the eradication of cccDNA from hepatocytes as well as suppression of HBV replication at different steps of the viral life cycle. 13/15
December 9, 2024 at 7:43 PM
The downstream effects of interferon alfa can result in the eradication of cccDNA from hepatocytes as well as suppression of HBV replication at different steps of the viral life cycle. 13/15
Because eradication of the cccDNA reservoir cannot be achieved with current treatments (except liver transplantation), a commonly used end point is a “functional cure,” defined as off-treatment sustained undetectable HBV DNA and HBsAg. 5/15
December 9, 2024 at 7:43 PM
Because eradication of the cccDNA reservoir cannot be achieved with current treatments (except liver transplantation), a commonly used end point is a “functional cure,” defined as off-treatment sustained undetectable HBV DNA and HBsAg. 5/15
Hepatitis B virus hijacks MRE11–RAD50–NBS1 complex to form its minichromosome
journals.plos.org/plospathogen...
journals.plos.org/plospathogen...
Hepatitis B virus hijacks MRE11–RAD50–NBS1 complex to form its minichromosome
Author summary Chronic hepatitis B virus (HBV) infection poses a major challenge due to the persistence of covalently closed circular DNA (cccDNA), a key barrier to effective treatment. Our study inve...
journals.plos.org
January 6, 2025 at 4:19 PM
Hepatitis B virus hijacks MRE11–RAD50–NBS1 complex to form its minichromosome
journals.plos.org/plospathogen...
journals.plos.org/plospathogen...
CTCF regulates hepatitis B virus cccDNA chromatin topology https://www.biorxiv.org/content/10.1101/2023.09.06.556185v1
CTCF regulates hepatitis B virus cccDNA chromatin topology https://www.biorxiv.org/content/10.1101/2023.09.06.556185v1
Hepatitis B Virus (HBV) is a small DNA virus that replicates via an episomal covalently closed circu
www.biorxiv.org
September 6, 2023 at 11:20 PM
CTCF regulates hepatitis B virus cccDNA chromatin topology https://www.biorxiv.org/content/10.1101/2023.09.06.556185v1
The authors included RRIDs in their None paper! We value the author's support of reproducibility. #ReproducibleResearch #STMpublishing #STMpublishing
Host factor RBM25 promotes HBV replication through Yin Yang 1-mediated cccDNA transcription
doi.org
August 12, 2025 at 7:01 AM
The authors included RRIDs in their None paper! We value the author's support of reproducibility. #ReproducibleResearch #STMpublishing #STMpublishing
RRIDs were included in this None paper. We value the author's support of reproducibility. #ReproducibleResearch #OpenScience #STMpublishing
CRISPR-mediated proximity labeling unveils ABHD14B as a host factor to regulate HBV cccDNA transcriptional activity
doi.org
July 23, 2025 at 7:04 AM
RRIDs were included in this None paper. We value the author's support of reproducibility. #ReproducibleResearch #OpenScience #STMpublishing
Does HBV truly disappear after chronic hepatitis B treatment?
New #mLife perspective introduces “cure-related occult HBV infection,” highlighting cccDNA persistence, HBV reactivation risk, and the need for long-term monitoring after HBsAg loss.
doi.org/10.1002/mlf2...
New #mLife perspective introduces “cure-related occult HBV infection,” highlighting cccDNA persistence, HBV reactivation risk, and the need for long-term monitoring after HBsAg loss.
doi.org/10.1002/mlf2...
September 7, 2026 at 1:56 AM
Does HBV truly disappear after chronic hepatitis B treatment?
New #mLife perspective introduces “cure-related occult HBV infection,” highlighting cccDNA persistence, HBV reactivation risk, and the need for long-term monitoring after HBsAg loss.
doi.org/10.1002/mlf2...
New #mLife perspective introduces “cure-related occult HBV infection,” highlighting cccDNA persistence, HBV reactivation risk, and the need for long-term monitoring after HBsAg loss.
doi.org/10.1002/mlf2...
🚨 Breakthrough in Hepatitis B Research! 🚨
🦠 Scientists at Memorial Sloan Kettering Cancer Center, Weill Cornell Medicine, & The Rockefeller University have uncovered a new way to disrupt HBV infection—using a drug already in clinical trials for cancer!
🦠 Scientists at Memorial Sloan Kettering Cancer Center, Weill Cornell Medicine, & The Rockefeller University have uncovered a new way to disrupt HBV infection—using a drug already in clinical trials for cancer!
A nucleosome switch primes hepatitis B virus infection
A reconstituted cccDNA platform facilitated the discovery of an early chromatinization
event that promotes transcription of the hepatitis B virus (HBV) regulatory X gene.
The use of a small-molecule c...
www.cell.com
February 20, 2025 at 6:39 PM
🚨 Breakthrough in Hepatitis B Research! 🚨
🦠 Scientists at Memorial Sloan Kettering Cancer Center, Weill Cornell Medicine, & The Rockefeller University have uncovered a new way to disrupt HBV infection—using a drug already in clinical trials for cancer!
🦠 Scientists at Memorial Sloan Kettering Cancer Center, Weill Cornell Medicine, & The Rockefeller University have uncovered a new way to disrupt HBV infection—using a drug already in clinical trials for cancer!
Structural basis of the hepatitis B virus X protein in complex with DDB1 | PNAS www.pnas.org/doi/10.1073/...
Structural basis of the hepatitis B virus X protein in complex with DDB1 | PNAS
A cure for chronic hepatitis B requires eliminating or permanently silencing covalently
closed circular DNA (cccDNA). A pivotal target of this appr...
www.pnas.org
June 16, 2025 at 3:56 AM
Structural basis of the hepatitis B virus X protein in complex with DDB1 | PNAS www.pnas.org/doi/10.1073/...