Nature research paper: Astrocyte CCN1 stabilizes neural circuits in the adult brain
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Astrocyte CCN1 stabilizes neural circuits in the adult brain - Nature
Neural circuits in adult mouse visual cortex are stabilized by astrocytes, which secrete CCN1, resulting in reduced plasticity and increased maturation of multiple cell types.
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December 24, 2025 at 3:36 PM
Nature research paper: Astrocyte CCN1 stabilizes neural circuits in the adult brain
go.nature.com/3KWK2Hw
go.nature.com/3KWK2Hw
Astrocytes put the brakes on brain plasticity in mice by secreting the protein CCN1 to stabilize existing circuitry, a Nature study shows.
By Holly Barker
#neuroskyence
www.thetransmitter.org/astrocytes/a...
By Holly Barker
#neuroskyence
www.thetransmitter.org/astrocytes/a...
Astrocytes stabilize circuits in adult mouse brain
The glial cells secrete a protein that suppresses plasticity post-development.
www.thetransmitter.org
January 6, 2026 at 3:14 PM
Astrocytes put the brakes on brain plasticity in mice by secreting the protein CCN1 to stabilize existing circuitry, a Nature study shows.
By Holly Barker
#neuroskyence
www.thetransmitter.org/astrocytes/a...
By Holly Barker
#neuroskyence
www.thetransmitter.org/astrocytes/a...
CCN1 Enhances Tumor Immunosuppression through Collagen-Mediated Chemokine Secretion in Pancreatic Cancer
advanced.onlinelibrary.wiley.com/doi/10.1002/...
advanced.onlinelibrary.wiley.com/doi/10.1002/...
CCN1 Enhances Tumor Immunosuppression through Collagen‐Mediated Chemokine Secretion in Pancreatic Cancer
CCN1 modulates the tumor microenvironment in pancreatic cancer by promoting collagen-dependent chemokine production, thereby facilitating immune evasion. Deletion of CCN1 not only suppresses tumor gr....
advanced.onlinelibrary.wiley.com
May 9, 2025 at 1:09 PM
CCN1 Enhances Tumor Immunosuppression through Collagen-Mediated Chemokine Secretion in Pancreatic Cancer
advanced.onlinelibrary.wiley.com/doi/10.1002/...
advanced.onlinelibrary.wiley.com/doi/10.1002/...
I hope there's some kinda character selection like in CCN1 and 2!!! this looks incredible though!!
November 25, 2024 at 1:20 PM
I hope there's some kinda character selection like in CCN1 and 2!!! this looks incredible though!!
CCN1 forms a complex with GPC4 and heparin to fine-tune signaling activities for embryonic cortical neural stem cell maintenance https://www.biorxiv.org/content/10.1101/2025.05.16.654402v1
May 20, 2025 at 11:30 AM
CCN1 forms a complex with GPC4 and heparin to fine-tune signaling activities for embryonic cortical neural stem cell maintenance https://www.biorxiv.org/content/10.1101/2025.05.16.654402v1
CCN1 Enhances Tumor Immunosuppression through Collagen-Mediated Chemokine Secretion in #PancreaticCancer 🧪 advanced.onlinelibrary.wiley.com/doi/10.1002/...
CCN1 Enhances Tumor Immunosuppression through Collagen‐Mediated Chemokine Secretion in Pancreatic Cancer
CCN1 modulates the tumor microenvironment in pancreatic cancer by promoting collagen-dependent chemokine production, thereby facilitating immune evasion. Deletion of CCN1 not only suppresses tumor gr...
advanced.onlinelibrary.wiley.com
April 29, 2025 at 7:55 AM
CCN1 Enhances Tumor Immunosuppression through Collagen-Mediated Chemokine Secretion in #PancreaticCancer 🧪 advanced.onlinelibrary.wiley.com/doi/10.1002/...
Lesion-remote #astrocytes drive microglia-mediated white matter repair. McCallum et al. show that CCN1+ astrocytes reprogram #microglia for myelin debris clearance after CNS injury, promoting recovery.
https://www.nature.com/articles/s41586-025-09887-y
#WhiteMatter #Demyelination #Neuroimmunology
https://www.nature.com/articles/s41586-025-09887-y
#WhiteMatter #Demyelination #Neuroimmunology
Lesion-remote astrocytes govern microglia-mediated white matter repair - Nature
After spinal cord injury, lesion-remote astrocytes acquire heterogeneous, spatially restricted reactivity states that shape neuroinflammation, neural repair and neurological recovery.
www.nature.com
May 12, 2026 at 8:16 AM
Lesion-remote #astrocytes drive microglia-mediated white matter repair. McCallum et al. show that CCN1+ astrocytes reprogram #microglia for myelin debris clearance after CNS injury, promoting recovery.
https://www.nature.com/articles/s41586-025-09887-y
#WhiteMatter #Demyelination #Neuroimmunology
https://www.nature.com/articles/s41586-025-09887-y
#WhiteMatter #Demyelination #Neuroimmunology
Neural circuits in adult mouse visual cortex are stabilized by astrocytes, which secrete CCN1, resulting in reduced plasticity and increased maturation of multiple cell types.
Astrocyte CCN1 stabilizes neural circuits in the adult brain - Nature
www.nature.com
December 18, 2025 at 12:23 PM
Neural circuits in adult mouse visual cortex are stabilized by astrocytes, which secrete CCN1, resulting in reduced plasticity and increased maturation of multiple cell types.
CCN1/CYR61-mediated meticulous patrolling by Ly6Clow monocytes fuels vascular inflammation http://www.pnas.org/content/113/33/E4847
December 8, 2024 at 6:23 AM
CCN1/CYR61-mediated meticulous patrolling by Ly6Clow monocytes fuels vascular inflammation http://www.pnas.org/content/113/33/E4847
A new Nature study reveals that a lesion remote astroglial subtype can actively reprogram microglia to clear myelin debris and promote whitematter repair uncovering a CCN1 mediated astrocyte microglia axis that enhances functional recovery after spinal cord injury
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Lesion-remote astrocytes govern microglia-mediated white matter repair - Nature
After spinal cord injury, lesion-remote astrocytes acquire heterogeneous, spatially restricted reactivity states that shape neuroinflammation, neural repair and neurological recovery.
www.nature.com
December 18, 2025 at 5:43 PM
A new Nature study reveals that a lesion remote astroglial subtype can actively reprogram microglia to clear myelin debris and promote whitematter repair uncovering a CCN1 mediated astrocyte microglia axis that enhances functional recovery after spinal cord injury
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The authors included RRIDs in their in iScience paper! RRIDs improve reproducibility in scientific research. #accelerateopenscience #OpenResearch #OpenScience
CCN1/Cyr61 associates with β-amyloid levels in human cerebrospinal fluids
Read the full paper: CCN1/Cyr61 associates with β-amyloid levels in human cerebrospinal fluids
doi.org
June 7, 2026 at 7:00 AM
The authors included RRIDs in their in iScience paper! RRIDs improve reproducibility in scientific research. #accelerateopenscience #OpenResearch #OpenScience
RRID:AB_2535844 from @thermofishersci.bsky.social was used by authors in their iScience paper. RRIDs improve reproducibility in scientific research. #OpenResearch #BetterScience #ReproducibleResearch
Loss of DDI2 rewires proteostasis through CCN1-driven compensatory autophagy
Read the full paper: Loss of DDI2 rewires proteostasis through CCN1-driven compensatory autophagy
doi.org
February 20, 2026 at 8:00 AM
RRID:AB_2535844 from @thermofishersci.bsky.social was used by authors in their iScience paper. RRIDs improve reproducibility in scientific research. #OpenResearch #BetterScience #ReproducibleResearch
"These cell-communication network proteins [CCN1 & CCN2] are best known for their roles in scarring..but in the context of #APS, they appeared to serve a different purpose.": buff.ly/YbF2mbS
via @sciencex.bsky.social
#AntiphospholipidSyndrome #BloodVessels #Autoimmune #MedSky
via @sciencex.bsky.social
#AntiphospholipidSyndrome #BloodVessels #Autoimmune #MedSky
Key proteins in rare autoimmune disease identified
Antiphospholipid syndrome is an autoimmune disease that impacts about one in every 2,000 individuals.
buff.ly
October 3, 2025 at 2:30 PM
"These cell-communication network proteins [CCN1 & CCN2] are best known for their roles in scarring..but in the context of #APS, they appeared to serve a different purpose.": buff.ly/YbF2mbS
via @sciencex.bsky.social
#AntiphospholipidSyndrome #BloodVessels #Autoimmune #MedSky
via @sciencex.bsky.social
#AntiphospholipidSyndrome #BloodVessels #Autoimmune #MedSky
We found that #myelin debris induced astrocyte CCN1. Astrocyte CCN1 is an evolutionarily conserved feature of white matter damage and is found in other modules of demyelination including lysolecithin, EAE (thx Meares lab), human MS (thx Dutta lab) and human SCI. 6/n
March 17, 2024 at 5:52 PM
We found that #myelin debris induced astrocyte CCN1. Astrocyte CCN1 is an evolutionarily conserved feature of white matter damage and is found in other modules of demyelination including lysolecithin, EAE (thx Meares lab), human MS (thx Dutta lab) and human SCI. 6/n
Astrocyte CCN1 stabilizes neural circuits in the adult brain https://www.biorxiv.org/content/10.1101/2024.03.14.585077v1
Astrocyte CCN1 stabilizes neural circuits in the adult brain https://www.biorxiv.org/content/10.1101/2024.03.14.585077v1
Neural circuits in many brain regions are refined by experience. Sensory circuits support higher pla
www.biorxiv.org
March 15, 2024 at 1:18 AM
Astrocyte CCN1 stabilizes neural circuits in the adult brain https://www.biorxiv.org/content/10.1101/2024.03.14.585077v1
[🍬 Fresh Jelly Drop] Tubule-derived CCN1 drives renal repair via αvβ5-STAT6-ARG1-dependent reprogramming of macrophages - Cell Death & Disease
Affiliate marketing pack for <Tubule-derived CCN1 drives renal repair via αvβ5-STAT6-ARG1-dependent reprogramming of macrophages - Cell Death & Disease> - nature.com
CanCan Jelly: 126 affiliate products from amazon asos shopee_id etc. matched!
cancancan.cc
December 21, 2025 at 11:24 PM
[🍬 Fresh Jelly Drop] Tubule-derived CCN1 drives renal repair via αvβ5-STAT6-ARG1-dependent reprogramming of macrophages - Cell Death & Disease
CCN1 is an astrocyte-secreted factor that stabilizes neuronal circuits by coordinating the maturation state of multiple cell types @nature.com @salkinstitute.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
December 17, 2025 at 5:46 PM
CCN1 is an astrocyte-secreted factor that stabilizes neuronal circuits by coordinating the maturation state of multiple cell types @nature.com @salkinstitute.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Helping Spinal Cords Heal. The neural support cell, the astrocyte, plays a crucial role in spinal cord healing following injury. #spinalcord #injury #astrocyte #ccn1
February 26, 2026 at 7:10 PM
Helping Spinal Cords Heal. The neural support cell, the astrocyte, plays a crucial role in spinal cord healing following injury. #spinalcord #injury #astrocyte #ccn1
The authors included RRIDs in their Developmental Cell paper! Thanks for making your methods matter! #STMpublishing #reproducibility #accelerateopenscience
Mitochondrial CCN1 drives ferroptosis via fatty acid β-oxidation
doi.org
May 20, 2025 at 7:01 AM
The authors included RRIDs in their Developmental Cell paper! Thanks for making your methods matter! #STMpublishing #reproducibility #accelerateopenscience
Scientists at the Salk Institute have now discovered a molecule that is critical for stabilizing brain circuits in adulthood: a protein called CCN1 secreted by star-shaped cells called astrocytes.
www.salk.edu/news-release...
www.salk.edu/news-release...
December 19, 2025 at 9:38 PM
Scientists at the Salk Institute have now discovered a molecule that is critical for stabilizing brain circuits in adulthood: a protein called CCN1 secreted by star-shaped cells called astrocytes.
www.salk.edu/news-release...
www.salk.edu/news-release...
A paper using RRID:AB_330744 (from Cell Signaling Technology) was just published in iScience see "Injured tubular epithelia-derived CCN1 promotes the mobilization of fibroblasts toward injury sites after kidney injury". We appreciate the author's support of reproducibility. #reproducibility
doi.org
April 9, 2025 at 7:00 AM
A paper using RRID:AB_330744 (from Cell Signaling Technology) was just published in iScience see "Injured tubular epithelia-derived CCN1 promotes the mobilization of fibroblasts toward injury sites after kidney injury". We appreciate the author's support of reproducibility. #reproducibility
【注目プレスリリース】CCN1/Cyr61はヒト脳脊髄液においてβアミロイド量と相関する ～アルツハイマー病の病態に関連しうる臨床的マーカーとしての発見～ / 国立長寿医療研究センター
https://research-er.jp/articles/view/157051
https://research-er.jp/articles/view/157051
CCN1/Cyr61はヒト脳脊髄液においてβアミロイド量と相関する ～アルツハイマー病の病態に関連しうる臨床的マーカーとしての発見～
2026.06.12 国立長寿医療研究センター プレスリリース 国立研究開発法人国立長寿医療研究センター（理事長：荒井 秀典。以下 国立長寿医療研究センター）分子...
research-er.jp
June 12, 2026 at 3:23 AM
【注目プレスリリース】CCN1/Cyr61はヒト脳脊髄液においてβアミロイド量と相関する ～アルツハイマー病の病態に関連しうる臨床的マーカーとしての発見～ / 国立長寿医療研究センター
https://research-er.jp/articles/view/157051
https://research-er.jp/articles/view/157051
A new machine learning model based on plasma proteomics for the identification of #Parkinsons involves 11 proteins (APOH, ARG1, CCN1, CXCL1, CXCL8, DDC, GRAP2, IL1RAP, OSM, PRL, & SPRY2), tested on 3 external cohorts
academic.oup.com/brain/advanc...
academic.oup.com/brain/advanc...
Machine learning model based on plasma proteomics for the identification of Parkinson’s disease
Leveraging advances in high-throughput plasma proteomics and machine learning, Adewale et al. identify an 11-protein biomarker panel that accurately distin
academic.oup.com
April 22, 2026 at 9:10 PM
A new machine learning model based on plasma proteomics for the identification of #Parkinsons involves 11 proteins (APOH, ARG1, CCN1, CXCL1, CXCL8, DDC, GRAP2, IL1RAP, OSM, PRL, & SPRY2), tested on 3 external cohorts
academic.oup.com/brain/advanc...
academic.oup.com/brain/advanc...
A protein called CCN1, secreted by astrocytes, has been identified as a key regulator of neural circuit stability in the adult brain, offering new therapeutic possibilities for neurological conditions.
How do brains stay stable, and when might a dose of flexibility be helpful?
Young minds are easily molded. Each new experience rewires a child's brain circuitry, adding and removing synaptic connections between neurons.
medicalxpress.com
December 17, 2025 at 4:00 PM
A protein called CCN1, secreted by astrocytes, has been identified as a key regulator of neural circuit stability in the adult brain, offering new therapeutic possibilities for neurological conditions.
The CCN1 pathway could now be a prime target for new therapeutics designed to support learning and plasticity in conditions like Alzheimer’s disease, depression, or PTSD, or to promote neural repair after injury or stroke.
Read more: www.salk.edu/news-release...
Read more: www.salk.edu/news-release...
How do brains stay stable, and when might a dose of flexibility be helpful? - Salk Institute for Biological Studies
LA JOLLA—Young minds are easily molded. Each new experience rewires a child’s brain circuitry, adding and removing synaptic connections between neurons. These wiring patterns become more stable with a...
www.salk.edu
December 19, 2025 at 9:39 PM
The CCN1 pathway could now be a prime target for new therapeutics designed to support learning and plasticity in conditions like Alzheimer’s disease, depression, or PTSD, or to promote neural repair after injury or stroke.
Read more: www.salk.edu/news-release...
Read more: www.salk.edu/news-release...