Diverse S-layer anchoring mechanisms create an epiplasmic space in prokaryotic cell envelopes www.sciencedirect.com/science/arti... #jcampubs
September 30, 2026 at 3:57 PM
Diverse S-layer anchoring mechanisms create an epiplasmic space in prokaryotic cell envelopes www.sciencedirect.com/science/arti... #jcampubs
Diverse S-layer anchoring mechanisms create an epiplasmic space in prokaryotic cell envelopes.
Our review with @bupbuse.bsky.social and @vikramalva.bsky.social discussing a cellular compartment created by the S-layer out in Current Opinion in Microbiology.
www.sciencedirect.com/science/arti...
Our review with @bupbuse.bsky.social and @vikramalva.bsky.social discussing a cellular compartment created by the S-layer out in Current Opinion in Microbiology.
www.sciencedirect.com/science/arti...
September 30, 2026 at 8:48 AM
Diverse S-layer anchoring mechanisms create an epiplasmic space in prokaryotic cell envelopes.
Our review with @bupbuse.bsky.social and @vikramalva.bsky.social discussing a cellular compartment created by the S-layer out in Current Opinion in Microbiology.
www.sciencedirect.com/science/arti...
Our review with @bupbuse.bsky.social and @vikramalva.bsky.social discussing a cellular compartment created by the S-layer out in Current Opinion in Microbiology.
www.sciencedirect.com/science/arti...
Archaeal PG structure was characterized in the late 70s by pioneering work of Kandler and König on cell envelopes, which supported Woese’s proposal of Archaea as a third domain of life. It showed clear differences with bacterial PG, making it resistant to well-known enzymes (remember lysozyme?) 3/9
September 23, 2026 at 3:19 PM
Archaeal PG structure was characterized in the late 70s by pioneering work of Kandler and König on cell envelopes, which supported Woese’s proposal of Archaea as a third domain of life. It showed clear differences with bacterial PG, making it resistant to well-known enzymes (remember lysozyme?) 3/9
Interested in #archaea, #methane, #cell-envelopes?
New paper out @nature.com !
We discovered an enzyme that specifically cleaves the cell wall of methanogens, revealing a new chemical structure of archaeal peptidoglycan, 50 yrs after its first description
www.nature.com/articles/s41...
#MicroSky 🧵👇
New paper out @nature.com !
We discovered an enzyme that specifically cleaves the cell wall of methanogens, revealing a new chemical structure of archaeal peptidoglycan, 50 yrs after its first description
www.nature.com/articles/s41...
#MicroSky 🧵👇
www.nature.com
September 23, 2026 at 3:19 PM
Interested in #archaea, #methane, #cell-envelopes?
New paper out @nature.com !
We discovered an enzyme that specifically cleaves the cell wall of methanogens, revealing a new chemical structure of archaeal peptidoglycan, 50 yrs after its first description
www.nature.com/articles/s41...
#MicroSky 🧵👇
New paper out @nature.com !
We discovered an enzyme that specifically cleaves the cell wall of methanogens, revealing a new chemical structure of archaeal peptidoglycan, 50 yrs after its first description
www.nature.com/articles/s41...
#MicroSky 🧵👇
The multifaceted role of atomic force microscopy in bacteriology
@cp-trendsmicrobiol.bsky.social by @carolinaborrelli.bsky.social, @ejadouglas.bsky.social, @bugsinblood.bsky.social and Bart Hoogenboom @imperialcollegeldn.bsky.social
www.cell.com/trends/micro...
@cp-trendsmicrobiol.bsky.social by @carolinaborrelli.bsky.social, @ejadouglas.bsky.social, @bugsinblood.bsky.social and Bart Hoogenboom @imperialcollegeldn.bsky.social
www.cell.com/trends/micro...
The multifaceted role of atomic force microscopy in bacteriology
Atomic force microscopy (AFM) has become a powerful tool to provide nanoscale insights
into the spatial organization, biomechanics, and intermolecular interactions of the
cell envelopes of living bact...
www.cell.com
September 2, 2026 at 7:59 PM
The multifaceted role of atomic force microscopy in bacteriology
@cp-trendsmicrobiol.bsky.social by @carolinaborrelli.bsky.social, @ejadouglas.bsky.social, @bugsinblood.bsky.social and Bart Hoogenboom @imperialcollegeldn.bsky.social
www.cell.com/trends/micro...
@cp-trendsmicrobiol.bsky.social by @carolinaborrelli.bsky.social, @ejadouglas.bsky.social, @bugsinblood.bsky.social and Bart Hoogenboom @imperialcollegeldn.bsky.social
www.cell.com/trends/micro...
There are thousands of places alongside the motorway network that this could have been sited. But the brown envelopes said otherwise.
Councillors ruining people's lives should face consequences, preferably involving a 3x2m cell.
Councillors ruining people's lives should face consequences, preferably involving a 3x2m cell.
September 2, 2026 at 11:06 AM
There are thousands of places alongside the motorway network that this could have been sited. But the brown envelopes said otherwise.
Councillors ruining people's lives should face consequences, preferably involving a 3x2m cell.
Councillors ruining people's lives should face consequences, preferably involving a 3x2m cell.
The multifaceted role of atomic force microscopy in bacteriology
The multifaceted role of atomic force microscopy in bacteriology
Atomic force microscopy (AFM) has become a powerful tool to provide nanoscale insights into the spatial organization, biomechanics, and intermolecular interactions of the cell envelopes of living bacteria in real time and under near-native conditions. Focusing on recent literature, we discuss how AFM has advanced our understanding of Gram-positive, Gram-negative, and mycobacterial cell envelope architectures, as well as the mechanisms of action of established and novel antimicrobials. We also summarize how AFM can be used to probe the adhesion, virulence, and immune evasion of pathogens through single-molecule and single-cell force spectroscopy.
dlvr.it
August 31, 2026 at 7:23 PM
The multifaceted role of atomic force microscopy in bacteriology
2. When you wash, USE SOAP.
Water alone does basically nothing. In fact, bacteria and viruses tend to like that stuff.
Soap dismantles the cohesion of bacteria's cell membranes and viruses' lipid envelopes.
Hand sanitizer is less effective, doesn't remove grime, and should be a last resort.
Water alone does basically nothing. In fact, bacteria and viruses tend to like that stuff.
Soap dismantles the cohesion of bacteria's cell membranes and viruses' lipid envelopes.
Hand sanitizer is less effective, doesn't remove grime, and should be a last resort.
August 30, 2026 at 9:12 AM
2. When you wash, USE SOAP.
Water alone does basically nothing. In fact, bacteria and viruses tend to like that stuff.
Soap dismantles the cohesion of bacteria's cell membranes and viruses' lipid envelopes.
Hand sanitizer is less effective, doesn't remove grime, and should be a last resort.
Water alone does basically nothing. In fact, bacteria and viruses tend to like that stuff.
Soap dismantles the cohesion of bacteria's cell membranes and viruses' lipid envelopes.
Hand sanitizer is less effective, doesn't remove grime, and should be a last resort.
Read the Review “Anti-type VI tactics: bacterial defenses against type VI secretion system attacks” from Eric Cascales et al. to explore how bacteria defend against lethal attacks, from tit-for-tat counterattacks to reinforced cell envelopes and protective aggregation: lnkd.in/emU-SBaZ
LinkedIn
This link will take you to a page that’s not on LinkedIn
lnkd.in
August 20, 2026 at 12:59 PM
Read the Review “Anti-type VI tactics: bacterial defenses against type VI secretion system attacks” from Eric Cascales et al. to explore how bacteria defend against lethal attacks, from tit-for-tat counterattacks to reinforced cell envelopes and protective aggregation: lnkd.in/emU-SBaZ
August 7, 2026 at 10:05 AM
captchas get more baffling by the day but I can't decide whether it's because they actually make less sense or because the pictures are so bad that my elderly eyes just can't tell what I'm looking at anymore.
July 24, 2026 at 5:43 PM
captchas get more baffling by the day but I can't decide whether it's because they actually make less sense or because the pictures are so bad that my elderly eyes just can't tell what I'm looking at anymore.
I used to create Fauvist masterworks w colored pencils in my transgendered isolation cell in the piss poor prison town Cañon City jail like Van Gogh in his 🛌room at Arles, & though we bought envelopes w pre-paid postage the violent white state terrorists never mailed 'em to my therapist 2 mi. away.
Woman with a Hat (1905) scandalized the Salon d'Automne. Matisse painted his wife Amélie in vivid colors, her face streaked green and pink. Critic Louis Vauxcelles dubbed the painters fauves, or wild beasts, unintentionally giving the Fauvist movement its name.
July 19, 2026 at 12:01 PM
I used to create Fauvist masterworks w colored pencils in my transgendered isolation cell in the piss poor prison town Cañon City jail like Van Gogh in his 🛌room at Arles, & though we bought envelopes w pre-paid postage the violent white state terrorists never mailed 'em to my therapist 2 mi. away.
Safe Redosable Low-Immunogenic In Vivo CAR-T Therapy for B Cell Malignancies and Solid Tumors [new]
via engineered viral envelopes for T-cell targeting, restricted exp, low immunogenicity, enabling repeat dosing for diverse cancers.
via engineered viral envelopes for T-cell targeting, restricted exp, low immunogenicity, enabling repeat dosing for diverse cancers.
July 1, 2026 at 3:06 PM
Safe Redosable Low-Immunogenic In Vivo CAR-T Therapy for B Cell Malignancies and Solid Tumors [new]
via engineered viral envelopes for T-cell targeting, restricted exp, low immunogenicity, enabling repeat dosing for diverse cancers.
via engineered viral envelopes for T-cell targeting, restricted exp, low immunogenicity, enabling repeat dosing for diverse cancers.
🦠Mycobacteria include major human and animal pathogens, environmental species, and key models for studying bacterial cell envelopes, drug resistance, host adaptation, and phage defense.
Six #mLife papers highlights recent advances in Mycobacteria research. ⬇️
Six #mLife papers highlights recent advances in Mycobacteria research. ⬇️
June 1, 2026 at 2:36 AM
🦠Mycobacteria include major human and animal pathogens, environmental species, and key models for studying bacterial cell envelopes, drug resistance, host adaptation, and phage defense.
Six #mLife papers highlights recent advances in Mycobacteria research. ⬇️
Six #mLife papers highlights recent advances in Mycobacteria research. ⬇️
Enterovirus-induced cleavage of Mitofusin 2 generates mitophagosomes for enveloped virion release www.science.org/doi/10.1126/...
Enterovirus-induced cleavage of Mitofusin 2 generates mitophagosomes for enveloped virion release
EV-D68, a cause of paralysis disease, usurps mitochondrial degradation vesicles as envelopes for new virions to exit the cell.
www.science.org
April 24, 2026 at 1:22 AM
Enterovirus-induced cleavage of Mitofusin 2 generates mitophagosomes for enveloped virion release www.science.org/doi/10.1126/...
Happy to share the finalized version of my paper on phage lysis in bacteria with unique envelopes! 🎉
Bacteriophages target membrane-anchored glycopolymers to promote host cell lysis and progeny release
www.pnas.org/doi/10.1073/...
Bacteriophages target membrane-anchored glycopolymers to promote host cell lysis and progeny release
www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
April 23, 2026 at 5:34 PM
Happy to share the finalized version of my paper on phage lysis in bacteria with unique envelopes! 🎉
Bacteriophages target membrane-anchored glycopolymers to promote host cell lysis and progeny release
www.pnas.org/doi/10.1073/...
Bacteriophages target membrane-anchored glycopolymers to promote host cell lysis and progeny release
www.pnas.org/doi/10.1073/...
www.sciencedirect.com/science/arti... 🧪 great review and recommend next steps
Computational microbiology: Where is artificial intelligence addressing the barriers to large-scale simulations of bacterial cell envelopes?
Molecular dynamics simulations allow the investigation of the time-resolved mechanics of large, complex biological systems such as the Gram-negative b…
www.sciencedirect.com
April 2, 2026 at 11:06 AM
www.sciencedirect.com/science/arti... 🧪 great review and recommend next steps
Hopanoids and steroids form part of cellular membranes, confering order and stability in addition to multiple other roles. However, our mechanistic understanding of the cellular roles of hopanoids is still in its infancy and limited to a select few of the many types of hopanoids.
March 29, 2026 at 4:21 PM
Hopanoids and steroids form part of cellular membranes, confering order and stability in addition to multiple other roles. However, our mechanistic understanding of the cellular roles of hopanoids is still in its infancy and limited to a select few of the many types of hopanoids.
(BioRxiv All) Hyperosmolar stress promotes the release of small extracellular vesicles containing metabolic proteins from corneal epithelial cells: Purpose: Hyperosmolar stress (HOS) is a major contributor to corneal epithelial cell damage in dry eye disease. We have… #BioRxiv #MassSpecRSS
Hyperosmolar stress promotes the release of small extracellular vesicles containing metabolic proteins from corneal epithelial cells
Purpose: Hyperosmolar stress (HOS) is a major contributor to corneal epithelial cell damage in dry eye disease. We have previously shown that HOS damages mitochondria and impairs cell metabolism in corneal epithelial cells. Small extracellular vesicles (sEVs) are cell-derived lipid envelopes that are present in all body fluids, including tears. Prior studies suggest that sEV release and composition may be linked with changes in cell metabolism. In this study, we tested the effects of HOS on sEV release and composition, and found that sEV cargo may reflect early, underlying changes in dry eye disease. Methods: Telomerase-immortalized human corneal epithelial (hTCEpi) cells were treated with 450 mOsm NaCl for five days to induce chronic HOS. sEVs were isolated using differential centrifugation followed by iodixanol density gradient flotation. Particle number was determined using Nanoparticle Tracking Analysis (NTA). Mass spectrometry was used to assess the sEV proteome, and selected proteins were validated by immunoblot. Proteome pathways were analyzed using KEGG and CORUM. Results: Pathway analysis revealed an increase in metabolic proteins and proteasome components in sEV cargo released from hTCEpi cells exposed to HOS. These proteins were increased more than fourfold in HOS-sEVs. Examination of proteins involved in the endosomal pathway and NTA further confirmed an increase in HOS-sEV release. Conclusion: Our findings suggest a potential mechanism whereby corneal epithelial cells exposed to HOS retain proteins involved in maintaining tissue integrity, while simultaneously releasing unneeded proteins involved in cell metabolism. The presence of metabolic proteins in sEVs may serve as early indicators of dry eye disease.
dlvr.it
March 28, 2026 at 6:15 PM
(BioRxiv All) Hyperosmolar stress promotes the release of small extracellular vesicles containing metabolic proteins from corneal epithelial cells: Purpose: Hyperosmolar stress (HOS) is a major contributor to corneal epithelial cell damage in dry eye disease. We have… #BioRxiv #MassSpecRSS
Congrats to @MontclareLabs Jonathan Sun, Nada Haq-Siddiqi, Zara Hedaya, & @ccny colleagues Chengyu Sun, Seungri Kim, Xi Chen on a new publication on remodeling E. Coli peptidoglycan for water responsive actuation in @ActaBio! Check it out at www.sciencedirect.com/science/arti...
#NSFfunded
#NSFfunded
Modulation of Peptidoglycan Crosslink Network in Escherichia coli Enhances Water-Responsive Actuation
Peptidoglycan (PG), the primary load-bearing component of bacterial cell envelopes, is a bio-derived material whose mechanical and hydration propertie…
www.sciencedirect.com
February 18, 2026 at 5:23 PM
Congrats to @MontclareLabs Jonathan Sun, Nada Haq-Siddiqi, Zara Hedaya, & @ccny colleagues Chengyu Sun, Seungri Kim, Xi Chen on a new publication on remodeling E. Coli peptidoglycan for water responsive actuation in @ActaBio! Check it out at www.sciencedirect.com/science/arti...
#NSFfunded
#NSFfunded