1️⃣ We are super happy to announce our latest paper in Nature Communications! 🚀
We show how targeting ELOVL6 disrupts c-MYC-driven lipid metabolism in PDAC, enhancing chemosensitivity.
📄 Read more: doi.org/10.1038/s414...
#PDAC #CancerResearch #ELOVL6 🧪
We show how targeting ELOVL6 disrupts c-MYC-driven lipid metabolism in PDAC, enhancing chemosensitivity.
📄 Read more: doi.org/10.1038/s414...
#PDAC #CancerResearch #ELOVL6 🧪
Targeting ELOVL6 to disrupt c-MYC driven lipid metabolism in pancreatic cancer enhances chemosensitivity - Nature Communications
Overexpression of c-MYC regulates tumor metabolism in pancreatic ductal adenocarcinoma (PDAC). Here the authors identify ELOVL6, a fatty acid elongase regulated by c-MYC, as a potential therapeutic ta...
doi.org
February 16, 2025 at 3:55 PM
1️⃣ We are super happy to announce our latest paper in Nature Communications! 🚀
We show how targeting ELOVL6 disrupts c-MYC-driven lipid metabolism in PDAC, enhancing chemosensitivity.
📄 Read more: doi.org/10.1038/s414...
#PDAC #CancerResearch #ELOVL6 🧪
We show how targeting ELOVL6 disrupts c-MYC-driven lipid metabolism in PDAC, enhancing chemosensitivity.
📄 Read more: doi.org/10.1038/s414...
#PDAC #CancerResearch #ELOVL6 🧪
There are some differences; mostly in vertical stretch, quality, brightness and contrast, the image on PubPeer is quite large and the similarities should be clear: pubpeer.com/publications...
PubPeer - Targeting claudin-4 enhances CDDP-chemosensitivity in gastri...
There are comments on PubPeer for publication: Targeting claudin-4 enhances CDDP-chemosensitivity in gastric cancer (2019)
pubpeer.com
March 16, 2026 at 10:16 PM
There are some differences; mostly in vertical stretch, quality, brightness and contrast, the image on PubPeer is quite large and the similarities should be clear: pubpeer.com/publications...
New preprint from the lab for any DNA repair or replication stress geeks out there!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A nuclease-driven mechanism of post-replicative ssDNA gap suppression.
The persistence of post-replicative ssDNA gaps following PRIMPOL-mediated replication repriming is linked to chemosensitivity, and in all models reported to date the nuclease MRE11 has been implicated...
www.biorxiv.org
October 22, 2025 at 6:56 PM
New preprint from the lab for any DNA repair or replication stress geeks out there!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
One-carbon metabolism controls colorectal cancer cell state and chemosensitivity through chromatin remodeling https://www.biorxiv.org/content/10.64898/2026.09.30.755690v1
October 2, 2026 at 8:25 AM
One-carbon metabolism controls colorectal cancer cell state and chemosensitivity through chromatin remodeling https://www.biorxiv.org/content/10.64898/2026.09.30.755690v1
One-carbon metabolism controls colorectal cancer cell state and chemosensitivity through chromatin remodeling https://www.biorxiv.org/content/10.64898/2026.09.30.755690v1
October 2, 2026 at 8:25 AM
One-carbon metabolism controls colorectal cancer cell state and chemosensitivity through chromatin remodeling https://www.biorxiv.org/content/10.64898/2026.09.30.755690v1
2) The histone chaperone CAF1 promotes PRIMPOL recruitment to restart stalled forks through ssDNA gap formation. doi.org/10.1093/nar/...
CAF-1 promotes efficient PrimPol recruitment to nascent DNA for single-stranded DNA gap formation
Abstract. Suppression of single-stranded DNA (ssDNA) gap accumulation at replication forks has emerged as a potential determinant of chemosensitivity in ho
doi.org
December 18, 2024 at 3:45 PM
2) The histone chaperone CAF1 promotes PRIMPOL recruitment to restart stalled forks through ssDNA gap formation. doi.org/10.1093/nar/...
Online Now: RAD51 succinylation regulates homologous recombination and contributes to the chemosensitivity in cancer Online now:
RAD51 succinylation regulates homologous recombination and contributes to the chemosensitivity in cancer
Wang et al. show that OXCT1 and HDAC11 regulate RAD51 K285 succinylation, thereby suppressing homologous recombination repair and enhancing chemosensitivity.
dlvr.it
February 11, 2026 at 8:14 PM
Online Now: RAD51 succinylation regulates homologous recombination and contributes to the chemosensitivity in cancer Online now:
A rationale for combining KRAS/ERK inhibitors with standard-of-care chemotherapies in pancreatic cancer
David M. Virshup & team report on the suppression of the master regulator of differentiation and chemosensitivity—GATA6 expression—in PC models: doi.org/10.1172/JCI1...
David M. Virshup & team report on the suppression of the master regulator of differentiation and chemosensitivity—GATA6 expression—in PC models: doi.org/10.1172/JCI1...
February 2, 2026 at 5:15 PM
A rationale for combining KRAS/ERK inhibitors with standard-of-care chemotherapies in pancreatic cancer
David M. Virshup & team report on the suppression of the master regulator of differentiation and chemosensitivity—GATA6 expression—in PC models: doi.org/10.1172/JCI1...
David M. Virshup & team report on the suppression of the master regulator of differentiation and chemosensitivity—GATA6 expression—in PC models: doi.org/10.1172/JCI1...
ZNF831, by inhibiting STAT3/Bcl2, promotes apoptosis & enhances chemosensitivity to #Capecitabine & #Gemcitabine, highlighting it as a novel tumor suppressor, potential #Biomarker & #TherapeuticTarget for #BreastCancer.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
December 17, 2025 at 1:25 AM
ZNF831, by inhibiting STAT3/Bcl2, promotes apoptosis & enhances chemosensitivity to #Capecitabine & #Gemcitabine, highlighting it as a novel tumor suppressor, potential #Biomarker & #TherapeuticTarget for #BreastCancer.
#OpenAccess: doi.org/10.1016/j.ge...
#OpenAccess: doi.org/10.1016/j.ge...
We are super happy to announce our new paper in @naturecomms.bsky.social ELOVL6 regulates lipid metabolism in PDAC, impacting tumor plasticity and drug response. Targeting ELOVL6 enhances sensitivity to Abraxane, opening new therapeutic avenues. www.nature.com/articles/s41... #PancreaticCancer 🧪
Targeting ELOVL6 to disrupt c-MYC driven lipid metabolism in pancreatic cancer enhances chemosensitivity - Nature Communications
Overexpression of c-MYC regulates tumor metabolism in pancreatic ductal adenocarcinoma (PDAC). Here the authors identify ELOVL6, a fatty acid elongase regulated by c-MYC, as a potential therapeutic ta...
www.nature.com
February 16, 2025 at 3:27 PM
We are super happy to announce our new paper in @naturecomms.bsky.social ELOVL6 regulates lipid metabolism in PDAC, impacting tumor plasticity and drug response. Targeting ELOVL6 enhances sensitivity to Abraxane, opening new therapeutic avenues. www.nature.com/articles/s41... #PancreaticCancer 🧪
Nice paper from @sleemmz.bsky.social et al underscoring the importance of stem cell transdetermination in CRC. RXR, YAP, and AP1 signalling collectively control access to revival stem cells and inhibition of these nodes limits plasticity to improve chemosensitivity.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer - Nature Genetics
Oncofetal (OnF) reprogramming, driven by YAP and AP-1, induces phenotypic plasticity and therapy resistance in WNT-dependent colorectal cancer (CRC). Targeting the OnF state in combination with chemot...
www.nature.com
February 11, 2025 at 9:01 AM
Nice paper from @sleemmz.bsky.social et al underscoring the importance of stem cell transdetermination in CRC. RXR, YAP, and AP1 signalling collectively control access to revival stem cells and inhibition of these nodes limits plasticity to improve chemosensitivity.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
fucking chemosensitivity
February 25, 2026 at 8:11 PM
fucking chemosensitivity
A study using CRISPR gene editing reduced drug-resistance genes in ovarian cancer cells, making them more sensitive to treatment. #CancerResearch #GeneEditing
www.rimpacts.com/rd/p?c=10172...
www.rimpacts.com/rd/p?c=10172...
Crispr/Cas9, a New Approach to Successful Knockdown of Abcb1/P-Glycoprotein and Reversal of Chemosensitivity in Human Epithelial Ovarian Cancer Cell Line
A study using CRISPR gene editing reduced drug-resistance genes in ovarian cancer cells, making them more sensitive to treatment. #CancerResearch #GeneEditing
www.rimpacts.com
October 18, 2025 at 3:38 PM
A study using CRISPR gene editing reduced drug-resistance genes in ovarian cancer cells, making them more sensitive to treatment. #CancerResearch #GeneEditing
www.rimpacts.com/rd/p?c=10172...
www.rimpacts.com/rd/p?c=10172...
RRID:AB_2107436 from @proteintech.bsky.social was used by authors in their Molecular Cell paper. Thanks for making your methods matter! #STMpublishing #BetterScience #ReproducibleResearch
RAD51 succinylation regulates homologous recombination and contributes to the chemosensitivity in cancer
Read the full paper: RAD51 succinylation regulates homologous recombination and contributes to the chemosensitivity in cancer
doi.org
February 12, 2026 at 4:55 PM
RRID:AB_2107436 from @proteintech.bsky.social was used by authors in their Molecular Cell paper. Thanks for making your methods matter! #STMpublishing #BetterScience #ReproducibleResearch
Aptamer-directed, nanovesicle-mediated potentiates chemosensitivity in 2 cholangiocarcinoma models.
#liversky #oncsky #sciencesky
journals.lww.com/hep/abstract...
#liversky #oncsky #sciencesky
journals.lww.com/hep/abstract...
Aptamer-directed, nanovesicle-mediated targeting of... : Hepatology
ranscriptome-targeting therapeutics.
Approach & Results:
Milk-derived nanovesicles (MNVs) were loaded with short interfering RNAs targeting YAP, the downstream effector of the Hippo pathway; LCK, a...
journals.lww.com
February 12, 2025 at 8:00 PM
Aptamer-directed, nanovesicle-mediated potentiates chemosensitivity in 2 cholangiocarcinoma models.
#liversky #oncsky #sciencesky
journals.lww.com/hep/abstract...
#liversky #oncsky #sciencesky
journals.lww.com/hep/abstract...
RRIDs were included in this in Epigenomics paper. Thanks for making your methods matter! #STMpublishing #accelerateopenscience #ReproducibleResearch
Estrogen-induced epigenetic silencing of myotrophin reduces proliferation and is associated with chemosensitivity in hepatocellular carcinoma cells
Read the full paper: Estrogen-induced epigenetic silencing of myotrophin reduces proliferation and is associated with chemosensitivity in hepatocellular carcinoma cells
doi.org
April 17, 2026 at 7:04 AM
RRIDs were included in this in Epigenomics paper. Thanks for making your methods matter! #STMpublishing #accelerateopenscience #ReproducibleResearch
Yes and no. Altitude adaptations include higher Hbmass, altered buffer capacity, changes in chemosensitivity etc. intermittent activity will be easier. Mexico has the advantage.
July 2, 2026 at 8:33 PM
Yes and no. Altitude adaptations include higher Hbmass, altered buffer capacity, changes in chemosensitivity etc. intermittent activity will be easier. Mexico has the advantage.
RRIDs were included in this in Cell Death Discovery paper. Thanks for making your methods matter! #OpenScience #BetterScience #methodsmatter
Trim15 stabilizes VDAC3 via ubiquitination to suppress autophagy and enhance chemosensitivity in hypopharyngeal squamous cell carcinoma - Cell Death Discovery
Read the full paper: Trim15 stabilizes VDAC3 via ubiquitination to suppress autophagy and enhance chemosensitivity in hypopharyngeal squamous cell carcinoma
doi.org
February 11, 2026 at 8:02 AM
RRIDs were included in this in Cell Death Discovery paper. Thanks for making your methods matter! #OpenScience #BetterScience #methodsmatter
RRIDs were included in this None paper. We value the author's support of reproducibility. #reproducibility #STMpublishing #reproducibility
Lamins regulate cancer cell plasticity and chemosensitivity
doi.org
August 12, 2025 at 7:02 AM
RRIDs were included in this None paper. We value the author's support of reproducibility. #reproducibility #STMpublishing #reproducibility
RRID:AB_2749837 from @proteintech.bsky.social was used by authors in their Cancer Research paper. Thanks for making your methods matter! #RRID #STMpublishing #BetterScience
Subcellular Redistribution of Endomembrane GPR15 Promotes NAD+-Mediated Metabolic Reprogramming and Boosts 5-FU Chemosensitivity in Colorectal Cancer
Read the full paper: Subcellular Redistribution of Endomembrane GPR15 Promotes NAD+-Mediated Metabolic Reprogramming and Boosts 5-FU Chemosensitivity in Colorectal Cancer
doi.org
May 7, 2026 at 7:01 AM
RRID:AB_2749837 from @proteintech.bsky.social was used by authors in their Cancer Research paper. Thanks for making your methods matter! #RRID #STMpublishing #BetterScience
RRID:AB_2299495 was used by @proteintech.bsky.social in their Scientific Reports paper. RRIDs improve reproducibility in scientific research. #methodsmatter #OpenScience #OpenScience
PDZK1 inhibits MRP2-mediated oxaliplatin chemosensitivity in hepatocellular carcinoma
doi.org
May 7, 2025 at 11:01 PM
RRID:AB_2299495 was used by @proteintech.bsky.social in their Scientific Reports paper. RRIDs improve reproducibility in scientific research. #methodsmatter #OpenScience #OpenScience
RRIDs were included in this paper. We value the author's support of reproducibility. #STMpublishing #accelerateopenscience #STMpublishing
CDC7 stabilized by KRAS signaling reactivation impairs chemosensitivity in KRAS-mutant colorectal cancer
doi.org
November 14, 2025 at 8:00 AM
RRIDs were included in this paper. We value the author's support of reproducibility. #STMpublishing #accelerateopenscience #STMpublishing
RRID:Addgene_99375, was just reported to be used in "Targeting ELOVL6 to disrupt c-MYC driven lipid metabolism in pancreatic cancer enhances chemosensitivity". Thank you for making your methods matter! #methodsmatter #reproducibility
doi.org
March 27, 2025 at 10:12 PM
RRID:Addgene_99375, was just reported to be used in "Targeting ELOVL6 to disrupt c-MYC driven lipid metabolism in pancreatic cancer enhances chemosensitivity". Thank you for making your methods matter! #methodsmatter #reproducibility
RRIDs were included in this None paper. We value the author's support of reproducibility. #ReproducibleResearch #accelerateopenscience #accelerateopenscience
KLF5-regulated ZDHHC8 reduces chemosensitivity in high-grade serous ovarian cancer through β-catenin signaling
doi.org
August 15, 2025 at 7:00 AM
RRIDs were included in this None paper. We value the author's support of reproducibility. #ReproducibleResearch #accelerateopenscience #accelerateopenscience