#cholangitis
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enirenberg.bsky.social
In case you needed another reason to hate Epstein-Barr virus- it looks like it might cause primary sclerosing cholangitis:

www.nature.com/articles/s41...
T and B cell responses against Epstein–Barr virus in primary sclerosing cholangitis - Nature Medicine
Interrogation of electronic health records and the B and T cell repertoires of people with PSC shows a link between Epstein–Barr virus and primary sclerosing cholangitis, an incurable autoimmune liver...
www.nature.com
June 13, 2025 at 2:25 AM
drlongissimus.bsky.social
Bats get descending cholangitis
October 7, 2025 at 11:40 PM
charityschmidt.bsky.social
My results are in . The doctor called they think I have Primary Biliary Cholangitis which is an autoimmune disease. It’s not curable, but it’s maintainable. I’ll have to take medicine. I will live a long, healthy life. I see a specialist in October to figure out what to do next.
September 25, 2026 at 4:51 PM
ibdgastrodocsg.bsky.social
Primary sclerosing cholangitis.

#LiverSky #IBDSky
November 16, 2024 at 5:12 PM
kateytomatey.bsky.social
Please share - a woman in Victoria BC is seeking a living liver donor. I donated a kidney two years ago - being part of the organ donation process is pretty neat and the folks at BC Transplant are amazing. Please give this article a read to learn more. #yyj

vicnews.com/2026/01/07/v...
Victoria woman seeks living liver donor after incurable disease diagnosis - Victoria News
Primary sclerosing cholangitis affects 1 in 10,000 Canadians and can lead to liver failure and death
vicnews.com
January 9, 2026 at 6:47 AM
sophief.eurosky.social
Falls Sie noch einen Grund brauchen, das #Epstein-Barr -Virus zu hassen: Es sieht so aus, als könnte es eine primär sklerosierende Cholangitis verursachen:
June 13, 2025 at 9:00 PM
thelancet.com
Primary biliary cholangitis is a chronic autoimmune liver disease.

A Review in @lancetgastrohep.bsky.social looks at how new treatments and advances can improve personalised care to control liver damage, relieve symptoms & prevent severe liver disease: tinyurl.com/y86972su
Primary biliary cholangitis and the narrowing gap towards optimal disease control
Although infrequent, primary biliary cholangitis is not indolent and remains a burdensome chronic autoimmune biliary disease. Progressive biliary injury and cholestasis results in complications of bil...
tinyurl.com
June 30, 2025 at 11:35 AM
megothelioma.bsky.social
Picture-perfect "onion-skinning" in a case of primary sclerosing cholangitis 🧅 🧅

#pathsky #pathology #liverpath
January 28, 2025 at 2:27 PM
mrspac.medsky.social
Started rapid firing husband with my UWORLD GI question and he is UPSET

“ITS NEVER ASCENDING CHOLANGITIS OK???? ITS JUST NOT. WHY ARE 30% OF YOUR QUESTIONS ABOUT ASCENDING CHOLANGITIS”
June 25, 2026 at 2:32 AM
enirenberg.bsky.social
Also... EBV is so much more than multiple sclerosis. It seems to have major roles in a bunch of autoimmune diseases (including lupus and primary biliary cholangitis), and it also causes a bunch of different kinds of cancer. Forfeiting an attempt to enhance control of it is actually psychotic.
February 13, 2026 at 2:14 AM
ibdgastrodocsg.bsky.social
Primary biliary cholangitis

- predominantly females, 40-70yo
- triggers: smoking, xenobiotics
- histology: non-suppurative destructive cholangitis, florid duct lesion
- treatment: UDCA, OCA, ?PPAR agonists

#LiverSky #MedSky
November 17, 2024 at 1:41 AM
absteward.bsky.social
🔥 💥Late-Breakers |COBRA RCT
1-day of antibiotic treatment after adequate endoscopic biliary drainage is non-inferior to 4-7 days in adults with acute cholangitis.
💡 Shorter is better+source control
Practice-changing? #ESCMIDGlobal2026 #idsky
April 20, 2026 at 4:40 PM
dougasladlermd.bsky.social
Ascending cholangitis treated with an uncovered biliary stent. #gastroenterology #medical @stentingwoman.bsky.social
November 17, 2024 at 5:07 PM
jama.com
Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease that predominantly affects women ages 40 to 60 years.

💡 This JAMA Insights discusses the clinical presentation, diagnosis, and treatment of PBC.

ja.ma/43T7yeF
Published online November 10, 2025, JAMA Insights, Primary Biliary Cholangitis, by Michele M. Tana, MD, MHS; Gideon M. Hirschfield, MA, MBBChir, PhD. Figure. Primary Biliary Cholangitis (PBC)—From Diagnosis to Personalized Care.
November 10, 2025 at 5:15 PM
dominicgrun.bsky.social
Our study on rare immune cell networks governing liver cholangitis is now online! Using multiplexed single-cell and spatial omics, we discovered a triad of cholangiocytes, dendritic cells and gdT cells regulating the inflammatory and fibrotic tissue response. Rare immune cells matter!
rdcu.be/fc60M
An immunobiliary single-cell atlas resolves crosstalk between type 2 conventional dendritic cells and γδ T cells in cholangitis
Nature Communications - Primary sclerosing cholangitis (PSC) is an autoimmune condition affecting the liver. Here, the authors generate an immunobiliary transcriptomic atlas and show that dendritic...
rdcu.be
April 14, 2026 at 10:17 AM
botaintensiv.bsky.social
Die primäre biliäre Cholangitis (PBC) ist eine seltene, autoimmunvermittelte Entzündung der Gallengänge, welche eine chronische Cholestase bedingt und in einer Leberzirrhose münden kann.
Mit Elafibranor scheint eine neue wirksame Therapie gefunden.
www.nejm.org/doi/full/10....
Efficacy and Safety of Elafibranor in Primary Biliary Cholangitis | NEJM
Original Article from The New England Journal of Medicine — Efficacy and Safety of Elafibranor in Primary Biliary Cholangitis
www.nejm.org
November 14, 2023 at 8:11 PM
statnews.com
The FDA approved a new treatment for primary biliary cholangitis, an autoimmune liver disease mainly affecting women that causes decreased liver function, debilitating itching, and fatigue.

www.statnews.com/2024/08/14/g...
Gilead wins U.S. approval for drug to treat autoimmune liver disease
The FDA has approved a new treatment for primary biliary cholangitis, an autoimmune liver disease mainly affecting women.
www.statnews.com
August 14, 2024 at 7:49 PM
bhmullish.bsky.social
Pleased that #FARGO - a randomised, multicentre, placebo-controlled phase IIa trial of #FMT to treat #PSC - is running and recruiting. Have a look at the protocol paper out now in #BMJOpen: doi.org/10.1136/bmjo... @pscsupport.bsky.social @cholestasisdoc.bsky.social
FAecal micRobiota transplantation in primary sclerosinG chOlangitis (FARGO): study protocol for a randomised, multicentre, phase IIa, placebo-controlled trial
Introduction Primary sclerosing cholangitis (PSC) is the classical hepatobiliary manifestation of inflammatory bowel disease (IBD). The strong association between gut and liver inflammation has driven...
doi.org
January 7, 2025 at 7:30 AM
jonathanrydermd.bsky.social
New RCT from @cmijournal.bsky.social

Multicenter non-inferiority 2015-2023 in South Korea

In cholangitis with biliary drainage,
Treat based on BCx only (experimental) vs treat based on BCx & biliary Cx (control)

Bile Cx +: 83%
BCx +: 40%

www.clinicalmicrobiologyandinfection.com/article/S119...
January 29, 2025 at 2:51 AM
joostphdrenth.bsky.social
Michael Trauner @uniwien on sclerosing cholangitis
@ERN_RARE_LIVER Academy
Highlights differential diagnosis of sclerosing cholangitis
Malignancy kills ~50% PSC patients
@uniklinik_hd @my_ueg
April 10, 2025 at 11:47 AM
thelancet.com
Primary sclerosing cholangitis is a rare liver disease, characterised by biliary inflammation and fibrosis.

A Seminar explores the clinical features, pathogenesis, and challenges and opportunities in managing the disease: spkl.io/63323A4P8d
Clinical characteristics of primary sclerosing cholangitis. (A) The disease affects the biliary tree through inflammation and fibrosis, which results in multifocal biliary strictures and a high risk of cholangiocarcinoma. (B) When the disease progresses, high-grade strictures, often with prestenotic dilatation, can develop, leading to biliary obstruction and clinical symptoms. (C) Fatigue, itching, jaundice, bacterial cholangitis, and intermittent or persistent right upper-quadrant abdominal pain are common symptoms and signs in primary sclerosing cholangitis. Primary sclerosing cholangitis is associated with inflammatory bowel disease and 50–80% of affected individuals have concomitant inflammatory bowel disease. Primary sclerosing cholangitis inflammatory bowel disease shows distinct features from classic isolated inflammatory bowel disease, often with extensive colitis, a patchy inflammatory distribution that shows dominance of inflammation in the ascending colon, rectal sparing, and an increased risk of colorectal dysplasia compared with colitis without primary sclerosing cholangitis. (D) The inflammation almost always involves the colon and isolated ileal disease is rare. Reproduced with permission from Kari C Toverud.
April 19, 2026 at 11:04 AM
rubyslippahs.bsky.social
Sharing from a Kansas City FB group:

I’m asking for your help. I need a liver transplant soon due to liver cirrhosis caused by Primary Sclerosing Cholangitis (PSC), and I’m currently searching for a living liver donor.

1/5
My Liver My Life. I AM IN NEED OF A LIVER Transplant SOON - Due to LIVER CIRRHOSIS caused by PRIMARY SCLEROSING CHOLANGITIS (PSC). I am in need of an A or O BLOOD TYPE DONOR I am currently seeking a living donor. If you would like more information about donating a directed donor, please visit the University of Pittsburgh Living Organ donor information at https://www.upmc.com/services/transplant/patients/living-donor/become To be a living-liver donor, you must be between 18 and 60 years old. Thank you for your prayers, support, and for helping save a life. ♡
September 5, 2026 at 6:41 PM
pingtech.bsky.social
Yes, they regenerate, but some times a full organ is required - not just a piece.
- signed, a liver transplant recipient living with primary biliary cholangitis.
January 9, 2026 at 2:13 PM
steventong.bsky.social
ESCMID 2026 highlights

COBRA Trial – One day is enough

Dutch RCT: 1 day of antibiotics after ERCP drainage for cholangitis was non‑inferior to 4–7 days.

Bottom line: Antibiotic durations can safely be much shorter once source control is achieved.

#IDSky

clarityinitiative.org/escmid-2026-...
Clarity Initiative
Clinical Literature Appraisal and Research education in InfecTious diseases
clarityinitiative.org
May 14, 2026 at 11:37 AM
ihavethatonvinyl.com
liver: autoimmune hepatitis, primary biliary cholangitis, which i got because my body can't tolerate statins
gallbladder: gone
pancreas: cysts
heart: stent
kidney (new!): a growing "spot" which could be a lesion or a tumor. who knows!
April 7, 2026 at 11:42 PM