Look at this 🙂 #CryoEM
Structural basis for CTCF-mediated chromatin organization by @lucas.farnunglab.com @voslab.org
www.biorxiv.org/content/10.6...
Structural basis for CTCF-mediated chromatin organization by @lucas.farnunglab.com @voslab.org
www.biorxiv.org/content/10.6...
February 9, 2026 at 8:32 AM
Look at this 🙂 #CryoEM
Structural basis for CTCF-mediated chromatin organization by @lucas.farnunglab.com @voslab.org
www.biorxiv.org/content/10.6...
Structural basis for CTCF-mediated chromatin organization by @lucas.farnunglab.com @voslab.org
www.biorxiv.org/content/10.6...
Thrilled to share that my postdoc research is published today in @science.org! We found that DNA repair uses cohesin complexes to build new chromatin loops that guide the homology search and boost accurate repair! 1/n
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Cohesin drives chromatin scanning during the RAD51-mediated homology search
Cohesin folds genomes into chromatin loops, the roles of which are under debate. We found that double-strand breaks (DSBs) induce de novo formation of chromatin loops in human cells, with the loop bas...
www.science.org
December 4, 2025 at 9:50 PM
Thrilled to share that my postdoc research is published today in @science.org! We found that DNA repair uses cohesin complexes to build new chromatin loops that guide the homology search and boost accurate repair! 1/n
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
A must-read for histone afficionados: our new review on 'Histone-mediated chromatin organization in prokaryotes and viruses' www.cell.com/trends/bioch... @samuelschwab.bsky.social @vikramalva.bsky.social
Histone-mediated chromatin organization in prokaryotes and viruses
Histones are fundamental chromatin-organizing proteins in eukaryotes and archaea,
where they assemble into (hyper)nucleosomes that wrap DNA. Recent studies have expanded
the known repertoire of histon...
www.cell.com
June 30, 2025 at 7:35 AM
A must-read for histone afficionados: our new review on 'Histone-mediated chromatin organization in prokaryotes and viruses' www.cell.com/trends/bioch... @samuelschwab.bsky.social @vikramalva.bsky.social
Now online - the Review "Histone-mediated chromatin organization in prokaryotes and viruses" from @samuelschwab.bsky.social @vikramalva.bsky.social @damelab.bsky.social and co.
#histones #DNAorganization #chromatin #eukaryogenesis
Read it here 👉 authors.elsevier.com/sd/article/S...
#histones #DNAorganization #chromatin #eukaryogenesis
Read it here 👉 authors.elsevier.com/sd/article/S...
July 2, 2025 at 8:07 PM
Now online - the Review "Histone-mediated chromatin organization in prokaryotes and viruses" from @samuelschwab.bsky.social @vikramalva.bsky.social @damelab.bsky.social and co.
#histones #DNAorganization #chromatin #eukaryogenesis
Read it here 👉 authors.elsevier.com/sd/article/S...
#histones #DNAorganization #chromatin #eukaryogenesis
Read it here 👉 authors.elsevier.com/sd/article/S...
Very excited to share our new Nature study!
We discovered that replication stress stabilizes CTCF-dependent chromatin loops enclosing stressed nascent DNA, where G9a-mediated heterochromatin protects it from nucleolytic degradation. rdcu.be/frzLg
Huge thanks to all our collaborators and co-authors!
We discovered that replication stress stabilizes CTCF-dependent chromatin loops enclosing stressed nascent DNA, where G9a-mediated heterochromatin protects it from nucleolytic degradation. rdcu.be/frzLg
Huge thanks to all our collaborators and co-authors!
Replication-stress-induced chromatin loops protect fork stability - Nature
Replication stress induces the formation of transient chromatin loops that enclose de novo heterochromatin-enriched stalled replication forks.
www.nature.com
July 1, 2026 at 7:15 PM
Very excited to share our new Nature study!
We discovered that replication stress stabilizes CTCF-dependent chromatin loops enclosing stressed nascent DNA, where G9a-mediated heterochromatin protects it from nucleolytic degradation. rdcu.be/frzLg
Huge thanks to all our collaborators and co-authors!
We discovered that replication stress stabilizes CTCF-dependent chromatin loops enclosing stressed nascent DNA, where G9a-mediated heterochromatin protects it from nucleolytic degradation. rdcu.be/frzLg
Huge thanks to all our collaborators and co-authors!
Our new preprint 🧬🔗 www.biorxiv.org/content/10.1...
BRD4-NUT forms liquid-like condensates that locally constrain nucleosomes via BRD4-mediated crosslinking— physical control of #chromatin by #LLPS transcription condensates. @semeigazin.bsky.social @katsuminami.bsky.social @masaashimazoe.bsky.social
BRD4-NUT forms liquid-like condensates that locally constrain nucleosomes via BRD4-mediated crosslinking— physical control of #chromatin by #LLPS transcription condensates. @semeigazin.bsky.social @katsuminami.bsky.social @masaashimazoe.bsky.social
July 10, 2025 at 4:21 AM
Our new preprint 🧬🔗 www.biorxiv.org/content/10.1...
BRD4-NUT forms liquid-like condensates that locally constrain nucleosomes via BRD4-mediated crosslinking— physical control of #chromatin by #LLPS transcription condensates. @semeigazin.bsky.social @katsuminami.bsky.social @masaashimazoe.bsky.social
BRD4-NUT forms liquid-like condensates that locally constrain nucleosomes via BRD4-mediated crosslinking— physical control of #chromatin by #LLPS transcription condensates. @semeigazin.bsky.social @katsuminami.bsky.social @masaashimazoe.bsky.social
Happy to share part of my postdoctoral work at the @lucas.farnunglab.com lab. Great collaboration with @voslab.org and @andersshansen.bsky.social. “Structural basis for CTCF-mediated chromatin organization” www.biorxiv.org/content/10.6...
February 9, 2026 at 3:22 PM
Happy to share part of my postdoctoral work at the @lucas.farnunglab.com lab. Great collaboration with @voslab.org and @andersshansen.bsky.social. “Structural basis for CTCF-mediated chromatin organization” www.biorxiv.org/content/10.6...
Excited to share our latest review on histone-mediated chromatin organization in prokaryotes and viruses! 🧬 @mpi-bio-fml.bsky.social
A must-read for histone afficionados: our new review on 'Histone-mediated chromatin organization in prokaryotes and viruses' www.cell.com/trends/bioch... @samuelschwab.bsky.social @vikramalva.bsky.social
Histone-mediated chromatin organization in prokaryotes and viruses
Histones are fundamental chromatin-organizing proteins in eukaryotes and archaea,
where they assemble into (hyper)nucleosomes that wrap DNA. Recent studies have expanded
the known repertoire of histon...
www.cell.com
June 30, 2025 at 9:33 AM
Excited to share our latest review on histone-mediated chromatin organization in prokaryotes and viruses! 🧬 @mpi-bio-fml.bsky.social
Delighted to share that our study is now out @cp-cellstemcell.bsky.social www.cell.com/cell-stem-ce... Congrats to Dr. @federicamosti.bsky.social for the culmination of a beautiful thesis!
March 19, 2026 at 9:15 PM
Delighted to share that our study is now out @cp-cellstemcell.bsky.social www.cell.com/cell-stem-ce... Congrats to Dr. @federicamosti.bsky.social for the culmination of a beautiful thesis!
New preprint from our lab! An H3.3 knockout does two things at once: it removes H3.3 from chromatin and destabilizes DAXX. We disentangle those functions and find that DAXX-mediated H3.3 deposition can be uncoupled from ERV silencing.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
March 23, 2026 at 10:59 PM
New preprint from our lab! An H3.3 knockout does two things at once: it removes H3.3 from chromatin and destabilizes DAXX. We disentangle those functions and find that DAXX-mediated H3.3 deposition can be uncoupled from ERV silencing.
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Happy to share our new review on Polycomb-mediated 3D chromatin interactions! Thanks to @mileshuseyin.bsky.social and @andersshansen.bsky.social for great discussions throughout the process :)
Excited to share @suminkim.bsky.social and @mileshuseyin.bsky.social 's new Current Opinion review on how Polycomb complexes mediate 3D genome interactions including mechanistic models and potential roles in gene regulation:
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
February 19, 2026 at 12:57 AM
Happy to share our new review on Polycomb-mediated 3D chromatin interactions! Thanks to @mileshuseyin.bsky.social and @andersshansen.bsky.social for great discussions throughout the process :)
Deaminase-mediated chromatin accessibility profiling with single-allele resolution www.biorxiv.org/content/10.1...
December 23, 2024 at 6:50 PM
Deaminase-mediated chromatin accessibility profiling with single-allele resolution www.biorxiv.org/content/10.1...
Fine-scale chromatin mapping uncovers principles of cis-regulatory element interactions. #NBThighlight www.cell.com/cell/fulltex...
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions
Li et al. apply base-pair resolution Micro Capture-C ultra to map chromatin contacts
between individual motifs within cis-regulatory elements and reveal a unified model
of biophysically mediated enhan...
www.cell.com
November 10, 2025 at 8:58 AM
Fine-scale chromatin mapping uncovers principles of cis-regulatory element interactions. #NBThighlight www.cell.com/cell/fulltex...
this looks very interesting with numerous implications for nuclear biology and gene expression.
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions: Cell www.cell.com/cell/fulltex...
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions: Cell www.cell.com/cell/fulltex...
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions
Li et al. apply base-pair resolution Micro Capture-C ultra to map chromatin contacts
between individual motifs within cis-regulatory elements and reveal a unified model
of biophysically mediated enhan...
www.cell.com
November 9, 2025 at 5:07 PM
this looks very interesting with numerous implications for nuclear biology and gene expression.
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions: Cell www.cell.com/cell/fulltex...
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions: Cell www.cell.com/cell/fulltex...
Our latest is online now, we discovered that enhancers cause surrounding chromatin to acquire euchromatin modifications and produce non-coding RNA making regions without enhancer activity look like enhancers. doi.org/10.1101/2025...
Enhancers mediate euchromatin hopping at chromatin contact points
Enhancer-mediated gene activation involves the recruitment of chromatin modifiers and RNA polymerase to target promoters, but it is unknown if enhancers influence chromatin beyond their target genes. ...
doi.org
September 8, 2025 at 1:26 AM
Our latest is online now, we discovered that enhancers cause surrounding chromatin to acquire euchromatin modifications and produce non-coding RNA making regions without enhancer activity look like enhancers. doi.org/10.1101/2025...
Chromatin Loop prediction via Accessibility Model for Protein-mediated loops
github: github.com/chikit2077/...
github: github.com/chikit2077/...
January 22, 2026 at 3:15 PM
Chromatin Loop prediction via Accessibility Model for Protein-mediated loops
github: github.com/chikit2077/...
github: github.com/chikit2077/...
Excited to share our hot-off-the-press @biorxivpreprint.bsky.social
that explores how PRC1-mediated H2AK119ub deposition safeguards lineage fidelity during forebrain development. Fantastic work by @lucyadoyle.bsky.social and our colleagues & collaborators. 🥳🧬🧠🔬
www.biorxiv.org/content/10.1...
that explores how PRC1-mediated H2AK119ub deposition safeguards lineage fidelity during forebrain development. Fantastic work by @lucyadoyle.bsky.social and our colleagues & collaborators. 🥳🧬🧠🔬
www.biorxiv.org/content/10.1...
H2AK119ub Safeguards Against Ectopic Transcription Factor Mediated Gene Activation in the Developing Forebrain
The PRC1 complex regulates developmental gene expression in mammals by ubiquitinating histones (H2AK119ub) and nucleating repressive chromatin interactions. Human genetic data and functional experimen...
www.biorxiv.org
July 12, 2025 at 12:50 AM
Excited to share our hot-off-the-press @biorxivpreprint.bsky.social
that explores how PRC1-mediated H2AK119ub deposition safeguards lineage fidelity during forebrain development. Fantastic work by @lucyadoyle.bsky.social and our colleagues & collaborators. 🥳🧬🧠🔬
www.biorxiv.org/content/10.1...
that explores how PRC1-mediated H2AK119ub deposition safeguards lineage fidelity during forebrain development. Fantastic work by @lucyadoyle.bsky.social and our colleagues & collaborators. 🥳🧬🧠🔬
www.biorxiv.org/content/10.1...
What an amazing assay.
DAF-seq, the evolution of Fiber-seq from the Andrew Stergachis group, using the @pacbio.bsky.social platform:
www.biorxiv.org/content/10.1...
This will revolutionise our understanding of transcriptional regulation and functional non-coding variants.
DAF-seq, the evolution of Fiber-seq from the Andrew Stergachis group, using the @pacbio.bsky.social platform:
www.biorxiv.org/content/10.1...
This will revolutionise our understanding of transcriptional regulation and functional non-coding variants.
Deaminase-assisted single-molecule and single-cell chromatin fiber sequencing
Gene regulation is mediated by the co-occupancy of numerous proteins along individual chromatin fibers. However, our tools for deeply profiling how proteins co-occupy individual fibers, especially at ...
www.biorxiv.org
October 4, 2025 at 12:06 PM
What an amazing assay.
DAF-seq, the evolution of Fiber-seq from the Andrew Stergachis group, using the @pacbio.bsky.social platform:
www.biorxiv.org/content/10.1...
This will revolutionise our understanding of transcriptional regulation and functional non-coding variants.
DAF-seq, the evolution of Fiber-seq from the Andrew Stergachis group, using the @pacbio.bsky.social platform:
www.biorxiv.org/content/10.1...
This will revolutionise our understanding of transcriptional regulation and functional non-coding variants.
PRC1 and CTCF-Mediated Transition from Poised to Active Chromatin Loops Drives Bivalent Gene Activation https://www.biorxiv.org/content/10.1101/2024.11.13.623456v1
PRC1 and CTCF-Mediated Transition from Poised to Active Chromatin Loops Drives Bivalent Gene Activation https://www.biorxiv.org/content/10.1101/2024.11.13.623456v1
Polycomb Repressive Complex 1 (PRC1) and CCCTC-binding factor (CTCF) are critical regulators of 3D c
www.biorxiv.org
November 16, 2024 at 3:34 AM
PRC1 and CTCF-Mediated Transition from Poised to Active Chromatin Loops Drives Bivalent Gene Activation https://www.biorxiv.org/content/10.1101/2024.11.13.623456v1
Cohesin drives chromatin scanning during the RAD51-mediated homology search www.science.org/doi/10.1126/...
Cohesin drives chromatin scanning during the RAD51-mediated homology search
Cohesin folds genomes into chromatin loops, the roles of which are under debate. We found that double-strand breaks (DSBs) induce de novo formation of chromatin loops in human cells, with the loop bas...
www.science.org
December 6, 2025 at 1:42 AM
Cohesin drives chromatin scanning during the RAD51-mediated homology search www.science.org/doi/10.1126/...
1/n
Really excited to share our latest pre-print on the role of cohesin in homology search, now available on bioRxiv!
www.biorxiv.org/content/10.1...
Really excited to share our latest pre-print on the role of cohesin in homology search, now available on bioRxiv!
www.biorxiv.org/content/10.1...
Cohesin drives chromatin scanning during the RAD51-mediated homology search.
Cohesin folds genomes into chromatin loops, whose roles are under debate. We report that double strand breaks (DSB) induce de novo formation of chromatin loops, with the break positioned at the loop b...
www.biorxiv.org
February 13, 2025 at 1:16 AM
1/n
Really excited to share our latest pre-print on the role of cohesin in homology search, now available on bioRxiv!
www.biorxiv.org/content/10.1...
Really excited to share our latest pre-print on the role of cohesin in homology search, now available on bioRxiv!
www.biorxiv.org/content/10.1...
Great work from the lab of @jojdavies.bsky.social
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions
www.cell.com/cell/fulltex...
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions
www.cell.com/cell/fulltex...
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions
Li et al. apply base-pair resolution Micro Capture-C ultra to map chromatin contacts
between individual motifs within cis-regulatory elements and reveal a unified model
of biophysically mediated enhan...
www.cell.com
November 17, 2025 at 6:55 AM
Great work from the lab of @jojdavies.bsky.social
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions
www.cell.com/cell/fulltex...
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions
www.cell.com/cell/fulltex...
Single-cell chromatin landscapes visualize epigenetic barriers and reveal lineage-specific Polycomb-mediated repression https://www.biorxiv.org/content/10.64898/2026.05.04.722686v1
May 7, 2026 at 4:31 PM
Single-cell chromatin landscapes visualize epigenetic barriers and reveal lineage-specific Polycomb-mediated repression https://www.biorxiv.org/content/10.64898/2026.05.04.722686v1
Structural basis for CTCF-mediated chromatin organization https://www.biorxiv.org/content/10.64898/2026.02.06.704447v1
February 9, 2026 at 3:18 AM
Structural basis for CTCF-mediated chromatin organization https://www.biorxiv.org/content/10.64898/2026.02.06.704447v1