in CK2, Khazars were crucial for my attempts to convert Poland to Judaism
November 3, 2026 at 7:36 PM
in CK2, Khazars were crucial for my attempts to convert Poland to Judaism
November 3, 2026 at 8:04 AM
A CK2-β-TrCP kinase-E3 ubiquitin ligase cascade is a metabolic sensor regulating tryptophan 2,3-dioxygenase stability
A CK2-β-TrCP kinase-E3 ubiquitin ligase cascade is a metabolic sensor regulating tryptophan 2,3-dioxygenase stability
How metabolic enzyme levels are regulated is poorly understood. Studying the tryptophan (Trp)-metabolizing enzyme TDO2, Thielen et al. discover a CK2 kinase-β-TrCP E3 ligase pathway that regulates stability in response to substrate availability. Trp occupation of an exosite restricts degron accessibility, whereas low Trp releases the degron for phosphorylation-ubiquitylation-mediated degradation.
dlvr.it
November 5, 2026 at 11:58 PM
A CK2-β-TrCP kinase-E3 ubiquitin ligase cascade is a metabolic sensor regulating tryptophan 2,3-dioxygenase stability
War Thunder 14th birthday event, man. And I've been playing since 2015. Also the year I got Sunless Sea, CK2, EU4, HoI3, Elite Dangerous oh and also the year I realized I'm trans
November 4, 2026 at 11:48 PM
War Thunder 14th birthday event, man. And I've been playing since 2015. Also the year I got Sunless Sea, CK2, EU4, HoI3, Elite Dangerous oh and also the year I realized I'm trans
isn't there a sentinel in hammerfell (remembers this vaguely from the ck2 mod)
November 3, 2026 at 4:16 PM
isn't there a sentinel in hammerfell (remembers this vaguely from the ck2 mod)
Ck2 type shenanigans endure
November 3, 2026 at 6:34 PM
Ck2 type shenanigans endure
CK2 and DBT promote temperature compensation of the Drosophila circadian clock via distinct pathways
#Drosophila
#Drosophila
CK2 and DBT promote temperature compensation of the Drosophila circadian clock via distinct pathways
#Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
November 6, 2026 at 5:24 PM
CK2 and DBT promote temperature compensation of the Drosophila circadian clock via distinct pathways
#Drosophila
#Drosophila
Some random landless Noble in every ck2 campaign:
October 30, 2026 at 3:57 PM
Some random landless Noble in every ck2 campaign:
Like, go look at CK2. All the dlc is like a trillion dollars.
October 31, 2026 at 6:12 PM
Like, go look at CK2. All the dlc is like a trillion dollars.
New in @cp-molcell.bsky.social “A CK2–β-TrCP kinase-E3 ubiquitin ligase cascade is a metabolic sensor regulating Tryptophan 2,3-dioxygenase stability”
alinathielen.bsky.social et al.
alinathielen.bsky.social et al.
November 5, 2026 at 5:57 PM
New in @cp-molcell.bsky.social “A CK2–β-TrCP kinase-E3 ubiquitin ligase cascade is a metabolic sensor regulating Tryptophan 2,3-dioxygenase stability”
alinathielen.bsky.social et al.
alinathielen.bsky.social et al.
Tour de force work from Brenda Shulman's lab shows how it pays to read papers published many decades ago.
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
A CK2-β-TrCP kinase-E3 ubiquitin ligase cascade is a metabolic sensor regulating tryptophan 2,3-dioxygenase stability
How metabolic enzyme levels are regulated is poorly understood. Studying the tryptophan
(Trp)-metabolizing enzyme TDO2, Thielen et al. discover a CK2 kinase-β-TrCP E3 ligase
pathway that regulates sta...
www.cell.com
October 28, 2026 at 11:24 PM
Tour de force work from Brenda Shulman's lab shows how it pays to read papers published many decades ago.
www.cell.com/molecular-ce...
www.cell.com/molecular-ce...
A paper using RRID:AB_760350 from @dshb-antibodies.bsky.social was just published in iScience. RRIDs improve reproducibility in scientific research. #STMpublishing #RRID #reproducibility
CK2 and DBT promote temperature compensation of the Drosophila circadian clock via distinct pathways
Read the full paper: CK2 and DBT promote temperature compensation of the Drosophila circadian clock via distinct pathways
doi.org
November 1, 2026 at 7:00 AM
A paper using RRID:AB_760350 from @dshb-antibodies.bsky.social was just published in iScience. RRIDs improve reproducibility in scientific research. #STMpublishing #RRID #reproducibility
Our latest work from Macurek’s lab is now out in NAR! Following our favorite phosphatase PPM1D/WIP1 took us down an unexpected path into the nucleolus.
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
Dynamic phosphorylation of TCOF1 controlled by CK2 and PPM1D regulates nucleolar condensation and RNA polymerase I activity
Abstract. The nucleolus is a membrane-less organelle essential for ribosomal DNA (rDNA) transcription and ribosome biogenesis, yet the mechanisms regulatin
academic.oup.com
November 1, 2026 at 7:17 PM
Our latest work from Macurek’s lab is now out in NAR! Following our favorite phosphatase PPM1D/WIP1 took us down an unexpected path into the nucleolus.
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
kinda unrelated, but Western Xia is one of my favourite countries to play as on CK2 lol
October 27, 2026 at 10:07 PM
kinda unrelated, but Western Xia is one of my favourite countries to play as on CK2 lol
Tbh of all the things that Putin could talk at me about, medieval Slavic history would probably be my favorite to listen to. Just constantly interrupting him with questions about whether it’s properly portrayed in CK2.
October 28, 2026 at 5:58 PM
Tbh of all the things that Putin could talk at me about, medieval Slavic history would probably be my favorite to listen to. Just constantly interrupting him with questions about whether it’s properly portrayed in CK2.
I prefer CK2 myself, but mostly because I'm more into medieval history plus I enjoy playing as actual character with traits.
October 26, 2026 at 11:09 PM
I prefer CK2 myself, but mostly because I'm more into medieval history plus I enjoy playing as actual character with traits.
CK2 game update. My last ruler was killed by his wife who hated him lol. It was good timing because he went insane and appointed his horse chancellor, so now I'm Hastain
October 24, 2026 at 9:51 PM
CK2 game update. My last ruler was killed by his wife who hated him lol. It was good timing because he went insane and appointed his horse chancellor, so now I'm Hastain
I myself am playing CK2. Ghurids are a cool start; you can steamroll Persia and southern India.
October 22, 2026 at 10:16 AM
I myself am playing CK2. Ghurids are a cool start; you can steamroll Persia and southern India.
Oh yeah!! I really love CK2 and 3. Idk if im any good at them but I certainly have fun bumbling around 😆
October 21, 2026 at 4:04 PM
Oh yeah!! I really love CK2 and 3. Idk if im any good at them but I certainly have fun bumbling around 😆
Character congruent work that gets kinda...boring.
I played a lot of CK2 and it was fun to sprinkle a mad king or queen with relatively non maliciously awful characters, but an entire run of blood...the game offers way more than that! Its a waste!
I played a lot of CK2 and it was fun to sprinkle a mad king or queen with relatively non maliciously awful characters, but an entire run of blood...the game offers way more than that! Its a waste!
October 20, 2026 at 11:29 PM
Character congruent work that gets kinda...boring.
I played a lot of CK2 and it was fun to sprinkle a mad king or queen with relatively non maliciously awful characters, but an entire run of blood...the game offers way more than that! Its a waste!
I played a lot of CK2 and it was fun to sprinkle a mad king or queen with relatively non maliciously awful characters, but an entire run of blood...the game offers way more than that! Its a waste!
Check out my contribution to the #crusaderkings2 subreddit’s community succession save! #ck2 www.reddit.com/r/crusaderki...
From the crusaderkings2 community on Reddit
Explore this post and more from the crusaderkings2 community
www.reddit.com
October 20, 2026 at 1:08 AM
Check out my contribution to the #crusaderkings2 subreddit’s community succession save! #ck2 www.reddit.com/r/crusaderki...
CK2α O-GlcNAcylation affects its conformational stability and modulates its ability to phosphorylate RAD51#glycotimee#Glycobiologyy
CK2α O-GlcNAcylation affects its conformational stability and modulates its ability to phosphorylate RAD51
text/html; charset=UTF-8
academic.oup.com
October 18, 2026 at 1:39 PM
CK2α O-GlcNAcylation affects its conformational stability and modulates its ability to phosphorylate RAD51#glycotimee#Glycobiologyy
Cheguei naquele ponto em CK2 em que eu já pintei tanto o mapa que guerra não tem mais graça então a distração é planejar assassinatos aleatórios. Eu estou ciente que não é algo saudável.
October 18, 2026 at 8:13 PM
Cheguei naquele ponto em CK2 em que eu já pintei tanto o mapa que guerra não tem mais graça então a distração é planejar assassinatos aleatórios. Eu estou ciente que não é algo saudável.
🔥🔥 NEW SPEEDRUN RECORD VERIFIED! 🔥🔥
🎮 Game: Crusader Kings II
🏆 Category: Casanova
⏱ Time: 0h 7m 15s 633ms
👤 Player: datrandompanda
🔗 Link: https://www.speedrun.com/ck2/runs/z14x6x9z
🎮 Game: Crusader Kings II
🏆 Category: Casanova
⏱ Time: 0h 7m 15s 633ms
👤 Player: datrandompanda
🔗 Link: https://www.speedrun.com/ck2/runs/z14x6x9z
October 17, 2026 at 8:19 PM
🔥🔥 NEW SPEEDRUN RECORD VERIFIED! 🔥🔥
🎮 Game: Crusader Kings II
🏆 Category: Casanova
⏱ Time: 0h 7m 15s 633ms
👤 Player: datrandompanda
🔗 Link: https://www.speedrun.com/ck2/runs/z14x6x9z
🎮 Game: Crusader Kings II
🏆 Category: Casanova
⏱ Time: 0h 7m 15s 633ms
👤 Player: datrandompanda
🔗 Link: https://www.speedrun.com/ck2/runs/z14x6x9z