I KNEW IT YES
I LOVE CONFORMATIONS YIPPIEEE!!!
Artist: meowwniz
I LOVE CONFORMATIONS YIPPIEEE!!!
Artist: meowwniz
February 11, 2026 at 7:01 PM
I KNEW IT YES
I LOVE CONFORMATIONS YIPPIEEE!!!
Artist: meowwniz
I LOVE CONFORMATIONS YIPPIEEE!!!
Artist: meowwniz
chairing the conformations goodnight.. no bromo though
September 25, 2026 at 3:40 PM
chairing the conformations goodnight.. no bromo though
In fact, in one recent study, people were shown to prefer the less extreme versions of three different dog breeds over the most extreme.
Same breeds, different conformations 👇
9/
Same breeds, different conformations 👇
9/
March 8, 2026 at 1:35 PM
In fact, in one recent study, people were shown to prefer the less extreme versions of three different dog breeds over the most extreme.
Same breeds, different conformations 👇
9/
Same breeds, different conformations 👇
9/
4- But as one wise reviewer pointed out, we have become somewhat obsessed about ACE2 conformations at the cell surface and hadnt looked closely enough at the virus itself. So what do we see when we do that?
September 25, 2026 at 12:09 PM
4- But as one wise reviewer pointed out, we have become somewhat obsessed about ACE2 conformations at the cell surface and hadnt looked closely enough at the virus itself. So what do we see when we do that?
Researchers have developed a #DeepLearning system called BioEmu that rapidly generates diverse protein conformations, enabling fast, accurate insights into protein flexibility and function.
Learn more this week in Science: https://scim.ag/3JdQVD4
Learn more this week in Science: https://scim.ag/3JdQVD4
August 14, 2025 at 6:05 PM
Researchers have developed a #DeepLearning system called BioEmu that rapidly generates diverse protein conformations, enabling fast, accurate insights into protein flexibility and function.
Learn more this week in Science: https://scim.ag/3JdQVD4
Learn more this week in Science: https://scim.ag/3JdQVD4
Wait for official announcements/conformations, kids.
square when they find the valve employee that just leaked the entire Kingdom Hearts 4 world list
September 9, 2026 at 4:05 AM
Wait for official announcements/conformations, kids.
Encode protein structures as a series of discrete tokens, train a language model, and sample protein structural conformations given the sequence.
arxiv.org/abs/2410.18403
arxiv.org/abs/2410.18403
April 25, 2025 at 9:11 PM
Encode protein structures as a series of discrete tokens, train a language model, and sample protein structural conformations given the sequence.
arxiv.org/abs/2410.18403
arxiv.org/abs/2410.18403
8- Now to simplify things, it turns out Veros alone did the same. So ACE2 conformations are not regulating Spike here. What is happening though is an intact Spike FCS in Omicron lineages is leading to obliteration of Spike from viral particles. Inactivate the FCS by R685P &.....
September 25, 2026 at 12:13 PM
8- Now to simplify things, it turns out Veros alone did the same. So ACE2 conformations are not regulating Spike here. What is happening though is an intact Spike FCS in Omicron lineages is leading to obliteration of Spike from viral particles. Inactivate the FCS by R685P &.....
Senate Conformations only require a simple majority.
Budget bill requires 60.
Budget bill requires 60.
March 12, 2025 at 8:54 PM
Senate Conformations only require a simple majority.
Budget bill requires 60.
Budget bill requires 60.
Great community assessment here. Still unable to find alternate conformations. Protein dynamics the next big obstacle clearly 👀
December 2, 2024 at 4:34 PM
Great community assessment here. Still unable to find alternate conformations. Protein dynamics the next big obstacle clearly 👀
Run BioEmu in Colab - just click "Runtime → Run all"! Our notebook uses ColabFold to generate MSAs, BioEmu to predict trajectories, and Foldseek to cluster conformations.
Thanks @jjimenezluna.bsky.social for the help!
🌐 colab.research.google.com/github/sokry...
📄 www.biorxiv.org/content/10.1...
Thanks @jjimenezluna.bsky.social for the help!
🌐 colab.research.google.com/github/sokry...
📄 www.biorxiv.org/content/10.1...
Google Colab
colab.research.google.com
March 29, 2025 at 9:50 AM
Run BioEmu in Colab - just click "Runtime → Run all"! Our notebook uses ColabFold to generate MSAs, BioEmu to predict trajectories, and Foldseek to cluster conformations.
Thanks @jjimenezluna.bsky.social for the help!
🌐 colab.research.google.com/github/sokry...
📄 www.biorxiv.org/content/10.1...
Thanks @jjimenezluna.bsky.social for the help!
🌐 colab.research.google.com/github/sokry...
📄 www.biorxiv.org/content/10.1...
High-resolution template matching of the human ribosome in situ by Lippincott-Schwartz Lab @hhmijanelia.bsky.social @hhmi.bsky.social. >40 conformations within together reveal molecular dynamics of the elongation cycle with previously unknown bending and “spring-like” motion.
December 3, 2024 at 12:21 PM
High-resolution template matching of the human ribosome in situ by Lippincott-Schwartz Lab @hhmijanelia.bsky.social @hhmi.bsky.social. >40 conformations within together reveal molecular dynamics of the elongation cycle with previously unknown bending and “spring-like” motion.
The variability across the 20 conformations in a typical NMR ensemble in the PDB represents the uncertainty from the lack of experimental data and not the dynamics of the protein in solution
Thanks for coming to my TED talk
Thanks for coming to my TED talk
January 31, 2025 at 7:17 PM
The variability across the 20 conformations in a typical NMR ensemble in the PDB represents the uncertainty from the lack of experimental data and not the dynamics of the protein in solution
Thanks for coming to my TED talk
Thanks for coming to my TED talk
Some of these conformations are going to be 🔥
Sarcastically speaking , were so lucky to have our very own agent of misinformation ‼️https://www.thebulwark.com/p/rfk-jr-one-man-plague-vaccines-covid-hhs
RFK Jr. Is a One-Man Plague
It’s not just that he’s misinformed. It’s the way his mind works that’s dangerous.
www.thebulwark.com
December 10, 2024 at 7:32 AM
Some of these conformations are going to be 🔥
Scientists have created an actual treatment for prions, the cause of Creutzfeldt–Jakob disease in humans, chronic wasting disease in deer, & mad cow disease.
"Brainwide silencing of prion protein by AAV-mediated delivery of an engineered compact epigenetic editor". #ShareGoodNewsToo
"Brainwide silencing of prion protein by AAV-mediated delivery of an engineered compact epigenetic editor". #ShareGoodNewsToo
Brainwide silencing of prion protein by AAV-mediated delivery of an engineered compact epigenetic editor
Prion disease is caused by misfolding of the prion protein (PrP) into pathogenic self-propagating conformations, leading to rapid-onset dementia and death. However, elimination of endogenous PrP halts...
www.science.org
February 3, 2025 at 3:55 PM
Scientists have created an actual treatment for prions, the cause of Creutzfeldt–Jakob disease in humans, chronic wasting disease in deer, & mad cow disease.
"Brainwide silencing of prion protein by AAV-mediated delivery of an engineered compact epigenetic editor". #ShareGoodNewsToo
"Brainwide silencing of prion protein by AAV-mediated delivery of an engineered compact epigenetic editor". #ShareGoodNewsToo
Through real-time imaging of live cells, researchers reveal yet another level of complexity in the spatiotemporal regulation of G protein–coupled receptors, the targets of approximately 30% of all FDA-approved drugs.
Learn more in #ScienceSignaling: https://scim.ag/4dKehNL
Learn more in #ScienceSignaling: https://scim.ag/4dKehNL
Location-biased β-arrestin conformations direct GPCR signaling
Biosensors reveal the effects of β-arrestin conformations on GPCR signaling at different subcellular locations.
scim.ag
March 27, 2026 at 3:00 PM
Through real-time imaging of live cells, researchers reveal yet another level of complexity in the spatiotemporal regulation of G protein–coupled receptors, the targets of approximately 30% of all FDA-approved drugs.
Learn more in #ScienceSignaling: https://scim.ag/4dKehNL
Learn more in #ScienceSignaling: https://scim.ag/4dKehNL
☕Meiring, Mahapatra et al. show that expanded microtubule lattice conformations, such as those induced by small-molecule taxanes, can lead to the release of GEF-H1 and thus induce RhoA activation.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Taxane-induced conformational changes in the microtubule lattice activate GEF-H1-dependent RhoA signalling - Nature Cell Biology
Meiring, Mahapatra et al. show that expanded microtubule lattice conformations, such as those induced by small-molecule taxanes, can lead to the release of GEF-H1 and thus induce RhoA activation.
www.nature.com
September 28, 2026 at 3:01 PM
☕Meiring, Mahapatra et al. show that expanded microtubule lattice conformations, such as those induced by small-molecule taxanes, can lead to the release of GEF-H1 and thus induce RhoA activation.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Small proteins can be more complex than they look!
We know proteins fluctuate between different conformations- but by how much? How does it vary from protein to protein? Can highly stable domains have low stability segments? @ajrferrari.bsky.social experimentally tested >5,000 domains to find out!
We know proteins fluctuate between different conformations- but by how much? How does it vary from protein to protein? Can highly stable domains have low stability segments? @ajrferrari.bsky.social experimentally tested >5,000 domains to find out!
March 26, 2025 at 4:21 PM
Small proteins can be more complex than they look!
We know proteins fluctuate between different conformations- but by how much? How does it vary from protein to protein? Can highly stable domains have low stability segments? @ajrferrari.bsky.social experimentally tested >5,000 domains to find out!
We know proteins fluctuate between different conformations- but by how much? How does it vary from protein to protein? Can highly stable domains have low stability segments? @ajrferrari.bsky.social experimentally tested >5,000 domains to find out!
Our entrance into protein design! Inverse folding steered by external sources of information, and for multiple conformations. By the amazing @kaiyi94.bsky.social and @kjamali.bsky.social!
Download our code and try it yourself. 🥳
Download our code and try it yourself. 🥳
Excited to share our paper at #ICML: All-atom inverse protein folding through discrete flow matching with @kjamali.bsky.social and @sjorsscheres.bsky.social : openreview.net/forum?id=8tQdw…. If you are at ICML, let’s connect and talk generative models&protein design!
OpenReview
Promoting openness in scientific communication and the peer-review process
https://openreview.net/forum?id=8tQdw…
July 15, 2025 at 7:18 AM
Our entrance into protein design! Inverse folding steered by external sources of information, and for multiple conformations. By the amazing @kaiyi94.bsky.social and @kjamali.bsky.social!
Download our code and try it yourself. 🥳
Download our code and try it yourself. 🥳
We introduce ConforNets, a mechanism for conformational control in AlphaFold3 models
- SoTA at producing diverse conformations on every multistate benchmark (N=104)
- Novel capability: transfer state from one protein to another
Outperforms BioEmu, ConforMix and AFsample3
🧵1/8
- SoTA at producing diverse conformations on every multistate benchmark (N=104)
- Novel capability: transfer state from one protein to another
Outperforms BioEmu, ConforMix and AFsample3
🧵1/8
April 21, 2026 at 8:19 PM
We introduce ConforNets, a mechanism for conformational control in AlphaFold3 models
- SoTA at producing diverse conformations on every multistate benchmark (N=104)
- Novel capability: transfer state from one protein to another
Outperforms BioEmu, ConforMix and AFsample3
🧵1/8
- SoTA at producing diverse conformations on every multistate benchmark (N=104)
- Novel capability: transfer state from one protein to another
Outperforms BioEmu, ConforMix and AFsample3
🧵1/8
Hey dems.. stop these insane conformations today! They are danger to the American people! 🇺🇸
February 4, 2025 at 11:30 AM
Hey dems.. stop these insane conformations today! They are danger to the American people! 🇺🇸
they are indoctrinating our kids in college now by saying that proteins exist as a statistical ensemble of many different conformations. this is woke insanity. proteins have one fold, as determined by the folding energy landscapes global minimum
December 26, 2025 at 2:20 AM
they are indoctrinating our kids in college now by saying that proteins exist as a statistical ensemble of many different conformations. this is woke insanity. proteins have one fold, as determined by the folding energy landscapes global minimum
AlphaFold (the archetype): genAI to predict 3D protein structure from amino acid sequence
New ChromoGen: genAI to predict 3D genome structure from DNA sequence
www.science.org/doi/10.1126/...
New ChromoGen: genAI to predict 3D genome structure from DNA sequence
www.science.org/doi/10.1126/...
ChromoGen: Diffusion model predicts single-cell chromatin conformations
The generative AI technique dubbed ChromoGen predicts chromatin structures from DNA sequence and its accessibility.
www.science.org
February 1, 2025 at 6:47 PM
AlphaFold (the archetype): genAI to predict 3D protein structure from amino acid sequence
New ChromoGen: genAI to predict 3D genome structure from DNA sequence
www.science.org/doi/10.1126/...
New ChromoGen: genAI to predict 3D genome structure from DNA sequence
www.science.org/doi/10.1126/...
Les recherches visant à fabriquer des molécules et des cellules dites miroir, dans des conformations qui n’existent pas dans la nature, s’accélèrent. Mais devant les inconnues et les risques potentiels de cette forme de vie inédite, des spécialistes appellent à un moratoire.
Par Lise Barnéoud
Par Lise Barnéoud
De l’autre côté du miroir, la vie fait peur
Les recherches visant à fabriquer des molécules et des cellules dites miroir, dans des conformations qui n’existent pas dans la nature, s’accélèrent. Mais devant les inconnues et les risques potentiels de cette forme de vie inédite, des spécialistes appellent à un moratoire.
l.mediapart.fr
November 1, 2025 at 7:51 PM
Les recherches visant à fabriquer des molécules et des cellules dites miroir, dans des conformations qui n’existent pas dans la nature, s’accélèrent. Mais devant les inconnues et les risques potentiels de cette forme de vie inédite, des spécialistes appellent à un moratoire.
Par Lise Barnéoud
Par Lise Barnéoud