A bacterial protein fragment called corisin drives pulmonary fibrosis by infiltrating and disrupting cells' quality-control systems, researchers at the University of Illinois Urbana-Champaign and Mie…

A bacterial protein fragment called corisin drives pulmonary fibrosis by infiltrating and disrupting cells' quality-control systems, researchers at the University of Illinois Urbana-Champaign and Mie University in Japan found in a new study.

A bacterial protein fragment called corisin drives pulmonary fibrosis by infiltrating and disrupting cells' quality-control systems, researchers at the University of Illinois Urbana-Champaign and Mie ...

Scientists discovered that a gut bacteria molecule called corisin can travel to the kidneys, triggering inflammation and scarring that lead to diabetic kidney fibrosis. By attaching to albumin in the ...

A molecule made by bacteria in the gut can hitch a ride to the kidneys, where it sets off a chain reaction of inflammation, scarring and fibrosis—a serious complication of diabetes and a leading cause of kidney failure—according to a new study from researchers at the University of Illinois Urbana-Champaign and Mie University in Japan.

Japanese and U.S. researchers have found that a bacterial peptide called corisin can promote lung scarring associated with deadly idiopathic pulmonary fibrosis, offering a possible path to treatment.

A bacterial protein fragment called corisin drives pulmonary fibrosis by infiltrating and disrupting cells' quality-control systems, researchers at the University of Illinois Urbana-Champaign and Mie University in Japan found in a new study. Meanwhile, blocking corisin with an antibody impeded the damage. The researchers published their findings in Nature Communications.

2026.08.18 三重大学 プレスリリース ポイント肺線維症患者の肺から、細菌由来因子「corisin(コリシン)」の遺伝子配列を特定し、コリシンがヒトの肺内に実際...

Scientists discovered that a gut bacteria molecule called corisin can travel to the kidneys, triggering inflammation and scarring that lead to diabetic kidney fibrosis. By attaching to albumin in the ...

Here, the authors identify the microbiota-derived corisin as a driver of diabetic kidney fibrosis via cellular aging and show that targeting corisin with a monoclonal antibody alleviates disease in mi...

Onderzoekers hebben ontdekt dat een darmmolecuul nierschade veroorzaakt. Het stofje corisin reist via het bloed en richt schade aan in de nieren. Met antistoffen kon dit effect bij muizen sterk worden afgeremd. Er gloort daarmee hoop aan de horizon wat een nieuwe behandeling voor diabetici betreft...

Scientists discovered that a gut bacteria molecule called corisin can travel to the kidneys, triggering inflammation and scarring that lead to diabetic kidney fibrosis. By attaching to albumin in the ...

Scientists discovered that a gut bacteria molecule called corisin can travel to the kidneys, triggering inflammation and scarring that lead to diabetic kidney fibrosis. By attaching to albumin in the blood, corisin infiltrates kidney tissue and accelerates damage. In animal studies, antibodies that neutralize corisin slowed disease progression, offering hope for new treatments beyond dialysis and transplants.

Scientists discovered that a gut bacteria molecule called corisin can travel to the kidneys, triggering inflammation and scarring that lead to diabetic kidney fibrosis. By attaching to albumin in the blood, corisin infiltrates kidney tissue and accelerates damage. In animal studies, antibodies that neutralize corisin slowed disease progression, offering hope for new treatments beyond dialysis and transplants.

This cross-sectional study included 35 patients with diabetic chronic kidney disease (CKD) who presented to our institutions between June and December 2023. Inclusion criteria consisted of a diagnosis of DM and CKD. Patients undergoing anticancer treatment and those with incomplete...

Emerging research from the University of Illinois Urbana-Champaign in collaboration with Mie University in Japan has uncovered a pivotal role for a gut bacteria-produced molecule in driving diabetic kidney fibrosis, a leading cause of kidney failure worldwide. This molecule, known as corisin, is a small peptide secreted by Staphylococcus species residing in the human gut microbiota. Scientists have revealed that corisin can traverse the complex biological pathways from the intestine to the kidneys, where it triggers a cascade of inflammatory events culminating in cellular aging, tissue scarring, and ultimately, diminished renal function.

In a groundbreaking new study set to reshape our understanding of chronic kidney disease progression, researchers have identified a novel link between gut microbiota-derived peptides and accelerated kidney fibrosis via mechanisms tied to cellular aging. The work, published in Nature Communications, unravels how a bacterial peptide named corisin acts as a molecular catalyst, accelerating fibrotic processes that ultimately damage renal function.