Thanks to @itsmeawais.bsky.social and Lucia Gomez who carried out this work, and @silvianeuro.bsky.social and @mveronicapravata.bsky.social for the organoid assays.
Hope you enjoy the read and let us know what you think!
#Neuroscience #CorticalDevelopment #Evolution #EvoDevo

🧠 Scientific seminar @ Cajal Institute with
Dr. Teresa Guillamón (Cajal Institute/CNC): “Spontaneous activity shapes sensory circuits in the developing cortex.”
🗓 Fri, Oct 24 – 12:30 PM
Join us!
#Neuroscience #CorticalDevelopment #CNC #InstitutoCajal

🚨🧠 New in Nature: “TSC tunes progenitor balance and upper-layer neuron generation in neocortex”.

Read below 👇

DOI: doi.org/10.1038/s415...

#DevBio #EvoDevo #Neuroscience #Science #CorticalDevelopment #RadialGlia #Neocortex #Neurogenesis

Just got back from the @corticodevelopment.bsky.social conference in Giardini Naxos — such an inspiring and insightful experience. Grateful for the people, the ideas, and (of course) the Sicilian food! 🇮🇹🧠✨ #CorticalDevelopment #Sicily

LOF Slc35a2 in oligodendrocytes results in severe hypomyelination, a reduction of oligodendrocytes, and reactive gliosis.
doi.org/10.1111/epi....

#epilepsy #ILAE #epilepsia #hypomyelination #malformations #corticaldevelopment #MOGHE #Slc35a2

Abnormal HCN4 channel expression is observed at both P21 and P28 in RhebS16H neurons.
doi.org/10.1111/epi....

#epilepsy #epilepsia #ILAE #corticaldevelopment #focalcorticaldysplasia #HCNchannels #mTOR #tuberoussclerosiscomplex

New paper led by Dr. Yu Gao, a scientist in my lab, on single cell #patch-seq and #multiomics of #primate #corticaldevelopment and assessment of #autism gene #CHD8. authors.elsevier.com/c/1l7dg3BtfH...

This review outlines #CorticalDevelopment and genetic causes of malformations of cortical development, highlighting PI3K/PTEN/AKT/mTOR signaling, advances in diagnosis and models, and emerging targeted therapeutic strategies. #IntellectualDisability

Read: doi.org/10.1016/j.ge...