Upcoming exFAT Linux Driver Patch Can Boost Sequential Read Performance By ~10% - https://www.phoronix.com/news/exFAT-Faster-Seq-Reads-10p
Upcoming exFAT Linux Driver Patch Can Boost Sequential Read Performance By ~10%
A patch for the open-source exFAT file-system driver for Linux can boost the sequential read performance by about 10% in preliminary tests...
www.phoronix.com
January 17, 2026 at 1:57 AM
Upcoming exFAT Linux Driver Patch Can Boost Sequential Read Performance By ~10% - https://www.phoronix.com/news/exFAT-Faster-Seq-Reads-10p
🥂In a recent study in our journal, the authors combine single-cell transcriptomics with Patch-seq and metabolomics to dissect primate anterior insular cortex. They identify two von Economo neuron (VEN) subtypes and a VEN signal-processing strategy.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
An atlas of primate insular cortex reveals a signal-processing strategy in von Economo neurons - Nature Cell Biology
Liu, Huang, Shen, Shao, Jing and collaborators combine single-cell transcriptomics with Patch-seq and metabolomics to dissect primate anterior insular cortex. They identify two von Economo neuron (VEN...
www.nature.com
July 24, 2026 at 3:00 PM
🥂In a recent study in our journal, the authors combine single-cell transcriptomics with Patch-seq and metabolomics to dissect primate anterior insular cortex. They identify two von Economo neuron (VEN) subtypes and a VEN signal-processing strategy.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Nature research paper: Connectomics of predicted Sst transcriptomic types in mouse visual cortex
https://go.nature.com/43NhyqH
https://go.nature.com/43NhyqH
Connectomics of predicted Sst transcriptomic types in mouse visual cortex - Nature
The authors use Patch-seq and electron microscopy datasets to relate synaptic connectivity to the transcriptomic cell type of different types of inhibitory neuron.
go.nature.com
April 14, 2025 at 4:38 PM
Nature research paper: Connectomics of predicted Sst transcriptomic types in mouse visual cortex
https://go.nature.com/43NhyqH
https://go.nature.com/43NhyqH
☕Liu, Huang, Shen, Shao, Jing et al. combine single-cell transcriptomics with Patch-seq and metabolomics to dissect primate anterior insular cortex. They identify two von Economo neuron (VEN) subtypes and a VEN signal-processing strategy.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
An atlas of primate insular cortex reveals a signal-processing strategy in von Economo neurons - Nature Cell Biology
Liu, Huang, Shen, Shao, Jing and collaborators combine single-cell transcriptomics with Patch-seq and metabolomics to dissect primate anterior insular cortex. They identify two von Economo neuron (VEN...
www.nature.com
July 27, 2026 at 6:14 PM
☕Liu, Huang, Shen, Shao, Jing et al. combine single-cell transcriptomics with Patch-seq and metabolomics to dissect primate anterior insular cortex. They identify two von Economo neuron (VEN) subtypes and a VEN signal-processing strategy.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Ok this was a fun patch. Sequencer into Plaits, Seq CV to V/Oct and Seq Gate to Plaits Trggr. Plaits heavily modulated. Basimilus IA sequenced Gate to Trig and CV to BIA Decay. BIA thru Beads for effects. 2 sep audio tracks. 32-step random Euclidean from Pam’s as modulation source. Perfct random
January 19, 2025 at 6:48 AM
Ok this was a fun patch. Sequencer into Plaits, Seq CV to V/Oct and Seq Gate to Plaits Trggr. Plaits heavily modulated. Basimilus IA sequenced Gate to Trig and CV to BIA Decay. BIA thru Beads for effects. 2 sep audio tracks. 32-step random Euclidean from Pam’s as modulation source. Perfct random
BOOM! Human DRG patch-seq with Nav1.8 and Nav1.7 upregulation associated with a history pain in organ donors. www.biorxiv.org/content/10.1... Great stuff from the #PRECISIONPain Center at WashU led by @robgereau.bsky.social
Human sensory neurons exhibit cell-type-specific, pain-associated differences in intrinsic excitability and expression of SCN9A and SCN10A
Despite the prevalence of chronic pain, the approval of novel, non-opioid therapeutics has been slow. A major translational challenge in analgesic development is the difference in gene expression and ...
www.biorxiv.org
March 27, 2025 at 11:03 AM
BOOM! Human DRG patch-seq with Nav1.8 and Nav1.7 upregulation associated with a history pain in organ donors. www.biorxiv.org/content/10.1... Great stuff from the #PRECISIONPain Center at WashU led by @robgereau.bsky.social
I had a tricky clone run that had a fusion protein containing kanamycin resistance while on an Ampicillin plasmid, that I needed to clone into a kanamycin plasmid. Did a patch plate with few colonies. Growth on kan (left) but not on amp (R) while still glowy is correct clone. Got em! PCR and seq now
May 18, 2025 at 6:56 PM
I had a tricky clone run that had a fusion protein containing kanamycin resistance while on an Ampicillin plasmid, that I needed to clone into a kanamycin plasmid. Did a patch plate with few colonies. Growth on kan (left) but not on amp (R) while still glowy is correct clone. Got em! PCR and seq now
V nice #rstats R Dev Day Seattle patch now in r-devel! Team @pipinghotdata.com 🎊
Now works naturally:
seq(to=Sys.Date(), by='day', length.out=30) # 30 days ending today
seq(Sys.Date()-50, Sys.Date()) # 1-by-1 dates, no need for by=
Ancient wishlist from me!!
github.com/r-devel/r-sv...
Now works naturally:
seq(to=Sys.Date(), by='day', length.out=30) # 30 days ending today
seq(Sys.Date()-50, Sys.Date()) # 1-by-1 dates, no need for by=
Ancient wishlist from me!!
github.com/r-devel/r-sv...
seq.Date() & seq.POSIXt(): `from` now optional; refactoring "in sync" · r-devel/r-svn@faf9394
git-svn-id: https://svn.r-project.org/R/trunk@87502 00db46b3-68df-0310-9c12-caf00c1e9a41
github.com
January 2, 2025 at 2:23 PM
V nice #rstats R Dev Day Seattle patch now in r-devel! Team @pipinghotdata.com 🎊
Now works naturally:
seq(to=Sys.Date(), by='day', length.out=30) # 30 days ending today
seq(Sys.Date()-50, Sys.Date()) # 1-by-1 dates, no need for by=
Ancient wishlist from me!!
github.com/r-devel/r-sv...
Now works naturally:
seq(to=Sys.Date(), by='day', length.out=30) # 30 days ending today
seq(Sys.Date()-50, Sys.Date()) # 1-by-1 dates, no need for by=
Ancient wishlist from me!!
github.com/r-devel/r-sv...
If you find microglia genes in your neuronal patch-seq datasets have no fear, it's been reported before and can be computationally cleaned out. www.cell.com/iscience/ful...
Investigating microglia-neuron crosstalk by characterizing microglial contamination in human and mouse patch-seq datasets
Cellular neuroscience; Techniques in neuroscience; Transcriptomics
www.cell.com
January 21, 2025 at 2:04 PM
If you find microglia genes in your neuronal patch-seq datasets have no fear, it's been reported before and can be computationally cleaned out. www.cell.com/iscience/ful...
Even with my love of omics, we've patched hundreds cells for an ongoing patch-seq project in Oxford and there just isn't a good alternative to an expert at a rig
February 25, 2025 at 1:38 PM
Even with my love of omics, we've patched hundreds cells for an ongoing patch-seq project in Oxford and there just isn't a good alternative to an expert at a rig
Realized it would be fun to patch a Boundary Layer function with a seq where the seq controls the Bound input of the function (which opens lpg)
Seq out mult'd to a quantizer & pitch input so the higher the sequencer step the higher the pitch but the shorter and less loud the played note
#eurorack
Seq out mult'd to a quantizer & pitch input so the higher the sequencer step the higher the pitch but the shorter and less loud the played note
#eurorack
October 23, 2025 at 11:58 PM
Realized it would be fun to patch a Boundary Layer function with a seq where the seq controls the Bound input of the function (which opens lpg)
Seq out mult'd to a quantizer & pitch input so the higher the sequencer step the higher the pitch but the shorter and less loud the played note
#eurorack
Seq out mult'd to a quantizer & pitch input so the higher the sequencer step the higher the pitch but the shorter and less loud the played note
#eurorack
Seq 2025.2 is on its way later today!
This patch includes a few changes that missed the cut-off for inclusion in 2025.1; you can check out what's coming in: github.com/datalust/seq...
This patch includes a few changes that missed the cut-off for inclusion in 2025.1; you can check out what's coming in: github.com/datalust/seq...
datalust/seq-tickets
Issues, design discussions and feature roadmap for the Seq log server - datalust/seq-tickets
github.com
June 17, 2025 at 11:12 PM
Seq 2025.2 is on its way later today!
This patch includes a few changes that missed the cut-off for inclusion in 2025.1; you can check out what's coming in: github.com/datalust/seq...
This patch includes a few changes that missed the cut-off for inclusion in 2025.1; you can check out what's coming in: github.com/datalust/seq...
Connectomics of predicted Sst transcriptomic types in mouse visual cortex
www.nature.com/articles/s41...
🥰🥰🥰
www.nature.com/articles/s41...
🥰🥰🥰
Connectomics of predicted Sst transcriptomic types in mouse visual cortex - Nature
The authors use Patch-seq and electron microscopy datasets to relate synaptic connectivity to the transcriptomic cell type of different types of inhibitory neuron.
www.nature.com
April 18, 2025 at 3:58 AM
Connectomics of predicted Sst transcriptomic types in mouse visual cortex
www.nature.com/articles/s41...
🥰🥰🥰
www.nature.com/articles/s41...
🥰🥰🥰
🎛️ Dive into deep sound design with Machina, the $29 VST3 synth from T3kNo-Logic. Intuitive controls, powerful engine. Share your favorite synth patch idea! gumroad.com/l/mzkks #IndieHustle
Machina VST
Bio-cyber synth. $29 VST3 — waveforms, 16-step seq, FX. thenftmatrix.gumroad.com/l/mzkks
thenftmatrix.gumroad.com
September 17, 2026 at 4:00 PM
🎛️ Dive into deep sound design with Machina, the $29 VST3 synth from T3kNo-Logic. Intuitive controls, powerful engine. Share your favorite synth patch idea! gumroad.com/l/mzkks #IndieHustle
🍰Read also the News & Views article written by Roman A. Romanov:
👉https://rdcu.be/fwgUy
www.nature.com/articles/s41...
👉https://rdcu.be/fwgUy
www.nature.com/articles/s41...
Primate neurons with special signalling logic - Nature Cell Biology
Von Economo neurons are linked to higher cognition but remain poorly understood. A study now combines Patch-seq and transcriptomics in macaques to define their molecular identity, diversity and signal...
www.nature.com
July 27, 2026 at 6:14 PM
🍰Read also the News & Views article written by Roman A. Romanov:
👉https://rdcu.be/fwgUy
www.nature.com/articles/s41...
👉https://rdcu.be/fwgUy
www.nature.com/articles/s41...
👍A comprehensive atlas of cell types in the mouse cochlear nucleus using Patch-seq and snRNA-seq buff.ly/4gGjSmZ
Molecular logic for cellular specializations that initiate the auditory parallel processing pathways - Nature Communications
Neurons in cochlear nucleus are highly specialized for neural coding of sounds. Here, authors show all cochlear nucleus cell types are defined by distinct transcriptomic profiles, thus uncovering the molecular logic driving cellular specialization.
buff.ly
June 1, 2026 at 10:33 AM
👍A comprehensive atlas of cell types in the mouse cochlear nucleus using Patch-seq and snRNA-seq buff.ly/4gGjSmZ
Interesting. We observed similar shift of inter-trial activity between air puffs in a previous study: www.nature.com/articles/s41.... No humans and no Ketamine in there, only mice. But we can trigger the same shift with subcortical stimulation (hypothalamus/habenula projection).
Esr1+ hypothalamic-habenula neurons shape aversive states - Nature Neuroscience
The authors find a surprising diversity in hypothalamic neurons projecting to habenula, and using patch-sequencing (Patch-seq), identify an estrogen receptor-expressing neuron type that signals aversi...
www.nature.com
June 1, 2025 at 5:48 PM
Interesting. We observed similar shift of inter-trial activity between air puffs in a previous study: www.nature.com/articles/s41.... No humans and no Ketamine in there, only mice. But we can trigger the same shift with subcortical stimulation (hypothalamus/habenula projection).
Spindle neurons in human cortex show unique firing and transcriptomic profiles, revealed by studying 134 cells with patch clamp and 124 with RNA-seq. Fascinating insights! PMID:42120382, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-72935-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
Spindle neurons in human cortex possess distinctive firing properties and transcriptomic signatures | Nature Communications
Spindle neurons (SPNs), also known as von Economo neurons (VENs), are predominantly found in large-brained species including humans. SPNs in human neocortex are implicated in cognitive functions and affected in various brain disorders. Despite their unique morphology, whether SPNs possess distinctive electrophysiological properties and transcriptomic identities remains unclear. Here, we performed whole-cell patch clamp recording (134 cells) together with RNA-sequencing (patch-seq, 124 cells) on visually identified SPNs and pyramidal cells (PCs) in human cortical slices. Compared with putative extratelencephalic-projecting PCs, SPNs possess less complex proximal apical dendrites and emanate axons from the basal dendritic trunk. Additionally, they exhibit heightened excitability and characteristic firing properties, including robust bursting and persistent firing pattern. Patch-seq analysis revealed transcriptomic heterogeneity within SPNs, and identified their fingerprint genes. Collect
doi.org
June 15, 2026 at 10:00 AM
Going to #SfN23? Don't miss our satellite event! We will demonstrate how to access the #openscience resources available from Allen Brain Map including transcriptomic, ephys, morphology, and multimodal patch-seq datasets.
Learn more and register alleninstitute.org/events/sfn20...
Learn more and register alleninstitute.org/events/sfn20...
November 2, 2023 at 5:25 PM
Going to #SfN23? Don't miss our satellite event! We will demonstrate how to access the #openscience resources available from Allen Brain Map including transcriptomic, ephys, morphology, and multimodal patch-seq datasets.
Learn more and register alleninstitute.org/events/sfn20...
Learn more and register alleninstitute.org/events/sfn20...
We've just pushed a tiny 2025.1 patch that fixes indexing on single-core machines/containers 😅
Multi-core boxes are unaffected and can ignore this one.
github.com/datalust/seq...
Multi-core boxes are unaffected and can ignore this one.
github.com/datalust/seq...
2025.1 Patch 1 Milestone · datalust/seq-tickets
Issues, design discussions and feature roadmap for the Seq log server - 2025.1 Patch 1 Milestone · datalust/seq-tickets
github.com
May 22, 2025 at 12:59 AM
We've just pushed a tiny 2025.1 patch that fixes indexing on single-core machines/containers 😅
Multi-core boxes are unaffected and can ignore this one.
github.com/datalust/seq...
Multi-core boxes are unaffected and can ignore this one.
github.com/datalust/seq...
Today's tiny quality-of-life improvement:
If you regularly use the "From now" date range option, grab the latest 2025.1 patch and try Ctrl+Space N 💡
github.com/datalust/seq...
If you regularly use the "From now" date range option, grab the latest 2025.1 patch and try Ctrl+Space N 💡
github.com/datalust/seq...
June 2, 2025 at 12:15 AM
Today's tiny quality-of-life improvement:
If you regularly use the "From now" date range option, grab the latest 2025.1 patch and try Ctrl+Space N 💡
github.com/datalust/seq...
If you regularly use the "From now" date range option, grab the latest 2025.1 patch and try Ctrl+Space N 💡
github.com/datalust/seq...
Making music relying heavily on random generators (patch/seq) or even worse, AI. Where is your musical voice in any of this? How can a voice develop in this environment? How is any part of you expressed in this way? The illusion of choice is not even a phantom of creativity. LEGO-ass music.
November 27, 2024 at 12:01 AM
Making music relying heavily on random generators (patch/seq) or even worse, AI. Where is your musical voice in any of this? How can a voice develop in this environment? How is any part of you expressed in this way? The illusion of choice is not even a phantom of creativity. LEGO-ass music.
In Search of Transcriptomic Correlates of Neuronal Firing-Rate Adaptation across Subtypes, Regions and Species: A Patch-seq Analysis https://www.biorxiv.org/content/10.1101/2024.12.05.627057v1
December 10, 2024 at 1:15 PM
In Search of Transcriptomic Correlates of Neuronal Firing-Rate Adaptation across Subtypes, Regions and Species: A Patch-seq Analysis https://www.biorxiv.org/content/10.1101/2024.12.05.627057v1
In Search of Transcriptomic Correlates of Neuronal Firing-Rate Adaptation across Subtypes, Regions and Species: A Patch-seq Analysis https://www.biorxiv.org/content/10.1101/2024.12.05.627057v1
December 10, 2024 at 1:15 PM
In Search of Transcriptomic Correlates of Neuronal Firing-Rate Adaptation across Subtypes, Regions and Species: A Patch-seq Analysis https://www.biorxiv.org/content/10.1101/2024.12.05.627057v1