The molecular mechanisms of hair greying and how to prevent it
"Dedifferentiation maintains melanocyte stem cells in a dynamic niche"
www.nature.com/articles/s41...
"Dedifferentiation maintains melanocyte stem cells in a dynamic niche"
www.nature.com/articles/s41...
March 10, 2025 at 1:28 AM
The molecular mechanisms of hair greying and how to prevent it
"Dedifferentiation maintains melanocyte stem cells in a dynamic niche"
www.nature.com/articles/s41...
"Dedifferentiation maintains melanocyte stem cells in a dynamic niche"
www.nature.com/articles/s41...
Mouse stem cells that regenerate muscle are derived by organoid dedifferentiation of myoblasts go.nature.com/47lBikW
rdcu.be/ereQN
rdcu.be/ereQN
Organoid culture promotes dedifferentiation of mouse myoblasts into stem cells capable of complete muscle regeneration - Nature Biotechnology
Mouse stem cells that regenerate muscle are derived by organoid dedifferentiation of myoblasts.
go.nature.com
June 18, 2025 at 1:17 PM
Mouse stem cells that regenerate muscle are derived by organoid dedifferentiation of myoblasts go.nature.com/47lBikW
rdcu.be/ereQN
rdcu.be/ereQN
James Nowotny @umaryland.edu - blastema formation in annelid regeneration #PASEDB2025 #regeneration #worm #dedifferentiation
July 24, 2025 at 6:22 PM
James Nowotny @umaryland.edu - blastema formation in annelid regeneration #PASEDB2025 #regeneration #worm #dedifferentiation
Plants are unique in that single somatic cells have the remarkable potential to dedifferentiate and regenerate entirely new plants. However, the cell types and regulatory dynamics enabling dedifferentiation competence have not been fully explored... until now ⬇️ (1/12)
May 23, 2026 at 2:54 PM
Plants are unique in that single somatic cells have the remarkable potential to dedifferentiate and regenerate entirely new plants. However, the cell types and regulatory dynamics enabling dedifferentiation competence have not been fully explored... until now ⬇️ (1/12)
Thrilled to announce our newest preprint on #dedifferentiation in Arabidopsis 🧬🌱. We used scRNA-seq and hormone treatments to track transcriptional reprogramming in diverse somatic cell types and found what we think is some pretty cool biology. Feedback welcome! www.biorxiv.org/content/10.6...
www.biorxiv.org
May 22, 2026 at 2:20 PM
Thrilled to announce our newest preprint on #dedifferentiation in Arabidopsis 🧬🌱. We used scRNA-seq and hormone treatments to track transcriptional reprogramming in diverse somatic cell types and found what we think is some pretty cool biology. Feedback welcome! www.biorxiv.org/content/10.6...
🎄 Day 14 of the 24 Days of Development ✨🧬
Interested in the history of cellular dedifferentiation🧫? Explore Betty Hay’s pioneering contributions and how her work continues to shape regeneration biology🦎 doi.org/10.1016/j.yd...
Interested in the history of cellular dedifferentiation🧫? Explore Betty Hay’s pioneering contributions and how her work continues to shape regeneration biology🦎 doi.org/10.1016/j.yd...
December 14, 2025 at 5:18 PM
🎄 Day 14 of the 24 Days of Development ✨🧬
Interested in the history of cellular dedifferentiation🧫? Explore Betty Hay’s pioneering contributions and how her work continues to shape regeneration biology🦎 doi.org/10.1016/j.yd...
Interested in the history of cellular dedifferentiation🧫? Explore Betty Hay’s pioneering contributions and how her work continues to shape regeneration biology🦎 doi.org/10.1016/j.yd...
New paper alert! 🚨 We show that age-related neural dedifferentiation in scene-selective cortex is tied to changes in eye movements. Using simultaneous fMRI + eye-tracking, we found that younger adults’ fixations covary with scene specificity, but this link weakens with age.
Link in post below 👇
Link in post below 👇
September 22, 2025 at 8:59 PM
New paper alert! 🚨 We show that age-related neural dedifferentiation in scene-selective cortex is tied to changes in eye movements. Using simultaneous fMRI + eye-tracking, we found that younger adults’ fixations covary with scene specificity, but this link weakens with age.
Link in post below 👇
Link in post below 👇
When I see some molecular player in this kind of adaptive, environmentally sensitive switching of cell state (here including dedifferentiation to an intestinal stem-cell-like state), I figure it's going to include the following. /2
October 1, 2026 at 7:12 PM
When I see some molecular player in this kind of adaptive, environmentally sensitive switching of cell state (here including dedifferentiation to an intestinal stem-cell-like state), I figure it's going to include the following. /2
And I hadn't heard about dedifferentiation in this context. It must be tightly regulated because there are so many things that could go wrong as, in this paper, colon cancer.
October 1, 2026 at 10:33 PM
And I hadn't heard about dedifferentiation in this context. It must be tightly regulated because there are so many things that could go wrong as, in this paper, colon cancer.
2nd Best Student Talk award is for James Nowotny @umaryland.edu ! Congrats! Identifying cell dedifferentiation process of annelid regeneration process #PASEDB2025 #worms #regeneration
July 25, 2025 at 8:29 PM
2nd Best Student Talk award is for James Nowotny @umaryland.edu ! Congrats! Identifying cell dedifferentiation process of annelid regeneration process #PASEDB2025 #worms #regeneration
Lactate dehydrogenase A (#LDHA)-driven metabolic and epigenetic reprogramming in beta cell dedifferentiation during diabetes development, identifying LDHA inhibition as a promising therapeutic target. #DiabetesResearch #Pancreatic-β-cell #Dedifferentiaton link.springer.com/article/10.1...
LDHA induces beta cell dedifferentiation in diabetes through metabolic and epigenetic reprogramming - Diabetologia
Aims/hypothesis Pancreatic beta cell dedifferentiation underlies the reversible reduction in beta cell mass and function in diabetes. Exploratory research into interventional targets and adjuvant ther...
link.springer.com
December 22, 2025 at 10:58 AM
Lactate dehydrogenase A (#LDHA)-driven metabolic and epigenetic reprogramming in beta cell dedifferentiation during diabetes development, identifying LDHA inhibition as a promising therapeutic target. #DiabetesResearch #Pancreatic-β-cell #Dedifferentiaton link.springer.com/article/10.1...
It still surprises me just how little we know. Basically everything you touched on there- intrinsic disorder, dedifferentiation, condensates has only been uncovered in the ~15 years and these are fundamental aspects of how biology works. Imagine what we'll know in 15 years. Impossible to predict.
October 1, 2026 at 7:32 PM
It still surprises me just how little we know. Basically everything you touched on there- intrinsic disorder, dedifferentiation, condensates has only been uncovered in the ~15 years and these are fundamental aspects of how biology works. Imagine what we'll know in 15 years. Impossible to predict.
🧪 Epigenetic inheritance of acquired traits via stem cells dedifferentiation/differentiation or transdifferentiation cycles by Arshak Alexanian
thenode.biologists.com/epigenetic-i...
thenode.biologists.com/epigenetic-i...
Epigenetic inheritance of acquired traits via stem cells dedifferentiation/differentiation or transdifferentiation cycles - the Node
Do cells carry memories of the whole body into the next generation? For more than two millennia, biologists and philosophers have debated whether traits
thenode.biologists.com
February 10, 2026 at 12:12 PM
🧪 Epigenetic inheritance of acquired traits via stem cells dedifferentiation/differentiation or transdifferentiation cycles by Arshak Alexanian
thenode.biologists.com/epigenetic-i...
thenode.biologists.com/epigenetic-i...
“Loss of wnt10a or of Wnt/β-catenin activity blocks the [osteoblast] dedifferentiation program, whereas wnt10a overexpression enhances dedifferentiation and is sufficient to induce it even without injury.”
New work from Weidinger Lab at Uni-Ulm 🐟
New work from Weidinger Lab at Uni-Ulm 🐟
Wnt/β-catenin signaling promotes zebrafish osteoblast dedifferentiation by wnt10a-mediated inhibition of NF-κB https://www.biorxiv.org/content/10.64898/2025.12.29.696582v1
January 2, 2026 at 12:07 PM
“Loss of wnt10a or of Wnt/β-catenin activity blocks the [osteoblast] dedifferentiation program, whereas wnt10a overexpression enhances dedifferentiation and is sufficient to induce it even without injury.”
New work from Weidinger Lab at Uni-Ulm 🐟
New work from Weidinger Lab at Uni-Ulm 🐟
Endocrine dysfunction and #diabetes is promoted by β cell dedifferentiation and loss of cellular identity in people with Wolfram syndrome, and ameliorated by inhibition of TXNIP #islets #genetics www.science.org/doi/10.1126/...
β cell dedifferentiation, the underlying mechanism of diabetes in Wolfram syndrome
β cell dedifferentiation underlies diabetes mellitus in Wolfram syndrome, and Txnip inhibition prevents β cell regression in Wfs1-deficient mice.
www.science.org
February 19, 2025 at 7:19 PM
Endocrine dysfunction and #diabetes is promoted by β cell dedifferentiation and loss of cellular identity in people with Wolfram syndrome, and ameliorated by inhibition of TXNIP #islets #genetics www.science.org/doi/10.1126/...
New paper in Imaging Neuroscience by Saana M. Korkki, Alireza Salami, et al:
Dedifferentiation of caudate functional organization is linked to reduced D1 dopamine receptor availability and poorer memory function in aging
doi.org/10.1162/imag...
Dedifferentiation of caudate functional organization is linked to reduced D1 dopamine receptor availability and poorer memory function in aging
doi.org/10.1162/imag...
February 5, 2025 at 6:57 AM
New paper in Imaging Neuroscience by Saana M. Korkki, Alireza Salami, et al:
Dedifferentiation of caudate functional organization is linked to reduced D1 dopamine receptor availability and poorer memory function in aging
doi.org/10.1162/imag...
Dedifferentiation of caudate functional organization is linked to reduced D1 dopamine receptor availability and poorer memory function in aging
doi.org/10.1162/imag...
Identification of interactions among adipocytes, immune cells and beta cells in the pancreas microenvironment might contribute to beta cell failure and dedifferentiation in type 2 #diabetes @diabetologiajnl.bsky.social link.springer.com/article/10.1...
Intrapancreatic adipocytes and beta cell dedifferentiation in human type 2 diabetes - Diabetologia
Aims/hypothesis Fat deposition in the pancreas is implicated in beta cell dysfunction and the progress of type 2 diabetes. However, there is limited evidence to confirm the correlation and explore how...
link.springer.com
March 12, 2025 at 10:08 AM
Identification of interactions among adipocytes, immune cells and beta cells in the pancreas microenvironment might contribute to beta cell failure and dedifferentiation in type 2 #diabetes @diabetologiajnl.bsky.social link.springer.com/article/10.1...
Pre-mRNA splicing regulates cellular dedifferentiation via lipid metabolism in a cytokinin-dependent manner in Arabidopsis (Ami Takeuchi , Toshiki Ishikawa , Toshihiro Arae , et al) doi.org/10.1093/plph... #PlantScience @aspbofficial
August 28, 2026 at 5:22 PM
Pre-mRNA splicing regulates cellular dedifferentiation via lipid metabolism in a cytokinin-dependent manner in Arabidopsis (Ami Takeuchi , Toshiki Ishikawa , Toshihiro Arae , et al) doi.org/10.1093/plph... #PlantScience @aspbofficial
Welcome the Blue Exodus with a new preprint collab with my old gaff @mcf-uom.bsky.social @Ashelab
www.biorxiv.org/content/10.1...
Cytoneme-dependent BMP signalling promotes stem cell fitness and is necessary for dedifferentiation in the #Drosophila ovarian germline
www.biorxiv.org/content/10.1...
Cytoneme-dependent BMP signalling promotes stem cell fitness and is necessary for dedifferentiation in the #Drosophila ovarian germline
Ovarian germline stem cell dedifferentiation is cytoneme-dependent
Progenitor cell dedifferentiation is important for stem cell maintenance during tissue repair and age-related stem cell decline. Here, we use Drosophila ovarian germ cells as a model to study the role...
www.biorxiv.org
November 20, 2024 at 10:49 PM
Welcome the Blue Exodus with a new preprint collab with my old gaff @mcf-uom.bsky.social @Ashelab
www.biorxiv.org/content/10.1...
Cytoneme-dependent BMP signalling promotes stem cell fitness and is necessary for dedifferentiation in the #Drosophila ovarian germline
www.biorxiv.org/content/10.1...
Cytoneme-dependent BMP signalling promotes stem cell fitness and is necessary for dedifferentiation in the #Drosophila ovarian germline
1970s: C.elegans as a model system; Stem cell therapy; Regeneration by dedifferentiation and/or transdifferentiation; Transgenesis; Complete lineage of an animal; Genetics of pattern formation; Epithelial adult stem cells; Stem cell niche; In vitro fertilization.
February 4, 2025 at 6:12 PM
1970s: C.elegans as a model system; Stem cell therapy; Regeneration by dedifferentiation and/or transdifferentiation; Transgenesis; Complete lineage of an animal; Genetics of pattern formation; Epithelial adult stem cells; Stem cell niche; In vitro fertilization.
IL-17RA signaling promotes the dedifferentiation of Paneth progenitors through ADAM17 to regenerate gut epithelium post-irradiation @natcomms.nature.com
www.nature.com/articles/s41... @stonybrooku.bsky.social
www.nature.com/articles/s41... @stonybrooku.bsky.social
March 17, 2026 at 6:23 PM
IL-17RA signaling promotes the dedifferentiation of Paneth progenitors through ADAM17 to regenerate gut epithelium post-irradiation @natcomms.nature.com
www.nature.com/articles/s41... @stonybrooku.bsky.social
www.nature.com/articles/s41... @stonybrooku.bsky.social
Cell-specific dedifferentiation in Arabidopsis thaliana https://www.biorxiv.org/content/10.64898/2026.05.21.726904v1
May 22, 2026 at 6:03 AM
Cell-specific dedifferentiation in Arabidopsis thaliana https://www.biorxiv.org/content/10.64898/2026.05.21.726904v1
We found that despite the existence of a conserved dedifferentiation program (activated at the onset of dedifferentiation), cell fate transitions are highly heterogeneous. Even when initiated from the same starting cell! What promotes this diversity in reprogramming remains to be discovered.
May 23, 2026 at 2:54 PM
We found that despite the existence of a conserved dedifferentiation program (activated at the onset of dedifferentiation), cell fate transitions are highly heterogeneous. Even when initiated from the same starting cell! What promotes this diversity in reprogramming remains to be discovered.
The brain represents the world around us as a series of neural states - stable patterns of activity that change as we move from one event to the next.
New paper by @selmalugtmeijer.bsky.social showing that neural states get longer as people age. #PsychSciSky
nature.com/articles/s42003-025-08792-4
New paper by @selmalugtmeijer.bsky.social showing that neural states get longer as people age. #PsychSciSky
nature.com/articles/s42003-025-08792-4
Temporal dedifferentiation of neural states with age during naturalistic viewing - Communications Biology
Movie fMRI data reveals age-related lengthening of neural states in visual and prefrontal regions, reflecting reduced temporal differentiation while preserved alignment with perceived events suggests stable coarse event segmentation.
www.nature.com
September 30, 2025 at 4:03 PM
The brain represents the world around us as a series of neural states - stable patterns of activity that change as we move from one event to the next.
New paper by @selmalugtmeijer.bsky.social showing that neural states get longer as people age. #PsychSciSky
nature.com/articles/s42003-025-08792-4
New paper by @selmalugtmeijer.bsky.social showing that neural states get longer as people age. #PsychSciSky
nature.com/articles/s42003-025-08792-4