This is specifically about Virginia which has the largest concentration of DPCs in the world, but the issues it highlights pertain to DPCs no matter where they’re located.
youtu.be/fAPusgiz4B8?...
youtu.be/fAPusgiz4B8?...
Hidden Costs of the Cloud: Data Centers in Virginia
YouTube video by Piedmont Environmental Council
youtu.be
April 29, 2026 at 9:23 PM
This is specifically about Virginia which has the largest concentration of DPCs in the world, but the issues it highlights pertain to DPCs no matter where they’re located.
youtu.be/fAPusgiz4B8?...
youtu.be/fAPusgiz4B8?...
July 21, 2025 at 12:59 PM
Charlotte from DPCS Studio created an entire "random brand" using RANDOM.ORG and AI tools - and documented the whole process. We love it when people get creative with our randomness.
A fun & fab read from DPCS Studio:
www.dpcstudio.org/random-brand
#Creativity #BrandDesign #Randomness #AI
A fun & fab read from DPCS Studio:
www.dpcstudio.org/random-brand
#Creativity #BrandDesign #Randomness #AI
Random Brand — DPCS
www.dpcstudio.org
May 12, 2026 at 11:18 AM
Charlotte from DPCS Studio created an entire "random brand" using RANDOM.ORG and AI tools - and documented the whole process. We love it when people get creative with our randomness.
A fun & fab read from DPCS Studio:
www.dpcstudio.org/random-brand
#Creativity #BrandDesign #Randomness #AI
A fun & fab read from DPCS Studio:
www.dpcstudio.org/random-brand
#Creativity #BrandDesign #Randomness #AI
Out now in @science.org
DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality | Science www.science.org/doi/10.1126/...
DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality | Science www.science.org/doi/10.1126/...
DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality
DNA-protein cross-links (DPCs) are highly toxic DNA lesions that block replication and transcription, but their impact on organismal physiology is unclear. We identified a role for the metalloprotease...
www.science.org
January 30, 2026 at 12:34 PM
Out now in @science.org
DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality | Science www.science.org/doi/10.1126/...
DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality | Science www.science.org/doi/10.1126/...
Godspeed little DPCs! 😋
January 17, 2025 at 11:03 PM
Godspeed little DPCs! 😋
Happy to share a review written with the wonderful @jstingele.bsky.social on transcription-coupled DPC repair, featuring an overview of new methods, close comparison with TC-NER, comments on clinical implications and plenty of discussion of the unknowns.
www.cell.com/trends/cell-...
www.cell.com/trends/cell-...
Transcription-coupled repair of DNA–protein crosslinks
DNA–protein crosslinks (DPCs) are highly toxic DNA lesions that are relevant to multiple
human diseases. They are caused by various endogenous and environmental agents, and
from the actions of enzymes...
www.cell.com
December 2, 2024 at 7:39 AM
Happy to share a review written with the wonderful @jstingele.bsky.social on transcription-coupled DPC repair, featuring an overview of new methods, close comparison with TC-NER, comments on clinical implications and plenty of discussion of the unknowns.
www.cell.com/trends/cell-...
www.cell.com/trends/cell-...
This is about Virginia specifically, but the problems it highlights affect DPCs no matter where they are. They must be stopped. They will be the death of us. The people who are profiting from them are the people who should pay for them, NOT taxpayers thru subsidies.
youtu.be/fAPusgiz4B8?...
youtu.be/fAPusgiz4B8?...
Hidden Costs of the Cloud: Data Centers in Virginia
YouTube video by Piedmont Environmental Council
youtu.be
June 1, 2026 at 4:12 PM
This is about Virginia specifically, but the problems it highlights affect DPCs no matter where they are. They must be stopped. They will be the death of us. The people who are profiting from them are the people who should pay for them, NOT taxpayers thru subsidies.
youtu.be/fAPusgiz4B8?...
youtu.be/fAPusgiz4B8?...
Unrepaired DNA-protein crosslinks cause a process that leads to premature aging and embryonic lethality in mice.
The findings in Science reveal a previously unrecognized link between defective DNA repair and immune-driven inflammatory disease. https://scim.ag/4qdZWf9
The findings in Science reveal a previously unrecognized link between defective DNA repair and immune-driven inflammatory disease. https://scim.ag/4qdZWf9
DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality
DNA-protein cross-links (DPCs) are highly toxic DNA lesions that block replication and transcription, but their impact on organismal physiology is unclear. We identified a role for the metalloprotease...
www.science.org
February 4, 2026 at 8:25 PM
Unrepaired DNA-protein crosslinks cause a process that leads to premature aging and embryonic lethality in mice.
The findings in Science reveal a previously unrecognized link between defective DNA repair and immune-driven inflammatory disease. https://scim.ag/4qdZWf9
The findings in Science reveal a previously unrecognized link between defective DNA repair and immune-driven inflammatory disease. https://scim.ag/4qdZWf9
As a chief election officer running a precinct in PWC, I agree. These letters always go out on Friday with tips and things to watch for; we've also had specific training around DPCs. Eric Olsen always does a good job.
April 18, 2026 at 10:22 PM
As a chief election officer running a precinct in PWC, I agree. These letters always go out on Friday with tips and things to watch for; we've also had specific training around DPCs. Eric Olsen always does a good job.
Researchers have identified cullin E3 ubiquitin ligase Rtt101p as key player in repairing DNA−protein crosslinks (DPCs) during #DNA #replication. Rtt101p's role is crucial across #cellCycle phases, ensuring genomic integrity. #Yeast #Genetics #CellBiology www.yeastgenome.org/reference/39...
November 12, 2025 at 10:16 PM
Researchers have identified cullin E3 ubiquitin ligase Rtt101p as key player in repairing DNA−protein crosslinks (DPCs) during #DNA #replication. Rtt101p's role is crucial across #cellCycle phases, ensuring genomic integrity. #Yeast #Genetics #CellBiology www.yeastgenome.org/reference/39...
Good! They will be the death of us if they aren’t stopped. This film is from Virginia but it highlights the issues that come with DPCs no matter where they are.
youtu.be/fAPusgiz4B8?...
youtu.be/fAPusgiz4B8?...
Hidden Costs of the Cloud: Data Centers in Virginia
YouTube video by Piedmont Environmental Council
youtu.be
May 27, 2026 at 9:18 PM
Good! They will be the death of us if they aren’t stopped. This film is from Virginia but it highlights the issues that come with DPCs no matter where they are.
youtu.be/fAPusgiz4B8?...
youtu.be/fAPusgiz4B8?...
Really glad Houston went well.
It was probably the most fluid broadcast I've been apart of so far, but also the matches were clean until the DPCs the end.
Proud of how I'm finally getting sleep before casting weekends instead of being worried all the time......
It was probably the most fluid broadcast I've been apart of so far, but also the matches were clean until the DPCs the end.
Proud of how I'm finally getting sleep before casting weekends instead of being worried all the time......
March 27, 2026 at 8:59 PM
Really glad Houston went well.
It was probably the most fluid broadcast I've been apart of so far, but also the matches were clean until the DPCs the end.
Proud of how I'm finally getting sleep before casting weekends instead of being worried all the time......
It was probably the most fluid broadcast I've been apart of so far, but also the matches were clean until the DPCs the end.
Proud of how I'm finally getting sleep before casting weekends instead of being worried all the time......
More on "persistent" vs "non-persistent" autism?--study of N=213 children (N=134 persistent, N=79 non) link.springer.com/article/10.1... 32.1% of children classified as "persistent" had ADHD, 34.3% had ID, 6% had anxiety; vs 19%, 0%, 7.6% of children classified as "non-persistent," respectively?
Developmental and Psychiatric Conditions Among 5–7 Year Old Children with Non-persistent and Persistent Autism - Journal of Autism and Developmental Disorders
To describe the types and frequency of developmental and psychiatric conditions (DPCs) in early school-age children who were diagnosed with ASD as toddlers and to compare rates of DPCs in children who...
link.springer.com
November 12, 2024 at 11:32 AM
More on "persistent" vs "non-persistent" autism?--study of N=213 children (N=134 persistent, N=79 non) link.springer.com/article/10.1... 32.1% of children classified as "persistent" had ADHD, 34.3% had ID, 6% had anxiety; vs 19%, 0%, 7.6% of children classified as "non-persistent," respectively?
Today, cinnamon trees are grown for 2 years, then coppiced, peeled, and dried. The tree stumps sprout new limbs. Some of the bark is sold whole in flakes or quills; some is powdered. www.youtube.com/watch?v=DPCs...
Did you know cinnamon is actually the bark of a tree? See it's fascinating farm to fork journey
YouTube video by Eat Happy Project
www.youtube.com
December 1, 2024 at 7:27 PM
Today, cinnamon trees are grown for 2 years, then coppiced, peeled, and dried. The tree stumps sprout new limbs. Some of the bark is sold whole in flakes or quills; some is powdered. www.youtube.com/watch?v=DPCs...
'DNA-protein cross-links (DPCs) are highly toxic DNA lesions that block replication and transcription, but their impact on organismal physiology is unclear. We identified a role for the metalloprotease SPRTN in preventing DPC-driven immunity and its pathological consequences.'
DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality
DNA-protein cross-links (DPCs) are highly toxic DNA lesions that block replication and transcription, but their impact on organismal physiology is unclear. We identified a role for the metalloprotease...
www.science.org
February 10, 2026 at 9:41 AM
'DNA-protein cross-links (DPCs) are highly toxic DNA lesions that block replication and transcription, but their impact on organismal physiology is unclear. We identified a role for the metalloprotease SPRTN in preventing DPC-driven immunity and its pathological consequences.'
Excellent video from Virginia which has the largest concentration of DPCs in the world. Stop ‘em
If you can. Vote for people who are committed to stopping them!
youtu.be/fAPusgiz4B8?...
If you can. Vote for people who are committed to stopping them!
youtu.be/fAPusgiz4B8?...
Hidden Costs of the Cloud: Data Centers in Virginia
YouTube video by Piedmont Environmental Council
youtu.be
May 16, 2026 at 11:46 AM
Excellent video from Virginia which has the largest concentration of DPCs in the world. Stop ‘em
If you can. Vote for people who are committed to stopping them!
youtu.be/fAPusgiz4B8?...
If you can. Vote for people who are committed to stopping them!
youtu.be/fAPusgiz4B8?...
(BioRxiv All) Living Cells Employ Ubiquitin-Proteasomal System and Nucleotide Excision Repair Pathways to Remove Reactive Oxygen Species-Induced DNA-Protein Crosslinks (ROS-DPCs).: Oxidative DNA damage caused by endogenous reactive oxygen species (ROS) is a key driver of… #BioRxiv #MassSpecRSS
Living Cells Employ Ubiquitin-Proteasomal System and Nucleotide Excision Repair Pathways to Remove Reactive Oxygen Species-Induced DNA-Protein Crosslinks (ROS-DPCs).
Oxidative DNA damage caused by endogenous reactive oxygen species (ROS) is a key driver of mutagenesis, cellular dysfunction, and aging, contributing to diseases like cancer, neurodegeneration, rheumatoid arthritis, cardiovascular disorders, and diabetes. Although more than 20 oxidative base lesions have been identified, ROS-induced DNA-protein crosslinks (DPCs) are poorly characterized. ROS-DPCs are unusually bulky and highly toxic lesions that accumulate in metabolically active tissues with age, but their identities, biological consequences, and repair in living cells have remained elusive. In the present work, we characterized ROS-DPCs in human fibrosarcoma (HT1080) cells treated with hydrogen peroxide (H2O2) and elucidated the mechanisms of their removal. Mass spectrometry-based proteomics has identified over 100 cellular proteins that participated in DPC formation, most of which are involved in DNA metabolism. Our data further reveal that DNA replication and transcription facilitate DPC detection and identify a critical role of the ubiquitin-proteasomal system (UPS), replication-coupled activity of SPRTN metalloprotease, and nucleotide excision repair (NER) in removing ROS-induced DPCs. ROS-DPC formation was blocked by pretreatment with metabolically stable and cell-permeable glutathione (GSH) analog ( {Psi}-GSH), suggesting a possible therapeutic strategy for preventing diseases associated with increased ROS levels.
dlvr.it
February 10, 2026 at 4:04 AM
(BioRxiv All) Living Cells Employ Ubiquitin-Proteasomal System and Nucleotide Excision Repair Pathways to Remove Reactive Oxygen Species-Induced DNA-Protein Crosslinks (ROS-DPCs).: Oxidative DNA damage caused by endogenous reactive oxygen species (ROS) is a key driver of… #BioRxiv #MassSpecRSS
Don’t believe a word out of their mouths. They will profit we will pay with things like safe drinking water. This video is from Virginia, which has the highest concentration of DPCs in the world. The problems it highlights affect DPCs no matter where they are.
youtu.be/fAPusgiz4B8?...
youtu.be/fAPusgiz4B8?...
Hidden Costs of the Cloud: Data Centers in Virginia
YouTube video by Piedmont Environmental Council
youtu.be
May 23, 2026 at 4:20 PM
Don’t believe a word out of their mouths. They will profit we will pay with things like safe drinking water. This video is from Virginia, which has the highest concentration of DPCs in the world. The problems it highlights affect DPCs no matter where they are.
youtu.be/fAPusgiz4B8?...
youtu.be/fAPusgiz4B8?...
These need to go where the people building them live. This video is about Virginia, but the issues it raises are endemic to DPCs no matter where they are:
youtu.be/fAPusgiz4B8?...
youtu.be/fAPusgiz4B8?...
Hidden Costs of the Cloud: Data Centers in Virginia
YouTube video by Piedmont Environmental Council
youtu.be
May 6, 2026 at 9:19 PM
These need to go where the people building them live. This video is about Virginia, but the issues it raises are endemic to DPCs no matter where they are:
youtu.be/fAPusgiz4B8?...
youtu.be/fAPusgiz4B8?...
Oh no, Gretchen! DPCs will be the death of us.
This is all so twisted.
Residents say no, and it still happens at the bidding of tech billionaires and glad-handed politicians.
Residents say no, and it still happens at the bidding of tech billionaires and glad-handed politicians.
Democratic Gov. Gretchen Whitmer joined tech CEOs and at a groundbreaking ceremony for a $16 billion data center in rural Michigan that has faced local resistance. Saline Township’s board voted to deny the rezoning of land for the project after residents gave public comments in opposition.
June 2, 2026 at 9:29 PM
Oh no, Gretchen! DPCs will be the death of us.
eh o terceiro pedido >seguido< d ifood q eu peço errado pq nao prestei atencao no q tava escrito . coincidentemente começou a acontecer isso dpçs q voltei a fuma makonha
October 11, 2024 at 8:13 PM
eh o terceiro pedido >seguido< d ifood q eu peço errado pq nao prestei atencao no q tava escrito . coincidentemente começou a acontecer isso dpçs q voltei a fuma makonha
here's the trailer from the 2023 Direct, the new one today didn't show much new footage but it's out on Dec 26 in Japan:
www.youtube.com/watch?v=dpcS...
www.youtube.com/watch?v=dpcS...
Stray Children - Official Japanese Trailer | Nintendo Direct 2023
YouTube video by GameTrailers
www.youtube.com
August 27, 2024 at 3:31 PM
here's the trailer from the 2023 Direct, the new one today didn't show much new footage but it's out on Dec 26 in Japan:
www.youtube.com/watch?v=dpcS...
www.youtube.com/watch?v=dpcS...
Mushrooms are a fantastic tool for chronic pain, and we teach you how to do it the right way. are you ready to start your journey?
calendly.com/ariane-dpcs/...
#healingjourney #chronicpain #psilocybin #cannabis
calendly.com/ariane-dpcs/...
#healingjourney #chronicpain #psilocybin #cannabis
December 12, 2024 at 10:25 PM
Mushrooms are a fantastic tool for chronic pain, and we teach you how to do it the right way. are you ready to start your journey?
calendly.com/ariane-dpcs/...
#healingjourney #chronicpain #psilocybin #cannabis
calendly.com/ariane-dpcs/...
#healingjourney #chronicpain #psilocybin #cannabis