New paper about molting in nematodes. 🙂https://www.biorxiv.org/content/10.1101/2025.01.27.634690v1
Multiple losses of ecdysone receptor genes in nematodes: an alternative evolutionary scenario of molting regulation
Molting is a hallmark feature of ecdysozoans, including arthropods, tardigrades, and nematodes. Ecdysone hormones play a crucial role in regulating the molting process of different ecdysozoan taxa. In...
www.biorxiv.org
January 28, 2025 at 6:50 AM
New paper about molting in nematodes. 🙂https://www.biorxiv.org/content/10.1101/2025.01.27.634690v1
Revised refereed preprint:
www.biorxiv.org/content/10.1...
Revision work lead by @longweibai.bsky.social
Our work reveals how the #microbiota helps buffer #malnutrition: L. plantarum sustains intestinal activity of the steroid hormone ecdysone, expanding the midgut and supporting systemic growth.
www.biorxiv.org/content/10.1...
Revision work lead by @longweibai.bsky.social
Our work reveals how the #microbiota helps buffer #malnutrition: L. plantarum sustains intestinal activity of the steroid hormone ecdysone, expanding the midgut and supporting systemic growth.
November 23, 2025 at 6:19 AM
Revised refereed preprint:
www.biorxiv.org/content/10.1...
Revision work lead by @longweibai.bsky.social
Our work reveals how the #microbiota helps buffer #malnutrition: L. plantarum sustains intestinal activity of the steroid hormone ecdysone, expanding the midgut and supporting systemic growth.
www.biorxiv.org/content/10.1...
Revision work lead by @longweibai.bsky.social
Our work reveals how the #microbiota helps buffer #malnutrition: L. plantarum sustains intestinal activity of the steroid hormone ecdysone, expanding the midgut and supporting systemic growth.
@shumpei-yamakawa.bsky.social Barf & @hejnol.bsky.social show that loss of cdysone receptor genes is not exceptional in Caenorhabditis, but has occurred at least 3 times in Rhabditina and Tylenchina nematodes.
🔗 doi.org/10.1093/molbev/msag102
#evobio #molbio #celegans
🔗 doi.org/10.1093/molbev/msag102
#evobio #molbio #celegans
Multiple losses of ecdysone receptor genes in nematodes: an alternative evolutionary scenario of molting regulation
Abstract. Molting is a hallmark feature of ecdysozoans, including arthropods, tardigrades, and nematodes. Ecdysone hormones play a crucial role in regulati
doi.org
May 26, 2026 at 2:30 PM
@shumpei-yamakawa.bsky.social Barf & @hejnol.bsky.social show that loss of cdysone receptor genes is not exceptional in Caenorhabditis, but has occurred at least 3 times in Rhabditina and Tylenchina nematodes.
🔗 doi.org/10.1093/molbev/msag102
#evobio #molbio #celegans
🔗 doi.org/10.1093/molbev/msag102
#evobio #molbio #celegans
keep this on the dl but ecdysone enanthate
July 11, 2025 at 8:53 PM
keep this on the dl but ecdysone enanthate
The hormone binds with ecdysone receptors which in turn activate genes that had been switched off, initiating the metamorphosis process.
Think of it as insects and crabs having a form of multiple super-puberties
Think of it as insects and crabs having a form of multiple super-puberties
April 11, 2024 at 3:58 AM
The hormone binds with ecdysone receptors which in turn activate genes that had been switched off, initiating the metamorphosis process.
Think of it as insects and crabs having a form of multiple super-puberties
Think of it as insects and crabs having a form of multiple super-puberties
Terry, D., Schweibenz, C., Moberg, K. (2024). Local Ecdysone synthesis in a wounded epithelium sustains developmental delay and promotes regeneration in Drosophila. Development, 151(12) journals.biologists.com/dev/article/...
Local Ecdysone synthesis in a wounded epithelium sustains developmental delay and promotes regeneration in Drosophila
Highlighted Article: Damaged Drosophila epithelia induce a developmental pause by shutting down Ecdysone (Ec) production. Although activity of the Ec receptor drops in uninjured tissues, it rises with...
journals.biologists.com
March 5, 2025 at 10:18 PM
Terry, D., Schweibenz, C., Moberg, K. (2024). Local Ecdysone synthesis in a wounded epithelium sustains developmental delay and promotes regeneration in Drosophila. Development, 151(12) journals.biologists.com/dev/article/...
Well, ecdysone does sound like a tastier spice.
September 25, 2024 at 10:12 PM
Well, ecdysone does sound like a tastier spice.
Apparently in insects it’s ecdysone, says Wikipedia. Only vertebrates use testosterone as a sex hormone
September 25, 2024 at 10:11 PM
Apparently in insects it’s ecdysone, says Wikipedia. Only vertebrates use testosterone as a sex hormone
Ecdysone regulates phagocytic cell fate of epithelial cells in developing #Drosophila eggs. New study from Gaurab Ghosh, Mohit Prasad and colleagues (Indian Institute of Science Education and Research Kolkata): rupress.org/jcb/article/...
#Development #CellDeath #Oogenesis
#Development #CellDeath #Oogenesis
June 4, 2025 at 8:28 PM
Ecdysone regulates phagocytic cell fate of epithelial cells in developing #Drosophila eggs. New study from Gaurab Ghosh, Mohit Prasad and colleagues (Indian Institute of Science Education and Research Kolkata): rupress.org/jcb/article/...
#Development #CellDeath #Oogenesis
#Development #CellDeath #Oogenesis
Ghosh, Prasad et al. elucidate the role of ecdysone signaling in orchestrating the removal of nurse cells by transforming the epithelial follicle cells to a phagocytic fate during late #Drosophila #oogenesis. rupress.org/jcb/article/...
#Development #CellDeath
#Development #CellDeath
May 28, 2025 at 4:09 PM
Ghosh, Prasad et al. elucidate the role of ecdysone signaling in orchestrating the removal of nurse cells by transforming the epithelial follicle cells to a phagocytic fate during late #Drosophila #oogenesis. rupress.org/jcb/article/...
#Development #CellDeath
#Development #CellDeath
Multiple losses of ecdysone receptor genes in nematodes: an alternative evolutionary scenario of molting regulation https://www.biorxiv.org/content/10.1101/2025.01.27.634690v1
January 28, 2025 at 4:33 AM
Multiple losses of ecdysone receptor genes in nematodes: an alternative evolutionary scenario of molting regulation https://www.biorxiv.org/content/10.1101/2025.01.27.634690v1
Latest from the lab. MS previously preprinted (see below) and finally published in print @dev-journal.bsky.social
journals.biologists.com/dev/article/...
Review process via @reviewcommons.org and @dev-journal.bsky.social
1/3
journals.biologists.com/dev/article/...
Review process via @reviewcommons.org and @dev-journal.bsky.social
1/3
January 26, 2026 at 12:44 PM
Latest from the lab. MS previously preprinted (see below) and finally published in print @dev-journal.bsky.social
journals.biologists.com/dev/article/...
Review process via @reviewcommons.org and @dev-journal.bsky.social
1/3
journals.biologists.com/dev/article/...
Review process via @reviewcommons.org and @dev-journal.bsky.social
1/3
Definitely ecdysone. But what are the kind of cracked lines and square overlapping with the molecule structure ?
March 8, 2026 at 9:56 PM
Definitely ecdysone. But what are the kind of cracked lines and square overlapping with the molecule structure ?
Launching the molecular genetic investigation of the ecdysone signaling cascade: a tribute to David S. Hogness (1925-2019)
#Drosophila
#Drosophila
Launching the molecular genetic investigation of the ecdysone signaling cascade: a tribute to David S. Hogness (1925-2019)
#Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
November 12, 2025 at 6:23 PM
Launching the molecular genetic investigation of the ecdysone signaling cascade: a tribute to David S. Hogness (1925-2019)
#Drosophila
#Drosophila
Latest preprint from the Lab, co-led by Cathy Ramos, lecturer in the team and pushed to the final line by Longwei Bai, Ph’d candidate.
Deals with microbiome (what else… 😉), guts and steroid hormone in flies.
#MicroSky #MicrobiomeSky #SymbioSky #DevBio #Drosofeed
www.biorxiv.org/content/10.1...
Deals with microbiome (what else… 😉), guts and steroid hormone in flies.
#MicroSky #MicrobiomeSky #SymbioSky #DevBio #Drosofeed
www.biorxiv.org/content/10.1...
Drosophila larval gut transcriptome reveals a microbe-mediated intestinal tissue growth via Ecdysone during adaptive growth
Juvenile growth is an adaptive trait since chronic undernutrition leads to reduced growth rate and delayed maturation. Using Drosophila and mouse gnotobiotic models, we previously established the evol...
www.biorxiv.org
February 8, 2025 at 1:25 PM
Latest preprint from the Lab, co-led by Cathy Ramos, lecturer in the team and pushed to the final line by Longwei Bai, Ph’d candidate.
Deals with microbiome (what else… 😉), guts and steroid hormone in flies.
#MicroSky #MicrobiomeSky #SymbioSky #DevBio #Drosofeed
www.biorxiv.org/content/10.1...
Deals with microbiome (what else… 😉), guts and steroid hormone in flies.
#MicroSky #MicrobiomeSky #SymbioSky #DevBio #Drosofeed
www.biorxiv.org/content/10.1...
Ecdysone-mediated intestinal growth contributes to microbiota-driven developmental plasticity under malnutrition
#Drosophila
#Drosophila
Ecdysone-mediated intestinal growth contributes to microbiota-driven developmental plasticity under malnutrition
#Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
January 26, 2026 at 11:23 AM
Ecdysone-mediated intestinal growth contributes to microbiota-driven developmental plasticity under malnutrition
#Drosophila
#Drosophila
Powell and Ables @eastcarolinauniv.bsky.social discuss work from Ghosh et al. (rupress.org/jcb/article/...), which reveals that ecdysone signaling reprograms epithelial follicle cells toward a phagocytic fate during #Drosophila late #oogenesis. rupress.org/jcb/article/...
July 17, 2025 at 4:15 PM
Powell and Ables @eastcarolinauniv.bsky.social discuss work from Ghosh et al. (rupress.org/jcb/article/...), which reveals that ecdysone signaling reprograms epithelial follicle cells toward a phagocytic fate during #Drosophila late #oogenesis. rupress.org/jcb/article/...
olympics rep: ma’am do you have any idea why your urine is 94% ecdysone? that’s not even a steroid we test for. the lab techs unionized when they saw the color. they say tolerance has gone too far
me, plaintively, from within my hideously athletic chrysalis: a goop is allowed to compete
me, plaintively, from within my hideously athletic chrysalis: a goop is allowed to compete
February 12, 2025 at 12:10 AM
olympics rep: ma’am do you have any idea why your urine is 94% ecdysone? that’s not even a steroid we test for. the lab techs unionized when they saw the color. they say tolerance has gone too far
me, plaintively, from within my hideously athletic chrysalis: a goop is allowed to compete
me, plaintively, from within my hideously athletic chrysalis: a goop is allowed to compete
We have a “box” covering some of the Hogness publication record in this paper 🔽.
But those Crete meeting summaries from 1978-1988 & beyond are worth reading too.
I think the first was written by Walter Gehring; the later ones by Ashburner.
pmc.ncbi.nlm.nih.gov/articles/PMC...
But those Crete meeting summaries from 1978-1988 & beyond are worth reading too.
I think the first was written by Walter Gehring; the later ones by Ashburner.
pmc.ncbi.nlm.nih.gov/articles/PMC...
Launching the molecular genetic investigation of the ecdysone signaling cascade: a tribute to David S. Hogness (1925–2019)
The steroid hormone 20-OH-ecdysone (“ecdysone”) regulates viability, metamorphosis, and fertility in insects. Fifty years ago, little was known about the molecular basis of ecdysone action except for ...
pmc.ncbi.nlm.nih.gov
July 28, 2026 at 2:33 PM
We have a “box” covering some of the Hogness publication record in this paper 🔽.
But those Crete meeting summaries from 1978-1988 & beyond are worth reading too.
I think the first was written by Walter Gehring; the later ones by Ashburner.
pmc.ncbi.nlm.nih.gov/articles/PMC...
But those Crete meeting summaries from 1978-1988 & beyond are worth reading too.
I think the first was written by Walter Gehring; the later ones by Ashburner.
pmc.ncbi.nlm.nih.gov/articles/PMC...
Hee!
You could go down the hall & talk with @peiferlabunc.bsky.social — as a fellow Hogness grandchild he knows a lot of these stories too.
To answer the OP, yes, “copia” was named for high-copy number & abundant RNAs, but much was never published.
See also:
pmc.ncbi.nlm.nih.gov/articles/PMC...
You could go down the hall & talk with @peiferlabunc.bsky.social — as a fellow Hogness grandchild he knows a lot of these stories too.
To answer the OP, yes, “copia” was named for high-copy number & abundant RNAs, but much was never published.
See also:
pmc.ncbi.nlm.nih.gov/articles/PMC...
Launching the molecular genetic investigation of the ecdysone signaling cascade: a tribute to David S. Hogness (1925–2019)
The steroid hormone 20-OH-ecdysone (“ecdysone”) regulates viability, metamorphosis, and fertility in insects. Fifty years ago, little was known about the molecular basis of ecdysone action except for ...
pmc.ncbi.nlm.nih.gov
July 28, 2026 at 2:19 PM
Hee!
You could go down the hall & talk with @peiferlabunc.bsky.social — as a fellow Hogness grandchild he knows a lot of these stories too.
To answer the OP, yes, “copia” was named for high-copy number & abundant RNAs, but much was never published.
See also:
pmc.ncbi.nlm.nih.gov/articles/PMC...
You could go down the hall & talk with @peiferlabunc.bsky.social — as a fellow Hogness grandchild he knows a lot of these stories too.
To answer the OP, yes, “copia” was named for high-copy number & abundant RNAs, but much was never published.
See also:
pmc.ncbi.nlm.nih.gov/articles/PMC...
Drosophila larval gut transcriptome reveals a microbe-mediated intestinal tissue growth via Ecdysone during adaptive growth https://www.biorxiv.org/content/10.1101/2025.02.07.637066v1
February 8, 2025 at 12:34 PM
Drosophila larval gut transcriptome reveals a microbe-mediated intestinal tissue growth via Ecdysone during adaptive growth https://www.biorxiv.org/content/10.1101/2025.02.07.637066v1
The #adipose tissue has an apical-basal #polarity required for Col IV-dependent cell-cell #adhesion. New study from Jameela Almasoud, Cyril Andrieu, Bren Hunyi Lee, and Anna Franz @ucl-cdb.bsky.social @ucl.ac.uk: rupress.org/jcb/article/...
#Development #Drosophila #Ecdysone #Collagen
#Development #Drosophila #Ecdysone #Collagen
January 14, 2026 at 2:30 PM
The #adipose tissue has an apical-basal #polarity required for Col IV-dependent cell-cell #adhesion. New study from Jameela Almasoud, Cyril Andrieu, Bren Hunyi Lee, and Anna Franz @ucl-cdb.bsky.social @ucl.ac.uk: rupress.org/jcb/article/...
#Development #Drosophila #Ecdysone #Collagen
#Development #Drosophila #Ecdysone #Collagen
Amazing paper on how metabolites act as signaling factors which impact growth and development by ways which are not limited to merely changes in flux, energy production and biogenesis.
#Drosophila #metabolism #ecdysone #Ampk #interorgancommunication
#Drosophila #metabolism #ecdysone #Ampk #interorgancommunication
💫NEW: @telemanlab.bsky.social & co demonstrate that #AMPK can be activated by signaling metabolite, #adenosine, under non-stress conditions during #Drosophila development. The intestine regulates adenosine levels, thus, remotely controlling wing disc AMPK activation and growth.
bit.ly/4gX6njF
bit.ly/4gX6njF
Remote control of AMPK via extracellular adenosine controls tissue growth - Nature Cell Biology
Zhang et al. demonstrate that AMPK can be activated by signalling metabolite, adenosine, under non-stress conditions during Drosophila development. The intestine regulates adenosine levels, thus, remotely controlling wing disc AMPK activation and growth.
bit.ly
October 7, 2025 at 10:07 PM
Amazing paper on how metabolites act as signaling factors which impact growth and development by ways which are not limited to merely changes in flux, energy production and biogenesis.
#Drosophila #metabolism #ecdysone #Ampk #interorgancommunication
#Drosophila #metabolism #ecdysone #Ampk #interorgancommunication