BOOO!
Here is a scary video for the #Halloween fans 🎃
A cell with a ghostly face.
🟠: Rab5A - an early endosome marker.
📹: @anhhle2702.bsky.social, UCL
#FluorescenceFriday
Here is a scary video for the #Halloween fans 🎃
A cell with a ghostly face.
🟠: Rab5A - an early endosome marker.
📹: @anhhle2702.bsky.social, UCL
#FluorescenceFriday
October 30, 2026 at 7:39 PM
BOOO!
Here is a scary video for the #Halloween fans 🎃
A cell with a ghostly face.
🟠: Rab5A - an early endosome marker.
📹: @anhhle2702.bsky.social, UCL
#FluorescenceFriday
Here is a scary video for the #Halloween fans 🎃
A cell with a ghostly face.
🟠: Rab5A - an early endosome marker.
📹: @anhhle2702.bsky.social, UCL
#FluorescenceFriday
1/ Our review is out in Yeast! 🍄🧬
"Spatial gene expression in fungi: mRNA localization, condensates, and beyond"
From budding yeast to hyphae to multinucleate AM fungi: how fungi put the right mRNA in the right place to drive polarity and morphogenesis.
doi.org/10.1002/yea....
"Spatial gene expression in fungi: mRNA localization, condensates, and beyond"
From budding yeast to hyphae to multinucleate AM fungi: how fungi put the right mRNA in the right place to drive polarity and morphogenesis.
doi.org/10.1002/yea....
November 3, 2026 at 9:36 AM
1/ Our review is out in Yeast! 🍄🧬
"Spatial gene expression in fungi: mRNA localization, condensates, and beyond"
From budding yeast to hyphae to multinucleate AM fungi: how fungi put the right mRNA in the right place to drive polarity and morphogenesis.
doi.org/10.1002/yea....
"Spatial gene expression in fungi: mRNA localization, condensates, and beyond"
From budding yeast to hyphae to multinucleate AM fungi: how fungi put the right mRNA in the right place to drive polarity and morphogenesis.
doi.org/10.1002/yea....
This means that when cargo concentrations on an Endosome are high, then PI(3)P is also high and vice versa! And we could directly demonstrate this connection by live cell microscopy of single endosomes trafficking transferrin!
November 3, 2026 at 4:19 PM
This means that when cargo concentrations on an Endosome are high, then PI(3)P is also high and vice versa! And we could directly demonstrate this connection by live cell microscopy of single endosomes trafficking transferrin!
STRIPAK associates with Rabex5-Rabaptin5 to promote Rab5-dependent early endosome formation and EGFR transport https://www.biorxiv.org/content/10.64898/2026.10.28.762573v1
October 30, 2026 at 12:30 PM
STRIPAK associates with Rabex5-Rabaptin5 to promote Rab5-dependent early endosome formation and EGFR transport https://www.biorxiv.org/content/10.64898/2026.10.28.762573v1
Endosome motility controls light-responsive reproductive development and secondary metabolite production in Aspergillus CurrentBiology
Endosome motility controls light-responsive reproductive development and secondary metabolite production in Aspergillus
Kumar, Allen, Oster et al. show that motility of PxdA-marked early endosomes in Aspergillus nidulans is required for light-responsive development and production of secondary metabolites. In the pathogen A. fumigatus, PxdA loss also alters secondary metabolites. This links organelle dynamics to reproductive fate and secondary metabolite output in filamentous fungi.
dlvr.it
November 6, 2026 at 3:31 AM
Endosome motility controls light-responsive reproductive development and secondary metabolite production in Aspergillus CurrentBiology
Endosome motility controls light-responsive reproductive development and secondary metabolite production in Aspergillus CurrentBiology
Endosome motility controls light-responsive reproductive development and secondary metabolite production in Aspergillus
Kumar, Allen, Oster et al. show that motility of PxdA-marked early endosomes in Aspergillus nidulans is required for light-responsive development and production of secondary metabolites. In the pathogen A. fumigatus, PxdA loss also alters secondary metabolites. This links organelle dynamics to reproductive fate and secondary metabolite output in filamentous fungi.
dlvr.it
November 4, 2026 at 2:31 PM
Endosome motility controls light-responsive reproductive development and secondary metabolite production in Aspergillus CurrentBiology
A study in Cell reveals the role for Prf1 in directly inducing ferroptosis in tumor cells.
🔹Perforin-mediated pore formation promotes transferrin receptor endocytosis.
🔹Endosome–mitochondria contacts facilitate mitochondrial iron accumulation.
🔹Higher Prf1 level is associated with enhanced survival.
🔹Perforin-mediated pore formation promotes transferrin receptor endocytosis.
🔹Endosome–mitochondria contacts facilitate mitochondrial iron accumulation.
🔹Higher Prf1 level is associated with enhanced survival.
November 4, 2026 at 9:00 AM
A study in Cell reveals the role for Prf1 in directly inducing ferroptosis in tumor cells.
🔹Perforin-mediated pore formation promotes transferrin receptor endocytosis.
🔹Endosome–mitochondria contacts facilitate mitochondrial iron accumulation.
🔹Higher Prf1 level is associated with enhanced survival.
🔹Perforin-mediated pore formation promotes transferrin receptor endocytosis.
🔹Endosome–mitochondria contacts facilitate mitochondrial iron accumulation.
🔹Higher Prf1 level is associated with enhanced survival.
First we need to establish how endosomal PI(3)P is organised. Using recombinant biosensors we can detect free PI(3)P and find that it is segregated into specific domains: High free PI(3)P on the bulk endosome and low PI(3)P in the retrieval domains, marked by Retromer component VPS35:
November 3, 2026 at 4:19 PM
First we need to establish how endosomal PI(3)P is organised. Using recombinant biosensors we can detect free PI(3)P and find that it is segregated into specific domains: High free PI(3)P on the bulk endosome and low PI(3)P in the retrieval domains, marked by Retromer component VPS35:
STRIPAK associates with Rabex5-Rabaptin5 to promote Rab5-dependent early endosome formation and EGFR transport https://www.biorxiv.org/content/10.64898/2026.10.28.762573v1
October 30, 2026 at 12:30 PM
STRIPAK associates with Rabex5-Rabaptin5 to promote Rab5-dependent early endosome formation and EGFR transport https://www.biorxiv.org/content/10.64898/2026.10.28.762573v1
STRIPAK associates with Rabex5-Rabaptin5 to promote Rab5-dependent early endosome formation and EGFR transport #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.10.28.762573v1
https://www.biorxiv.org/content/10.64898/2026.10.28.762573v1
October 30, 2026 at 2:02 PM
STRIPAK associates with Rabex5-Rabaptin5 to promote Rab5-dependent early endosome formation and EGFR transport #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.10.28.762573v1
https://www.biorxiv.org/content/10.64898/2026.10.28.762573v1
CryoEM structures of human NHE6 and NHE9 - Na⁺/H⁺ exchangers that help fine-tune endosome pH.
Excited to be a part of this study lead by @chembiohub.bsky.social, Jesper Hansen, and Ashley Pike with Gamma Chi, Giulio Superti-Furga, @madamescientist.bsky.social and Bayer
doi.org/10.1038/s414...
Excited to be a part of this study lead by @chembiohub.bsky.social, Jesper Hansen, and Ashley Pike with Gamma Chi, Giulio Superti-Furga, @madamescientist.bsky.social and Bayer
doi.org/10.1038/s414...
High-resolution structures of human NHE6 and NHE9 elucidate endosomal ion and lipid interactions - Nature Communications
NHE6 and NHE9 regulate endosomal pH and are linked to neurological disease. Here, the authors report cryo-EM structures of human NHE9 and two NHE6 splice isoforms, revealing sodium and lipid- binding ...
doi.org
October 23, 2026 at 4:44 PM
CryoEM structures of human NHE6 and NHE9 - Na⁺/H⁺ exchangers that help fine-tune endosome pH.
Excited to be a part of this study lead by @chembiohub.bsky.social, Jesper Hansen, and Ashley Pike with Gamma Chi, Giulio Superti-Furga, @madamescientist.bsky.social and Bayer
doi.org/10.1038/s414...
Excited to be a part of this study lead by @chembiohub.bsky.social, Jesper Hansen, and Ashley Pike with Gamma Chi, Giulio Superti-Furga, @madamescientist.bsky.social and Bayer
doi.org/10.1038/s414...
Inside Lilly's $1.1B METiS TechBio deal: HKEX 18C filings, LipidBERT's scaffold trap, and why 98% of LNPs die in the endosome.
https://duklee.net/blog/2026-10-21-eli-lilly-metis-1-1b-lnp-endosomal-escape-physical-biology-deep-dive
https://duklee.net/blog/2026-10-21-eli-lilly-metis-1-1b-lnp-endosomal-escape-physical-biology-deep-dive
The $1.1 Billion LNP Mirage and the 98% Endosomal Graveyard: Inside Eli Lilly
On October 19, 2026, Eli Lilly signed a collaboration worth up to $1.1 billion with Hong Kong-listed AI drug delivery unicorn METiS TechBio (7666.HK) to license its AiLNP platform. Starting from a Socratic dialogue on what Lilly is actually buying and why endosomal escape is the hardest problem in b
duklee.net
October 22, 2026 at 2:01 AM
Inside Lilly's $1.1B METiS TechBio deal: HKEX 18C filings, LipidBERT's scaffold trap, and why 98% of LNPs die in the endosome.
https://duklee.net/blog/2026-10-21-eli-lilly-metis-1-1b-lnp-endosomal-escape-physical-biology-deep-dive
https://duklee.net/blog/2026-10-21-eli-lilly-metis-1-1b-lnp-endosomal-escape-physical-biology-deep-dive
A paper using RRID:AB_528121 from @dshb-antibodies.bsky.social was just published in eLife. Thanks for making your methods matter! #reproducibility #OpenResearch #STMpublishing
Endosome-associated Rab GTPases control distinct aspects of neural circuit assembly
Read the full paper: Endosome-associated Rab GTPases control distinct aspects of neural circuit assembly
doi.org
October 17, 2026 at 7:00 AM
A paper using RRID:AB_528121 from @dshb-antibodies.bsky.social was just published in eLife. Thanks for making your methods matter! #reproducibility #OpenResearch #STMpublishing
Late endosome trafficking is slower in regenerated dendrites
#Drosophila
#Drosophila
Late endosome trafficking is slower in regenerated dendrites
#Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
October 16, 2026 at 4:23 AM
Late endosome trafficking is slower in regenerated dendrites
#Drosophila
#Drosophila
Endosome-associated Rab GTPases control distinct aspects of neural circuit assembly
#Drosophila
#Drosophila
Endosome-associated Rab GTPases control distinct aspects of neural circuit assembly
#Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
October 14, 2026 at 4:23 AM
Endosome-associated Rab GTPases control distinct aspects of neural circuit assembly
#Drosophila
#Drosophila
@thermofishersci.bsky.social's resource, RRID:AB_2576217, was just reported to be used in the paper. Thanks for making your methods matter! #BetterScience #RRID #STMpublishing
Structural Mechanisms of DNAJC13 Dimeric Assembly and InsP6 binding in Recycling Endosome Regulation
Read the full paper: Structural Mechanisms of DNAJC13 Dimeric Assembly and InsP6 binding in Recycling Endosome Regulation
doi.org
October 13, 2026 at 7:01 AM
@thermofishersci.bsky.social's resource, RRID:AB_2576217, was just reported to be used in the paper. Thanks for making your methods matter! #BetterScience #RRID #STMpublishing
The authors included RRIDs in their in Current Biology paper! We value the author's support of reproducibility. #OpenResearch #reproducibility #BetterScience
Endosome motility controls light-responsive reproductive development and secondary metabolite production in Aspergillus
Read the full paper: Endosome motility controls light-responsive reproductive development and secondary metabolite production in Aspergillus
doi.org
October 9, 2026 at 7:06 AM
The authors included RRIDs in their in Current Biology paper! We value the author's support of reproducibility. #OpenResearch #reproducibility #BetterScience
RRIDs were included in this in ACTA HISTOCHEMICA ET CYTOCHEMICA paper. We value the author's support of reproducibility. #RRID #accelerateopenscience #ReproducibleResearch
Intracellular Localization of PD-L1 in Rab10-positive Open Tubular Endosome System of Cancer Cells
Read the full paper: Intracellular Localization of PD-L1 in Rab10-positive Open Tubular Endosome System of Cancer Cells
doi.org
October 9, 2026 at 7:10 AM
RRIDs were included in this in ACTA HISTOCHEMICA ET CYTOCHEMICA paper. We value the author's support of reproducibility. #RRID #accelerateopenscience #ReproducibleResearch
ESCRT-related proteins regulate vacuolar trafficking and cytokinesis in the moss Physcomitrium patens
Ruan et al.
nph.onlinelibrary.wiley.com/share/MXCEGA...
Ruan et al.
nph.onlinelibrary.wiley.com/share/MXCEGA...
October 8, 2026 at 2:35 PM
ESCRT-related proteins regulate vacuolar trafficking and cytokinesis in the moss Physcomitrium patens
Ruan et al.
nph.onlinelibrary.wiley.com/share/MXCEGA...
Ruan et al.
nph.onlinelibrary.wiley.com/share/MXCEGA...
Endosome motility controls light-responsive reproductive development and secondary metabolite production in Aspergillus
@currentbiology.bsky.social from @samreckpeterson.bsky.social
with @kellerlab.bsky.social
www.cell.com/current-biol...
@currentbiology.bsky.social from @samreckpeterson.bsky.social
with @kellerlab.bsky.social
www.cell.com/current-biol...
Endosome motility controls light-responsive reproductive development and secondary metabolite production in Aspergillus
Kumar, Allen, Oster et al. show that motility of PxdA-marked early endosomes in Aspergillus
nidulans is required for light-responsive development and production of secondary
metabolites. In the pathog...
www.cell.com
October 8, 2026 at 7:12 AM
Endosome motility controls light-responsive reproductive development and secondary metabolite production in Aspergillus
@currentbiology.bsky.social from @samreckpeterson.bsky.social
with @kellerlab.bsky.social
www.cell.com/current-biol...
@currentbiology.bsky.social from @samreckpeterson.bsky.social
with @kellerlab.bsky.social
www.cell.com/current-biol...
The authors included RRIDs in their in iScience paper! We value the author's support of reproducibility. #OpenScience #methodsmatter #RRID
Centrosomal P4.1-associated protein is a novel regulator of ESCRT pathway function during endosome maturation
Read the full paper: Centrosomal P4.1-associated protein is a novel regulator of ESCRT pathway function during endosome maturation
doi.org
October 8, 2026 at 7:06 AM
The authors included RRIDs in their in iScience paper! We value the author's support of reproducibility. #OpenScience #methodsmatter #RRID
Multiple overlapping SNARE complexes drive endosome maturation in Drosophila nephrocytes
#Drosophila
#Drosophila
Multiple overlapping SNARE complexes drive endosome maturation in Drosophila nephrocytes
#Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
October 6, 2026 at 10:23 AM
Multiple overlapping SNARE complexes drive endosome maturation in Drosophila nephrocytes
#Drosophila
#Drosophila
This #FluorescenceFriday we have an Endosome sorting itself out!
37min of PI(3)P (green) positive sorting endosome with fluorescent Transferrin in Magenta. The sorting of Transferrin is tightly interlinked with PI(3)P intensity. Soon we will publish how cargo sorting controls PI(3)P levels!
37min of PI(3)P (green) positive sorting endosome with fluorescent Transferrin in Magenta. The sorting of Transferrin is tightly interlinked with PI(3)P intensity. Soon we will publish how cargo sorting controls PI(3)P levels!
October 2, 2026 at 1:10 PM
This #FluorescenceFriday we have an Endosome sorting itself out!
37min of PI(3)P (green) positive sorting endosome with fluorescent Transferrin in Magenta. The sorting of Transferrin is tightly interlinked with PI(3)P intensity. Soon we will publish how cargo sorting controls PI(3)P levels!
37min of PI(3)P (green) positive sorting endosome with fluorescent Transferrin in Magenta. The sorting of Transferrin is tightly interlinked with PI(3)P intensity. Soon we will publish how cargo sorting controls PI(3)P levels!
The authors included RRIDs in their in EMBO Reports paper! We value the author's support of reproducibility. #BetterScience #ReproducibleResearch #STMpublishing
Local translation of endosome-associated lc3b mRNA in axons contributes to endosomal clearance
Read the full paper: Local translation of endosome-associated lc3b mRNA in axons contributes to endosomal clearance
doi.org
October 1, 2026 at 7:01 AM
The authors included RRIDs in their in EMBO Reports paper! We value the author's support of reproducibility. #BetterScience #ReproducibleResearch #STMpublishing
While the endosome release pathway clearly correlates with myopathy, we still don't now the relevance of the MDV release pathway to MFN2 disease - though it does lead to a 2-3 fold increase in cGAS-STING inflammation.
September 30, 2026 at 12:58 PM
While the endosome release pathway clearly correlates with myopathy, we still don't now the relevance of the MDV release pathway to MFN2 disease - though it does lead to a 2-3 fold increase in cGAS-STING inflammation.