The “light-year number” for distant objects in cosmology is a distance (in light-years) obtained from the expansion history via the scale ...

Gulf partnerships offer a practical way for European countries to expand capacity and diversify compute providers.

Eurowings carried more than 18 million passengers on 129,000 flights during the first nine months of 2026. Its third-quarter load factor rose to 88%, while the airline reported a customer Net Promoter Score of 46 and positive crew ratings from 85% of travellers. Berlin is a focus of its winter 2026/27 expansion, with two additional aircraft, increased frequencies and new winter services to Bologna, Rome, Nice, Kuusamo and Lisbon. Eurowings will serve 38 destinations from Berlin Brandenburg Airport during the season. From 1 December, its Premium BIZ Seat will be offered on all Dubai flights and selected services to London, Mallorca and Málaga.

Background: With the rapid expansion of #health care data, multiple international standardized terminology systems have been developed and refined to ensure semantic interoperability, which is a crucial factor in facilitating collaborative use. Objective: This study aimed to evaluate the real-world use and applicability of standardized terminology systems by mapping clinical terms from routine cancer care and to propose guidelines that optimize mapping. Methods: Clinical terms generated during cancer care at the National Cancer Center Korea were extracted and mapped to multiple target terminology systems: the Korean Standard Classification of Diseases; ; Logical Observation Identifiers Names and Codes; RxNorm; Anatomical Therapeutic Chemical classification; and Systematized Nomenclature of Medicine Clinical Terms (SNOMED CT). A multidisciplinary working group of #health care information managers, data experts, and oncologists verified the mapping outcomes, calculated the cross-verification discordance rate, and compared the coverage across systems. Results: A total of 3472 source terms were identified across 7 domains: chief complaint, diagnosis, laboratory test, imaging test, surgery/procedure, medication, and radiation therapy. With postcoordination and predefined mapping guidelines, SNOMED CT achieved high overall mapping rates (98.3%‐100%) across domains. Applying postcoordination as needed substantially improved exact semantic match rates, which exceeded 90% in most domains. However, more than 40% of source terms were broadly mapped in the imaging test and radiation therapy domains because procedural details such as imaging technique and radiation field configuration could not be represented in SNOMED CT. The cross-verification discordance rate between mappers, defined as the proportion of source terms with disagreement, remained low (0.3%‐1.3%). RxNorm and Logical Observation Identifiers Names and Codes showed complementary strengths within their specialized domains, adding detail or specificity where SNOMED CT was less complete. Conclusions: Standardized terminology systems are feasible and effective in encoding clinical terms for cancer care. SNOMED CT was the most comprehensive, and predefined mapping guidelines provide a structured framework for mapping and consensus resolution. Domain-specific systems should be used alongside SNOMED CT, and all systems should be updated regularly to reflect evolving clinical practice.

Sports playoff and tournament expansion is inevitable, with the amount of money at stake. But not all are immune to a watered-down product

Spinocerebellar ataxia type 17 (SCA17) is an age-related neurodegenerative disorder caused by polyglutamine expansion in the TATA-binding protein (TBP). TBP is a core transcription factor, but pathogenic polyglutamine expansion likely rewires cellular programs beyond transcription. Here, we utilized Drosophila strains that express wild-type (WT) or pathogenic (SCA17) TBP in neurons or skeletal muscle, which we analyzed vs. controls via TMT mass spectrometry, profiling of eight post-translational modifications, and RNA-seq. Shared TBP-WT and TBP-SCA17 responses predominated, impacting ribosomes and mitochondria while repressing innate immunity. Disease-specific effects were narrower and tissue-dependent: SCA17 activated xenobiotic, retinoid, and glutathione-redox pathways in the CNS, but attenuated anabolism in muscle compared to TBP-WT. Many proteomic changes occurred independently of mRNA changes, implicating post-transcriptional mechanisms. Knockdown of select SCA17-regulated proteins reduced cytotoxicity, validating omics-identified modifiers of SCA17 pathology. These findings distinguish shared TBP dosage effects from disease-linked, tissue-specific polyglutamine responses and identify evolutionarily conserved targets for SCA17.

According to The Insight Partners, The Erlotinib Hydrochloride Market size is expected to reach US$ 1.91 Billion by 2034 from US$ 1.29 Billion in 2025. The market is estimated to record a CAGR of 4.46% from 2026 to 2034. Global Erlotinib Hydrochloride market is poised for steady expansion over the next decade as the global oncology landscape continues to evolve. Erlotinib hydrochloride, a targeted epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, has played a significant role in the treatment of non-small cell lung cancer (NSCLC) and pancreatic cancer.

The global automotive thermal management market size is projected to reach US$ 41.8 billion by 2034 from US$ 17.24 billion in 2025. The market is anticipated to register a CAGR of 10.34% during the forecast period 2026-2034. Key Growth Drivers The increasing sales of electric and hybrid vehicles represent a major factor supporting market expansion. These vehicles require sophisticated thermal management systems to maintain optimal operating temperatures, improve efficiency, and support the performance and lifespan of batteries and other critical components.

Se está produciendo una expansión del mercado de los biocombustibles debido al encarecimiento de los combustibles fósiles.

Calculates effect-size-informed y-axis recommendations for visualizations of independent, repeated-measures, and mixed designs. Summarizes selected error bars, estimates conditional standardized contrasts, and generalizes range-expansion rules using constants from single-factor, two-level studies of Cohen's d. Recommendations beyond that studied setting have not been empirically validated. Provides numerical results and 'ggplot2' visualizations, including summary plots and preservation of supplied plot layouts. Confidence-interval adjustment options follow the distinctions in Cousineau (2017) &lt;<a href="https://doi.org/10.5709%2Facp-0214-z" target="_top">doi:10.5709/acp-0214-z</a>&gt;, including difference adjustment and combined repeated-measures adjustment. Within-subject base intervals use the normalization of Cousineau (2005) &lt;<a href="https://doi.org/10.20982%2Ftqmp.01.1.p042" target="_top">doi:10.20982/tqmp.01.1.p042</a>&gt; with the bias correction of Morey (2008) &lt;<a href="https://doi.org/10.20982%2Ftqmp.04.2.p061" target="_top">doi:10.20982/tqmp.04.2.p061</a>&gt;. Correlation-only intervals and intervals with both adjustments are separate options. These references support confidence-interval construction, not the range-expansion calibration.

Translation initiation factor 2 (IF2) is a universally conserved component of the protein synthesis machinery. Here, Fer et al. show that IF2 terminal extensions couple translation initiation to stress adaptation, highlighting a mechanism by which evolutionary expansion of core proteins enables regulatory flexibility in changing environments.