From Germany
Handgrip strength parameters as predictors of post-COVID syndrome severity and muscle weakness in an observational study
s4me.info/threads/hand...
Screenshot from latest Science for ME weekly update
#MEcfs #LongCovid
Handgrip strength parameters as predictors of post-COVID syndrome severity and muscle weakness in an observational study
s4me.info/threads/hand...
Screenshot from latest Science for ME weekly update
#MEcfs #LongCovid
October 13, 2026 at 12:29 AM
From Germany
Handgrip strength parameters as predictors of post-COVID syndrome severity and muscle weakness in an observational study
s4me.info/threads/hand...
Screenshot from latest Science for ME weekly update
#MEcfs #LongCovid
Handgrip strength parameters as predictors of post-COVID syndrome severity and muscle weakness in an observational study
s4me.info/threads/hand...
Screenshot from latest Science for ME weekly update
#MEcfs #LongCovid
[Parkinson’s disease: review] Pauletti et al.: "Fatigability in PD reflects impaired motor system ability to sustain or adapt neural output during prolonged activity." doi.org/10.1016/j.cl...
October 13, 2026 at 12:09 PM
[Parkinson’s disease: review] Pauletti et al.: "Fatigability in PD reflects impaired motor system ability to sustain or adapt neural output during prolonged activity." doi.org/10.1016/j.cl...
How fast does a muscle lose its strength during hard exercise? With Maximilien Bowen, Pierre Samozino, Mylène Vonderscher and Baptiste Morel, we proposed one mathematical model for steady, all-out and ramp efforts, in the Journal of Theoretical Biology (2024). 🧵 #ExercisePhysiology
September 27, 2026 at 2:15 PM
How fast does a muscle lose its strength during hard exercise? With Maximilien Bowen, Pierre Samozino, Mylène Vonderscher and Baptiste Morel, we proposed one mathematical model for steady, all-out and ramp efforts, in the Journal of Theoretical Biology (2024). 🧵 #ExercisePhysiology
Mechanics and Energetics of Gait in Older Adults: Investigating Mechanisms of Fatigability-Dr. Boyer
UofC Kinesiology Seminar Series
youtu.be/SLjZ8MxOEEI?...
UofC Kinesiology Seminar Series
youtu.be/SLjZ8MxOEEI?...
Mechanics and Energetics of Gait in Older Adults: Investigating Mechanisms of Fatigability-Dr. Boyer
YouTube video by UofC Kinesiology Seminar Series
youtu.be
September 21, 2026 at 11:15 PM
Mechanics and Energetics of Gait in Older Adults: Investigating Mechanisms of Fatigability-Dr. Boyer
UofC Kinesiology Seminar Series
youtu.be/SLjZ8MxOEEI?...
UofC Kinesiology Seminar Series
youtu.be/SLjZ8MxOEEI?...
Measured with ASL, a technique that magnetically tags your own blood as contrast.
The study is framed around cognitive fatigue & went hunting for fatigability - the idea that performance progressively decays during a demanding task as you run out. It didn't find that.
The study is framed around cognitive fatigue & went hunting for fatigability - the idea that performance progressively decays during a demanding task as you run out. It didn't find that.
September 22, 2026 at 5:13 AM
Measured with ASL, a technique that magnetically tags your own blood as contrast.
The study is framed around cognitive fatigue & went hunting for fatigability - the idea that performance progressively decays during a demanding task as you run out. It didn't find that.
The study is framed around cognitive fatigue & went hunting for fatigability - the idea that performance progressively decays during a demanding task as you run out. It didn't find that.
1978 #MyalgicE
Muscular fatigability
Abnormal muscular fatigability is the dominant clinical feature of the disease. It has been suggested by Dr David Wilkie that this phenomenon might result from damage to mitochondria. Parish (1974) also considered that 'there is a prolonged metabolic disorder in
Muscular fatigability
Abnormal muscular fatigability is the dominant clinical feature of the disease. It has been suggested by Dr David Wilkie that this phenomenon might result from damage to mitochondria. Parish (1974) also considered that 'there is a prolonged metabolic disorder in
September 9, 2026 at 2:07 PM
1978 #MyalgicE
Muscular fatigability
Abnormal muscular fatigability is the dominant clinical feature of the disease. It has been suggested by Dr David Wilkie that this phenomenon might result from damage to mitochondria. Parish (1974) also considered that 'there is a prolonged metabolic disorder in
Muscular fatigability
Abnormal muscular fatigability is the dominant clinical feature of the disease. It has been suggested by Dr David Wilkie that this phenomenon might result from damage to mitochondria. Parish (1974) also considered that 'there is a prolonged metabolic disorder in
อาการกำเริบในจุดที่อุบาทที่สุด กุจะหายใจไม่ออกละเนี่ย เจ็บอ่าาาาา รุ้สึกหายใจไม่ค่อยออกด้วย fatigability+1000 เหนื่อยง่ายขึ้น200% แน่นๆไปหมดเลย ฮรึ่ยยย เป็นบ่อยๆละอยากจะไอด้วย ไม่รู้ว่ามันเป็นโรคติดเชื้ออะไรใหม่หรือมันแค่เป็นเพราะอาการมันกำเริบละมันโดนกล้ามเนื้อละเนี่ย จะแบ้ แบบยืนๆอยู่ก็เหมือนต้องสูดหายใจแรงๆเพราะมันหายใจไม่ค่อยออกอะ แบบมันตันๆ
August 25, 2026 at 3:40 PM
อาการกำเริบในจุดที่อุบาทที่สุด กุจะหายใจไม่ออกละเนี่ย เจ็บอ่าาาาา รุ้สึกหายใจไม่ค่อยออกด้วย fatigability+1000 เหนื่อยง่ายขึ้น200% แน่นๆไปหมดเลย ฮรึ่ยยย เป็นบ่อยๆละอยากจะไอด้วย ไม่รู้ว่ามันเป็นโรคติดเชื้ออะไรใหม่หรือมันแค่เป็นเพราะอาการมันกำเริบละมันโดนกล้ามเนื้อละเนี่ย จะแบ้ แบบยืนๆอยู่ก็เหมือนต้องสูดหายใจแรงๆเพราะมันหายใจไม่ค่อยออกอะ แบบมันตันๆ
[Post-COVID-19 condition] Sebastianelli et al.: "Altered post-exercise depression was associated with higher fatigue and exertion, supporting altered central fatigability in post-COVID-19 condition." doi.org/10.1016/j.cl...
August 25, 2026 at 12:39 AM
[Post-COVID-19 condition] Sebastianelli et al.: "Altered post-exercise depression was associated with higher fatigue and exertion, supporting altered central fatigability in post-COVID-19 condition." doi.org/10.1016/j.cl...
10) Link to the study:
Bedard et al. 2026. Central origin of fatigability in Myalgic encephalomyelitis/chronic fatigue syndrome revealed by multimodal neuroimaging.
Bedard et al. 2026. Central origin of fatigability in Myalgic encephalomyelitis/chronic fatigue syndrome revealed by multimodal neuroimaging.
Central origin of fatigability in Myalgic encephalomyelitis/chronic fatigue syndrome revealed by multimodal neuroimaging
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating chronic disease characterized by physical and mental fatigue, post-exert…
www.sciencedirect.com
August 6, 2026 at 8:43 AM
10) Link to the study:
Bedard et al. 2026. Central origin of fatigability in Myalgic encephalomyelitis/chronic fatigue syndrome revealed by multimodal neuroimaging.
Bedard et al. 2026. Central origin of fatigability in Myalgic encephalomyelitis/chronic fatigue syndrome revealed by multimodal neuroimaging.
From Myalgic Encephalomyelitis International Consensus Primer (over a decade ago)
"cardinal symptom: a pathological low threshold of fatigability that is characterized by an inability to produce sufficient energy on demand."
NIH didn't really move the ball forward!
drive.google.com/file/d/1A0Bv...
"cardinal symptom: a pathological low threshold of fatigability that is characterized by an inability to produce sufficient energy on demand."
NIH didn't really move the ball forward!
drive.google.com/file/d/1A0Bv...
August 4, 2026 at 3:12 AM
From Myalgic Encephalomyelitis International Consensus Primer (over a decade ago)
"cardinal symptom: a pathological low threshold of fatigability that is characterized by an inability to produce sufficient energy on demand."
NIH didn't really move the ball forward!
drive.google.com/file/d/1A0Bv...
"cardinal symptom: a pathological low threshold of fatigability that is characterized by an inability to produce sufficient energy on demand."
NIH didn't really move the ball forward!
drive.google.com/file/d/1A0Bv...
![Central origin of fatigability in Myalgic encephalomyelitis/chronic fatigue syndrome revealed by multimodal neuroimaging — Bedard et al
"Our most novel results relate to the lack of neuromuscular adaptation in ME/CFS compared to the [Healthy Volunteers]." "ME/CFS did not change their muscular and brain activity as measured via DI, EEG, BOLD, and CMC, and as a result, they demonstrated fatigue earlier than HV"
Article | Thread](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:43rudsv62fuwsmnk7oppgtdy/bafkreidypmmkn3nh4azbuykcmu3rptaj6se4uiu7jh6h6vln7ff7oqqgyq)
Central origin of fatigability in Myalgic encephalomyelitis/chronic fatigue syndrome revealed by multimodal neuroimaging — Bedard et al
"Our most novel results relate to the lack of neuromuscular adaptation in ME/CFS compared to the [Healthy Volunteers]."
#MECFS
"Our most novel results relate to the lack of neuromuscular adaptation in ME/CFS compared to the [Healthy Volunteers]."
#MECFS
Article Link
www.sciencedirect.com
August 3, 2026 at 1:20 AM
Central origin of fatigability in Myalgic encephalomyelitis/chronic fatigue syndrome revealed by multimodal neuroimaging — Bedard et al
"Our most novel results relate to the lack of neuromuscular adaptation in ME/CFS compared to the [Healthy Volunteers]."
#MECFS
"Our most novel results relate to the lack of neuromuscular adaptation in ME/CFS compared to the [Healthy Volunteers]."
#MECFS
I also have s fibro diagnosis, but I suspect my pain is downstream of the ME biology issues. I have found low dose naltrexone helpful for that pain.
It doesn't help my muscle fatigability...
Nothing about this is easy...
It doesn't help my muscle fatigability...
Nothing about this is easy...
July 27, 2026 at 3:14 PM
I also have s fibro diagnosis, but I suspect my pain is downstream of the ME biology issues. I have found low dose naltrexone helpful for that pain.
It doesn't help my muscle fatigability...
Nothing about this is easy...
It doesn't help my muscle fatigability...
Nothing about this is easy...
Repeated Handgrip Strength Variability in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Separating Disease-Related Fatigability from Force Gradation https://www.medrxiv.org/content/10.64898/2026.07.22.26358672v1
July 24, 2026 at 10:25 PM
Repeated Handgrip Strength Variability in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Separating Disease-Related Fatigability from Force Gradation https://www.medrxiv.org/content/10.64898/2026.07.22.26358672v1
Proud to share our latest paper evaluating short, practical cognitive tests for monitoring athletes’ fatigability in challenging environments, and how this testing can help support performance in the field.
doi.org/10.1371/jour...
doi.org/10.1371/jour...
Assessment of cognitive performance and fatigability in elite athletes: Short and portable protocols for field monitoring under hypoxia
Purpose This study aimed to evaluate whether short (~15 min) cognitive protocols can detect fatigability in normoxia versus normobaric hypoxia in elite youth athletes, using tasks directly transferabl...
doi.org
July 21, 2026 at 7:46 AM
Proud to share our latest paper evaluating short, practical cognitive tests for monitoring athletes’ fatigability in challenging environments, and how this testing can help support performance in the field.
doi.org/10.1371/jour...
doi.org/10.1371/jour...
Post-stroke fatigue can impact daily activities & motor recovery. In this review, authors examined the literature on post-stroke motor fatigability & studies of underlying mechanisms. They report on limitations of prior work & recommendations for future research.
pubmed.ncbi.nlm.nih.gov/41787254/
pubmed.ncbi.nlm.nih.gov/41787254/
July 1, 2026 at 12:15 PM
Post-stroke fatigue can impact daily activities & motor recovery. In this review, authors examined the literature on post-stroke motor fatigability & studies of underlying mechanisms. They report on limitations of prior work & recommendations for future research.
pubmed.ncbi.nlm.nih.gov/41787254/
pubmed.ncbi.nlm.nih.gov/41787254/
This recent paper in NNR reports the prevalence of walking and cognitive fatigability, and the associated clinical characteristics, in a large sample of people with progressive #MultipleSclerosis using baseline data from the CogEx Study. #neurorehabilitation 🧪 🧠📈 journals.sagepub.com/doi/abs/10.1...
Prevalence and Associated Clinical Characteristics of Walking-Related Motor, Cognitive, and Fatigability in Progressive Multiple Sclerosis: Baseline Results From the CogEx Study - Cintia Ramari, Mieke...
Background: People with progressive multiple sclerosis (PMS) present motor (eg, walking) and cognitive impairments, and report fatigue. Fatigue encompasses fati...
journals.sagepub.com
June 3, 2024 at 5:24 PM
This recent paper in NNR reports the prevalence of walking and cognitive fatigability, and the associated clinical characteristics, in a large sample of people with progressive #MultipleSclerosis using baseline data from the CogEx Study. #neurorehabilitation 🧪 🧠📈 journals.sagepub.com/doi/abs/10.1...
Authors examined the between-day reliability of gait characteristics & their changes in people w/ multiple sclerosis & identified metrics w/ better reliability that could be used in future clinical trials & studies on walking fatigability. 🧪 #neurorehabilitation
journals.sagepub.com/doi/abs/10.1...
journals.sagepub.com/doi/abs/10.1...
March 30, 2024 at 4:33 PM
Authors examined the between-day reliability of gait characteristics & their changes in people w/ multiple sclerosis & identified metrics w/ better reliability that could be used in future clinical trials & studies on walking fatigability. 🧪 #neurorehabilitation
journals.sagepub.com/doi/abs/10.1...
journals.sagepub.com/doi/abs/10.1...
Looking at ladder climb function authors noticed fatigability in the male mice compared to female mice. While the results authors report fit with previous reports, I am not impressed with the study and the analysis.
July 6, 2026 at 8:06 AM
Looking at ladder climb function authors noticed fatigability in the male mice compared to female mice. While the results authors report fit with previous reports, I am not impressed with the study and the analysis.
Hm. "We observed no changes in objective fatigability as assessed by fatigue ratios as well as recovery ratio in either group." Plus the huge problem that a third of participants dropped out. it's hard for "intention-to-treat" to mitigate such a large LTFU.
December 25, 2024 at 6:58 PM
Hm. "We observed no changes in objective fatigability as assessed by fatigue ratios as well as recovery ratio in either group." Plus the huge problem that a third of participants dropped out. it's hard for "intention-to-treat" to mitigate such a large LTFU.
Don't just train to be fast when fresh. Train to remain yourself when tired.
marathonhandbook.com/durability-f...
marathonhandbook.com/durability-f...
Durability, Fatigability, Repeatability, Resilience: The New Language Of Endurance Running
VO2 max, lactate threshold, and running economy are the tidy little triangle that’s been used to explain endurance performance for a long time.
marathonhandbook.com
May 28, 2026 at 8:07 PM
Don't just train to be fast when fresh. Train to remain yourself when tired.
marathonhandbook.com/durability-f...
marathonhandbook.com/durability-f...
power training shortens motor unit contraction time, strength training buffs maximal strength, and endurance training reduces fatigability. disuse is bad for all three.
motor units are recruited from weakest to strongest. when all motor units are engaged, they fire faster to give an extra boost.
motor units are recruited from weakest to strongest. when all motor units are engaged, they fire faster to give an extra boost.
February 10, 2025 at 9:35 AM
power training shortens motor unit contraction time, strength training buffs maximal strength, and endurance training reduces fatigability. disuse is bad for all three.
motor units are recruited from weakest to strongest. when all motor units are engaged, they fire faster to give an extra boost.
motor units are recruited from weakest to strongest. when all motor units are engaged, they fire faster to give an extra boost.