Early Notch signals from fibroblastic reticular cells program effector CD8+ T cell differentiation
doi.org/10.1084/jem....
@jem.org
doi.org/10.1084/jem....
@jem.org
March 20, 2025 at 9:27 PM
Early Notch signals from fibroblastic reticular cells program effector CD8+ T cell differentiation
doi.org/10.1084/jem....
@jem.org
doi.org/10.1084/jem....
@jem.org
Nature research paper: Fibroblastic reticular cells direct the initiation of T cell responses via CD44
go.nature.com/4qxGBXl
go.nature.com/4qxGBXl
Fibroblastic reticular cells direct the initiation of T cell responses via CD44 - Nature
CD44 expressed by fibroblastic reticular cells in secondary lymphoid organs regulates trafficking of dendritic cells, and thus has an essential role in the priming of T cells and the adaptive immune response.
go.nature.com
January 27, 2026 at 9:08 AM
Nature research paper: Fibroblastic reticular cells direct the initiation of T cell responses via CD44
go.nature.com/4qxGBXl
go.nature.com/4qxGBXl
Fibroblastic reticular cells direct the initiation of T cell responses via CD44 @nature.com @the-de-lab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 21, 2026 at 6:06 PM
Fibroblastic reticular cells direct the initiation of T cell responses via CD44 @nature.com @the-de-lab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Fibroblastic reticular cells of the spleen coordinate inflammation for optimal antiviral T cell responses and protective memory
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
June 5, 2025 at 1:12 AM
Fibroblastic reticular cells of the spleen coordinate inflammation for optimal antiviral T cell responses and protective memory
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
NEW @preprintclub.bsky.social Journal Club of @biorxiv-immuno.bsky.social paper by @makris1.bsky.social @actonlab.bsky.social showing that loss of podoplanin in fibroblastic reticular cells results in decreased antibody levels and smaller germinal centres after immunization
Podoplanin mediates stromal–immune crosstalk in the lymph node - Nature Reviews Immunology
A preprint by Makris et al. shows that podoplanin is a key regulator of the functions of fibroblastic reticular cells in lymph nodes, by modulating interactions with immune cells.
www.nature.com
February 6, 2025 at 1:32 PM
NEW @preprintclub.bsky.social Journal Club of @biorxiv-immuno.bsky.social paper by @makris1.bsky.social @actonlab.bsky.social showing that loss of podoplanin in fibroblastic reticular cells results in decreased antibody levels and smaller germinal centres after immunization
#WeekendRead! #LocationLocationLocation! #EveryCellIsAnImmuneCell! Turley Muller Wu Lane &co show @natimmunol.nature.com that fibroblastic reticular cells in lymph nodes produce Flt3l to support survival & proliferation of dendritic cells allowing T cell responses during immunization or infection!!
Fibroblastic FLT3L supports lymph node dendritic cells in the interfollicular niche - Nature Immunology
Turley and colleagues find that Gremlin1-expressing lymph node fibroblastic reticular cells support dendritic cell homeostasis via provision of FLT3L.
www.nature.com
November 22, 2025 at 3:58 PM
#WeekendRead! #LocationLocationLocation! #EveryCellIsAnImmuneCell! Turley Muller Wu Lane &co show @natimmunol.nature.com that fibroblastic reticular cells in lymph nodes produce Flt3l to support survival & proliferation of dendritic cells allowing T cell responses during immunization or infection!!
CXCL12+ fibroblastic reticular cells in lymph nodes facilitate immune tolerance by regulating T cell–mediated alloimmunity @jclinical-invest.bsky.social
www.jci.org/articles/vie...
www.jci.org/articles/vie...
May 6, 2025 at 10:57 PM
CXCL12+ fibroblastic reticular cells in lymph nodes facilitate immune tolerance by regulating T cell–mediated alloimmunity @jclinical-invest.bsky.social
www.jci.org/articles/vie...
www.jci.org/articles/vie...
I’m pleased to share my latest work, published in Science Advances.
In this study, we investigated how fibroblastic reticular cells (FRCs) that populate the white pulp of the spleen regulate immune responses to viral infections.
#immunology #immunosky
www.science.org/doi/10.1126/...
In this study, we investigated how fibroblastic reticular cells (FRCs) that populate the white pulp of the spleen regulate immune responses to viral infections.
#immunology #immunosky
www.science.org/doi/10.1126/...
Splenic fibroblastic reticular cells orchestrate dendritic cell maturation and facilitate CD8+ T cell priming and protective memory
Fibroblastic reticular cells of the spleen coordinate inflammation for optimal antiviral T cell responses and protective memory.
www.science.org
June 5, 2025 at 12:32 AM
I’m pleased to share my latest work, published in Science Advances.
In this study, we investigated how fibroblastic reticular cells (FRCs) that populate the white pulp of the spleen regulate immune responses to viral infections.
#immunology #immunosky
www.science.org/doi/10.1126/...
In this study, we investigated how fibroblastic reticular cells (FRCs) that populate the white pulp of the spleen regulate immune responses to viral infections.
#immunology #immunosky
www.science.org/doi/10.1126/...
De Sousa, Perkey, Le Corre, Maillard, Labrecque et al. @umontreal.ca show that fibroblastic reticular cells are the source of Notch ligands promoting the differentiation of short-lived effector CD8+ T cells. rupress.org/jem/article/...
#InfectiousDisease #HostDefense #LymphocyteBiology
#InfectiousDisease #HostDefense #LymphocyteBiology
March 20, 2025 at 6:20 PM
De Sousa, Perkey, Le Corre, Maillard, Labrecque et al. @umontreal.ca show that fibroblastic reticular cells are the source of Notch ligands promoting the differentiation of short-lived effector CD8+ T cells. rupress.org/jem/article/...
#InfectiousDisease #HostDefense #LymphocyteBiology
#InfectiousDisease #HostDefense #LymphocyteBiology
A firm lump in the arch of the foot may be plantar fibromatosis, a benign condition characterized by slow-growing fibroblastic nodules within the plantar fascia.
🔗 Link: wikism.org/Plantar_Fibroma
#SportsMedicine #FootPain #Podiatry #Orthopedics #ClinicalPearls
🔗 Link: wikism.org/Plantar_Fibroma
#SportsMedicine #FootPain #Podiatry #Orthopedics #ClinicalPearls
September 2, 2026 at 3:41 AM
A firm lump in the arch of the foot may be plantar fibromatosis, a benign condition characterized by slow-growing fibroblastic nodules within the plantar fascia.
🔗 Link: wikism.org/Plantar_Fibroma
#SportsMedicine #FootPain #Podiatry #Orthopedics #ClinicalPearls
🔗 Link: wikism.org/Plantar_Fibroma
#SportsMedicine #FootPain #Podiatry #Orthopedics #ClinicalPearls
Fantastic new paper from @the-de-lab.bsky.social showing how the CMV m11 protein drives immune evasion by blocking CD44-dependent, FRC-mediated DC migration in the spleen, ultimately dampening antiviral CD8⁺ T cell priming @monashuniversity.bsky.social www.nature.com/articles/s41...
Fibroblastic reticular cells direct the initiation of T cell responses via CD44 - Nature
CD44 expressed by fibroblastic reticular cells in secondary lymphoid organs regulates trafficking of dendritic cells, and thus has an essential role in the priming of T cells and the adaptive immune r...
www.nature.com
January 23, 2026 at 4:03 AM
Fantastic new paper from @the-de-lab.bsky.social showing how the CMV m11 protein drives immune evasion by blocking CD44-dependent, FRC-mediated DC migration in the spleen, ultimately dampening antiviral CD8⁺ T cell priming @monashuniversity.bsky.social www.nature.com/articles/s41...
Fibroblastic FLT3L supports lymph node dendritic cells in the interfollicular niche @natimmunol.nature.com
@genentech.bsky.social
www.nature.com/articles/s41...
@genentech.bsky.social
www.nature.com/articles/s41...
November 18, 2025 at 5:39 PM
Fibroblastic FLT3L supports lymph node dendritic cells in the interfollicular niche @natimmunol.nature.com
@genentech.bsky.social
www.nature.com/articles/s41...
@genentech.bsky.social
www.nature.com/articles/s41...
No one quite knows why they show nuclear WT1, but it is very helpful. CADM3 expression is more specific but no one has the antibody. They often contain scattered keratin, or less often Desmin-positive cells. The Brigham group wrote a nice big series. pubmed.ncbi.nlm.nih.gov/35713642/
Superficial CD34-Positive Fibroblastic Tumor: A Clinicopathologic, Immunohistochemical, and Molecular Study of 59 Cases - PubMed
Superficial CD34-positive fibroblastic tumor (SCD34FT) is a rare soft tissue neoplasm that shows overlapping features with PRDM10 -rearranged soft tissue tumor ( PRDM10 -STT). This study characterizes...
pubmed.ncbi.nlm.nih.gov
February 5, 2025 at 7:16 PM
No one quite knows why they show nuclear WT1, but it is very helpful. CADM3 expression is more specific but no one has the antibody. They often contain scattered keratin, or less often Desmin-positive cells. The Brigham group wrote a nice big series. pubmed.ncbi.nlm.nih.gov/35713642/
Specialized fibroblastic reticular cells underpin interconnected T cell environments with dedicated microenvironmental niches that promotes antitumor immunity in lung cancer
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
November 19, 2024 at 5:15 PM
Specialized fibroblastic reticular cells underpin interconnected T cell environments with dedicated microenvironmental niches that promotes antitumor immunity in lung cancer
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Inflammatory myofibroblastic tumour: collapsed L lung, dilated mucus filled bronchi. Rare tumour comprising myofibroblastic and fibroblastic spindle cells. Most commonly found in children and young adults.
👤 Case courtesy of Christin Wei Tong Lim, radiopaedia.org/cases/192175
#RadSky #MedSky
👤 Case courtesy of Christin Wei Tong Lim, radiopaedia.org/cases/192175
#RadSky #MedSky
February 16, 2025 at 3:30 PM
Inflammatory myofibroblastic tumour: collapsed L lung, dilated mucus filled bronchi. Rare tumour comprising myofibroblastic and fibroblastic spindle cells. Most commonly found in children and young adults.
👤 Case courtesy of Christin Wei Tong Lim, radiopaedia.org/cases/192175
#RadSky #MedSky
👤 Case courtesy of Christin Wei Tong Lim, radiopaedia.org/cases/192175
#RadSky #MedSky
JEM’s February issue is here! rupress.org/jem/issue/22...
🔬 The cover depicts fibroblastic reticular cells and vascular smooth muscle cells surrounding a high endothelial venule in a murine lymph node. See Kurz et al. (doi.org/10.1084/jem....)
🔬 The cover depicts fibroblastic reticular cells and vascular smooth muscle cells surrounding a high endothelial venule in a murine lymph node. See Kurz et al. (doi.org/10.1084/jem....)
February 2, 2026 at 3:02 PM
JEM’s February issue is here! rupress.org/jem/issue/22...
🔬 The cover depicts fibroblastic reticular cells and vascular smooth muscle cells surrounding a high endothelial venule in a murine lymph node. See Kurz et al. (doi.org/10.1084/jem....)
🔬 The cover depicts fibroblastic reticular cells and vascular smooth muscle cells surrounding a high endothelial venule in a murine lymph node. See Kurz et al. (doi.org/10.1084/jem....)
By IHC it is diffusely CD34-pos, shows strong nuclear WT1, and contains scattered desmin-pos cells. This is a superficial CD34-positive fibroblastic tumor. Very low grade tumor, often with PRDM10 fusions. Jody Carter, now in Edmonton, wrote this paper. pubmed.ncbi.nlm.nih.gov/23887307/
February 5, 2025 at 7:12 PM
By IHC it is diffusely CD34-pos, shows strong nuclear WT1, and contains scattered desmin-pos cells. This is a superficial CD34-positive fibroblastic tumor. Very low grade tumor, often with PRDM10 fusions. Jody Carter, now in Edmonton, wrote this paper. pubmed.ncbi.nlm.nih.gov/23887307/
Kurz, Lütge, Ludewig et al. elucidate the ontogeny of fibroblastic reticular cells and vascular smooth muscle cells in mouse lymph nodes from proliferating, CCL19-expressing progenitors & highlight the close lineage relationship of the progeny in the perivascular niche rupress.org/jem/article/...
November 26, 2025 at 6:02 PM
Kurz, Lütge, Ludewig et al. elucidate the ontogeny of fibroblastic reticular cells and vascular smooth muscle cells in mouse lymph nodes from proliferating, CCL19-expressing progenitors & highlight the close lineage relationship of the progeny in the perivascular niche rupress.org/jem/article/...
A common progenitor gives rise to fibroblastic reticular cells and vascular smooth muscle cells in murine lymph nodes @jem.org
rupress.org/jem/article/...
rupress.org/jem/article/...
November 26, 2025 at 8:41 PM
A common progenitor gives rise to fibroblastic reticular cells and vascular smooth muscle cells in murine lymph nodes @jem.org
rupress.org/jem/article/...
rupress.org/jem/article/...
Maybe looking at it more would help? It’s got branching, thick-walled vessels and haphazardly-arranged fibroblastic cells, like an SFT. CD34 is negative, but STAT6 is diffusely positive. This is a lipomatous SFT (previously lipomatous hemangiopericytoma). Not all SFT are CD34+.
January 13, 2025 at 3:07 PM
Maybe looking at it more would help? It’s got branching, thick-walled vessels and haphazardly-arranged fibroblastic cells, like an SFT. CD34 is negative, but STAT6 is diffusely positive. This is a lipomatous SFT (previously lipomatous hemangiopericytoma). Not all SFT are CD34+.
This is a cool paper
"The targeting of CD44 by CMV reveals CD44 as a molecule that is essential to the functioning of the FRC network and uncovers a previously unrecognized stroma-based mechanism that is critical for the generation of effective T cell responses." #Immunology
"The targeting of CD44 by CMV reveals CD44 as a molecule that is essential to the functioning of the FRC network and uncovers a previously unrecognized stroma-based mechanism that is critical for the generation of effective T cell responses." #Immunology
Fibroblastic reticular cells direct the initiation of T cell responses via CD44 - Nature
CD44 expressed by fibroblastic reticular cells in secondary lymphoid organs regulates trafficking of dendritic cells, and thus has an essential role in the priming of T cells and the adaptive immune r...
www.nature.com
January 22, 2026 at 2:43 PM
This is a cool paper
"The targeting of CD44 by CMV reveals CD44 as a molecule that is essential to the functioning of the FRC network and uncovers a previously unrecognized stroma-based mechanism that is critical for the generation of effective T cell responses." #Immunology
"The targeting of CD44 by CMV reveals CD44 as a molecule that is essential to the functioning of the FRC network and uncovers a previously unrecognized stroma-based mechanism that is critical for the generation of effective T cell responses." #Immunology
#Medsky🧪 #IDSky #immunosky Fibroblastic reticular cells are a population of stromal cells found in lymph nodes that are crucial for the maintenance of immunological niches and the support of immune responses during inflammation.
Pdf :
www.nature.com/articles/s41...
Pdf :
www.nature.com/articles/s41...
February 6, 2025 at 1:39 PM
#Medsky🧪 #IDSky #immunosky Fibroblastic reticular cells are a population of stromal cells found in lymph nodes that are crucial for the maintenance of immunological niches and the support of immune responses during inflammation.
Pdf :
www.nature.com/articles/s41...
Pdf :
www.nature.com/articles/s41...
This of course is what we now call “myxoinflammatory fibroblastic sarcoma”. Originally reported as “Inflammatory myxohyaline tumor of distal extremities with virocyte or Reed-Sternberg-like cells”. I think this older name helps us remember the distinctive diagnostic features of this sarcoma.
April 29, 2025 at 6:46 PM
This of course is what we now call “myxoinflammatory fibroblastic sarcoma”. Originally reported as “Inflammatory myxohyaline tumor of distal extremities with virocyte or Reed-Sternberg-like cells”. I think this older name helps us remember the distinctive diagnostic features of this sarcoma.
Myofibroblast programming blocks differentiation of TLS-organizing fibroblastic reticular cells in pancreatic cancer www.cell.com/cancer-cell...
June 1, 2026 at 2:15 PM
Myofibroblast programming blocks differentiation of TLS-organizing fibroblastic reticular cells in pancreatic cancer www.cell.com/cancer-cell...
Amazing @theaacr.bsky.social #CD study by @marasherman.bsky.social & #WomenInSTEM team showing how #pancreaticcancer
is naturally restrained by #fibroblastic/mesenchymal microenvironment engaging anti-tumor defenses until KITL loss.
So let’s coddle KITL people! aacrjournals.org/cancerdiscov...
is naturally restrained by #fibroblastic/mesenchymal microenvironment engaging anti-tumor defenses until KITL loss.
So let’s coddle KITL people! aacrjournals.org/cancerdiscov...
a drawing of two cats laying on top of each other on a white background .
ALT: a drawing of two cats laying on top of each other on a white background .
media.tenor.com
February 8, 2025 at 12:36 PM
Amazing @theaacr.bsky.social #CD study by @marasherman.bsky.social & #WomenInSTEM team showing how #pancreaticcancer
is naturally restrained by #fibroblastic/mesenchymal microenvironment engaging anti-tumor defenses until KITL loss.
So let’s coddle KITL people! aacrjournals.org/cancerdiscov...
is naturally restrained by #fibroblastic/mesenchymal microenvironment engaging anti-tumor defenses until KITL loss.
So let’s coddle KITL people! aacrjournals.org/cancerdiscov...