#focalepilepsy
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epilepsiajournal.bsky.social
Sleep-related hypermotor epilepsy—No longer controversial
doi.org/10.1111/epi....

#epilepsy #ilae #SHE #focalepilepsy #hypermotorseizures #sleep #parasomnias
April 1, 2025 at 4:07 PM
epilepsiajournal.bsky.social
Key point: LEV is the best choice when combined with antiepileptic clinical guidelines on the basis of its efficacy in decreasing seizure frequency.
doi.org/10.1111/epi....

#epilepsy #ILAE #antiseizuremedication #costeffectiveness #lacosamide #monotherapy #focalepilepsy
January 31, 2025 at 3:05 PM
epilepsiajournal.bsky.social
Key point: Several newer antiseizure medications, including the most recent, cenobamate, are now available for the treatment of focal epilepsy.
doi.org/10.1111/epi....

#epilepsy #ILAE #Cenobamate #SKlifescience #antiseizuremedications #drugresistantepilepsy #focalepilepsy
April 10, 2025 at 6:59 PM
epilepsiajournal.bsky.social
Key point: Seizure freedom has been a goal of epilepsy treatment for >25 years, but rates of seizure freedom have changed little during this time.
doi.org/10.1111/epi....

#epilepsy #ILAE # Cenobamate #SKlifescience #focalepilepsy #seizurefreedom
April 8, 2025 at 9:18 PM
epilepsiajournal.bsky.social
Key point: The study analyzed the prescribing behaviors of epileptologists and their consequences in WOCP already using VPA during 2014–2019.
doi.org/10.1111/epi....

#epilepsy #ILAE #focalepilepsy #tonicclonicseizures #Valproate
February 4, 2025 at 4:48 PM
epilepsiajournal.bsky.social
Key point: We calculated polygenic risk scores for genetic generalized epilepsy and for focal epilepsy in individuals from 257 multiplex epilepsy families.
onlinelibrary.wiley.com/doi/full/10....

#epilepsy #ILAE #familialepilepsy #focalepilepsy #geneticgeneralizedepilepsy #polygenicriskscores
March 18, 2025 at 4:12 PM
epilepsiajournal.bsky.social
Key point: As memory dysfunction is common in people with temporal lobe epilepsy, we explored spindle–slow wave coupling in this patient group compared to healthy controls.
doi.org/10.1111/epi....

#epilepsy #ILAE #cognition #coupling #focalepilepsy #highdensityEEG #sleep
April 1, 2025 at 4:06 PM
stiftungmichael.bsky.social
Sophie Adler, Michael-Preisträgerin 2025 erklärt, welchen Beitrag ihre Forschung zur medizinischen Versorgung von Menschen mit Epilepsie leistet.
#allgemeinegesundheitsversorgung #stiftungmichael #epilepsietherapie #epilepsy #brain #epilepsie #focalepilepsy #healthcoverage #LoveUCL
December 12, 2025 at 11:09 AM
epilepsiajournal.bsky.social
We evaluated the efficacy and safety of adjunctive cenobamate (100, 200, and 400 mg/day) in Asian patients with uncontrolled focal seizures.
doi.org/10.1111/epi....
#epilepsy #ILAE #epilepsia #antiseizuremedication #focalepilepsy #phase3 #refractory
A randomized, double‐blind, placebo‐controlled, multicenter study to evaluate the efficacy and safety of adjunctive cenobamate in Asian patients with focal seizures
A randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy and safety of adjunctive cenobamate in Asian patients with focal seizures.
doi.org
November 10, 2025 at 3:48 PM
epilepsiajournal.bsky.social
A multivariate measure for mapping deviations in brain microstructure was developed to characterize limbic pathology in patients with temporal lobe epilepsy.
doi.org/10.1111/epi....

#epilepsy #epilepsia #ILAE #diffusionMRI #drugresistant #focalepilepsy #MRI #NODDI #normativemodeling
August 25, 2025 at 4:00 PM
epilepsiajournal.bsky.social
We report the impact of climatic variables on hyponatremia-related hospitalizations in a well-phenotyped cohort of people with focal #epilepsy exposed to #carbamazepine or its derivatives.
doi.org/10.1111/epi....

#epilepsia #ILAE #antiseizuremedication #climatechange #focalepilepsy #hyponatremia
August 23, 2025 at 5:57 PM
epilepsiajournal.bsky.social
The CSMD genes are associated with epilepsies: CSMD2 with focal epilepsy/FCD and CSMD3 with a phenotype spectrum including focal epilepsy, febrile seizures, and DEE.
doi.org/10.1111/epi....

#epilepsy #epilepsia #ILAE #CSMD2 #CSMD3 #febrileseizures #focalepilepsy #infantilespasms
July 29, 2025 at 3:49 PM
epilepsiajournal.bsky.social
Key point: We scanned 31 patients with parallel transmit and conventional 7T magnetic resonance imaging (MRI), finding previously-unreported structural lesions in nine patients (29% of cases).
doi.org/10.1111/epi.... Open Access

#epilepsy #ilae #epilepsia #7TMRI #epilepsysurgery #focalepilepsy
April 14, 2025 at 2:46 PM
epilepsia-open.bsky.social
This post hoc analysis evaluates perampanel as first adjunctive therapy for epilepsy across different clinical and regional settings.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #antiseizuremedication #firstaddontherapy #focalepilepsy #focalonsetseizures #tonicclonicseizures #perampanel
November 20, 2025 at 5:18 PM
epilepsia-open.bsky.social
Key point: A low dose of antiseizure medications may be started in adults with a new diagnosis of focal epilepsy of unknown etiology and low seizure frequency.
doi.org/10.1002/epi4...

#epilepsy #ILAE #efficacy #focalepilepsy #lowdose #monotherapy #newlydiagnosedepilepsy #randomizedtrial
March 4, 2025 at 3:36 PM
jamaneurology.com
In adults with drug-resistant #FocalEpilepsy, cenobamate was associated with greater seizure reduction and seizure freedom vs brivaracetam, lacosamide, and perampanel, but with more adverse effects.

ja.ma/3ZE7zAN
Figure 1 displays adjusted odds ratios (ORs) and probabilities for seizure response at 6 months. Graph A shows ORs comparing antiseizure meds; graph B shows model-adjusted probabilities for each medication: Cenobamate, Lacosamide, Perampanel, Brivaracetam.
February 14, 2026 at 3:00 PM
jamaneurology.com
In adults with drug-resistant #FocalEpilepsy, cenobamate was associated with greater seizure reduction and seizure freedom vs brivaracetam, lacosamide, and perampanel, but with more adverse effects.

bit.ly/4qIo6il
Figure 1 shows adjusted odds ratios(ORs) and probabilities of 50% or greater response and greater than or equal to 3-month seizure freedom at 6-month follow-up. Graph A displays adjusted ORs in comparisons of antiseizure medications.
February 9, 2026 at 4:30 PM
familyvoicesal.bsky.social
"Focal epilepsy seizures can begin at any age—from infancy to adulthood—and usually are controlled with medication or other interventions."

#Epilepsy #Seizures #FocalSeizures #FocalEpilepsy
#EpilepsyAwarenessMonth

apple.news/AOltSv8cwRd-...
What to Know About Focal Epilepsy — Verywell
Focal epilepsy is when people have recurrent seizures that may cause symptoms affecting only one side of the body. Seizures in epilepsy can be focal or generalized.
apple.news
November 6, 2025 at 2:07 PM
ebiomedicine.bsky.social
Only ~1 in 500 seizure-focus spikes propagate to the thalamus during sleep—yet thalamic activity still predicts surgical failure in #FocalEpilepsy. New research in eBioMedicine helps explain why.
Cover of eBioMedicine, Volume 128 (June 2026). The layout features a clean white background with a scientific illustration at the bottom. Text headings list: an editorial on patient-derived organoid models, an article on thalamic interictal events during NREM sleep in focal epilepsy, and a review on intrathecal gene therapy for neurological disorders. The journal branding and website appear at the top.
June 10, 2026 at 1:14 PM