Excited to share the first pre-print from our lab! 🎉
This work was a fantastic collaboration with David G. McFadden's lab at @utswim.bsky.social, and a huge congratulations to our outstanding first author, Alex Nguyen.
#ChemicalBiology #CancerResearch #DrugDiscovery #ForwardGenetics #SCLC
This work was a fantastic collaboration with David G. McFadden's lab at @utswim.bsky.social, and a huge congratulations to our outstanding first author, Alex Nguyen.
#ChemicalBiology #CancerResearch #DrugDiscovery #ForwardGenetics #SCLC
Ultramutagenesis through combined Msh2 depletion and proofreading-deficient DNA polymerase ε expression enhances small molecule target identification in forward genetic screens
DNA mismatch repair (MMR) deficiency has been widely utilized in forward genetic screens to identify drug resistance mutations and elucidate the mechanisms of action of cytotoxic small molecules. Howe...
www.biorxiv.org
July 8, 2026 at 2:02 PM
Excited to share the first pre-print from our lab! 🎉
This work was a fantastic collaboration with David G. McFadden's lab at @utswim.bsky.social, and a huge congratulations to our outstanding first author, Alex Nguyen.
#ChemicalBiology #CancerResearch #DrugDiscovery #ForwardGenetics #SCLC
This work was a fantastic collaboration with David G. McFadden's lab at @utswim.bsky.social, and a huge congratulations to our outstanding first author, Alex Nguyen.
#ChemicalBiology #CancerResearch #DrugDiscovery #ForwardGenetics #SCLC
Excited to share our new paper, co-led by Gracyn Buenconsejo and me.
Why did a promising anti-#Cryptosporidium drug fail?
We asked whether the parasite itself might already be genetically prepared to escape treatment.
doi.org/10.1038/s415...
#Clofazimine #forwardgenetics
Why did a promising anti-#Cryptosporidium drug fail?
We asked whether the parasite itself might already be genetically prepared to escape treatment.
doi.org/10.1038/s415...
#Clofazimine #forwardgenetics
Genomic heterogeneity of NAD(P)H dehydrogenase predisposes Cryptosporidium to clofazimine resistance - Nature Microbiology
Forward and reverse genetics identifies the mode of action of clofazimine in the parasite Cryptosporidium. The genomic locus encoding the target is heterogeneous, and a resistance-conferring allele is...
doi.org
May 13, 2026 at 11:33 AM
Excited to share our new paper, co-led by Gracyn Buenconsejo and me.
Why did a promising anti-#Cryptosporidium drug fail?
We asked whether the parasite itself might already be genetically prepared to escape treatment.
doi.org/10.1038/s415...
#Clofazimine #forwardgenetics
Why did a promising anti-#Cryptosporidium drug fail?
We asked whether the parasite itself might already be genetically prepared to escape treatment.
doi.org/10.1038/s415...
#Clofazimine #forwardgenetics
🚨 New paper out! 🚨
🧬 Parasite sex as a discovery tool — new insights into Cryptosporidium virulence!
Huge thanks to my co-authors, collaborators & mentors 🙌
#Parasites #Cryptosporidium #Genetics #InfectiousDiseases #ForwardGenetics
www.sciencedirect.com/science/arti...
🧬 Parasite sex as a discovery tool — new insights into Cryptosporidium virulence!
Huge thanks to my co-authors, collaborators & mentors 🙌
#Parasites #Cryptosporidium #Genetics #InfectiousDiseases #ForwardGenetics
www.sciencedirect.com/science/arti...
Genetic crosses reveal genomic loci responsible for virulence in Cryptosporidium parvum infection
The relationship between parasite genotype and pathogenesis is largely unknown for Cryptosporidium, a leading cause of diarrheal disease in children. …
www.sciencedirect.com
September 18, 2025 at 10:13 PM
🚨 New paper out! 🚨
🧬 Parasite sex as a discovery tool — new insights into Cryptosporidium virulence!
Huge thanks to my co-authors, collaborators & mentors 🙌
#Parasites #Cryptosporidium #Genetics #InfectiousDiseases #ForwardGenetics
www.sciencedirect.com/science/arti...
🧬 Parasite sex as a discovery tool — new insights into Cryptosporidium virulence!
Huge thanks to my co-authors, collaborators & mentors 🙌
#Parasites #Cryptosporidium #Genetics #InfectiousDiseases #ForwardGenetics
www.sciencedirect.com/science/arti...