Catalytic methane functionalization and all it takes is... beryllium! We also compare the mechanisms of methane beryllation and borylation to reveal why Be finds it so easy @pubs.acs.org pubs.acs.org/doi/10.1021/...
Methane Beryllation Catalyzed by a Base Metal Complex
The homogeneous catalytic functionalization of methane is extremely challenging due to the relative nonpolarity and high C–H bond strength of this hydrocarbon. Here, using catalytic quantities (10 mol...
pubs.acs.org
March 11, 2025 at 7:45 PM
Catalytic methane functionalization and all it takes is... beryllium! We also compare the mechanisms of methane beryllation and borylation to reveal why Be finds it so easy @pubs.acs.org pubs.acs.org/doi/10.1021/...
Nature research paper: Copper-dependent halogenase catalyses unactivated C−H bond functionalization
https://go.nature.com/4hi9xhw
https://go.nature.com/4hi9xhw
Copper-dependent halogenase catalyses unactivated C−H bond functionalization - Nature
A halogenase enzyme uses the copper in its active site to catalyse iterative chlorinations on multiple unactivated carbon−hydrogen bonds, enabling carbon−hydrogen functionalization that is not achievable with an iron-based halogenase.
go.nature.com
January 30, 2025 at 9:12 AM
Nature research paper: Copper-dependent halogenase catalyses unactivated C−H bond functionalization
https://go.nature.com/4hi9xhw
https://go.nature.com/4hi9xhw
Light-activated hypervalent iodine agents enable diverse aliphatic C–H functionalization, from Song Lin and co-workers:
www.nature.com/articles/s41...
#chemsky
www.nature.com/articles/s41...
#chemsky
Light-activated hypervalent iodine agents enable diverse aliphatic C–H functionalization - Nature Chemistry
Aliphatic C–H functionalization is a valuable tool in organic synthesis. Now a hypervalent iodine reagent has been shown to release a potent hydrogen atom abstractor for C–H activation under mild phot...
www.nature.com
February 25, 2025 at 10:09 AM
Light-activated hypervalent iodine agents enable diverse aliphatic C–H functionalization, from Song Lin and co-workers:
www.nature.com/articles/s41...
#chemsky
www.nature.com/articles/s41...
#chemsky
In @science.org this week @zachwickens.bsky.social and collaborators find a way to do Z-selective elimination using thianthrenium chemistry in a versatile route to Z olefins.
chemsky 🧪
www.science.org/doi/10.1126/...
chemsky 🧪
www.science.org/doi/10.1126/...
Stereo-reversed E2 unlocks Z-selective C–H functionalization
The stereoselective functionalization of C–H bonds represents a central challenge in modern organic synthesis. Despite decades of innovation in C–H activation chemistry, methods for Z-selective functi...
www.science.org
September 18, 2025 at 10:14 PM
In @science.org this week @zachwickens.bsky.social and collaborators find a way to do Z-selective elimination using thianthrenium chemistry in a versatile route to Z olefins.
chemsky 🧪
www.science.org/doi/10.1126/...
chemsky 🧪
www.science.org/doi/10.1126/...
First post on Blue sky! Congratulations to graduate student Yorick Chiang and scientist Masa Ohashi on discovery of new copper dependent halogen from Nature @nature.com !
Many thanks to the wonderful collaborators!
www.nature.com/articles/s41...
Many thanks to the wonderful collaborators!
www.nature.com/articles/s41...
Copper-dependent halogenase catalyses unactivated C−H bond functionalization - Nature
A halogenase enzyme uses the copper in its active site to catalyse iterative chlorinations on multiple unactivated carbon−hydrogen bonds, enabling carbon−hydrogen functionalization that is not achieva...
www.nature.com
January 29, 2025 at 5:34 PM
First post on Blue sky! Congratulations to graduate student Yorick Chiang and scientist Masa Ohashi on discovery of new copper dependent halogen from Nature @nature.com !
Many thanks to the wonderful collaborators!
www.nature.com/articles/s41...
Many thanks to the wonderful collaborators!
www.nature.com/articles/s41...
Happy to share our latest article on functionalization of furfural derivatives by cobalt catalysis. Thank to @cramtitep.bsky.social for this collaboration and thank to @alessiamori.bsky.social. @casch-ipcm.bsky.social @ipcm-sorbonne.bsky.social @sorbonne-universite.fr
pubs.rsc.org/en/content/a...
pubs.rsc.org/en/content/a...
Complementary pathways in C–H functionalization of furfural derivatives with cobalt-hydride catalysis
This study reports the first cobalt-catalysed C–H functionalization of furfural derivatives, demonstrating distinct reactivities based on the substrate. Furfurylimines enable selective C5–H alkenylati...
pubs.rsc.org
September 26, 2025 at 7:36 AM
Happy to share our latest article on functionalization of furfural derivatives by cobalt catalysis. Thank to @cramtitep.bsky.social for this collaboration and thank to @alessiamori.bsky.social. @casch-ipcm.bsky.social @ipcm-sorbonne.bsky.social @sorbonne-universite.fr
pubs.rsc.org/en/content/a...
pubs.rsc.org/en/content/a...
We kick off day 2 of the #PhotoReAct symposium with Jerome Waser @lcsolab.bsky.social talking about synthetic methods revolving around the functionalization of weak bonds
December 3, 2024 at 8:08 AM
We kick off day 2 of the #PhotoReAct symposium with Jerome Waser @lcsolab.bsky.social talking about synthetic methods revolving around the functionalization of weak bonds
Thrilled to share our latest publication on DNA origami folding and functionalization! A fantastic collaboration with
@kgoepfrich.bsky.social and Anabel Lostao
teams. pubs.acs.org/doi/10.1021/... #DeDNAmers project 🧬with Jesús del Barrio @inmadivulga.bsky.social
@kgoepfrich.bsky.social and Anabel Lostao
teams. pubs.acs.org/doi/10.1021/... #DeDNAmers project 🧬with Jesús del Barrio @inmadivulga.bsky.social
January 27, 2025 at 9:58 PM
Thrilled to share our latest publication on DNA origami folding and functionalization! A fantastic collaboration with
@kgoepfrich.bsky.social and Anabel Lostao
teams. pubs.acs.org/doi/10.1021/... #DeDNAmers project 🧬with Jesús del Barrio @inmadivulga.bsky.social
@kgoepfrich.bsky.social and Anabel Lostao
teams. pubs.acs.org/doi/10.1021/... #DeDNAmers project 🧬with Jesús del Barrio @inmadivulga.bsky.social
Substitution, Elimination, and Integration of Methyl Groups in Terpenes Initiated by C–H Bond Functionalization
by John Hartwig and co-workers in ACS Central Science.
pubs.acs.org/doi/10.1021/...
@acspublications.bsky.social
#ChemSky #ACSCentralScience
by John Hartwig and co-workers in ACS Central Science.
pubs.acs.org/doi/10.1021/...
@acspublications.bsky.social
#ChemSky #ACSCentralScience
Substitution, Elimination, and Integration of Methyl Groups in Terpenes Initiated by C–H Bond Functionalization
Methyl groups are ubiquitous in natural products and biologically active compounds, but methods for their selective transformation in such structures are limited. For example, terpenoids contain many ...
pubs.acs.org
November 25, 2024 at 9:46 PM
Substitution, Elimination, and Integration of Methyl Groups in Terpenes Initiated by C–H Bond Functionalization
by John Hartwig and co-workers in ACS Central Science.
pubs.acs.org/doi/10.1021/...
@acspublications.bsky.social
#ChemSky #ACSCentralScience
by John Hartwig and co-workers in ACS Central Science.
pubs.acs.org/doi/10.1021/...
@acspublications.bsky.social
#ChemSky #ACSCentralScience
Our democratically elected #paperofthemonth is Cong's synthesis of a helical tubular, rigid dimer of [9]Cycloparaphenylene featuring very high CPL brightness! #chemsky
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
A Helical Tubular Dyad of [9]Cycloparaphenylene: Synthesis, Chiroptical Properties and Post‐Functionalization
Employing the site-specific functionalization strategy, a radially conjugated, helical tubular molecule has been constructed by covalently connecting [9]cycloparaphenylenes with three sp-hybridized a....
onlinelibrary.wiley.com
December 9, 2024 at 12:30 PM
Our democratically elected #paperofthemonth is Cong's synthesis of a helical tubular, rigid dimer of [9]Cycloparaphenylene featuring very high CPL brightness! #chemsky
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
I am once again using my foster kittens to illustrate catalytic polymer functionalization
August 8, 2025 at 8:27 PM
I am once again using my foster kittens to illustrate catalytic polymer functionalization
The Panetti Lab officially has funding! Thank you to the ACS PRF for funding our work looking into CO2 functionalization with light. cen.acs.org/acs-news/pro...
ACS Board approves 112 new PRF grants
The fall 2025 grants total $12,475,000 in researcher investments
cen.acs.org
November 12, 2025 at 3:36 PM
The Panetti Lab officially has funding! Thank you to the ACS PRF for funding our work looking into CO2 functionalization with light. cen.acs.org/acs-news/pro...
Research Highlight now online:
Deaminative aromatic functionalization by Joel Cejas-Sánchez
www.nature.com/articles/s44... ($)
Highlighting the @nature.com article by Xiaosong Xue, Xiaheng Zhang and co-workers
#Chemsky
Deaminative aromatic functionalization by Joel Cejas-Sánchez
www.nature.com/articles/s44... ($)
Highlighting the @nature.com article by Xiaosong Xue, Xiaheng Zhang and co-workers
#Chemsky
Deaminative aromatic functionalization - Nature Synthesis
Nature Synthesis - Deaminative aromatic functionalization
www.nature.com
November 24, 2025 at 3:35 PM
Research Highlight now online:
Deaminative aromatic functionalization by Joel Cejas-Sánchez
www.nature.com/articles/s44... ($)
Highlighting the @nature.com article by Xiaosong Xue, Xiaheng Zhang and co-workers
#Chemsky
Deaminative aromatic functionalization by Joel Cejas-Sánchez
www.nature.com/articles/s44... ($)
Highlighting the @nature.com article by Xiaosong Xue, Xiaheng Zhang and co-workers
#Chemsky
Modular α-Functionalization of Bowl-Shaped Subphthalocyanine Aromatics (@pubs.acs.org): pubs.acs.org/doi/10.1021/....
August 22, 2025 at 8:34 PM
Modular α-Functionalization of Bowl-Shaped Subphthalocyanine Aromatics (@pubs.acs.org): pubs.acs.org/doi/10.1021/....
Excited to share the publication of “Enhancing the Statistical Probability Factor in Triplet-Triplet Annihilation Photon Upconversion via TIPS Functionalization” in @chemicalscience.rsc.org
pubs.rsc.org/en/content/a...
pubs.rsc.org/en/content/a...
October 7, 2025 at 8:44 AM
Excited to share the publication of “Enhancing the Statistical Probability Factor in Triplet-Triplet Annihilation Photon Upconversion via TIPS Functionalization” in @chemicalscience.rsc.org
pubs.rsc.org/en/content/a...
pubs.rsc.org/en/content/a...
Sharing our 1st preprint on our work on organo-Ti photocatalysis! We've found that titanocenes are photoactive catalysts for alcohol activation by LMCT excitation, enabling β-scission of alkoxyl radicals for degradative functionalization. Congrats Jagrut, Ashley & the whole team!
Degradative Alcohol Functionalization by Titanocene Photocatalysis
Organotitanium complexes are scarcely employed in photocatalytic reactions despite their robust ligand-to-metal charge-transfer photo-chemistry. Herein, we describe the development of titanocene pho-t...
chemrxiv.org
June 11, 2025 at 2:27 PM
Sharing our 1st preprint on our work on organo-Ti photocatalysis! We've found that titanocenes are photoactive catalysts for alcohol activation by LMCT excitation, enabling β-scission of alkoxyl radicals for degradative functionalization. Congrats Jagrut, Ashley & the whole team!
Diruthenium catalysis: An efficient paradigm for directed C-H functionalization
doi.org/10.1016/j.cc...
doi.org/10.1016/j.cc...
February 20, 2026 at 5:23 PM
Diruthenium catalysis: An efficient paradigm for directed C-H functionalization
doi.org/10.1016/j.cc...
doi.org/10.1016/j.cc...
Carbodicarbene-Stibenium Ion-Mediated Functionalization of C(sp3)−H and C(sp)−H Bonds | Angewandte Chemie #ouryearinreview @gilliardgroup.bsky.social #maingroup #chemsky @angewandtechemie.bsky.social onlinelibrary.wiley.com/doi/10.1002/...
Carbodicarbene‐Stibenium Ion‐Mediated Functionalization of C(sp3)−H and C(sp)−H Bonds
A Lewis acidic carbodicarbene-stibenium ion mediates C(sp3)−H and C(sp)−H bond breaking of acetonitrile and terminal alkynes in the presence of an organic base. The resulting adducts were reacted wit...
onlinelibrary.wiley.com
December 16, 2024 at 5:29 PM
Carbodicarbene-Stibenium Ion-Mediated Functionalization of C(sp3)−H and C(sp)−H Bonds | Angewandte Chemie #ouryearinreview @gilliardgroup.bsky.social #maingroup #chemsky @angewandtechemie.bsky.social onlinelibrary.wiley.com/doi/10.1002/...
From our 60th anniversary collection 🎉
'Navigating electrochemical oxidative functionalization of olefins: selected mechanistic and synthetic examples' by Daniele Mazzarella (@mazda90.bsky.social) and colleagues.
pubs.rsc.org/en/content/a...
'Navigating electrochemical oxidative functionalization of olefins: selected mechanistic and synthetic examples' by Daniele Mazzarella (@mazda90.bsky.social) and colleagues.
pubs.rsc.org/en/content/a...
Navigating electrochemical oxidative functionalization of olefins: selected mechanistic and synthetic examples
The functionalization of olefins to form added-value compounds is a cornerstone of modern organic chemistry, promoting the synthesis of complex molecules from simple feedstock materials. In parallel, ...
pubs.rsc.org
March 4, 2025 at 10:01 AM
From our 60th anniversary collection 🎉
'Navigating electrochemical oxidative functionalization of olefins: selected mechanistic and synthetic examples' by Daniele Mazzarella (@mazda90.bsky.social) and colleagues.
pubs.rsc.org/en/content/a...
'Navigating electrochemical oxidative functionalization of olefins: selected mechanistic and synthetic examples' by Daniele Mazzarella (@mazda90.bsky.social) and colleagues.
pubs.rsc.org/en/content/a...
Just out in Science Advances @science.org! Chemical recycling of plastics to monomer accelerated through oxy-functionalization remote from the bond undergoing cleavage. Polymer conformation plays dominant role. @molecularfoundry.bsky.social @berkeleylab.lbl.gov www.science.org/doi/10.1126/...
Circularity in polydiketoenamine thermoplastics via control over reactive chain conformation
Controlling polymer chain conformation dictates reactivity and recyclability.
www.science.org
January 28, 2025 at 7:49 PM
Just out in Science Advances @science.org! Chemical recycling of plastics to monomer accelerated through oxy-functionalization remote from the bond undergoing cleavage. Polymer conformation plays dominant role. @molecularfoundry.bsky.social @berkeleylab.lbl.gov www.science.org/doi/10.1126/...
Our last contribution is now published online! The Clar’s Goblet molecule, proposed nearly 50 years ago but synthesized in 2020, is still giving us nice surprises upon functionalization! #theochem #compchem #chemsky
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
February 11, 2025 at 5:17 PM
Our last contribution is now published online! The Clar’s Goblet molecule, proposed nearly 50 years ago but synthesized in 2020, is still giving us nice surprises upon functionalization! #theochem #compchem #chemsky
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
How to achieve a high degree of functionalization on DNA origami in a cost-effective manner: pubs.acs.org/doi/10.1021/... It's been great to work with Siliva Hernandez-Ainsa again - twelve years after we first published on DNA origami together!
pubs.acs.org
January 27, 2025 at 6:14 PM
How to achieve a high degree of functionalization on DNA origami in a cost-effective manner: pubs.acs.org/doi/10.1021/... It's been great to work with Siliva Hernandez-Ainsa again - twelve years after we first published on DNA origami together!
Excited to share our latest research published in @natcomms.nature.com, where we explore a 1,6-addition of thiols to N-alkylpyridinium for site-selective dual modification of proteins. Congratulations to the team!
👉 www.nature.com/articles/s41...
#Bioconjugation
@seahling.bsky.social
👉 www.nature.com/articles/s41...
#Bioconjugation
@seahling.bsky.social
Chemoselective dual functionalization of proteins via 1,6-addition of thiols to trifunctional N-alkylpyridinium - Nature Communications
Chemoselective dual functionalization of proteins is an invaluable tool to introduce two distinct payloads to proteins. Here, the authors present N-alkylpyridinium reagents as soft electrophiles for c...
www.nature.com
June 9, 2025 at 9:06 AM
Excited to share our latest research published in @natcomms.nature.com, where we explore a 1,6-addition of thiols to N-alkylpyridinium for site-selective dual modification of proteins. Congratulations to the team!
👉 www.nature.com/articles/s41...
#Bioconjugation
@seahling.bsky.social
👉 www.nature.com/articles/s41...
#Bioconjugation
@seahling.bsky.social
Great job guys @incomeofficial.bsky.social conference in Berlin 👌 Demonstrating again the power of mechanochemistry associated with reactive extrusion, artificial intelligence and reactor functionalization 💪
September 16, 2025 at 7:54 AM
Great job guys @incomeofficial.bsky.social conference in Berlin 👌 Demonstrating again the power of mechanochemistry associated with reactive extrusion, artificial intelligence and reactor functionalization 💪
So excited about this word cloud feature on scholargoggler.com #chemsky
November 24, 2024 at 1:27 PM
So excited about this word cloud feature on scholargoggler.com #chemsky