#glomerulus
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drmohammadvaziri.bsky.social
sodium-glucose cotransporter-2 [SGLT-2])Inhibitors mohammadvazirimedicaleducation.wordpress.com/2026/09/16/s...
sodium-glucose cotransporter-2 [SGLT-2])Inhibitors
Glucose is freely filtered at the glomerulus and is promptly reabsorbed in the proximal tubule by a sodium-coupled active transport mechanism (ie, sodium-glucose cotransporter-2 [SGLT-2]). Normally…
mohammadvazirimedicaleducation.wordpress.com
September 16, 2026 at 4:30 PM
plosbiology.org
Mosquitoes use CO2 to sense if humans are nearby. Chih-Ying Su explores a @plosbiology.org study showing that CO2-sensing neurons in #mosquitoes can amplify each other’s signals, creating a neural echo chamber 🧪 Paper: buff.ly/jk3046I Primer: buff.ly/lf5AOVg
Comparative circuit architecture of CO2- and odor-sensing OSNs in mosquitoes and flies. Left: Insect olfactory sensory neurons (OSNs) expressing the same receptor converge onto a single glomerulus (circle) in the antennal lobe, where they synapse onto projection neurons (PNs). This study focuses on two circuit motifs: recurrent OSN-to-OSN connections (for signal amplification) and feedforward OSN-to-PN connections (for information relay). Middle: OSNs also synapse onto inhibitory local neurons (LNs) When multiple OSNs are co-activated, they recruit local neurons to mediate global lateral inhibition for divisive normalization. In mosquitoes, both CO2- and odor-sensing OSNs express GABA receptors (likely at their axonal terminals), rendering them susceptible to this inhibition. Only CO2-sensing OSNs exhibit strong recurrent connections, which amplify their output signal and protect it from divisive normalization. Right: Strong recurrent connectivity is observed among mosquito CO2-sensing OSNs, but is absent in either CO2- or odor-sensing OSNs of fruit flies.
September 15, 2026 at 1:02 PM
plosbiology.org
Mosquitoes use CO2 to sense if humans are nearby. Chih-Ying Su explores a @plosbiology.org study showing that CO2-sensing neurons in #mosquitoes can amplify each other’s signals, creating a neural echo chamber 🧪 Paper: buff.ly/jk3046I Primer: buff.ly/lf5AOVg
Comparative circuit architecture of CO2- and odor-sensing OSNs in mosquitoes and flies. Left: Insect olfactory sensory neurons (OSNs) expressing the same receptor converge onto a single glomerulus (circle) in the antennal lobe, where they synapse onto projection neurons (PNs). This study focuses on two circuit motifs: recurrent OSN-to-OSN connections (for signal amplification) and feedforward OSN-to-PN connections (for information relay). Middle: OSNs also synapse onto inhibitory local neurons (LNs) When multiple OSNs are co-activated, they recruit local neurons to mediate global lateral inhibition for divisive normalization. In mosquitoes, both CO2- and odor-sensing OSNs express GABA receptors (likely at their axonal terminals), rendering them susceptible to this inhibition. Only CO2-sensing OSNs exhibit strong recurrent connections, which amplify their output signal and protect it from divisive normalization. Right: Strong recurrent connectivity is observed among mosquito CO2-sensing OSNs, but is absent in either CO2- or odor-sensing OSNs of fruit flies.
September 14, 2026 at 7:55 AM
plosbiology.org
Mosquitoes use CO2 to sense if humans are nearby. Chih-Ying Su explores a @plosbiology.org study showing that CO2-sensing neurons in #mosquitoes can amplify each other’s signals, creating a neural echo chamber 🧪 Paper: plos.io/4cFCPpV Primer: plos.io/4h9FSIy
Comparative circuit architecture of CO2- and odor-sensing OSNs in mosquitoes and flies. Left: Insect olfactory sensory neurons (OSNs) expressing the same receptor converge onto a single glomerulus (circle) in the antennal lobe, where they synapse onto projection neurons (PNs). This study focuses on two circuit motifs: recurrent OSN-to-OSN connections (for signal amplification) and feedforward OSN-to-PN connections (for information relay). Middle: OSNs also synapse onto inhibitory local neurons (LNs) When multiple OSNs are co-activated, they recruit local neurons to mediate global lateral inhibition for divisive normalization. In mosquitoes, both CO2- and odor-sensing OSNs express GABA receptors (likely at their axonal terminals), rendering them susceptible to this inhibition. Only CO2-sensing OSNs exhibit strong recurrent connections, which amplify their output signal and protect it from divisive normalization. Right: Strong recurrent connectivity is observed among mosquito CO2-sensing OSNs, but is absent in either CO2- or odor-sensing OSNs of fruit flies.
September 11, 2026 at 6:45 PM
kidneystories.bsky.social
lnkd.in/p/gkFb4kWP
#nkfw | Michael A. Crowley
Each kidney contains up to a million functioning units called nephrons. A nephron consists of a filtering unit of tiny blood vessels called a glomerulus attached to a tubule. When blood enters the glo...
lnkd.in
September 9, 2026 at 6:21 PM
thesampsonlab.bsky.social
Today’s Sampson Lab Dictionary word: glomerulus — a tiny but powerful filter inside the kidney that helps clean the blood and start the process of making urine.

Small structure, big job.

#SampsonLab #SampsonLabDictionary #Glomerulus #KidneyResearch
September 9, 2026 at 4:31 PM
arkanalabs.bsky.social
Here is today’s #eyeSCANdy! Acellular scanning EM of a glomerulus with membranous glomerulonephritis, stage II showing diffuse reticular appearance of GBM elaboration.
Photo courtesy of Dr. Stephen Bonsib. #renal #pathology #kidneypath
September 9, 2026 at 1:31 PM
yalenephrology.bsky.social
Our first fellowship interview day of the season started off right, with 2nd year fellow Dr. Paola Gudiño giving Renal Rounds on HIV and the kidney. Tat & gp160, TGFβ-driven matrix remodeling, mesangial apoptosis, and Sidekick-1 in the glomerulus!
@ubrewster.bsky.social @yaleschoolofmed.bsky.social
September 4, 2026 at 4:08 PM
neuroalc.bsky.social
#SciencePhoto_IN
“Between Two Landscapes”
Author: Cristina López
Lab: @nietoangela.bsky.social
"Section of a mouse kidney with renal fibrosis, stained with Sirius Red. At the center, a glomerulus between healthy tissue (yellow) and fibrotic tissue with collagen deposition (red)".
September 3, 2026 at 4:34 PM
ajpathology.bsky.social
#LegacyContent: Folliculin deletion in the mouse kidney results in cystogenesis of the loops of Henle via aberrant TFEB activation. @bcmhouston.bsky.social

#OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(25)00192-0/fulltext
Folliculin deletion in the mouse kidney results in cystogenesis of the loops of Henle via aberrant TFEB activation
The mammalian kidney contains numerous nephrons connected to the collecting ducts, and each nephron consists of a glomerulus, a proximal tubule, the loop of Henle (LoH), and a distal tubule. Folliculin (FLCN) is a causative gene for Birt-Hogg-Dubé (BHD) syndrome, which is characterized by a variety of manifestations including renal cysts and cancer. Although deletion of Flcn in the mouse collecting duct and distal nephron leads to cyst formation, its precise role in the entire nephron remains...
ajp.amjpathol.org
September 2, 2026 at 1:48 PM
arkanalabs.bsky.social
Here is today’s #eyeSCANdy! Acellular scanning EM of a glomerulus from a biopsy with membranous glomerulonephritis, stage II showing a reticular pattern of the subepithelial GBM.

Photo courtesy of Dr. Stephen Bonsib. #renal #pathology #kidneypath
August 26, 2026 at 1:02 PM
rokeefemd.bsky.social
The combination of hematuria, proteinuria, and casts on a UA is considered “nephritic sediment”. The presence of the sediment helps to localize the pathology to the glomerulus.
August 25, 2026 at 9:00 PM
sodatroubles.bsky.social
Clinicopathological features and outcomes of glomerular microangiopathy: a retrospective cohort study
#nephsky #nephrology
www.tandfonline.com/doi/full/10....
Clinicopathological features and outcomes of glomerular microangiopathy: a retrospective cohort study
Glomerular microangiopathy (GMA) is a group of diseases characterized pathologically by thrombotic microangiopathy (TMA) changes in the glomerulus without detectable microthrombi or intima edema of...
www.tandfonline.com
August 4, 2026 at 10:31 AM
theisn.org
4/Why does a liver virus hurt the kidney? The link is largely immunological. The isolation of immune complexes in the kidney suggests the pathogenesis has an immune-complex basis — antigen + antibody deposits that lodge in the glomerulus. pubmed.ncbi.nlm.nih.gov/14988643/
Hepatitis B virus-associated nephropathy - PubMed
A direct causal association between hepatitis B virus (HBV) infection and the development of nephropathy remains controversial. Epidemiological studies have shown that chronic carriage of HBV in some ...
pubmed.ncbi.nlm.nih.gov
July 30, 2026 at 4:36 PM
arkanalabs.bsky.social
1/ The photomicrograph shows a glomerulus on PAS stain with mesangial accumulation of homogenous PAS-pale material consistent with amyloid.

#renalpath #kidneypath #pathology #renal #pathtwitter
July 29, 2026 at 2:16 PM
arkanalabs.bsky.social
Here is today’s #eyeSCANdy! Acellular scanning EM of a glomerulus from a biopsy with membranous glomerulonephritis, stage II showing a reticular pattern of the subepithelial GBM.

Photo courtesy of Dr. Stephen Bonsib. #renal #pathology #kidneypath
July 29, 2026 at 1:03 PM
hswapnil.medsky.social
Both recipients of pig hearts developed acute tubular injury….and remained on CRRT till they passed away

What’s going on here?

www.kireports.org/article/S246.... In @kireports.bsky.social
Figure 1 Native kidney histopathology at autopsy in two cardiac xenotransplant recipients. (a, b) Light microscopy (hematoxylin and eosin). (a) Patient 1: proximal renal tubules with severe luminal dilatation and epithelial flattening and simplification; segments of denuded tubular basement membrane (arrow). Inset: preserved glomerulus. (b) Patient 2: proximal tubules with luminal dilatation, flattened epithelium, and cytoplasmic vacuolization. Inset: glomerulus with a subtle increase in mesangium (arrowheads). (c, d) Transmission electron microscopy. (c) Patient 1: glomerular capillaries with overall normal glomerular basement membrane and preserved podocyte foot processes without effacement. (d) Patient 2: glomerular capillaries with thickened glomerular basement membrane and increased mesangial matrix (M), consistent with early diabetic glomerulosclerosis; preserved podocyte foot processes without effacement (arrows), despite degenerative changes attributable to post-mortem autolysis. Scale bars: 50 μm (a, b; insets as marked); 6 μm (c); 4 μm (d).
July 28, 2026 at 11:58 AM
olgapavlasova.bsky.social
Felis glomerulus. Jedná se o druh častý, dalo by se říci až hojný, zejména v oblastech se sedacími vaky, a vyznačující se typickým vzhledem.
July 24, 2026 at 5:22 PM
biorxiv-physio.bsky.social
Glomerulus-Targeted Nanotherapy via Collagen IV-α3 Binding Enhances Renal Immunoregulation in Lupus Nephritis https://www.biorxiv.org/content/10.64898/2026.07.14.738533v1
July 20, 2026 at 11:08 PM
biorxivpreprint.bsky.social
Glomerulus-Targeted Nanotherapy via Collagen IV-α3 Binding Enhances Renal Immunoregulation in Lupus Nephritis https://www.biorxiv.org/content/10.64898/2026.07.14.738533v1
July 20, 2026 at 11:08 PM
yosephl.bsky.social
Just another preprint for some work I’ve been up to. An interesting approach to find foot processes in fluorescent kidney tissues. www.biorxiv.org/content/10.6...
Semi-automated reconstruction of glomerular architecture from 3D confocal microscopy data
Nephrons are the functional units of the kidney; within each nephron, the glomerulus is the initial site of selective filtration that allows removal of waste products while preserving proteins in the ...
www.biorxiv.org
July 16, 2026 at 12:30 AM
arkanalabs.bsky.social
1/ The photomicrograph shows an H&E stain of a hypercellular glomerulus with a lobular architecture most compatible with membranoproliferative pattern glomerulonephritis.

#renalpath #kidneypath #pathology #renal
July 14, 2026 at 4:41 PM
cjkhd.bsky.social
A case report, #patientperspective, and literature review of P3-positive ANCA-associated vasculitis with primary focal segmental glomerulosclerosis. #kidneyresearch

@sagepub.com @csnscn.bsky.social

doi.org/10.1177/2054...
Figure 2. Second kidney biopsy. (A) PAS, ×40 magnification demonstrating glomerulus with segmental sclerosis. (B) PAS, ×40 magnification demonstrating glomerulus with segmental fibrocellular crescent. (C) Electron microscopy image demonstrating glomerular capillary loop with extensive podocyte foot process effacement.
July 13, 2026 at 2:02 PM
sciences.skyfleet.blue
Glomage: A Multimodal Platform for High‐Content Morphological and RNA Profiling of Glomeruli in Zebrafish and Mouse Models (Adv. Sci. 39/2026)
Glomage: A Multimodal Platform for High‐Content Morphological and RNA Profiling of Glomeruli in Zebrafish and Mouse Models (Adv. Sci. 39/2026)
Glomage - A Platform for 3D Analyses of Kidney Glomeruli This cover image depicts a depth-color-coded projection of the filtration barrier in an isolated kidney glomerulus of a zebrafish larva. The glomerulus is a highly specialized compartment enabling selective blood filtration through a precisely organized cellular architecture. At its core, the transmembrane protein nephrin forms the slit diaphragm between interdigitating podocyte foot processes, maintaining filtration barrier integrity. In their Research Article (DOI: 10.1002/advs.202523662 ), Maximilian Schindler, Nicole Endlich, and colleagues present Glomage as a powerful multimodal imaging platform for structural and molecular profiling of glomeruli in zebrafish and mouse models. Glomage is an innovative and scalable cross-species approach that opens new dimensions in glomerular research.
advanced.onlinelibrary.wiley.com
July 13, 2026 at 10:29 AM
kidneystories.bsky.social
www.linkedin.com/posts/faiz-f...
#kidneyhealth #nephron #kidneyfunction #dialysis #hemodialysis #ckd #chronickidneydisease #nephrology #renalcare #medicaleducation #patienteducation | Faiz Farooqui
🩺 The Journey of One Nephron — Millions of Times, Every Day. Every kidney contains around 1 million nephrons, and each one works 24/7 to keep your body alive. Blood enters the glomerulus, where wate...
www.linkedin.com
July 7, 2026 at 6:34 AM