Negative trials matter. This study successfully removed GPCR autoantibodies from #LongCOVID patients, but symptoms didn't improve. That challenges one autoimmune hypothesis, though not autoimmunity as a whole.
Question: Does anyone know of other GPCR immunoadsorption studies underway?
Question: Does anyone know of other GPCR immunoadsorption studies underway?
Immunoadsorption Versus Sham Treatment for Post-COVID Syndrome: A Randomised Sham-Controlled Crossover Trial
Immunoadsorption was not effective in reducing symptom burden in post-Covid syndrome.
www.thelancet.com
July 1, 2026 at 1:33 PM
Negative trials matter. This study successfully removed GPCR autoantibodies from #LongCOVID patients, but symptoms didn't improve. That challenges one autoimmune hypothesis, though not autoimmunity as a whole.
Question: Does anyone know of other GPCR immunoadsorption studies underway?
Question: Does anyone know of other GPCR immunoadsorption studies underway?
Yet another GPCR that is critical for cancer pathogenesis and treatment response.
Now online in Cancer Discovery: GPR65 Inactivation in Tumor Cells Drives Antigen-Independent CAR-T Cell Resistance via Macrophage Remodeling - by Jayadev Mavuluri, Yogesh Dhungana, Jiyang Yu, Terrence Geiger, and colleagues doi.org/10.1158/2159... @stjuderesearch.bsky.social
February 25, 2025 at 4:30 PM
Yet another GPCR that is critical for cancer pathogenesis and treatment response.
my two academic interests are GPCR and the GPCR
November 28, 2024 at 2:42 AM
my two academic interests are GPCR and the GPCR
My longstanding observations with the Vagus Nerve damage in Long C-19 remains strong...
As per @harryspoelstra.bsky.social
#Nerve_of_Joffe 🤦🏻♂️
www.jacionline.org/article/S009...
As per @harryspoelstra.bsky.social
#Nerve_of_Joffe 🤦🏻♂️
www.jacionline.org/article/S009...
Autonomic dysfunction and vasoregulation in Long COVID-19 are linked to anti-GPCR autoantibodies
www.jacionline.org
November 23, 2025 at 12:04 PM
My longstanding observations with the Vagus Nerve damage in Long C-19 remains strong...
As per @harryspoelstra.bsky.social
#Nerve_of_Joffe 🤦🏻♂️
www.jacionline.org/article/S009...
As per @harryspoelstra.bsky.social
#Nerve_of_Joffe 🤦🏻♂️
www.jacionline.org/article/S009...
the maoist podcaster im listening to says 'idk i get why zhou enlai prevented the gpcr from spreading to the ministry of state security but it feels like a contradiction to cordon off any part of the state'
and i go
dawg
of course hes not going to let the security services kill each other
and i go
dawg
of course hes not going to let the security services kill each other
September 29, 2026 at 7:06 AM
the maoist podcaster im listening to says 'idk i get why zhou enlai prevented the gpcr from spreading to the ministry of state security but it feels like a contradiction to cordon off any part of the state'
and i go
dawg
of course hes not going to let the security services kill each other
and i go
dawg
of course hes not going to let the security services kill each other
My lab @stanfordmedicine.bsky.social is recruiting! We are looking for a postdoc at the interface of quantitative proteomics and G protein-coupled receptor (GPCR) biology:
postdocs.stanford.edu/prospective/...
#TeamMassSpec #Proteomics #GPCR #Postdoc
postdocs.stanford.edu/prospective/...
#TeamMassSpec #Proteomics #GPCR #Postdoc
Open Postdoctoral position, faculty mentor Ruth Huttenhain | Office of Postdoctoral Affairs
postdocs.stanford.edu
October 2, 2025 at 6:27 PM
My lab @stanfordmedicine.bsky.social is recruiting! We are looking for a postdoc at the interface of quantitative proteomics and G protein-coupled receptor (GPCR) biology:
postdocs.stanford.edu/prospective/...
#TeamMassSpec #Proteomics #GPCR #Postdoc
postdocs.stanford.edu/prospective/...
#TeamMassSpec #Proteomics #GPCR #Postdoc
Having personally sworn for years that insects don’t use GPCRs for odour detection, Suguru Takagi (@sugurutakagi.bsky.social) discovers that, in fact, they sometimes do …
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A GPCR signaling pathway in insect odor detection
Odor detection differs fundamentally in vertebrates, which use G protein-coupled receptors (GPCRs), and insects, which employ ion channels. Here, we report the first evidence for a GPCR defining tunin...
www.biorxiv.org
October 6, 2025 at 4:17 AM
Having personally sworn for years that insects don’t use GPCRs for odour detection, Suguru Takagi (@sugurutakagi.bsky.social) discovers that, in fact, they sometimes do …
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A first attempt to assemble GPCR aficionados here on 🦋 Let me know who I missed by replying below!
go.bsky.app/75ukb81
go.bsky.app/75ukb81
November 16, 2024 at 6:05 PM
A first attempt to assemble GPCR aficionados here on 🦋 Let me know who I missed by replying below!
go.bsky.app/75ukb81
go.bsky.app/75ukb81
Discovery of an adhesion GPCR regulating mating in choanoflagellates, by Alain Garcia de las Bayonas & Nicole King. Absolutely stunning work - choano cell biology is going next level www.biorxiv.org/content/10.6...
July 7, 2026 at 7:44 AM
Discovery of an adhesion GPCR regulating mating in choanoflagellates, by Alain Garcia de las Bayonas & Nicole King. Absolutely stunning work - choano cell biology is going next level www.biorxiv.org/content/10.6...
Large scale investigation of GPCR molecular dynamics data uncovers allosteric sites and lateral gateways
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Large scale investigation of GPCR molecular dynamics data uncovers allosteric sites and lateral gateways - Nature Communications
GPCR dynamics are critical for signal transmission into the cell. Here, the authors probe receptor plasticity using molecular dynamics simulations, enabling the detection of allosteric sites and drug ...
www.nature.com
March 2, 2025 at 9:18 AM
Large scale investigation of GPCR molecular dynamics data uncovers allosteric sites and lateral gateways
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Now online @nature.com!
Want to change the consequences of receptor activation?
Small molecules binding the GPCR-transducer interface change G protein subtype preference in predictable ways, enabling rational drug design 💥
So many new possibilities! 🧪🧠🟦
www.nature.com/articles/s41...
🧵👇
Want to change the consequences of receptor activation?
Small molecules binding the GPCR-transducer interface change G protein subtype preference in predictable ways, enabling rational drug design 💥
So many new possibilities! 🧪🧠🟦
www.nature.com/articles/s41...
🧵👇
Designing allosteric modulators to change GPCR G protein subtype selectivity - Nature
Studies of the G-protein-coupled receptor NTSR1 show that the G protein selectivity of this receptor can be modified by small molecules, enabling the design of drugs that work by switching receptor su...
www.nature.com
October 27, 2025 at 8:50 PM
Now online @nature.com!
Want to change the consequences of receptor activation?
Small molecules binding the GPCR-transducer interface change G protein subtype preference in predictable ways, enabling rational drug design 💥
So many new possibilities! 🧪🧠🟦
www.nature.com/articles/s41...
🧵👇
Want to change the consequences of receptor activation?
Small molecules binding the GPCR-transducer interface change G protein subtype preference in predictable ways, enabling rational drug design 💥
So many new possibilities! 🧪🧠🟦
www.nature.com/articles/s41...
🧵👇
Maoist historiography on GPCR and Reform and Opening
August 14, 2026 at 5:01 PM
Maoist historiography on GPCR and Reform and Opening
New preprint out! We identified a GPCR signaling pathway that adds a new layer of odor tuning to an otherwise ionotropic olfactory detection system.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A GPCR signaling pathway in insect odor detection
Odor detection differs fundamentally in vertebrates, which use G protein-coupled receptors (GPCRs), and insects, which employ ion channels. Here, we report the first evidence for a GPCR defining tunin...
www.biorxiv.org
October 5, 2025 at 6:32 PM
New preprint out! We identified a GPCR signaling pathway that adds a new layer of odor tuning to an otherwise ionotropic olfactory detection system.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Check out our work, where we discover how receptor GPCR senses pH! We solved a longstanding question by developing foundational GPCR DMS tech dev + structural bio! Led by brilliant PhD student @matthewkhoward.bsky.social and Nick Hoppe w/ @amanglik.bsky.social!
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
January 6, 2025 at 11:47 PM
Check out our work, where we discover how receptor GPCR senses pH! We solved a longstanding question by developing foundational GPCR DMS tech dev + structural bio! Led by brilliant PhD student @matthewkhoward.bsky.social and Nick Hoppe w/ @amanglik.bsky.social!
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Innervation density governs crosstalk of GPCR-based norepinephrine and dopamine sensors https://www.biorxiv.org/content/10.1101/2024.11.23.624963v1
Innervation density governs crosstalk of GPCR-based norepinephrine and dopamine sensors https://www.biorxiv.org/content/10.1101/2024.11.23.624963v1
GPCR-based fluorescent sensors are widely used to correlate neuromodulatory signaling with brain fun
www.biorxiv.org
November 23, 2024 at 9:15 PM
Innervation density governs crosstalk of GPCR-based norepinephrine and dopamine sensors https://www.biorxiv.org/content/10.1101/2024.11.23.624963v1
Today for the @inp-marseille.bsky.social seminar, we are welcoming @silviasposini.bsky.social from @iins-bordeaux.bsky.social and @imperialcollegeldn.bsky.social who tells us about GPCR trafficking in neurons
June 6, 2025 at 12:41 PM
Today for the @inp-marseille.bsky.social seminar, we are welcoming @silviasposini.bsky.social from @iins-bordeaux.bsky.social and @imperialcollegeldn.bsky.social who tells us about GPCR trafficking in neurons
"Time-resolved cryo-EM of G protein activation by a GPCR" #CryoEM #membrane #protein #structure #GPCR www.nature.com/articles/s41...
Time-resolved cryo-EM of G-protein activation by a GPCR - Nature
Time-resolved cryo-EM is used to capture structural transitions during G-protein activation stimulated by a G-protein-coupled receptor.
www.nature.com
March 17, 2024 at 9:28 PM
"Time-resolved cryo-EM of G protein activation by a GPCR" #CryoEM #membrane #protein #structure #GPCR www.nature.com/articles/s41...
In dem Flug zurück war gefühlt die halbe GPCR Community aus Deutschland. Wäre das Flugzeug abgestürzt, wäre das schon ein herber Schlag für die deutsche GPCR-Forschung gewesen 😅
February 22, 2025 at 4:14 PM
In dem Flug zurück war gefühlt die halbe GPCR Community aus Deutschland. Wäre das Flugzeug abgestürzt, wäre das schon ein herber Schlag für die deutsche GPCR-Forschung gewesen 😅
β-arrestin1 directly engages Gαs to sustain endosomal GPCR signaling www.biorxiv.org/content/10.64898/2026.09.27.754863v1 #cryoem
September 29, 2026 at 7:10 AM
β-arrestin1 directly engages Gαs to sustain endosomal GPCR signaling www.biorxiv.org/content/10.64898/2026.09.27.754863v1 #cryoem
Comparative Ligandability Analysis and new Nomenclature Allosteric GPCR binding sites
pubs.acs.org/doi/10.1021/...
tinyurl.com/ybthux9c
#GPCR #CADD #SBDD #ALLODD
pubs.acs.org/doi/10.1021/...
tinyurl.com/ybthux9c
#GPCR #CADD #SBDD #ALLODD
Comparative Study of Allosteric GPCR Binding Sites and Their Ligandability Potential
The steadily growing number of experimental G-protein-coupled receptor (GPCR) structures has revealed diverse locations of allosteric modulation, and yet few drugs target them. This gap highlights the...
pubs.acs.org
November 23, 2024 at 11:00 AM
Comparative Ligandability Analysis and new Nomenclature Allosteric GPCR binding sites
pubs.acs.org/doi/10.1021/...
tinyurl.com/ybthux9c
#GPCR #CADD #SBDD #ALLODD
pubs.acs.org/doi/10.1021/...
tinyurl.com/ybthux9c
#GPCR #CADD #SBDD #ALLODD
Takashi Yamamura, der über GPCR Autoantikörper und Hirnveränderungen spricht, sagt zu Beginn, er habe seine Arbeit an MECFS vor 10 Jahren wegen einer Patientin begonnen!
May 12, 2025 at 2:58 PM
Takashi Yamamura, der über GPCR Autoantikörper und Hirnveränderungen spricht, sagt zu Beginn, er habe seine Arbeit an MECFS vor 10 Jahren wegen einer Patientin begonnen!
Through real-time imaging of live cells, researchers reveal yet another level of complexity in the spatiotemporal regulation of G protein–coupled receptors, the targets of approximately 30% of all FDA-approved drugs.
Learn more in #ScienceSignaling: https://scim.ag/4dKehNL
Learn more in #ScienceSignaling: https://scim.ag/4dKehNL
Location-biased β-arrestin conformations direct GPCR signaling
Biosensors reveal the effects of β-arrestin conformations on GPCR signaling at different subcellular locations.
scim.ag
March 27, 2026 at 3:00 PM
Through real-time imaging of live cells, researchers reveal yet another level of complexity in the spatiotemporal regulation of G protein–coupled receptors, the targets of approximately 30% of all FDA-approved drugs.
Learn more in #ScienceSignaling: https://scim.ag/4dKehNL
Learn more in #ScienceSignaling: https://scim.ag/4dKehNL