they could substantially boost the antibody response to bird flu by vaccinating tonsil organoids with a five-antigen construct connecting the four seasonal antigens along with the bird-flu hemagglutinin, as opposed to getting a tepid response when vaccinating with just the bird-flu hemagglutinin or
January 2, 2025 at 5:11 PM
they could substantially boost the antibody response to bird flu by vaccinating tonsil organoids with a five-antigen construct connecting the four seasonal antigens along with the bird-flu hemagglutinin, as opposed to getting a tepid response when vaccinating with just the bird-flu hemagglutinin or
developed an innovative approach by creating a vaccine that stimulates immune responses against two key viral proteins- hemagglutinin (H5) AND neuraminidase (N1). Historically, most bird flu vaccines have concentrated primarily on the hemagglutinin protein. However, researchers here explored whether
April 22, 2025 at 4:04 PM
developed an innovative approach by creating a vaccine that stimulates immune responses against two key viral proteins- hemagglutinin (H5) AND neuraminidase (N1). Historically, most bird flu vaccines have concentrated primarily on the hemagglutinin protein. However, researchers here explored whether
I asked my aunt, the doctor,
to help me make sense
of the new article in Science
titled: “A single mutation
in bovine influenza
H5N1 hemagglutinin
switches specificity
to human receptors,”
and my aunt replied:
“it means that we are
a single mutation
away from catastrophe.”
to help me make sense
of the new article in Science
titled: “A single mutation
in bovine influenza
H5N1 hemagglutinin
switches specificity
to human receptors,”
and my aunt replied:
“it means that we are
a single mutation
away from catastrophe.”
December 6, 2024 at 12:21 AM
I asked my aunt, the doctor,
to help me make sense
of the new article in Science
titled: “A single mutation
in bovine influenza
H5N1 hemagglutinin
switches specificity
to human receptors,”
and my aunt replied:
“it means that we are
a single mutation
away from catastrophe.”
to help me make sense
of the new article in Science
titled: “A single mutation
in bovine influenza
H5N1 hemagglutinin
switches specificity
to human receptors,”
and my aunt replied:
“it means that we are
a single mutation
away from catastrophe.”
The final version of our study using pseudovirus deep mutational scanning to measure the effects of mutations influenza H5 hemagglutinin to inform viral surveillance is now published in PLoS Biology:
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Deep mutational scanning of H5 hemagglutinin to inform influenza virus surveillance
H5 influenza is considered a potential pandemic threat. Using deep mutational scanning, this work reveals how the >10,000 different possible amino-acid mutations in hemagglutinin affect cell entry, re...
journals.plos.org
November 13, 2024 at 2:04 PM
The final version of our study using pseudovirus deep mutational scanning to measure the effects of mutations influenza H5 hemagglutinin to inform viral surveillance is now published in PLoS Biology:
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Here is a link to @jbloomlab.bsky.social paper showing how mutations at H5 residue 226 (and other residues) can affect receptor specificity. 3/
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Deep mutational scanning of H5 hemagglutinin to inform influenza virus surveillance
H5 influenza is considered a potential pandemic threat. Using deep mutational scanning, this work reveals how the >10,000 different possible amino-acid mutations in hemagglutinin affect cell entry, re...
journals.plos.org
November 16, 2024 at 3:19 PM
Here is a link to @jbloomlab.bsky.social paper showing how mutations at H5 residue 226 (and other residues) can affect receptor specificity. 3/
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
punch out the pest’s lights- preferably before it can invade any cells. The influenza virus is studded with molecular hooks that it uses to latch on to vulnerable cells in our airways and lungs. This hook-like molecule, called hemagglutinin, is the principal antigen in the influenza vaccine. The
January 2, 2025 at 5:02 PM
punch out the pest’s lights- preferably before it can invade any cells. The influenza virus is studded with molecular hooks that it uses to latch on to vulnerable cells in our airways and lungs. This hook-like molecule, called hemagglutinin, is the principal antigen in the influenza vaccine. The
standard flu vaccine contains a mix of four versions of hemagglutinin- one for each of four commonly circulating influenza subtypes. The goal is to protect us from whichever of those subtypes eventually slips through our nostrils and takes up residence in our airways. The vaccine’s efficacy isn’t as
January 2, 2025 at 5:03 PM
standard flu vaccine contains a mix of four versions of hemagglutinin- one for each of four commonly circulating influenza subtypes. The goal is to protect us from whichever of those subtypes eventually slips through our nostrils and takes up residence in our airways. The vaccine’s efficacy isn’t as
Researchers in #ScienceTranslationalMedicine present new vaccines for H5 clade #influenza based on a stabilized H5 hemagglutinin stem, which improves the breadth and depth of antibody responses and protects against #H5N1 challenge in immunized mice. https://scim.ag/4aRgrcG
Stabilization of the H5 clade 2.3.4.4b hemagglutinin improves vaccine-elicited neutralizing antibody responses in mice
Vaccinating with a stabilized H5 hemagglutinin increases the proportion of humoral responses against neutralizing receptor binding site epitopes.
scim.ag
March 9, 2026 at 6:00 PM
Researchers in #ScienceTranslationalMedicine present new vaccines for H5 clade #influenza based on a stabilized H5 hemagglutinin stem, which improves the breadth and depth of antibody responses and protects against #H5N1 challenge in immunized mice. https://scim.ag/4aRgrcG
Really interesting new paper describing the structure of an H5 hemagglutinin in detail from a research team in Columbia. Apparently, the receptor-binding site of the H5 hemagglutinin is bound by an α-2,3-sialoside that needs to be displaced for binding receptors on cells.
Structure of a zoonotic H5N1 hemagglutinin reveals a receptor-binding site occupied by an auto-glycan
Morano et al. use cryo-EM to visualize the hemagglutinin from H5N1 A/Texas/37/2024
influenza, the strain responsible for the 2024 zoonotic outbreak. They find that the
receptor-binding site is bound t...
www.cell.com
February 2, 2025 at 5:23 PM
Really interesting new paper describing the structure of an H5 hemagglutinin in detail from a research team in Columbia. Apparently, the receptor-binding site of the H5 hemagglutinin is bound by an α-2,3-sialoside that needs to be displaced for binding receptors on cells.
The combined vaccine formulations provided complete cross-protection against HPAI H5N1 virus, and prevented environmental virus shedding, crucial for controlling avian influenza outbreaks.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
M2e nanovaccines supplemented with recombinant hemagglutinin protect chickens against heterologous HPAI H5N1 challenge - npj Vaccines
npj Vaccines - M2e nanovaccines supplemented with recombinant hemagglutinin protect chickens against heterologous HPAI H5N1 challenge
www.nature.com
January 2, 2025 at 9:37 PM
The combined vaccine formulations provided complete cross-protection against HPAI H5N1 virus, and prevented environmental virus shedding, crucial for controlling avian influenza outbreaks.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Paper just out in Science. We are one mutation away from human-to-human transmission of #H5N1 #BirdFlu
We are so screwed...
www.science.org/doi/10.1126/...
We are so screwed...
www.science.org/doi/10.1126/...
December 5, 2024 at 9:01 PM
Paper just out in Science. We are one mutation away from human-to-human transmission of #H5N1 #BirdFlu
We are so screwed...
www.science.org/doi/10.1126/...
We are so screwed...
www.science.org/doi/10.1126/...
current mRNA COVID-19 vaccines. For influenza, the neuraminidase protein is conserved across many strains of flu, prompting the immune response to multiple strains. The protein hemagglutinin is used to standardize flu vaccines because it is much more abundant on the surface of the virus. However, it
March 13, 2025 at 4:07 PM
current mRNA COVID-19 vaccines. For influenza, the neuraminidase protein is conserved across many strains of flu, prompting the immune response to multiple strains. The protein hemagglutinin is used to standardize flu vaccines because it is much more abundant on the surface of the virus. However, it
Who has a link to the full paper? I would like to read it out of work channels. Thanks
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
The uncleaved viral hemagglutinin HA0 increases influenza A virus resistance to thermal pasteurization
Two biological types of influenza virus are known and distinguished by the structure of the surface glycoprotein, hemagglutinin (HA). The noninfectiou…
www.sciencedirect.com
February 5, 2025 at 11:13 PM
Who has a link to the full paper? I would like to read it out of work channels. Thanks
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
In new study led by @timyu.bsky.social, we measure how mutations to H3 flu HA affect cell entry, stability & antibody escape
We find pleiotropic effects of mutations on these phenotypes shape evolution: epistasis alleviates cell-entry but not stability constraints
www.biorxiv.org/content/10.1...
We find pleiotropic effects of mutations on these phenotypes shape evolution: epistasis alleviates cell-entry but not stability constraints
www.biorxiv.org/content/10.1...
Pleiotropic mutational effects on function and stability constrain the antigenic evolution of influenza hemagglutinin
The evolution of human influenza virus hemagglutinin (HA) involves simultaneous selection to acquire antigenic mutations that escape population immunity while preserving protein function and stability...
www.biorxiv.org
May 27, 2025 at 4:23 PM
In new study led by @timyu.bsky.social, we measure how mutations to H3 flu HA affect cell entry, stability & antibody escape
We find pleiotropic effects of mutations on these phenotypes shape evolution: epistasis alleviates cell-entry but not stability constraints
www.biorxiv.org/content/10.1...
We find pleiotropic effects of mutations on these phenotypes shape evolution: epistasis alleviates cell-entry but not stability constraints
www.biorxiv.org/content/10.1...
Diminished sialoside binding in novel H5N1 influenza hemagglutinin variants identified in a human patient
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Diminished sialoside binding in novel H5N1 influenza hemagglutinin variants identified in a human patient - Nature Communications
This study explores the biochemical and structural roles of hemagglutinin mutations identified in a human case of H5N1 influenza and reports effects of the mutations in patient viral populations on su...
www.nature.com
September 29, 2026 at 1:18 PM
Diminished sialoside binding in novel H5N1 influenza hemagglutinin variants identified in a human patient
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Viral mutations are very worrying for the prospect of future human spread. A recent study found that a single amino acid mutation allows H5N1 to bind human hemagglutinin (HA) receptors, readily enabling human infection and human-to-human spread.
December 25, 2024 at 5:56 PM
Viral mutations are very worrying for the prospect of future human spread. A recent study found that a single amino acid mutation allows H5N1 to bind human hemagglutinin (HA) receptors, readily enabling human infection and human-to-human spread.
I'm proud of our new study showing that some people born in the 1990s have high levels of antibodies that cross-react to H3 viruses from the 1990s and....contemporary H1N1 viruses. Such a surprising story led by Grace Li, in collaboration with many Penn-CEIRR labs. 1/
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Childhood immunological imprinting of cross-subtype antibodies targeting the hemagglutinin head domain of influenza viruses
Influenza virus cross-subtype antibodies targeting the hemagglutinin (HA) head are rare. Here, we found that a large proportion of monoclonal antibodies (mAbs) isolated from individuals immunized with...
www.medrxiv.org
September 26, 2025 at 12:49 PM
I'm proud of our new study showing that some people born in the 1990s have high levels of antibodies that cross-react to H3 viruses from the 1990s and....contemporary H1N1 viruses. Such a surprising story led by Grace Li, in collaboration with many Penn-CEIRR labs. 1/
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Exciting discovery that could help pave the way to a universal flu vaccine. Currently typical flu vax target flu-hemagglutinin (HA) protein as we see a strong immune response but HA is variable meaning annual vax updates. research focused on the less variable neuraminidase (NA) of flu. #immunosky 🧪🧵
April 9, 2025 at 2:59 PM
Exciting discovery that could help pave the way to a universal flu vaccine. Currently typical flu vax target flu-hemagglutinin (HA) protein as we see a strong immune response but HA is variable meaning annual vax updates. research focused on the less variable neuraminidase (NA) of flu. #immunosky 🧪🧵
In order for efficient H-H transmission of avian viruses there needs to be a change from preferential recognition by the virus hemagglutinin of α2-3-sialyl-galactose-terminating host cell receptors /2
November 11, 2024 at 7:03 AM
In order for efficient H-H transmission of avian viruses there needs to be a change from preferential recognition by the virus hemagglutinin of α2-3-sialyl-galactose-terminating host cell receptors /2
Intra-patient neuraminidase mutations in avian H5N1 influenza virus reduce sialidase activity to complement weaker hemagglutinin binding and facilitate human infection
journals.plos.org/plospathogen...
journals.plos.org/plospathogen...
Intra-patient neuraminidase mutations in avian H5N1 influenza virus reduce sialidase activity to complement weaker hemagglutinin binding and facilitate human infection
Author summary Avian influenza viruses rarely infect humans because they bind poorly to receptors in the human airway. However, clade 2.2 H5N1 has caused an unusually high number of human infections, ...
journals.plos.org
January 24, 2026 at 1:36 PM
Intra-patient neuraminidase mutations in avian H5N1 influenza virus reduce sialidase activity to complement weaker hemagglutinin binding and facilitate human infection
journals.plos.org/plospathogen...
journals.plos.org/plospathogen...
