Every cardiac physiologist knows that remodeling of cardiac Cx43 is bad news for the heart. But the story goes beyond just the loss of intercellular coupling. In our new review, we explore the emerging role of Cx43 hemichannels as key players in cardiac disease.
Connexin‐43 remodelling and arrhythmias: hemichannels as key drivers of cardiac dysfunction
Abstract figure legend Connexin 43 (Cx43) is an integral membrane protein that assembles as hexamers to form hemichannels. In healthy hearts Cx43 hemichannels are primarily located at the intercalate...
physoc.onlinelibrary.wiley.com
May 5, 2025 at 8:35 PM
Every cardiac physiologist knows that remodeling of cardiac Cx43 is bad news for the heart. But the story goes beyond just the loss of intercellular coupling. In our new review, we explore the emerging role of Cx43 hemichannels as key players in cardiac disease.
Molecularly Distinct Innexin Gap Junction Channels and Undocked Hemichannels Regulate Glia Morphology and Function in Caenorhabditis elegans https://www.biorxiv.org/content/10.64898/2026.09.21.753071v1
September 25, 2026 at 11:15 PM
Molecularly Distinct Innexin Gap Junction Channels and Undocked Hemichannels Regulate Glia Morphology and Function in Caenorhabditis elegans https://www.biorxiv.org/content/10.64898/2026.09.21.753071v1
How are molecules transported through large-pore connexin hemichannels? My outstanding MD collaborator, Dr. Lyna Luo, has been pivotal in uncovering the key mechanisms. Don’t miss our findings and her latest review on this exciting topic! 1/3
November 20, 2024 at 6:00 PM
How are molecules transported through large-pore connexin hemichannels? My outstanding MD collaborator, Dr. Lyna Luo, has been pivotal in uncovering the key mechanisms. Don’t miss our findings and her latest review on this exciting topic! 1/3
Molecularly Distinct Innexin Gap Junction Channels and Undocked Hemichannels Regulate Glia Morphology and Function in Caenorhabditis elegans https://www.biorxiv.org/content/10.64898/2026.09.21.753071v1
September 25, 2026 at 11:15 PM
Molecularly Distinct Innexin Gap Junction Channels and Undocked Hemichannels Regulate Glia Morphology and Function in Caenorhabditis elegans https://www.biorxiv.org/content/10.64898/2026.09.21.753071v1
🚨🚨First paper of the year! I'm excited to share that our lab and collaborators have discovered that TRPV4/Cx43 hemichannels play a crucial role in endothelial hyperpolarization. Huge thanks to @piaburboa.bsky.social for continuing this fascinating work. physoc.onlinelibrary.wiley.com/doi/10.1113/...
February 22, 2025 at 1:40 AM
🚨🚨First paper of the year! I'm excited to share that our lab and collaborators have discovered that TRPV4/Cx43 hemichannels play a crucial role in endothelial hyperpolarization. Huge thanks to @piaburboa.bsky.social for continuing this fascinating work. physoc.onlinelibrary.wiley.com/doi/10.1113/...
Pleased to share that our latest study has been published in Hematologica!
@rdgplateletlabs.bsky.social
pubmed.ncbi.nlm.nih.gov/40045892/
@rdgplateletlabs.bsky.social
pubmed.ncbi.nlm.nih.gov/40045892/
Inter-platelet communication driving thrombus formation is regulated by extracellular calpain-1 cleavage of connexin 62 - PubMed
Connexin (Cx) gap junction proteins are expressed by a multitude of cells and function as plasma membrane hemichannels or dock to form intercellular communication tunnels. Whilst Cx43 has garnered con...
pubmed.ncbi.nlm.nih.gov
March 7, 2025 at 4:09 PM
Pleased to share that our latest study has been published in Hematologica!
@rdgplateletlabs.bsky.social
pubmed.ncbi.nlm.nih.gov/40045892/
@rdgplateletlabs.bsky.social
pubmed.ncbi.nlm.nih.gov/40045892/
CO<sub>2</sub>-dependent opening of connexin 43 hemichannels
CO2-dependent opening of connexin 43 hemichannels
Connexin43 is the most ubiquitously expressed connexin in the human body, and the CO2-dependent opening of Connexin43 hemichannels implies that CO2 may influence many physiological processes.
buff.ly
July 12, 2026 at 11:26 AM
CO<sub>2</sub>-dependent opening of connexin 43 hemichannels
The authors included RRIDs in their in eLife paper! Thanks for making your methods matter! #methodsmatter #STMpublishing #BetterScience
CO2-dependent opening of connexin 43 hemichannels
Read the full paper: CO2-dependent opening of connexin 43 hemichannels
doi.org
June 7, 2026 at 7:04 AM
The authors included RRIDs in their in eLife paper! Thanks for making your methods matter! #methodsmatter #STMpublishing #BetterScience
No, not really. They don’t form the right structure. You have to have 6. ColabFold and AlphaFold3 both do it…we need some way of limiting VRAM usage. The hemichannels are supposed to look like this…
www.rcsb.org/3d-view/7XQJ/1
www.rcsb.org/3d-view/7XQJ/1
3D View: 7XQJ
7XQJ: Hemichannel-focused structure of C-terminal truncated connexin43/Cx43/GJA1 gap junction intercellular channel in POPE nanodiscs (PLN conformation)
www.rcsb.org
December 2, 2024 at 7:42 AM
No, not really. They don’t form the right structure. You have to have 6. ColabFold and AlphaFold3 both do it…we need some way of limiting VRAM usage. The hemichannels are supposed to look like this…
www.rcsb.org/3d-view/7XQJ/1
www.rcsb.org/3d-view/7XQJ/1
💥Our next speaker is Nicholas Dale from the University of Warwick! 💥
Nicholas will discuss how connexin hemichannels are gated by CO2 via an evolutionarily conserved carbamylation mechanism, and examine the structural, physiological and evolutionary implications of connexin-mediated CO2 signalling
Nicholas will discuss how connexin hemichannels are gated by CO2 via an evolutionarily conserved carbamylation mechanism, and examine the structural, physiological and evolutionary implications of connexin-mediated CO2 signalling
May 13, 2026 at 9:53 AM
💥Our next speaker is Nicholas Dale from the University of Warwick! 💥
Nicholas will discuss how connexin hemichannels are gated by CO2 via an evolutionarily conserved carbamylation mechanism, and examine the structural, physiological and evolutionary implications of connexin-mediated CO2 signalling
Nicholas will discuss how connexin hemichannels are gated by CO2 via an evolutionarily conserved carbamylation mechanism, and examine the structural, physiological and evolutionary implications of connexin-mediated CO2 signalling
On the mechanisms of permselectivity of connexin hemichannels to small molecules https://www.biorxiv.org/content/10.1101/2025.03.12.642803v1
March 12, 2025 at 2:56 PM
On the mechanisms of permselectivity of connexin hemichannels to small molecules https://www.biorxiv.org/content/10.1101/2025.03.12.642803v1
Tonabersat suppresses priming/activation of the NOD-like receptor protein-3 (#NLRP3) inflammasome and decreases renal tubular epithelial-to-macrophage crosstalk in a model of diabetic kidney disease biosignaling.biomedcentral.com/articles/10....
👇👇👇 #hemichannels #connexin #inflammation #NephSky
👇👇👇 #hemichannels #connexin #inflammation #NephSky
Tonabersat suppresses priming/activation of the NOD-like receptor protein-3 (NLRP3) inflammasome and decreases renal tubular epithelial-to-macrophage crosstalk in a model of diabetic kidney disease - ...
Background Accompanied by activation of the NOD-like receptor protein 3 (NLRP3) inflammasome, aberrant connexin 43 (Cx43) hemichannel-mediated ATP release is situated upstream of inflammasome assembly...
biosignaling.biomedcentral.com
November 16, 2024 at 11:28 AM
Tonabersat suppresses priming/activation of the NOD-like receptor protein-3 (#NLRP3) inflammasome and decreases renal tubular epithelial-to-macrophage crosstalk in a model of diabetic kidney disease biosignaling.biomedcentral.com/articles/10....
👇👇👇 #hemichannels #connexin #inflammation #NephSky
👇👇👇 #hemichannels #connexin #inflammation #NephSky
Large-pore connexin hemichannels function as molecule transporters independently of ion conduction https://www.biorxiv.org/content/10.1101/2024.02.20.581300v1
Large-pore connexin hemichannels function as molecule transporters independently of ion conduction https://www.biorxiv.org/content/10.1101/2024.02.20.581300v1
Connexin hemichannels were identified as the first members of the eukaryotic large-pore channel fami
www.biorxiv.org
February 21, 2024 at 7:48 AM
Large-pore connexin hemichannels function as molecule transporters independently of ion conduction https://www.biorxiv.org/content/10.1101/2024.02.20.581300v1
Activity-dependent CO<sub>2</sub> production in the axon triggers opening of Connexin32 in the Schwann cell paranode
Activity-dependent CO2 production in the axon triggers opening of Connexin32 in the Schwann cell paranode
Gaseous CO2 acts as a neuron to glia messenger in peripheral myelin to trigger opening of Schwann Cell Cx32 hemichannels in response to axonal action potential propagation.
buff.ly
August 20, 2026 at 8:26 PM
Activity-dependent CO<sub>2</sub> production in the axon triggers opening of Connexin32 in the Schwann cell paranode
The authors included RRIDs in their paper! RRIDs improve reproducibility in scientific research. #OpenScience #accelerateopenscience #STMpublishing
Mechanisms of permselectivity of connexin hemichannels to small molecules
doi.org
November 23, 2025 at 8:01 AM
The authors included RRIDs in their paper! RRIDs improve reproducibility in scientific research. #OpenScience #accelerateopenscience #STMpublishing
The authors included RRIDs in their paper! Thanks for making your methods matter! #STMpublishing #OpenScience #methodsmatter
A hyperpolarizing neuron recruits undocked innexin hemichannels to transmit neural information in Caenorhabditis elegans
doi.org
December 5, 2025 at 8:00 AM
The authors included RRIDs in their paper! Thanks for making your methods matter! #STMpublishing #OpenScience #methodsmatter
Priscila A. Araujo of ucd-physiology.bsky.social et al. discuss connexin-43 remodelling and arrhythmias in relation to hemichannels as key drivers of cardiac dysfunction 🧬 ↔️
🔗 Read the #TopicalReview here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
🔗 Read the #TopicalReview here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
August 27, 2025 at 11:01 AM
Priscila A. Araujo of ucd-physiology.bsky.social et al. discuss connexin-43 remodelling and arrhythmias in relation to hemichannels as key drivers of cardiac dysfunction 🧬 ↔️
🔗 Read the #TopicalReview here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
🔗 Read the #TopicalReview here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
WO2026047782 describes antibody abEC1.1 targeting extracellular domains of connexin hemichannels (Cx26 Cx30 Cx32) to treat gliomas and tumor-related epilepsy. It inhibits ATP release and Ca2+ signaling, reduces proliferation markers, modulates microglia, and improves survival in preclinical models.
March 24, 2026 at 7:36 AM
WO2026047782 describes antibody abEC1.1 targeting extracellular domains of connexin hemichannels (Cx26 Cx30 Cx32) to treat gliomas and tumor-related epilepsy. It inhibits ATP release and Ca2+ signaling, reduces proliferation markers, modulates microglia, and improves survival in preclinical models.
"Connexin 43 hemichannels and related diseases"contributed by Yanfeng Zhang (AlaMab Therapeutics) and Jean X Jiang (University of Texas Health Science Center).
Free access of the full article through: academic.oup.com/abt/article/...
#Antibody #Therapeutics #mAbs
Free access of the full article through: academic.oup.com/abt/article/...
#Antibody #Therapeutics #mAbs
September 3, 2025 at 9:11 PM
"Connexin 43 hemichannels and related diseases"contributed by Yanfeng Zhang (AlaMab Therapeutics) and Jean X Jiang (University of Texas Health Science Center).
Free access of the full article through: academic.oup.com/abt/article/...
#Antibody #Therapeutics #mAbs
Free access of the full article through: academic.oup.com/abt/article/...
#Antibody #Therapeutics #mAbs
A paper using RRID:Addgene_167582 was just published in The Journal of Physiology see "Multiple carbamylation events are required for differential modulation of Cx26 hemichannels and gap junctions by CO2". We appreciate the author's support of reproducibility. #RRID #accelerateopenscience
doi.org
February 18, 2025 at 8:01 AM
A paper using RRID:Addgene_167582 was just published in The Journal of Physiology see "Multiple carbamylation events are required for differential modulation of Cx26 hemichannels and gap junctions by CO2". We appreciate the author's support of reproducibility. #RRID #accelerateopenscience
Activity-dependent CO<sub>2</sub> production in the axon triggers opening of Connexin32 in the Schwann cell paranode
Activity-dependent CO2 production in the axon triggers opening of Connexin32 in the Schwann cell paranode
Gaseous CO2 acts as a neuron to glia messenger in peripheral myelin to trigger opening of Schwann Cell Cx32 hemichannels in response to axonal action potential propagation.
buff.ly
August 21, 2026 at 8:21 AM
Activity-dependent CO<sub>2</sub> production in the axon triggers opening of Connexin32 in the Schwann cell paranode
Este es el doi completo.. doi.org/10.3390/ijms...
The Gap Junction Inhibitor Octanol Decreases Proliferation and Increases Glial Differentiation of Postnatal Neural Progenitor Cells
Neural precursor cells (NPCs) that persist in the postnatal/adult subventricular zone (SVZ) express connexins that form hemichannels and gap junctions. Gap junctional communication plays a role in NPC...
doi.org
January 16, 2025 at 6:55 AM
Este es el doi completo.. doi.org/10.3390/ijms...
Online now! #chembiol
Electrochemical sensor toolkit for simultaneous glutamate detection at edge of cleft and peri-soma
Liu et al. engineered electrochemical glutamate sensors (eGluSn) by integrating biologically engineered GluR with chemically designed ferrocene groups onto a nanoelectrode. These sensors provide quantitative, real-time measurement of Glu simultaneously at edge of cleft and peri-soma, revealing key roles for non-vesicular release pathways (xCT/hemichannels) in pathological models.
dlvr.it
June 3, 2025 at 3:30 PM
Online now! #chembiol