Molecularly Distinct Innexin Gap Junction Channels and Undocked Hemichannels Regulate Glia Morphology and Function in Caenorhabditis elegans https://www.biorxiv.org/content/10.64898/2026.09.21.753071v1
September 25, 2026 at 11:15 PM
Molecularly Distinct Innexin Gap Junction Channels and Undocked Hemichannels Regulate Glia Morphology and Function in Caenorhabditis elegans https://www.biorxiv.org/content/10.64898/2026.09.21.753071v1
Molecularly Distinct Innexin Gap Junction Channels and Undocked Hemichannels Regulate Glia Morphology and Function in Caenorhabditis elegans https://www.biorxiv.org/content/10.64898/2026.09.21.753071v1
September 25, 2026 at 11:15 PM
Molecularly Distinct Innexin Gap Junction Channels and Undocked Hemichannels Regulate Glia Morphology and Function in Caenorhabditis elegans https://www.biorxiv.org/content/10.64898/2026.09.21.753071v1
Targeting Macrophage Connexin 43 Hemichannels Suppresses Synovial Inflammation and Osteoarthritis https://www.biorxiv.org/content/10.64898/2026.09.04.749181v1
September 9, 2026 at 2:17 PM
Targeting Macrophage Connexin 43 Hemichannels Suppresses Synovial Inflammation and Osteoarthritis https://www.biorxiv.org/content/10.64898/2026.09.04.749181v1
Targeting Macrophage Connexin 43 Hemichannels Suppresses Synovial Inflammation and Osteoarthritis https://www.biorxiv.org/content/10.64898/2026.09.04.749181v1
September 9, 2026 at 2:17 PM
Targeting Macrophage Connexin 43 Hemichannels Suppresses Synovial Inflammation and Osteoarthritis https://www.biorxiv.org/content/10.64898/2026.09.04.749181v1
Activity-dependent CO<sub>2</sub> production in the axon triggers opening of Connexin32 in the Schwann cell paranode
Activity-dependent CO2 production in the axon triggers opening of Connexin32 in the Schwann cell paranode
Gaseous CO2 acts as a neuron to glia messenger in peripheral myelin to trigger opening of Schwann Cell Cx32 hemichannels in response to axonal action potential propagation.
buff.ly
August 21, 2026 at 8:21 AM
Activity-dependent CO<sub>2</sub> production in the axon triggers opening of Connexin32 in the Schwann cell paranode
Activity-dependent CO<sub>2</sub> production in the axon triggers opening of Connexin32 in the Schwann cell paranode
Activity-dependent CO2 production in the axon triggers opening of Connexin32 in the Schwann cell paranode
Gaseous CO2 acts as a neuron to glia messenger in peripheral myelin to trigger opening of Schwann Cell Cx32 hemichannels in response to axonal action potential propagation.
buff.ly
August 20, 2026 at 8:26 PM
Activity-dependent CO<sub>2</sub> production in the axon triggers opening of Connexin32 in the Schwann cell paranode
RRIDs were included in this in Frontiers in Physiology paper. RRIDs improve reproducibility in scientific research. #OpenScience #RRID #reproducibility
Frontiers | Connexin50 hemichannels are opened by CO2: implications for lens physiology
Connexin50 (Cx50) is expressed in lens fiber cells. As mutations in Cx50 cause cataracts, its physiological role in the lens must be important. We have used ...
doi.org
August 8, 2026 at 7:02 AM
RRIDs were included in this in Frontiers in Physiology paper. RRIDs improve reproducibility in scientific research. #OpenScience #RRID #reproducibility
Connexin50 hemichannels are opened by CO2: implications for lens physiology pubmed.ncbi.nlm.nih.gov/42558166/ #cryoem
August 8, 2026 at 2:53 AM
Connexin50 hemichannels are opened by CO2: implications for lens physiology pubmed.ncbi.nlm.nih.gov/42558166/ #cryoem
CO<sub>2</sub>-dependent opening of connexin 43 hemichannels
CO2-dependent opening of connexin 43 hemichannels
Connexin43 is the most ubiquitously expressed connexin in the human body, and the CO2-dependent opening of Connexin43 hemichannels implies that CO2 may influence many physiological processes.
buff.ly
July 12, 2026 at 11:26 AM
CO<sub>2</sub>-dependent opening of connexin 43 hemichannels
CO<sub>2</sub>-dependent opening of connexin 43 hemichannels
CO2-dependent opening of connexin 43 hemichannels
Connexin43 is the most ubiquitously expressed connexin in the human body, and the CO2-dependent opening of Connexin43 hemichannels implies that CO2 may influence many physiological processes.
buff.ly
July 12, 2026 at 8:21 AM
CO<sub>2</sub>-dependent opening of connexin 43 hemichannels
The authors included RRIDs in their in eLife paper! Thanks for making your methods matter! #methodsmatter #STMpublishing #BetterScience
CO2-dependent opening of connexin 43 hemichannels
Read the full paper: CO2-dependent opening of connexin 43 hemichannels
doi.org
June 7, 2026 at 7:04 AM
The authors included RRIDs in their in eLife paper! Thanks for making your methods matter! #methodsmatter #STMpublishing #BetterScience
CO2-dependent opening of connexin 43 hemichannels doi.org/10.7554/eLif...
CO2-dependent opening of connexin 43 hemichannels
Connexin43 is the most ubiquitously expressed connexin in the human body, and the CO2-dependent opening of Connexin43 hemichannels implies that CO2 may influence many physiological processes.
doi.org
June 4, 2026 at 3:03 PM
CO2-dependent opening of connexin 43 hemichannels doi.org/10.7554/eLif...
Antibody Therapeutics (IF=4.5, Oxford University Press) ⚡ Review Highlight - Connexin 43 hemichannels and related diseases
academic.oup.com/abt/article/...
#antibodydiscovery #antibodytherapeutics #biologics #connexin43 #hemichannel
academic.oup.com/abt/article/...
#antibodydiscovery #antibodytherapeutics #biologics #connexin43 #hemichannel
Connexin 43 hemichannels and related diseases
Statement of Significance: This article provides an overview of Connexin 43 hemichannels, elucidating their crucial involvement in various diseases and out
academic.oup.com
May 19, 2026 at 1:49 PM
Antibody Therapeutics (IF=4.5, Oxford University Press) ⚡ Review Highlight - Connexin 43 hemichannels and related diseases
academic.oup.com/abt/article/...
#antibodydiscovery #antibodytherapeutics #biologics #connexin43 #hemichannel
academic.oup.com/abt/article/...
#antibodydiscovery #antibodytherapeutics #biologics #connexin43 #hemichannel
💥Our next speaker is Nicholas Dale from the University of Warwick! 💥
Nicholas will discuss how connexin hemichannels are gated by CO2 via an evolutionarily conserved carbamylation mechanism, and examine the structural, physiological and evolutionary implications of connexin-mediated CO2 signalling
Nicholas will discuss how connexin hemichannels are gated by CO2 via an evolutionarily conserved carbamylation mechanism, and examine the structural, physiological and evolutionary implications of connexin-mediated CO2 signalling
May 13, 2026 at 9:53 AM
💥Our next speaker is Nicholas Dale from the University of Warwick! 💥
Nicholas will discuss how connexin hemichannels are gated by CO2 via an evolutionarily conserved carbamylation mechanism, and examine the structural, physiological and evolutionary implications of connexin-mediated CO2 signalling
Nicholas will discuss how connexin hemichannels are gated by CO2 via an evolutionarily conserved carbamylation mechanism, and examine the structural, physiological and evolutionary implications of connexin-mediated CO2 signalling
Imaging of putative ephapses with electron microscopy are reported in the heart perinexus (hemichannels and Na channels, 10-20nm junction gaps) and suprachiasmatic nucleus (20% of neuron surface area touching another neuron, junction gap tens to few hundreds nm judging from Fig. 6.). Links:
28/n
28/n
April 13, 2026 at 12:37 AM
Imaging of putative ephapses with electron microscopy are reported in the heart perinexus (hemichannels and Na channels, 10-20nm junction gaps) and suprachiasmatic nucleus (20% of neuron surface area touching another neuron, junction gap tens to few hundreds nm judging from Fig. 6.). Links:
28/n
28/n
Can’t wait to learn about some awesome science at Friday Afternoon Seminars!
For everyone @FredHutch.org, join us at 4:00 in Pelton to hear Caitlyn Fain from the Parkhurst Lab and Alex Doan from Human Biology’s @davidmacphersonlab.bsky.social share their latest discoveries!
For everyone @FredHutch.org, join us at 4:00 in Pelton to hear Caitlyn Fain from the Parkhurst Lab and Alex Doan from Human Biology’s @davidmacphersonlab.bsky.social share their latest discoveries!
April 10, 2026 at 9:33 PM
Can’t wait to learn about some awesome science at Friday Afternoon Seminars!
For everyone @FredHutch.org, join us at 4:00 in Pelton to hear Caitlyn Fain from the Parkhurst Lab and Alex Doan from Human Biology’s @davidmacphersonlab.bsky.social share their latest discoveries!
For everyone @FredHutch.org, join us at 4:00 in Pelton to hear Caitlyn Fain from the Parkhurst Lab and Alex Doan from Human Biology’s @davidmacphersonlab.bsky.social share their latest discoveries!
WO2026047782 describes antibody abEC1.1 targeting extracellular domains of connexin hemichannels (Cx26 Cx30 Cx32) to treat gliomas and tumor-related epilepsy. It inhibits ATP release and Ca2+ signaling, reduces proliferation markers, modulates microglia, and improves survival in preclinical models.
March 24, 2026 at 7:36 AM
WO2026047782 describes antibody abEC1.1 targeting extracellular domains of connexin hemichannels (Cx26 Cx30 Cx32) to treat gliomas and tumor-related epilepsy. It inhibits ATP release and Ca2+ signaling, reduces proliferation markers, modulates microglia, and improves survival in preclinical models.
Antibody Therapeutics (IF=4.5, Oxford University Press)
🔥🔥Connexin 43 hemichannels and related diseases
academic.oup.com/abt/article/...
#Connexin43 #hemichannel #diseasestherapeutictargets
🔥🔥Connexin 43 hemichannels and related diseases
academic.oup.com/abt/article/...
#Connexin43 #hemichannel #diseasestherapeutictargets
Connexin 43 hemichannels and related diseases
Statement of Significance: This article provides an overview of Connexin 43 hemichannels, elucidating their crucial involvement in various diseases and out
academic.oup.com
March 16, 2026 at 12:32 PM
Antibody Therapeutics (IF=4.5, Oxford University Press)
🔥🔥Connexin 43 hemichannels and related diseases
academic.oup.com/abt/article/...
#Connexin43 #hemichannel #diseasestherapeutictargets
🔥🔥Connexin 43 hemichannels and related diseases
academic.oup.com/abt/article/...
#Connexin43 #hemichannel #diseasestherapeutictargets
The authors included RRIDs in their paper! Thanks for making your methods matter! #STMpublishing #OpenScience #methodsmatter
A hyperpolarizing neuron recruits undocked innexin hemichannels to transmit neural information in Caenorhabditis elegans
doi.org
December 5, 2025 at 8:00 AM
The authors included RRIDs in their paper! Thanks for making your methods matter! #STMpublishing #OpenScience #methodsmatter
The authors included RRIDs in their paper! RRIDs improve reproducibility in scientific research. #OpenScience #accelerateopenscience #STMpublishing
Mechanisms of permselectivity of connexin hemichannels to small molecules
doi.org
November 23, 2025 at 8:01 AM
The authors included RRIDs in their paper! RRIDs improve reproducibility in scientific research. #OpenScience #accelerateopenscience #STMpublishing
This #EHUikerketa identifies microglial connexin43 (Cx43) hemichannels as a regulator of microglial reactivity in Alzheimer’s disease.
Connexin43 hemichannel blockade turns microglia neuroprotective and mitigates cognitive deficits in a mouse model of amyloidosis - Nature Communications
Microglia play a critical role in Alzheimer’s disease progression. Here, the authors show that knockout of microglial Cx43 or inhibition of Cx43 hemichannels by nanoparticle-delivered peptide mitigates cognitive deficits and neuropathology in APP/PS1 mice by inducing microglia into a neuroprotective state.
www.nature.com
November 2, 2025 at 9:05 PM
This #EHUikerketa identifies microglial connexin43 (Cx43) hemichannels as a regulator of microglial reactivity in Alzheimer’s disease.
Connexin and pannexin-formed hemichannels have emerged as pivotal, upstream amplifiers of neuroinflammation. Genetic ablation or pharmacological blockade of these channels shrinks lesions, preserves synaptic plasticity, restores blood-br...
#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #MedSky
#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #MedSky
Connexin and Pannexin Hemichannels: Broad‐Spectrum Players in Neuroinflammatory Signaling
Connexin and pannexin-formed hemichannels have emerged as pivotal, upstream amplifiers of neuroinflammation. Genetic ablation or pharmacological blockade of these channels shrinks lesions, preserves s
gregory-ms.com
September 17, 2025 at 7:20 AM
Connexin and pannexin-formed hemichannels have emerged as pivotal, upstream amplifiers of neuroinflammation. Genetic ablation or pharmacological blockade of these channels shrinks lesions, preserves synaptic plasticity, restores blood-br...
#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #MedSky
#MSchat #MS #Neurology #MultipleSclerosis #NeuroSky #MedSky
"Connexin 43 hemichannels and related diseases"contributed by Yanfeng Zhang (AlaMab Therapeutics) and Jean X Jiang (University of Texas Health Science Center).
Free access of the full article through: academic.oup.com/abt/article/...
#Antibody #Therapeutics #mAbs
Free access of the full article through: academic.oup.com/abt/article/...
#Antibody #Therapeutics #mAbs
September 3, 2025 at 9:11 PM
"Connexin 43 hemichannels and related diseases"contributed by Yanfeng Zhang (AlaMab Therapeutics) and Jean X Jiang (University of Texas Health Science Center).
Free access of the full article through: academic.oup.com/abt/article/...
#Antibody #Therapeutics #mAbs
Free access of the full article through: academic.oup.com/abt/article/...
#Antibody #Therapeutics #mAbs
Priscila A. Araujo of ucd-physiology.bsky.social et al. discuss connexin-43 remodelling and arrhythmias in relation to hemichannels as key drivers of cardiac dysfunction 🧬 ↔️
🔗 Read the #TopicalReview here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
🔗 Read the #TopicalReview here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
August 27, 2025 at 11:01 AM
Priscila A. Araujo of ucd-physiology.bsky.social et al. discuss connexin-43 remodelling and arrhythmias in relation to hemichannels as key drivers of cardiac dysfunction 🧬 ↔️
🔗 Read the #TopicalReview here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
🔗 Read the #TopicalReview here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
Walter Vásquez et al. examine the #pathophysiological role of connexin and pannexin hemichannels in neuromuscular disorders in this #TopicalReview 📖 🔍
🔗 Read it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
🔗 Read it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
August 25, 2025 at 1:02 PM
Walter Vásquez et al. examine the #pathophysiological role of connexin and pannexin hemichannels in neuromuscular disorders in this #TopicalReview 📖 🔍
🔗 Read it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
🔗 Read it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...