#hemolysin
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rridrobot.bsky.social
The authors included RRIDs in their in Scientific Reports paper! RRIDs improve reproducibility in scientific research. #RRID #accelerateopenscience #reproducibility
Genome-wide CRISPR screen reveals novel host factors required for Staphylococcus aureus α-hemolysin-mediated toxicity - Scientific Reports
Read the full paper: Genome-wide CRISPR screen reveals novel host factors required for Staphylococcus aureus α-hemolysin-mediated toxicity
doi.org
October 30, 2026 at 7:01 AM
rridrobot.bsky.social
RRIDs were included in this in Microbiology Spectrum paper. RRIDs improve reproducibility in scientific research. #RRID #OpenResearch #BetterScience
Genome-Wide CRISPR-Cas9 Screen Does Not Identify Host Factors Modulating Streptococcus agalactiae β-Hemolysin/Cytolysin-Induced Cell Death
Read the full paper: Genome-Wide CRISPR-Cas9 Screen Does Not Identify Host Factors Modulating Streptococcus agalactiae β-Hemolysin/Cytolysin-Induced Cell Death
doi.org
October 30, 2026 at 7:05 AM
rridrobot.bsky.social
The authors included RRIDs in their in mBio paper! Thanks for making your methods matter! #RRID #STMpublishing #ReproducibleResearch
The Extracellular Domain of the β2 Integrin β Subunit (CD18) Is Sufficient for Escherichia coli Hemolysin and Aggregatibacter actinomycetemcomitans Leukotoxin Cytotoxic Activity
Read the full paper: The Extracellular Domain of the β2 Integrin β Subunit (CD18) Is Sufficient for Escherichia coli Hemolysin and Aggregatibacter actinomycetemcomitans Leukotoxin Cytotoxic Activity
doi.org
October 30, 2026 at 7:05 AM
rridrobot.bsky.social
RRIDs were included in this in PLOS Biology paper. RRIDs improve reproducibility in scientific research. #methodsmatter #RRID #OpenScience
Caveolin 1 is a conserved host factor mediating Bacillus cereus hemolysin BL toxin cytolytic toxicity
Bacillus cereus hemolysin BL (HBL) uses the host receptors LITAF and CDIP1 for cytotoxicity, but the loss of both only protects the host partly. This study shows that Caveolin 1 completes a three-factor host system whose combined loss confers full resistance to HBL.
doi.org
October 30, 2026 at 7:02 AM
staph-papers.bsky.social
Porcine methicillin-resistant Staphylococcus aureus CC5/t002 from southwestern Nigeria lacks mec gene and carries PVL and IEC genes on prophages incorporated in the β-hemolysin region
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t.co
October 23, 2026 at 10:42 PM
bioinfoadv.bsky.social
Iron proved essential for growth, with complete deprivation abolishing it entirely, supporting a proposed hemolysin–iron–ROS–Hippo pathway potentially relevant to colorectal cancer progression.
October 21, 2026 at 10:02 AM
biorxiv-synthbio.bsky.social
Selective Recognition, Covalent Linkage and Chemical Exchange of Artificial Cells through Engineered α-Hemolysin https://www.biorxiv.org/content/10.64898/2026.10.16.759538v1
October 16, 2026 at 4:01 PM
biorxivpreprint.bsky.social
Selective Recognition, Covalent Linkage and Chemical Exchange of Artificial Cells through Engineered α-Hemolysin https://www.biorxiv.org/content/10.64898/2026.10.16.759538v1
October 16, 2026 at 4:01 PM
staph-papers.bsky.social
The transcriptional regulator ArcR represses virulence and γ-hemolysin expression in Staphylococcus aureus USA300 LAC
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t.co
October 4, 2026 at 6:42 AM
genesndiseases.bsky.social
Persistent #StaphylococcusAureus infection can evade immune clearance & drive chronic #BoneInfection.
This study reveals α-hemolysin suppresses NF-κB signaling while evading degradation, enabling immune escape.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
October 3, 2026 at 12:13 PM
carb-x.bsky.social
Dr. Broenstrup’s CARB-X-supported project, a first-in-class small-molecule inhibitor of the S. aureus a-hemolysin, is a Falling Walls Life Sciences Breakthrough of the Year finalist! Since 2020, CARB-X has provided $5.7M in funding and support to the program. Congrats! #IDSky 🧪

🔗 bit.ly/46vNUq2
helmholtzhzi.bsky.social Helmholtz-Zentrum für Infektionsforschung (HZI) @helmholtzhzi.bsky.social · Aug 31
Was, wenn wir Bakterien nicht direkt hemmen, sondern sie entwaffnen? Diese Idee eines #Pathoblockers ist für den Science Breakthrough of the Year nominiert! Im Interview mit #FallingWalls spricht Mark Brönstrup über die Entwicklung eines neuartigen #Antibiotikums. falling-walls.com/breakthrough...
Portrait von Mark Brönstrup vor einem weißen Hintergrund
September 10, 2026 at 12:58 PM
sigtrans-sttt.bsky.social
A vaccine carrier can do more than deliver antigens!

HlaH35A activates ADAM10–Notch2 signaling in #dendriticcells, promoting cDC2 differentiation and Th17/Tfh immunity to protect against acute Pseudomonas aeruginosa #LungInfection.

#STTT #OpenAccess: doi.org/10.1038/s413...
#Immunology
Alpha hemolysin enhances the immune response by modulating dendritic cell differentiation via ADAM10-Notch signaling
September 5, 2026 at 2:00 AM
rahmah98.bsky.social
A Cyclodextrin-Mediated Host-Guest Interactions Within alpha-Hemolysin Nanopore Platform for PFAS Identification https://pubmed.ncbi.nlm.nih.gov/42663954/
August 31, 2026 at 10:20 AM
plosbiology.org
Bacillus cereus #hemolysin BL (HBL) uses host receptors LITAF & CDIP1 for #cytotoxicity, but the loss of both only partially protects the host. This study shows that Caveolin 1 completes a 3-factor host system whose combined loss confers full resistance to HBL @plosbiology.org 🧪 plos.io/4xTXe2A
Left: Co-localization (yellow) of HBL-B (green) and CAV1 (red) on HT1080 cell surface. HT1080-WT, HT1080-dKO, and HT1080-tKO cells bound with HBL-B were stained with an anti-HBL-B antiserum (green) and an anti-CAV1 antibody (red). Merge images highlight co-localization (yellow) of HBL-B and CAV1. DAPI-stained nuclei (blue). Scale bar = 25 μm. Representative of three independent experiments with similar results. Right: In vivo role of CAV1 in HBL pathogenesis. Mice with indicated genotypes (WT, Cav1−/−, Litaf−/−/Cdip1−/− (dKO), Litaf−/−/Cdip1−/−/Cav1−/− (tKO)) were challenged with 2 µg HBL toxin (I.P. route) daily as indicated by red arrows. Of note, while all the Litaf−/−/Cdip1−/− (dKO) mice succumbed to 2-3 doses of HBL, the Litaf−/−/Cdip1−/−/Cav1−/− (tKO) mice were completely resistant to the HBL challenge that all the mice survived even with 5 doses of 2 µg HBL toxin challenge.
August 25, 2026 at 12:55 PM
plosbiology.org
Bacillus cereus #hemolysin BL (HBL) uses host receptors LITAF and CDIP1 for #cytotoxicity, but the loss of both only partially protects the host. This study shows that Caveolin 1 completes a 3-factor host system whose combined loss confers full resistance to HBL @plosbiology.org 🧪 plos.io/4xTXe2A
Left: Co-localization (yellow) of HBL-B (green) and CAV1 (red) on HT1080 cell surface. HT1080-WT, HT1080-dKO, and HT1080-tKO cells bound with HBL-B were stained with an anti-HBL-B antiserum (green) and an anti-CAV1 antibody (red). Merge images highlight co-localization (yellow) of HBL-B and CAV1. DAPI-stained nuclei (blue). Scale bar = 25 μm. Representative of three independent experiments with similar results. Right: In vivo role of CAV1 in HBL pathogenesis. Mice with indicated genotypes (WT, Cav1−/−, Litaf−/−/Cdip1−/− (dKO), Litaf−/−/Cdip1−/−/Cav1−/− (tKO)) were challenged with 2 µg HBL toxin (I.P. route) daily as indicated by red arrows. Of note, while all the Litaf−/−/Cdip1−/− (dKO) mice succumbed to 2-3 doses of HBL, the Litaf−/−/Cdip1−/−/Cav1−/− (tKO) mice were completely resistant to the HBL challenge that all the mice survived even with 5 doses of 2 µg HBL toxin challenge.
August 24, 2026 at 4:25 PM
plosbiology.org
Bacillus cereus #hemolysin BL (HBL) uses host receptors LITAF & CDIP1 for #cytotoxicity, but the loss of both only partially protects the host. This study shows that Caveolin 1 completes a 3-factor host system whose combined loss confers full resistance to HBL @plosbiology.org 🧪 plos.io/4xTXe2A
Left: Co-localization (yellow) of HBL-B (green) and CAV1 (red) on HT1080 cell surface. HT1080-WT, HT1080-dKO, and HT1080-tKO cells bound with HBL-B were stained with an anti-HBL-B antiserum (green) and an anti-CAV1 antibody (red). Merge images highlight co-localization (yellow) of HBL-B and CAV1. DAPI-stained nuclei (blue). Scale bar = 25 μm. Representative of three independent experiments with similar results. Right: In vivo role of CAV1 in HBL pathogenesis. Mice with indicated genotypes (WT, Cav1−/−, Litaf−/−/Cdip1−/− (dKO), Litaf−/−/Cdip1−/−/Cav1−/− (tKO)) were challenged with 2 µg HBL toxin (I.P. route) daily as indicated by red arrows. Of note, while all the Litaf−/−/Cdip1−/− (dKO) mice succumbed to 2-3 doses of HBL, the Litaf−/−/Cdip1−/−/Cav1−/− (tKO) mice were completely resistant to the HBL challenge that all the mice survived even with 5 doses of 2 µg HBL toxin challenge.
August 24, 2026 at 8:05 AM
oborkowski.bsky.social
Chemically tunable permeability of engineered alpha-Hemolysin in synthetic cells
doi.org/10.64898/202...
May 27, 2026 at 4:53 PM
ai10bro.bsky.social
Researchers have made significant strides in observing and monitoring the folding dynamics of various DNA motifs at a single-molecule level using α-hemolysin protein nanopore technology.

🔗 Source: https://pubmed.ncbi.nlm.nih.gov/42099004/
May 20, 2026 at 12:47 PM
staph-papers.bsky.social
The toxic effects of α-hemolysin and β-hemolysin produced by Staphylococcus aureus t.co/2bZuqubyut
The toxic effects of α-hemolysin and β-hemolysin produced by Staphylococcus aureus - PubMed
<span><i>Staphylococcus aureus</i> (<i>S. aureus</i>) is a Gram-positive bacterium widely distributed in nature, which can cause skin and soft tissue infections, sepsis, pneumonia and other invasive diseases....
t.co
June 13, 2026 at 6:42 AM
staph-papers.bsky.social
Targeting of Staphyloxanthin and α-Hemolysin by Natural Compound L-Malic Acid Suppresses Staphylococcus aureus Virulence
Targeting of Staphyloxanthin and α-Hemolysin by Natural Compound L-Malic Acid Suppresses Staphylococcus aureus Virulence - PubMed
The escalating prevalence of antibiotic resistance in Staphylococcus aureus has underscored the urgent necessity for groundbreaking anti-infective therapies that target novel pathways. Metabolic intermediates,...
t.co
May 31, 2026 at 11:34 AM
staph-papers.bsky.social
Multivalent nanobodies for potent and broad neutralization of Staphylococcus aureus toxins
Multivalent nanobodies for potent and broad neutralization of Staphylococcus aureus toxins - PubMed
Staphylococcus aureus is a leading cause of lethal bacteremia and pneumonia, which are driven by potent virulence factors such as T-cell superantigens and alpha hemolysin. S. aureus has among the highest...
t.co
May 21, 2026 at 10:05 AM
staph-papers.bsky.social
α-hemolysin targets LGALS3 (galectin 3) to promote intracellular survival of Staphylococcus aureus via lysosomal disruption and autophagy inhibition t.co/1FlG3nyY2l
α-hemolysin targets LGALS3 (galectin 3) to promote intracellular survival of Staphylococcus aureus via lysosomal disruption and autophagy inhibition - PubMed
Intracellular persistence caused by <i>Staphylococcus aureus</i> (<i>S. aureus</i>) is among the primary reasons for recurrence and difficulty in eradicating <i>S. aureus</i> infections. In this study,...
t.co
March 10, 2026 at 5:34 PM
staph-papers.bsky.social
An Imidazo[2,1-b][1,3,4]thiadiazole Derivative Inhibits the Virulence Factor α-Hemolysin by Blocking the Pullout of Its Stem Domain
An Imidazo[2,1-b][1,3,4]thiadiazole Derivative Inhibits the Virulence Factor α-Hemolysin by Blocking the Pullout of Its Stem Domain - PubMed
Staphylococcus aureus is a major human pathogen responsible for severe infections that necessitate alternative therapeutic strategies. Its key virulence factor α-hemolysin (Hla) mediates host cell damage...
t.co
February 23, 2026 at 12:05 PM
staph-papers.bsky.social
Xuebijing Injection in synergy with linezolid alleviates inflammatory injury in mice with MRSA pneumonia by inhibiting the Hla-NLRP3 pathway
[Xuebijing Injection in synergy with linezolid alleviates inflammatory injury in mice with MRSA pneumonia by inhibiting the Hla-NLRP3 pathway] - PubMed
LZD combined with XBJ produces enhanced efficacy for improving MRSA pneumonia possibly due to XBJ-induced inhibition of NLRP3-mediated inflammatory response via inhibiting α-hemolysin secretion.
t.co
February 4, 2026 at 11:05 AM
staph-papers.bsky.social
Staphylococcus aureus escapes endosomes and autophagosomes via α-hemolysin
Staphylococcus aureus escapes endosomes and autophagosomes via α-hemolysin - PubMed
The interplay between endosomal and autophagic pathways is crucial for intracellular transport and modulation of pathogen replication. However, the mechanisms underlying the interaction between endosomes...
t.co
January 6, 2026 at 6:34 PM