Our newest paper on the fascinating biology DRG neurons.
@eLife: Axon-specific microtubule regulation drives asymmetric regeneration of sensory neuron axons doi.org/10.7554/eLif...
Tour de force by Catarina Costa @i3suporto.bsky.social et al
@eLife: Axon-specific microtubule regulation drives asymmetric regeneration of sensory neuron axons doi.org/10.7554/eLif...
Tour de force by Catarina Costa @i3suporto.bsky.social et al
February 25, 2025 at 4:52 PM
Teixeira et al. @i3suporto.bsky.social identify the onconeural antigen CDR2 as an ER-localized adaptor for the microtubule-based motor cytoplasmic dynein-1 & show that CDR2 contributes to ER organization thru. its interaction w/ the integral ER membrane protein kinectin. rupress.org/jcb/article/...
July 10, 2025 at 4:27 PM
academic.oup.com/ecco-jcc/art...
Happy to share our most recent publication on how T cells glycosylation mediates #IBD progression to colorectal cancer defining the risk of colitis-associated cancer.
#glycotime Great work @eduardalgomes.bsky.social @i3suporto.bsky.social @GlycanTrigger
Happy to share our most recent publication on how T cells glycosylation mediates #IBD progression to colorectal cancer defining the risk of colitis-associated cancer.
#glycotime Great work @eduardalgomes.bsky.social @i3suporto.bsky.social @GlycanTrigger
T-cell branched glycosylation as a mediator of colitis-associated colorectal cancer progression: a potential new risk biomarker in inflammatory bowel disease
AbstractBackground and Aims. Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract, established as a risk facto
academic.oup.com
May 2, 2025 at 8:50 AM
Latest paper led by Rui Moura, collab with @AnnedesRieux @UCLouvain_be now @JCRnEDITORS. Lipid nanocapsules with retinoic acid significantly reduced disease severity and attenuated demyelination in encephalomyelitis model.
doi.org/10.1016/j.jc...
#MultipleSclerosis #i3SPapers
doi.org/10.1016/j.jc...
#MultipleSclerosis #i3SPapers
Redirecting
doi.org
March 10, 2026 at 8:36 AM
Latest paper led by Rui Moura, collab with @AnnedesRieux @UCLouvain_be now @JCRnEDITORS. Lipid nanocapsules with retinoic acid significantly reduced disease severity and attenuated demyelination in encephalomyelitis model.
doi.org/10.1016/j.jc...
#MultipleSclerosis #i3SPapers
doi.org/10.1016/j.jc...
#MultipleSclerosis #i3SPapers
In collaboration with @uspoficial.bsky.socialwe established a novel sensory neuron-integrated skin spheroid model for screening biological activity in neuronal pathways. Now online at ACS Biomaterials Science & Engineering. @pubs.acs.org #i3SPapers
pubs.acs.org/doi/full/10....
pubs.acs.org/doi/full/10....
May 24, 2025 at 11:18 AM
In collaboration with @uspoficial.bsky.socialwe established a novel sensory neuron-integrated skin spheroid model for screening biological activity in neuronal pathways. Now online at ACS Biomaterials Science & Engineering. @pubs.acs.org #i3SPapers
pubs.acs.org/doi/full/10....
pubs.acs.org/doi/full/10....
🚨New strategy against glioblastoma! Targeted nanoparticle for dual delivery of anti-angiogenic + glycolysis inhibitor, via intranasal route🧠
Led by Catarina Pacheco, collaboration with @icvs_uminho
and @SaludISCIII, now online @JCRnEDITORS
@i3suporto.bsky.social #i3SPapers
shre.ink/eky7
Led by Catarina Pacheco, collaboration with @icvs_uminho
and @SaludISCIII, now online @JCRnEDITORS
@i3suporto.bsky.social #i3SPapers
shre.ink/eky7
Redirecting
shre.ink
June 6, 2025 at 3:10 PM
🚨New strategy against glioblastoma! Targeted nanoparticle for dual delivery of anti-angiogenic + glycolysis inhibitor, via intranasal route🧠
Led by Catarina Pacheco, collaboration with @icvs_uminho
and @SaludISCIII, now online @JCRnEDITORS
@i3suporto.bsky.social #i3SPapers
shre.ink/eky7
Led by Catarina Pacheco, collaboration with @icvs_uminho
and @SaludISCIII, now online @JCRnEDITORS
@i3suporto.bsky.social #i3SPapers
shre.ink/eky7
Before taking our first steps toward developing an advanced 3D bladder tumor model (stay tuned!), we carried out an in-depth review to map the state of the art and key challenges and opportunities @ActaBiomaterialia
www.sciencedirect.com/science/arti...
#BladderCancer #3DModels #i3Spapers
www.sciencedirect.com/science/arti...
#BladderCancer #3DModels #i3Spapers
Modeling the human bladder tissue using three dimensional in vitro approaches as a tool for drug screening platforms
The main function of bladder tissue is urine accumulation and excretion, and it is composed of five layers (mucus layer, epithelial layer, lamina prop…
www.sciencedirect.com
December 11, 2025 at 11:50 AM
Before taking our first steps toward developing an advanced 3D bladder tumor model (stay tuned!), we carried out an in-depth review to map the state of the art and key challenges and opportunities @ActaBiomaterialia
www.sciencedirect.com/science/arti...
#BladderCancer #3DModels #i3Spapers
www.sciencedirect.com/science/arti...
#BladderCancer #3DModels #i3Spapers
Thrilled to share our latest review in Materials Today Bio on organ-on-chip models for evaluation of safety and efficacy of nanomedicines! Great collaboration with Helder Santos @ The University Medical Center Groningen
www.sciencedirect.com/science/arti...
#Nanomedicine #OrganOnChip #i3SPapers
www.sciencedirect.com/science/arti...
#Nanomedicine #OrganOnChip #i3SPapers
Organ-on-Chip Platforms for Nanoparticle Toxicity and Efficacy Assessment: Advancing Beyond Traditional In Vitro and In Vivo Models
Nanoparticles (NPs) have unique properties, such as their high surface-to-volume ratio, nanoscale size, and functionalization potential, make them pro…
www.sciencedirect.com
July 9, 2025 at 9:07 PM
Thrilled to share our latest review in Materials Today Bio on organ-on-chip models for evaluation of safety and efficacy of nanomedicines! Great collaboration with Helder Santos @ The University Medical Center Groningen
www.sciencedirect.com/science/arti...
#Nanomedicine #OrganOnChip #i3SPapers
www.sciencedirect.com/science/arti...
#Nanomedicine #OrganOnChip #i3SPapers
Our latest paper @DDTReMedia explores multidrug nanosystems for hard-to-treat #Glioblastoma, highlighting rational design, simultaneous/sequential delivery, active targeting and stimuli-responsivess. Led by Catarina Pacheco with @uminho.bsky.social
link.springer.com/article/10.1...
#i3SPapers
link.springer.com/article/10.1...
#i3SPapers
Rational design of anticancer multidrug nanosystems and their adaptation for glioblastoma treatment - Drug Delivery and Translational Research
Multidrug nanosystems emerged as an innovation in anticancer therapy, addressing key limitations of conventional mono- and combination therapies, such as poor tumor selectivity, systemic toxicity, low...
link.springer.com
December 17, 2025 at 9:17 PM
Our latest paper @DDTReMedia explores multidrug nanosystems for hard-to-treat #Glioblastoma, highlighting rational design, simultaneous/sequential delivery, active targeting and stimuli-responsivess. Led by Catarina Pacheco with @uminho.bsky.social
link.springer.com/article/10.1...
#i3SPapers
link.springer.com/article/10.1...
#i3SPapers
Particularly proud of this review paper @DDTReMedia by @Cespu pharmacy student Eva Morim, supervised by Catarina Pacheco on how intranasal drug delivery and nanocarrier-based systems can help bypass the BBB for treating neurological disorders.
link.springer.com/article/10.1... #i3SPapers
link.springer.com/article/10.1... #i3SPapers
Nanocarrier-based intranasal drug delivery for enhanced neurological disorders treatment - Drug Delivery and Translational Research
The blood–brain barrier (BBB) represents a major obstacle in the treatment of neurological disorders. While it plays a crucial role in protecting the central nervous system (CNS) from harmful xenobiot...
link.springer.com
December 4, 2025 at 6:24 PM
Particularly proud of this review paper @DDTReMedia by @Cespu pharmacy student Eva Morim, supervised by Catarina Pacheco on how intranasal drug delivery and nanocarrier-based systems can help bypass the BBB for treating neurological disorders.
link.springer.com/article/10.1... #i3SPapers
link.springer.com/article/10.1... #i3SPapers
A team of #i3S researchers has uncovered a mechanism that ensures a precise chromosome separation during #celldivision.
The finding can pave the way to the development of new therapies to treat faulty cell division-derived conditions, such as #cancer.
#i3Snews #i3Sresearch #i3Spapers #cancerresearch
The finding can pave the way to the development of new therapies to treat faulty cell division-derived conditions, such as #cancer.
#i3Snews #i3Sresearch #i3Spapers #cancerresearch
Novo mecanismo para corrigir erros associados a cancro descoberto por equipa portuguesa
Cientistas identificaram o gatilho para corrigir os erros na divisão celular (que dá origem a novas células). A descoberta detalha o funcionamento do corpo humano e dá pistas para combater o cancro.
tinyurl.com
May 28, 2025 at 10:57 AM
A team of #i3S researchers has uncovered a mechanism that ensures a precise chromosome separation during #celldivision.
The finding can pave the way to the development of new therapies to treat faulty cell division-derived conditions, such as #cancer.
#i3Snews #i3Sresearch #i3Spapers #cancerresearch
The finding can pave the way to the development of new therapies to treat faulty cell division-derived conditions, such as #cancer.
#i3Snews #i3Sresearch #i3Spapers #cancerresearch
First paper published in 2026 is out and is a blast! We show that CD44v6-targeted irinotecan nanoparticles + anti-PD-L1 immunotherapy considerably enhance tumor suppression in vivo. Work led by @AnaBaião, now online in @JCRnEDITORS doi.org/10.1016/j.jc...
#i3SPapers #Nanomedicine @CRS_FG_NANO
#i3SPapers #Nanomedicine @CRS_FG_NANO
Redirecting
doi.org
January 6, 2026 at 7:09 PM
First paper published in 2026 is out and is a blast! We show that CD44v6-targeted irinotecan nanoparticles + anti-PD-L1 immunotherapy considerably enhance tumor suppression in vivo. Work led by @AnaBaião, now online in @JCRnEDITORS doi.org/10.1016/j.jc...
#i3SPapers #Nanomedicine @CRS_FG_NANO
#i3SPapers #Nanomedicine @CRS_FG_NANO
Using our 3D intestinal inflamed model, we validated a new therapeutic strategy of mesalazine-loaded chitosan/alginate nanoparticles to effectively reduced the pro-inflammatory state. Collaboration with @Unesp now online in @CarbohydratePolymers
doi.org/10.1016/j.ca...
#Genegut #i3Spapers
doi.org/10.1016/j.ca...
#Genegut #i3Spapers
Redirecting
doi.org
December 16, 2025 at 7:56 PM
Using our 3D intestinal inflamed model, we validated a new therapeutic strategy of mesalazine-loaded chitosan/alginate nanoparticles to effectively reduced the pro-inflammatory state. Collaboration with @Unesp now online in @CarbohydratePolymers
doi.org/10.1016/j.ca...
#Genegut #i3Spapers
doi.org/10.1016/j.ca...
#Genegut #i3Spapers
Take a look on our recent paper at @JCREditors and learn how IBD-specific stimuli can be used to design smarter and more precise nanotherapies. Discover how disease hallmarks can guide drug delivery.
#i3SPapers #nanomedicines #IBD
doi.org/10.1016/j.jc...
#i3SPapers #nanomedicines #IBD
doi.org/10.1016/j.jc...
November 25, 2025 at 5:21 PM
Take a look on our recent paper at @JCREditors and learn how IBD-specific stimuli can be used to design smarter and more precise nanotherapies. Discover how disease hallmarks can guide drug delivery.
#i3SPapers #nanomedicines #IBD
doi.org/10.1016/j.jc...
#i3SPapers #nanomedicines #IBD
doi.org/10.1016/j.jc...
Our latest study on IBD presents an oxidative-responsive #nanomedicine for oral delivery of budesonide. Penetrates mucus, sheds its PEG corona in inflamed colon tissue and releases budesonide at target site. Now online
@JCRnEDITORS
#i3SPapers @crohnscolitisfdn.bsky.social
doi.org/10.1016/j.jc...
@JCRnEDITORS
#i3SPapers @crohnscolitisfdn.bsky.social
doi.org/10.1016/j.jc...
June 11, 2025 at 4:20 PM
Our latest study on IBD presents an oxidative-responsive #nanomedicine for oral delivery of budesonide. Penetrates mucus, sheds its PEG corona in inflamed colon tissue and releases budesonide at target site. Now online
@JCRnEDITORS
#i3SPapers @crohnscolitisfdn.bsky.social
doi.org/10.1016/j.jc...
@JCRnEDITORS
#i3SPapers @crohnscolitisfdn.bsky.social
doi.org/10.1016/j.jc...
A team of #i3S researchers has uncovered a mechanism that ensures a precise chromosome separation during #celldivision.
Team leader Carlos Conde and researcher Nelson Leça detail the implications of this discovery.
#i3Snews #i3Sresearch #i3Spapers #cancer #cancerresearch
Team leader Carlos Conde and researcher Nelson Leça detail the implications of this discovery.
#i3Snews #i3Sresearch #i3Spapers #cancer #cancerresearch
Investigadores portugueses lutam contra os erros na divisão celular
Um estudo liderado por cientistas do i3S, no Porto, abre portas ao desenvolvimento de novas terapêuticas para doenças como o cancro. A investigação assenta num mecanismo que permite corrigir erros na ...
tinyurl.com
June 27, 2025 at 9:43 AM
A team of #i3S researchers has uncovered a mechanism that ensures a precise chromosome separation during #celldivision.
Team leader Carlos Conde and researcher Nelson Leça detail the implications of this discovery.
#i3Snews #i3Sresearch #i3Spapers #cancer #cancerresearch
Team leader Carlos Conde and researcher Nelson Leça detail the implications of this discovery.
#i3Snews #i3Sresearch #i3Spapers #cancer #cancerresearch
#i3S researchers Gabriel Oliveira and Tânia Silva feature in a video intro in which they discuss their work and how they carried out the research featured in a paper recently published.
📺👀👇
#i3Sresearch #i3Spapers
📺👀👇
#i3Sresearch #i3Spapers
Author Spotlight: Scalable Drug Screening Protocol for Efficient Discovery of <i>M. abscessus</i> Treatments
Mycobacterium abscessus (Mab) infections are challenging to treat due to high intrinsic drug resistance, comparable to multidrug-resistant tuberculosis. ...
app.jove.com
January 28, 2025 at 10:07 AM
#i3S researchers Gabriel Oliveira and Tânia Silva feature in a video intro in which they discuss their work and how they carried out the research featured in a paper recently published.
📺👀👇
#i3Sresearch #i3Spapers
📺👀👇
#i3Sresearch #i3Spapers