#iGluRs
LightNews LightNews
cryoet.bsky.social
The lab does #BPS2025! We loved showcasing our new work on #iGluRs. #proudPI
wdhale.bsky.social W. D. Hale @wdhale.bsky.social · Feb 18
Great meeting at #BPS2025!

#iglur
February 19, 2025 at 7:56 PM
popstarlab.bsky.social
Awesome to meet up with old friends at #BPS2025
#iGluRs
February 17, 2025 at 11:35 PM
popstarlab.bsky.social
Downstream of #iGluRs!
lorenabenedetti.bsky.social Lorena Benedetti @lorenabenedetti.bsky.social · Dec 20
I am super excited to share our article addressing a longstanding question in neurobiology: how Ca²⁺ signaling cascades initiated at dendritic spines operate at a distance. Check it out here: authors.elsevier.com/sd/article/S... @cp-cell.bsky.social.
December 21, 2024 at 2:45 PM
andrewplested.bsky.social
Super paper. Temperature shock has interesting implications for structure solution in general.
#glutamate #iglurs
cryoet.bsky.social Ed Twomey @cryoet.bsky.social · Mar 26
Here's our newest study: we reveal the molecular principles of neuronal excitation by glutamate, and how physiological temperatures influence this process.

www.nature.com/articles/s41...
www.nature.com/articles/d41...

Led by @anish-mondal07.bsky.social, published in @natureportfolio.nature.com
March 26, 2025 at 7:29 PM
andrewplested.bsky.social
Wow so cool congrats Hiro and team! #iglurs
lab-furukawa.bsky.social Furukawa Lab @CSHL @lab-furukawa.bsky.social · Mar 25
Where does anti-NMDAR autoimmune encephalitis come from? Our new work suggests that ectopic NMDAR expression in tumors can trigger anti-cancer immunity, and the resulting antibodies may drive encephalitis-like symptoms. A dynamic Janowitz-Furukawa lab collaboration. www.nature.com/articles/s41...
Ectopic NMDAR expression in cancer unmasks germline-encoded autoimmunity - Nature
NMDAR expression is sufficient to induce B cell recruitment and affinity maturation, resulting in receptor-modulating antibodies that connect anti-cancer immunity and autoimmunity.
www.nature.com
March 25, 2026 at 5:15 PM
nature.com
Nature research paper: Glutamate gating of AMPA-subtype iGluRs at physiological temperatures

https://go.nature.com/425J93Y
Glutamate gating of AMPA-subtype iGluRs at physiological temperatures - Nature
Physiological temperatures augment activation of glutamate receptors, which enables the structural basis of neuronal excitation to be elucidated.
go.nature.com
March 27, 2025 at 9:41 AM
popstarlab.bsky.social
Join me in LA at #BPS2025 Annual Meeting to discuss how #biophysics can inform #sustainability.
Registration is still open!

@biophysicalsoc.bsky.social #science #iGluRs
December 12, 2024 at 10:23 AM
popstarlab.bsky.social
Happy Valentines Day to all friends and colleagues in #MyVillage
#science #biophysics #iGluRs #AAAS2025 #BPS2025
NMDA receptor and much more...
February 14, 2025 at 2:35 PM
cryoet.bsky.social
Here's our new preprint led by @wdhale.bsky.social with @rhuganir.bsky.social:

"Architecture, Activation, and Conformational Plasticity in the GluA4 AMPA Receptor"

www.biorxiv.org/content/10.1...

#iGluRs #cryoEM

Some key points below that Dylan discovered:
June 16, 2025 at 2:19 PM
andrewplested.bsky.social
#iglurs royalty
lwollmuth.bsky.social Lonnie Wollmuth @lwollmuth.bsky.social · Dec 5
At McGill visiting Derek. Wonderful science here. Lots of synaptic physiology. Very elegant. #iglur. #ionchannels
December 5, 2024 at 8:48 PM
popstarlab.bsky.social
Proud moment today for many! We gathered to celebrate #science #NMDA receptors #iGluRs and the most recent doctor of phylosophy: Dr. Mae G. Weaver!
December 20, 2024 at 6:26 PM
andrewplested.bsky.social
Wild.

#neuroskyence #biophysics #iglurs
biorxiv-biophys.bsky.social bioRxiv Biophysics @biorxiv-biophys.bsky.social · May 13
GluDs are ionotropic dopamine receptors tuned by G-proteins https://www.biorxiv.org/content/10.64898/2026.05.10.723887v1
May 14, 2026 at 5:34 AM
cryoet.bsky.social
🚨🧠🔬 Dopamine was discovered over a century ago, and has long been thought to only signal through metabotropic means. In our new preprint, we provide evidence that dopamine can directly signal through the "orphan" GluD ionotropic receptors.

More to come!

#iGluRs #neuroscience #dopamine #cryoEM
May 14, 2026 at 1:44 PM
laetitiamony.bsky.social
Congratulations to Pierre Paoletti who was elected at the French Academy of Sciences !
#iGluRs #NMDA

academie-sciences.prod.aa-testing.tech/sites/defaul...
academie-sciences.prod.aa-testing.tech
December 18, 2024 at 9:43 PM
andrewplested.bsky.social
#iglurs more intermediates and another bona fide open state. Congrats to all.
September 25, 2025 at 8:48 AM
channelomics.bsky.social
Glutamate gating of AMPA-subtype iGluRs at physiological temperatures | Nature
#ionchannels

www.nature.com/articles/s41...
April 2, 2025 at 10:39 AM
popstarlab.bsky.social
Congratulations, @Elias Aizenman, for well-deserved career recognition at
#ISZB-2024 meeting in Merida Mexico.

#science #zinc #biophysics #ionchannels #NMDA #iGluRs
December 7, 2024 at 3:24 AM
popstarlab.bsky.social
www.cell.com/biophysj/abs...
BPS2025 - Gating and regulation of kainate receptors
Kainate receptors, a subtype of ionotropic glutamate receptors (iGluRs), are tetrameric ligand-gated ion channels that mediate excitatory neurotransmission in central nervous system (CNS). These recep...
www.cell.com
February 19, 2025 at 7:10 PM
popstarlab.bsky.social
Congratulations, Ed! Well-deserved recognition of your work on iGluRs!
February 26, 2025 at 1:57 AM
andrewplested.bsky.social
Jelena Baranovic from the University of Edinburgh told us about her work on #iglurs and single channels.

She also got several sets of students to record single glycine receptors.

#BSMBC
Jelena Baranovic lecturing. Jelena at the setup.
September 18, 2026 at 7:37 AM
popstarlab.bsky.social
#science #biophysics #iGluRs
martinvoegele.bsky.social Martin Vögele @martinvoegele.bsky.social · Nov 9
Now online at JCTC:
“Is the Functional Response of a Receptor Determined by the Thermodynamics of Ligand Binding?”

Our answer: Yes, it is!
And we can use it to predict ligand efficacy.

pubs.acs.org/doi/10.1021/...
December 20, 2024 at 4:57 PM
popstarlab.bsky.social
www.nature.com/articles/s41...

More agonists for an "orphan"!
#iGluRs #Channels #SynapticTransmission
GluD1 is localized at cholinergic synapses and is an acetylcholine receptor - Molecular Psychiatry
Molecular Psychiatry - GluD1 is localized at cholinergic synapses and is an acetylcholine receptor
www.nature.com
June 15, 2026 at 6:09 PM
popstarlab.bsky.social
Interested in #iGluRs? See below!
February 3, 2025 at 4:59 PM
popstarlab.bsky.social
Post
#ISZB-2024 meeting, sightseeing in Merida Mexico.

#science #zinc #biophysics #ionchannels #NMDA #iGluRs
December 7, 2024 at 5:14 PM
andrewplested.bsky.social
Beautiful work. We love to see those single channels and the connection to these open channel structures is 🔥
#iGluRs
lab-furukawa.bsky.social Furukawa Lab @CSHL @lab-furukawa.bsky.social · Oct 29
How are NMDA receptor channel conductance states regulated? We uncover a mechanism for tuning ion flow and reveal striking diversity in neurosteroid binding. Our structures captured two distinct open-channel states. A fantastic collaboration with the Traynelis lab.
www.nature.com/articles/s41...
Mechanism of conductance control and neurosteroid binding in NMDA receptors - Nature
Ion-channel conductance levels are controlled by the bending patterns of pore-forming transmembrane helices in the heterotetrameric neuronal channel GluN1a-2B N-methyl-D-aspartate receptor.
www.nature.com
October 29, 2025 at 9:28 PM