#itaconate
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angryhacademic.bsky.social
- Concordance with itaconate shunt hypothesis: more energy for immune system, less energy for us
- Micronutrient deficiencies, e.g. itaconate-induced B12 inactivation
- Endocrine abnormalities
- Why vagus nerve stimulation can cause worsening: sickness behaviour = parasympathetic
November 4, 2026 at 9:17 PM
biorxivpreprint.bsky.social
MASH-in-a-dish reveals fatty acid-driven itaconate crosstalk between Kupffer cells and hepatocytes https://www.biorxiv.org/content/10.64898/2026.10.31.763289v1
November 2, 2026 at 6:45 PM
biorxiv-biochem.bsky.social
MASH-in-a-dish reveals fatty acid-driven itaconate crosstalk between Kupffer cells and hepatocytes https://www.biorxiv.org/content/10.64898/2026.10.31.763289v1
November 2, 2026 at 6:45 PM
biorxiv-microbiol.bsky.social
Integrative multi-omics decoding of the host response to Klebsiella pneumoniae infection reveals an itaconate-centred metabolic-immune axis and a spatially organised inflammatory programme https://www.biorxiv.org/content/10.64898/2026.10.29.762801v1
October 30, 2026 at 1:17 PM
biorxivpreprint.bsky.social
Integrative multi-omics decoding of the host response to Klebsiella pneumoniae infection reveals an itaconate-centred metabolic-immune axis and a spatially organised inflammatory programme https://www.biorxiv.org/content/10.64898/2026.10.29.762801v1
October 30, 2026 at 1:17 PM
prepub-singlecell.bsky.social
Integrative multi-omics decoding of the host response to Klebsiella pneumoniae infection reveals an itaconate-centred metabolic-immune axis and a spatially organised inflammatory programme #SingleCell 🧪🧬🖥️
https://www.biorxiv.org/content/10.64898/2026.10.29.762801v1
October 30, 2026 at 2:01 PM
canlightsource.bsky.social
#ResearchInAction: Researchers from McGill University are using the CLS to study #enzymes that let #bacteria destroy #itaconate, a small molecule our immune cells make when fighting bacteria. The team's findings could be used to design drugs that block those enzymes. https://bit.ly/4p5UBqq
Photo: Members of the research team, from left to right, Martin Schmeing (ball cap), Srobona Ghosh, Mike Tarry, and Anirudh Mantri.
October 22, 2026 at 5:31 PM
cp-cellchembiol.bsky.social
Chemoproteomic profiling of itaconate-derived protein modifications
Chemoproteomic profiling of itaconate-derived protein modifications
Wang et al. herein review recent progress in the systematic identification of post-translational modifications and non-covalent interactions mediated by the immunomodulatory metabolite itaconate using chemoproteomic methods. These studies have provided rich resources to guide future functional studies to better understand the multiple roles of itaconate in host-pathogen interactions.
dlvr.it
October 16, 2026 at 3:30 PM
ash.hematology.org
Explore the role of itaconate in stress erythropoiesis during the ASH Journal Club on Oct. 26, including how this anti-inflammatory metabolite may influence the differentiation of stress erythroid progenitor cells.

Save your spot! https://ow.ly/QY7P50ZWUvK

#Hematology #HemeSky #Medsky
October 13, 2026 at 1:01 PM
wamesmecfs.bsky.social
Dr Robert Phair talks about The itaconate shunt: a short circuit, two toxins, and a fuel leak [29 mins] +Transcript +Chapters
www.youtube.com/watch?v=RzRz...
Robert Phair, PhD, Integrative Bioinformatics Inc.
YouTube video by MECFS Collaborative Research Center at Stanford
www.youtube.com
October 12, 2026 at 1:39 PM
prepub-neurodegen.bsky.social
Human multiscale transcriptomics identifies the NLRP3 inflammasome as a convergent druggable target in Alzheimer’s disease: validation with dimethyl itaconate in 5xFAD mice #NeuroDegeneration 🧪🧠
https://www.researchsquare.com/article/rs-11103693/latest
October 8, 2026 at 10:03 AM
cp-cellchembiol.bsky.social
Online now! Online now! Chemoproteomic profiling of itaconate-derived protein modifications #chembiol
Chemoproteomic profiling of itaconate-derived protein modifications
Wang et al. herein review recent progress in the systematic identification of post-translational modifications and non-covalent interactions mediated by the immunomodulatory metabolite itaconate using chemoproteomic methods. These studies have provided rich resources to guide future functional studies to better understand the multiple roles of itaconate in host-pathogen interactions.
dlvr.it
September 25, 2026 at 3:30 PM
canlightsource.bsky.social
#ResearchInAction: Researchers from McGill University are using the CLS to study #enzymes that let #bacteria destroy #itaconate, a small molecule our immune cells make when fighting bacteria. The team's findings could be used to design drugs that block those enzymes. https://bit.ly/4p5UBqq
Photo: Members of the research team, from left to right, Martin Schmeing (ball cap), Srobona Ghosh, Mike Tarry, and Anirudh Mantri.
September 24, 2026 at 5:31 PM
midcatecrisis.bsky.social
This made me really hopeful. Someone in the comments said it should also be compatible with the itaconate shunt hypothesis (which has always made sense to me). I know the current research environment is challenging, but I hope this one gets through.
September 22, 2026 at 7:01 PM
lymecfs.bsky.social
Oh, wow, seeing CLYBL show up here is very exciting! It's an enzyme that's also key to the Itaconate Shunt as hypothesized by a.o. dr. Rob Phair. m.youtube.com/watch?v=RiVD... Plus I have reason to believe the Itaconate Shunt can disregulate cortisol as suggested here: patientledhypothesis.github.io
Rob Phair, PhD, Presents on the Itaconate Shunt Hypothesis for ME/CFS
YouTube video by Open Medicine Foundation - OMF
m.youtube.com
September 18, 2026 at 2:57 PM
rridrobot.bsky.social
The authors included RRIDs in their in Journal of Clinical Investigation paper! We value the author's support of reproducibility. #methodsmatter #OpenResearch #reproducibility
The immunometabolite itaconate stimulates OXGR1 to promote mucociliary clearance during the pulmonary innate immune response
Read the full paper: The immunometabolite itaconate stimulates OXGR1 to promote mucociliary clearance during the pulmonary innate immune response
doi.org
September 16, 2026 at 7:39 PM
exceedhergrasp1.bsky.social
Rob Phair up now: the Itaconate Shunt.
Itaconate Shunt: a short circuit, two toxins, and a fuel leak Rob Phair Integrative Bioinformatics Inc Mountain View, California USA
September 11, 2026 at 5:00 PM
exceedhergrasp1.bsky.social
Rob has included an image of the itaconate shunt. The diagram generates a sort of gate that can block off parts of the tricarboxylic acid (TCA/Krebs) cycle.
Basically shows the TCA cycle and itaconate shunt but it's a metabolic diagram and rather complex, so listing every chemical and its direction would likely be impossible to convey here understandably. I'll include a link.
September 11, 2026 at 5:04 PM
exceedhergrasp1.bsky.social
They induced a block in itaconate and demonstrated it did impair TCA cycle in zebrafish.

The talk is primarily focused on the theoretical aspects of how the shunt might work.
September 11, 2026 at 5:20 PM
exceedhergrasp1.bsky.social
Schematic of the proposed itaconate shunt and its effects on mitochondrial energy production. Cis-aconitate is diverted from the Krebs cycle into itaconate, itaconyl-CoA, and citramalyl-CoA, with carbon recycled toward pyruvate and acetyl-CoA or exported from the mitochondrion through a possible SLC25A10 transporter. The diagram proposes that this “short circuit” reduces NADH production and diverts succinyl-CoA from heme synthesis, impairing the electron transport chain, proton gradient, ATP generation, and cellular function.
September 11, 2026 at 5:25 PM
natmetabolism.nature.com
RESEARCH | J Tang, E Mills et al (DFCI/HMS; USA)

Macrophage-derived itaconate acts as paracrine inhibitor of adipose thermogenesis by blocking succinate uptake into brown adipose tissue🧪
Macrophage-derived itaconate is a negative regulator of adipose tissue thermogenesis - Nature Metabolism
Tang et al. reveal that macrophage-derived itaconate acts as a paracrine inhibitor of adipose tissue thermogenesis by blocking succinate uptake into brown adipose tissue.
dlvr.it
September 11, 2026 at 4:04 PM
cp-trendsendomet.bsky.social
Online Now: Itaconate #trends #endocrinology #metabolism
Itaconate
Itaconate is a Krebs cycle-derived metabolite generated by aconitate decarboxylase (ACOD1) from aconitate. Originally identified for its antimicrobial activity, itaconate is now recognised as an important link between metabolism and inflammation. Itaconate accumulates in myeloid cells following stimulation via Toll-like receptors and type I interferons, where it modulates inflammatory signalling pathways.
dlvr.it
September 10, 2026 at 12:23 PM
sigtrans-sttt.bsky.social
Itaconate connects cellular metabolism with #Inflammation and redox balance.

This review explores the context-dependent actions and therapeutic potential of the IRG1/ACOD1–itaconate axis across inflammatory, metabolic, immune, and #malignantdiseases.

#STTT #OpenAccess: doi.org/10.1038/s413...
Itaconate and its derivatives in human health and diseases
September 9, 2026 at 3:45 AM
labwaggoner.bsky.social
Review @sigtrans-sttt.bsky.social
Itaconate and its derivatives in human health and diseases
www.nature.com/articles/s41...
September 4, 2026 at 1:14 AM
openmedf.bsky.social
OMF’s Collaborative Center at Stanford University is investigating decreased mitochondrial membrane potential through the itaconate shunt hypothesis.   

Read more about the study on our website: https://
ow.ly/tmsE50ZHpuI
Regulation of the Itaconate Shunt in ME/CFS - Open Medicine Foundation
Explore new Stanford Collaboration study aiming to characterize the mitochondrial function in whole peripheral blood mononuclear cells in ME/CFS.
ow.ly
September 2, 2026 at 9:29 PM