Excited to share our @natgenet.nature.com study showing that epigenetically rewired transposable elements control AML leukemia stem cell properties and patient outcome.
Grateful to the team & collaborators. www.nature.com/articles/s41...
Grateful to the team & collaborators. www.nature.com/articles/s41...
Transposable elements shape stemness in normal and leukemic hematopoiesis - Nature Genetics
This study identifies distinct transposable element subfamilies as genetic determinants of stemness properties in normal and leukemic stem populations with clinical implications for patients with acut...
www.nature.com
May 5, 2026 at 1:56 PM
Excited to share our @natgenet.nature.com study showing that epigenetically rewired transposable elements control AML leukemia stem cell properties and patient outcome.
Grateful to the team & collaborators. www.nature.com/articles/s41...
Grateful to the team & collaborators. www.nature.com/articles/s41...
Open position: PhD Project "Targeting transient adaptations of leukemic stem cells to overcome chemotherapy resistance in acute myeloid #leukemia" - #Heidelberg University.
#science #career #jobs #sciencejobs #job #jobsearch #phd #phdposition
www.science.hr/jobs/230544/...
#science #career #jobs #sciencejobs #job #jobsearch #phd #phdposition
www.science.hr/jobs/230544/...
PhD Project
www.science.hr
May 18, 2026 at 7:01 PM
Open position: PhD Project "Targeting transient adaptations of leukemic stem cells to overcome chemotherapy resistance in acute myeloid #leukemia" - #Heidelberg University.
#science #career #jobs #sciencejobs #job #jobsearch #phd #phdposition
www.science.hr/jobs/230544/...
#science #career #jobs #sciencejobs #job #jobsearch #phd #phdposition
www.science.hr/jobs/230544/...
Looking forward to this talk by @mskcancercenter.bsky.social Susan Dewolf #637 Cross-Talk between Leukemic Blasts and T Cells Drives Targetable T Cell Dysfunction in the AML Tumor Microenvironment Session: 618. AML: Biomarkers
Sunday, Dec 8: 4:30 PM #ASH24 #leusm
ash.confex.com/ash/2024/web...
Sunday, Dec 8: 4:30 PM #ASH24 #leusm
ash.confex.com/ash/2024/web...
Paper: Cross-Talk between Leukemic Blasts and T Cells Drives Targetable T Cell Dysfunction in the AML Tumor Microenvironment
ash.confex.com
December 6, 2024 at 6:23 PM
Looking forward to this talk by @mskcancercenter.bsky.social Susan Dewolf #637 Cross-Talk between Leukemic Blasts and T Cells Drives Targetable T Cell Dysfunction in the AML Tumor Microenvironment Session: 618. AML: Biomarkers
Sunday, Dec 8: 4:30 PM #ASH24 #leusm
ash.confex.com/ash/2024/web...
Sunday, Dec 8: 4:30 PM #ASH24 #leusm
ash.confex.com/ash/2024/web...
Lysozyme-associated nephropathy heralding leukemic transformation in myelofibrosi
#nephsky #nephrology
ashpublications.org/blood/articl...
#nephsky #nephrology
ashpublications.org/blood/articl...
Lysozyme-associated nephropathy heralding leukemic transformation in myelofibrosis
ashpublications.org
August 7, 2026 at 5:25 AM
Lysozyme-associated nephropathy heralding leukemic transformation in myelofibrosi
#nephsky #nephrology
ashpublications.org/blood/articl...
#nephsky #nephrology
ashpublications.org/blood/articl...
Sounds promising! Glad to see RFK hasn’t deleted this study from PubMed yet pubmed.ncbi.nlm.nih.gov/41363805/
Universal Base-Edited CAR7 T Cells for T-Cell Acute Lymphoblastic Leukemia - PubMed
Universal BE-CAR7 T cells induced leukemic remission in patients with relapsed or refractory T-cell ALL, thus allowing successful allogeneic hematopoietic stem-cell transplantation in most of the patients. (Funded by the Medical Research Council and others; ISRCTN Registry number, ISRCTN15323014.).
pubmed.ncbi.nlm.nih.gov
January 31, 2026 at 4:29 PM
Sounds promising! Glad to see RFK hasn’t deleted this study from PubMed yet pubmed.ncbi.nlm.nih.gov/41363805/
Thrilled to share our latest research just published in Leukemia. www.nature.com/articles/s41...
Grateful to all co-authors for their dedicated effort and collaboration. @lundstem.bsky.social @lunduniversity.bsky.social
Grateful to all co-authors for their dedicated effort and collaboration. @lundstem.bsky.social @lunduniversity.bsky.social
Ontogeny-specific induction of the KMT2A::AFF1-fusion drives development of a distinct CD24 positive pre-leukemic state - Leukemia
Leukemia - Ontogeny-specific induction of the KMT2A::AFF1-fusion drives development of a distinct CD24 positive pre-leukemic state
www.nature.com
July 14, 2025 at 2:40 PM
Thrilled to share our latest research just published in Leukemia. www.nature.com/articles/s41...
Grateful to all co-authors for their dedicated effort and collaboration. @lundstem.bsky.social @lunduniversity.bsky.social
Grateful to all co-authors for their dedicated effort and collaboration. @lundstem.bsky.social @lunduniversity.bsky.social
Presenting new work from Drs. Shira Glushakow-Smith and Kira Gritsman (@gritsmanlab.bsky.social)!
@einsteinmededu.bsky.social scientists demonstrate that #AML leukemic stem cells exhibit a selective dependency on PI3Kα.
#OpenAccess 🔓
Learn more: https://go.nature.com/4hFQfnI
@einsteinmededu.bsky.social scientists demonstrate that #AML leukemic stem cells exhibit a selective dependency on PI3Kα.
#OpenAccess 🔓
Learn more: https://go.nature.com/4hFQfnI
September 30, 2026 at 8:46 PM
Presenting new work from Drs. Shira Glushakow-Smith and Kira Gritsman (@gritsmanlab.bsky.social)!
@einsteinmededu.bsky.social scientists demonstrate that #AML leukemic stem cells exhibit a selective dependency on PI3Kα.
#OpenAccess 🔓
Learn more: https://go.nature.com/4hFQfnI
@einsteinmededu.bsky.social scientists demonstrate that #AML leukemic stem cells exhibit a selective dependency on PI3Kα.
#OpenAccess 🔓
Learn more: https://go.nature.com/4hFQfnI
#ASH24 starts today! The Paralkar lab has one oral presentation and two posters - come visit us!
1) 🧪 Saturday Dec 7: 5:30pm: Poster #1275: Eleanor Sams (PhD candidate) presents a detailed map of rRNA transcription and abundance (quantified using FISH-Flow) across normal and leukemic hematopoiesis.
1) 🧪 Saturday Dec 7: 5:30pm: Poster #1275: Eleanor Sams (PhD candidate) presents a detailed map of rRNA transcription and abundance (quantified using FISH-Flow) across normal and leukemic hematopoiesis.
December 6, 2024 at 7:38 PM
#ASH24 starts today! The Paralkar lab has one oral presentation and two posters - come visit us!
1) 🧪 Saturday Dec 7: 5:30pm: Poster #1275: Eleanor Sams (PhD candidate) presents a detailed map of rRNA transcription and abundance (quantified using FISH-Flow) across normal and leukemic hematopoiesis.
1) 🧪 Saturday Dec 7: 5:30pm: Poster #1275: Eleanor Sams (PhD candidate) presents a detailed map of rRNA transcription and abundance (quantified using FISH-Flow) across normal and leukemic hematopoiesis.
CD19.CAR-T cell-derived extracellular vesicles express CAR and kill leukemic cells, contributing to antineoplastic therapy @BloodAdvances
doi.org/10.1182/bloo...
doi.org/10.1182/bloo...
February 5, 2025 at 6:53 PM
CD19.CAR-T cell-derived extracellular vesicles express CAR and kill leukemic cells, contributing to antineoplastic therapy @BloodAdvances
doi.org/10.1182/bloo...
doi.org/10.1182/bloo...
📣 New preprint 📣
We present a detailed map of nascent and mature ribosomal RNAs in mouse hematopoiesis and AML (including absolute rRNA molecule numbers), and outline principles of rDNA regulation.
Work by Eleanor Sams (@eleanor44.bsky.social) & Victoria Feist (@victoriafeist.bsky.social). (1/x)
We present a detailed map of nascent and mature ribosomal RNAs in mouse hematopoiesis and AML (including absolute rRNA molecule numbers), and outline principles of rDNA regulation.
Work by Eleanor Sams (@eleanor44.bsky.social) & Victoria Feist (@victoriafeist.bsky.social). (1/x)
Dynamics of Ribosomal RNA Transcription and Abundance in Normal and Leukemic Hematopoiesis
Transcription of ribosomal RNAs (rRNAs) from rDNA repeats is the first step of ribosome biogenesis, accounting for a major portion of all cellular transcription. Often regarded as a housekeeping proce...
www.biorxiv.org
August 2, 2025 at 5:50 PM
📣 New preprint 📣
We present a detailed map of nascent and mature ribosomal RNAs in mouse hematopoiesis and AML (including absolute rRNA molecule numbers), and outline principles of rDNA regulation.
Work by Eleanor Sams (@eleanor44.bsky.social) & Victoria Feist (@victoriafeist.bsky.social). (1/x)
We present a detailed map of nascent and mature ribosomal RNAs in mouse hematopoiesis and AML (including absolute rRNA molecule numbers), and outline principles of rDNA regulation.
Work by Eleanor Sams (@eleanor44.bsky.social) & Victoria Feist (@victoriafeist.bsky.social). (1/x)
Targeting BCL11B in CAR-engineered lymphoid progenitors drives NK-like cell development with prolonged anti-leukemic activity @moltherapy.bsky.social
www.cell.com/molecular-th...
www.cell.com/molecular-th...
February 16, 2025 at 4:33 PM
Targeting BCL11B in CAR-engineered lymphoid progenitors drives NK-like cell development with prolonged anti-leukemic activity @moltherapy.bsky.social
www.cell.com/molecular-th...
www.cell.com/molecular-th...
For various reasons, it's been a kinda stressful week.
In other news, I had my monthly cancer center appointment today. My leukemic cell count is way down from what it was in May. In May, about 35% of my white cells were bad. That number has been brought down to about 6%, so it's still going well.
In other news, I had my monthly cancer center appointment today. My leukemic cell count is way down from what it was in May. In May, about 35% of my white cells were bad. That number has been brought down to about 6%, so it's still going well.
September 18, 2026 at 2:36 AM
For various reasons, it's been a kinda stressful week.
In other news, I had my monthly cancer center appointment today. My leukemic cell count is way down from what it was in May. In May, about 35% of my white cells were bad. That number has been brought down to about 6%, so it's still going well.
In other news, I had my monthly cancer center appointment today. My leukemic cell count is way down from what it was in May. In May, about 35% of my white cells were bad. That number has been brought down to about 6%, so it's still going well.
Check out our new preprint on an epigenetic resistance mechanism to PI3 kinase inhibition in AML and a new combination therapy with an EZH1/2 inhibitor that depletes leukemic stem cells! Great effort by @thehematopoet and the whole team
So excited to share a pre-print of my thesis work! Check it out to see how we can leverage an epigenetic resistance mechanism to PI3K inhibitors to target leukemic stem cells!! (Spoiler alert: PRC2 is involved!) Really proud of this work conducted with @gritsmanlab.bsky.social
Exploiting an Epigenetic Resistance Mechanism to PI3 Kinase Inhibition in Leukemic Stem Cells https://www.biorxiv.org/content/10.1101/2025.07.11.663968v1
July 16, 2025 at 1:45 AM
Check out our new preprint on an epigenetic resistance mechanism to PI3 kinase inhibition in AML and a new combination therapy with an EZH1/2 inhibitor that depletes leukemic stem cells! Great effort by @thehematopoet and the whole team
Really cool work by Bobby Bowman (UPenn) and Ross Levine (MSK) using next-generation cancer models to study mutations order and dependency in leukemia.
www.cell.com/cancer-cell/...
www.cell.com/cancer-cell/...
In vivo models of subclonal oncogenesis and dependency in hematopoietic malignancy
Bowman et al. develop orthogonal DNA recombinase tools to sequentially and reversibly
control somatic mutations in leukemic evolution. These approaches identify how mutation
timing and order influence...
www.cell.com
November 18, 2024 at 2:10 PM
Really cool work by Bobby Bowman (UPenn) and Ross Levine (MSK) using next-generation cancer models to study mutations order and dependency in leukemia.
www.cell.com/cancer-cell/...
www.cell.com/cancer-cell/...
@biorxivpreprint.bsky.social Epigenetic control of S100A8/A9-driven monocytic inflammation licenses anti-leukemic functionality of immature NK cells during hematopoietic stem cell differentiation
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
March 28, 2026 at 4:32 PM
@biorxivpreprint.bsky.social Epigenetic control of S100A8/A9-driven monocytic inflammation licenses anti-leukemic functionality of immature NK cells during hematopoietic stem cell differentiation
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
#ASH24: Join MSK #leukemia specialist Dr. Susan De Wolf for her presentation on "Cross-Talk between Leukemic Blasts and T Cells Drives Targetable T Cell Dysfunction in the AML Tumor Microenvironment" today at 4:30p PT at
@ash-hematology.bsky.social.
Learn more: bit.ly/4g5K1LD
@ash-hematology.bsky.social.
Learn more: bit.ly/4g5K1LD
December 8, 2024 at 8:52 PM
#ASH24: Join MSK #leukemia specialist Dr. Susan De Wolf for her presentation on "Cross-Talk between Leukemic Blasts and T Cells Drives Targetable T Cell Dysfunction in the AML Tumor Microenvironment" today at 4:30p PT at
@ash-hematology.bsky.social.
Learn more: bit.ly/4g5K1LD
@ash-hematology.bsky.social.
Learn more: bit.ly/4g5K1LD
Exercise-induced NK mobilization combined with cytokine pre-activation yields an adoptive cell therapy product with superior anti-leukemic activity
@bloodadvances.bsky.social @uarizona.bsky.social
ashpublications.org/bloodadvance...
@bloodadvances.bsky.social @uarizona.bsky.social
ashpublications.org/bloodadvance...
January 18, 2026 at 1:34 AM
Exercise-induced NK mobilization combined with cytokine pre-activation yields an adoptive cell therapy product with superior anti-leukemic activity
@bloodadvances.bsky.social @uarizona.bsky.social
ashpublications.org/bloodadvance...
@bloodadvances.bsky.social @uarizona.bsky.social
ashpublications.org/bloodadvance...
Very cool study on leukemic stem cells, thank you @kentsisresearch.bsky.social for letting us be part of it!
A new KRG study led by Sumiko Takao @naturecomms.bsky.social uncovers how epigenetic mechanisms control human leukemia stem cells (LSCs) that fuel therapy resistance in AML. www.nature.com/articles/s41...
Epigenetic mechanisms controlling human leukemia stem cells and therapy resistance - Nature Communications
Acute myeloid leukemia (AML) arise from mutations of stem and progenitor cells. Here, authors identify a quiescent, label-retaining cell population in AML patient specimens that have tumor-initiation ...
www.nature.com
April 4, 2025 at 5:17 PM
Very cool study on leukemic stem cells, thank you @kentsisresearch.bsky.social for letting us be part of it!
ST2/IL-33 axis blockade inhibits regulatory T cell cytotoxicity towards CD8 T cells in the leukemic niche
www.nature.com/articles/s41...
@natcomms.nature.com @sophpacz.bsky.social
www.nature.com/articles/s41...
@natcomms.nature.com @sophpacz.bsky.social
July 21, 2025 at 12:26 PM
ST2/IL-33 axis blockade inhibits regulatory T cell cytotoxicity towards CD8 T cells in the leukemic niche
www.nature.com/articles/s41...
@natcomms.nature.com @sophpacz.bsky.social
www.nature.com/articles/s41...
@natcomms.nature.com @sophpacz.bsky.social
So excited to share a pre-print of my thesis work! Check it out to see how we can leverage an epigenetic resistance mechanism to PI3K inhibitors to target leukemic stem cells!! (Spoiler alert: PRC2 is involved!) Really proud of this work conducted with @gritsmanlab.bsky.social
Exploiting an Epigenetic Resistance Mechanism to PI3 Kinase Inhibition in Leukemic Stem Cells https://www.biorxiv.org/content/10.1101/2025.07.11.663968v1
July 15, 2025 at 9:37 PM
So excited to share a pre-print of my thesis work! Check it out to see how we can leverage an epigenetic resistance mechanism to PI3K inhibitors to target leukemic stem cells!! (Spoiler alert: PRC2 is involved!) Really proud of this work conducted with @gritsmanlab.bsky.social
Excited to share our latest research published today
@nature.com.web.brid.gy"Microbial metabolite drives aging-related clonal hematopoiesis via ALPK1"—study uncovering how diminished gut health and microbiome changes with age promote pre-leukemic cells & disease risk
www.nature.com/articles/s41...
@nature.com.web.brid.gy"Microbial metabolite drives aging-related clonal hematopoiesis via ALPK1"—study uncovering how diminished gut health and microbiome changes with age promote pre-leukemic cells & disease risk
www.nature.com/articles/s41...
April 23, 2025 at 6:17 PM
Excited to share our latest research published today
@nature.com.web.brid.gy"Microbial metabolite drives aging-related clonal hematopoiesis via ALPK1"—study uncovering how diminished gut health and microbiome changes with age promote pre-leukemic cells & disease risk
www.nature.com/articles/s41...
@nature.com.web.brid.gy"Microbial metabolite drives aging-related clonal hematopoiesis via ALPK1"—study uncovering how diminished gut health and microbiome changes with age promote pre-leukemic cells & disease risk
www.nature.com/articles/s41...
Ludwig @ox.ac.uk's Yang Shi presented at the first Plenary Session of #AACR25 on his recent preclinical study examining the perturbation of epigenetic and signaling pathways to force the differentiation of leukemic cells for the treatment of acute myelogenous leukemia (AML). Read more bit.ly/42hT6g7
April 27, 2025 at 3:42 PM
Ludwig @ox.ac.uk's Yang Shi presented at the first Plenary Session of #AACR25 on his recent preclinical study examining the perturbation of epigenetic and signaling pathways to force the differentiation of leukemic cells for the treatment of acute myelogenous leukemia (AML). Read more bit.ly/42hT6g7
So happy to share the latest preprint of the lab, with Marjorie Delahaye as the main actor of this great story. This work demonstrates that the bone marrow microenvironment can imprint (pre-)leukemic cell fate and influence the acquisition of secondary mutations
Signals from the bone marrow B cell niches shape pre-leukemic fate in murine B cell acute lymphoblastic leukemia
The bone marrow (BM) microenvironment plays a key role in supporting B cell development. In acute lymphoblastic leukemia (B-ALL), the acquisition of oncogenic driver mutations blocks B cell differenti...
www.biorxiv.org
February 17, 2025 at 11:19 PM
So happy to share the latest preprint of the lab, with Marjorie Delahaye as the main actor of this great story. This work demonstrates that the bone marrow microenvironment can imprint (pre-)leukemic cell fate and influence the acquisition of secondary mutations
Check out the latest article on malignant hematopoiesis - CBX7 Inhibitors Affect H3K9 Methyltransferase-Regulated Gene Repression in Leukemic Cells www.exphem.org/article/S030...
February 28, 2025 at 11:01 PM
Check out the latest article on malignant hematopoiesis - CBX7 Inhibitors Affect H3K9 Methyltransferase-Regulated Gene Repression in Leukemic Cells www.exphem.org/article/S030...
TGF-β suppresses both NK cell cytotoxicity and migration, limiting their ability to eliminate leukemic cells and infiltrate the bone marrow niche
www.dovepress.com/tgf--decreas...
www.dovepress.com/tgf--decreas...
June 24, 2025 at 1:17 PM
TGF-β suppresses both NK cell cytotoxicity and migration, limiting their ability to eliminate leukemic cells and infiltrate the bone marrow niche
www.dovepress.com/tgf--decreas...
www.dovepress.com/tgf--decreas...